10 results about "Bergamottin" patented technology

The invention discloses application of volatile components of Chuzhou chrysanthemum in preparation of medicines for treating depression and cognitive impairment. The volatile component of the Chuzhou chrysanthemum can be applied to preparation of drugs for treating depression; or preparing a medicine for treating cognitive impairment; or preparing a medicine for protecting neuroendocrine cells; or preparing medicines for treating nervous system diseases. The active ingredients are completely derived from the traditional medicinal plant Chuzhou chrysanthemum, and cell experiments prove that the active ingredients are non-toxic to nerve cells under the effective concentration (less than or equal to 50 mu g / mL) and can antagonize the damage effect of CORT. And compared with a synthetic drug, the anticipated side effect is smaller, and the patient compliance is better. According to the invention, it is found through molecular docking that Z-alpha-trans-bergamot alcohol and bornyl isovalerate have very strong binding activity with core targets EGFR and MAOB for the first time, the two compounds can be deeply developed as brand new lead compounds for treating neurological and mental diseases, and drug sources are expanded.

The invention belongs to the technical field of medicines, and particularly relates to application of bergamolactone serving as a Notum inhibitor, in particular to application of bergamolactone serving as the Notum inhibitor to treatment of Wnt signal channel abnormity related diseases. The bergamolactone disclosed by the invention has excellent pharmacological effects of inhibiting the activity of Notum, down-regulating the expression of Notum, up-regulating the expression of beta-catenin, exciting a Wnt / beta-catenin signal channel, resisting osteoporosis, promoting liver regeneration and liver injury recovery and resisting tumors, is good in safety, can be used for developing products with the activity, including reagents, medicines, medical instruments, health care products, foods and the like, and has a wide application prospect. The application prospect is good.

The invention relates to the technical field of medical application, in particular to application of bergamottin in preparation of a medicine for treating neuroblastoma. The invention discloses the application of bergamottin in treatment of neuroblastoma for the first time, the invention further discloses the application of bergamottin targeting PLOD2 to play an anti-tumor role for the first time, and pharmacodynamic experiment data shows that the bergamottin BGM inhibits tumor growth and neuroblastoma metastasis by targeting PLOD2 expression, and can be used for treating neuroblastoma. Therefore, the bergamotin can be used as a targeted anti-NB potential drug, so that a new target spot is provided for the treatment of neuroblastoma.

The purpose of the present invention is to provide a composition which has a lemon-like sour aroma, has a balanced aroma close to a fresh lemon peel aroma, exhibits a good aroma, has little bitter taste, and is suitable for imparting a lemon peel aroma to a beverage or the like. The invention relates to a composition which is characterized in that the composition contains limonene, citral and beta-caryophyllene, the weight ratio of limonene to beta-caryophyllene, namely limonene / beta-caryophyllene, is 250-2500, the weight ratio of citral to beta-caryophyllene, namely citral / beta-caryophyllene, is 5-110, the content of limonene is 2.5-90 wt%, and the content of beta-caryophyllene is 2.5-90 wt%. The content of bergamotin is 0.01% by weight or less.

The invention discloses a compound bergamot nasal cavity lotion and application thereof, and belongs to the technical field of medicines. According to the invention, the bergamotin, the sodium pyruvate, the honeysuckle flower extract and the lophatherum gracile polysaccharide are combined, the bergamotin can inhibit the combination of virus spike protein and ACE2, the sodium pyruvate can block a virus ROS signal channel, and the honeysuckle flower extract can resist inflammation and inhibit bacteria, through the combination of the substances, the dual mechanisms of physical flushing and drug permeation are realized, and the application prospect is wide. The obtained compound bergamot nasal cavity lotion achieves the synergistic effect, and the antiviral and anti-inflammatory effects are remarkably superior to those of a single-component lotion.

The objective of the present invention is to provide: a composition which has a lemon-like sour flavor, can be used for imparting a lemon peel flavor to a beverage or the like, and has little bitterness even when added to a beverage or the like, and in which aromatic scent is generated satisfactorily; and others. The present invention relates to a composition containing limonene and β-caryophyllene, wherein the weight ratio of limonene to β-caryophyllene (i.e., limonene / β-caryophyllene) is 250-2500, the content of limonene is 2.5-90 wt%, the content of bergamottin is 0.01 wt% or less, and at least one requirement selected from the group consisting of (a1) to (a7) is satisfied.

The application discloses a synthesis method and application of bergamottin, and comprises the following steps: (1) taking m-benzene triol as raw material, and synthesizing 5-methoxy-1,3-benzene diol through a selective etherification reaction; (2) adopting a Pechmann condensation reaction to prepare 5-methoxy-7-hydroxycoumarin; (3) obtaining 5-methoxy-7-allyloxy coumarin through an etherification reaction; (4) preparing 5-methoxy-6-allyl-7-hydroxycoumarin through a Claisen rearrangement reaction; (5) synthesizing 5-methoxypsoralen through an oxidation ring formation reaction; and (6) synthesizing the natural compound bergamottin through a demethylation reaction. The synthesis process is simple, raw materials are cheap, product separation and purification are simple, the yield is higher than 65%, the purity is above 99%, and the product can be produced on a large scale; meanwhile, the bergamottin shows superior antioxidant activity, and the antioxidant performance is superior to corresponding coumarin and benzofuran, and has potential application value.

The application discloses a synthesis method of bergamottin, which comprises the following steps: (1) taking m-benzene triol as raw material, and synthesizing 5-methoxy-1,3-benzene diol through a selective etherification reaction; (2) preparing 5-methoxy-7-hydroxycoumarin through a Pechmann condensation reaction; (3) obtaining 5-methoxy-7-allyloxy coumarin through an etherification reaction; (4) preparing 5-methoxy-6-allyl-7-hydroxycoumarin through a Claisen rearrangement reaction; and (5) synthesizing the natural compound bergamottin through an oxidation ring formation reaction. The synthesis method has the advantages of simple reaction process, cheap and easily obtained raw materials, simple product separation and purification, and high yield (all higher than 69%), and the purity of the bergamottin reaches more than 99%, so that the method can be used for large-scale production and has a wide application prospect.

The present invention provides compositions comprising dihydrokaempferol. The compositions of the present invention can be topically applied to the skin of a subject. The present invention further provides methods of applying compositions comprising dihydrokaempferol to improve or treat skin conditions. The compositions of the present invention can also be applied to improve the overall appearance of the skin.

The invention provides a composition containing ergothioneine as well as a preparation method and application of the composition. A first aspect of the present application provides a composition comprising ergothioneine, anthocyanin, and bergamotin. Anthocyanin can effectively prevent excessive generation of melanin and improve existing melanin pigmentation to a certain extent, and meanwhile bergamottin can inhibit melanin generation and improve melanin pigmentation through multiple signal channels. On the basis, the two components are compounded and matched with ergothioneine with certain anti-inflammatory and anti-oxidation effects, and the melanin pigmentation improving effect better than that of single use or reuse of the two components can be achieved.