41 results about "Umbelliferone" patented technology

A UGT2B inhibitor capable of increasing the bio-availability of a drug, is a compound in a free base or a pharmaceutically acceptable salt form that is selected from the group consisting of: capillarisin, isorhamnetin, β-naphthoflavone, α-naphthoflavone, hesperetin, terpineol, (+)-limonene, β-myrcene, swertiamarin, eriodictyol, cineole, apigenin, baicalin, ursolic acid, isovitexin, lauryl alcohol, puerarin, trans-cinnamaldehyde, 3-phenylpropyl acetate, isoliquritigenin, paeoniflorin, gallic acid, genistein, glycyrrhizin, protocatechuic acid, ethyl myristate, umbelliferone, PEG (Polyethylene glycol) 400, PEG 2000, PEG 4000, Tween 20, Tween 60, Tween 80, BRIJ® 58, BRIJ® 76, Pluronic® F68, Pluronic® F127, and a combination thereof. A UGT2B enhancer capable of enhancing a clearance rate of morphine-like analgesic agents, is a compound in a free base or a pharmaceutically acceptable salt form that is selected from the group consisting of: nordihydroguaiaretic acid, wogonin, trans-cinnamic acid, baicalein, quercetin, daidzein, oleanolic acid, homoorientin, hesperetin, narigin, neohesperidin, (+)-epicatechin, hesperidin, liquiritin, eriodictyol, formononetin, quercitrin, genkwanin, kaempferol, isoquercitrin, (+)-catechin, naringenin, daidzin, (−)-epicatechin, luteolin-7-glucoside, ergosterol, rutin, luteolin, ethyl myristate, apigenin, 3-phenylpropyl acetate, umbelliferone, glycyrrhizin, protocatechuic acid, poncirin, isovitexin, 6-gingerol, cineole, genistein, trans-cinnamaldehyde, and a combination thereof.

In some embodiments, the present invention is directed to a method for chemically modifying 7-substituted coumarins to produce polymerizable monomers that are used to prepare photoresponsive materials. In one embodiment, 7-hydroxy-coumarin (umbelliferone) is so modified. The present invention also relates to the photoresponsive linear polymers, copolymers, and hybrid network materials produced from the polymerizable monomers, and the method for their preparation.

Polymers and copolymers of polymerizable fluorescent compounds of 7-hydroxycoumarin such as Ethyl-2-methacrylate Umbelliferone-4-acetate are provided. In addition, a sensor comprising this polymer notably for detecting and/or assaying nitrated and organophosphorus compounds, explosives, and toxic compounds is provided.

The invention discloses a preparation method of a carbon dot fluorescent probe. The method comprises the following steps: stirring and dispersing an umbelliferone derivative and amino acids in an aqueous solution, performing a reaction at 180-200 DEG C for 12-15 h, centrifuging the obtained suspension to remove large particles, filtering the obtained supernatant by a 0.22-0.25 [mu]m filter membrane to thoroughly remove the large particles, and dialyzing and freeze-drying the filtered supernatant to obtain the product. The probe can realize high-sensitivity and high-selectivity detection of Fe<3+>. The synthesis strategy of the carbon dot hybrid material is provided, a new way is opened up for ion detection, and high-selectivity and specific recognition of iron ions in a water phase is realized.

The invention discloses radix peucedani health tea and a preparation method thereof, and relates to the technical field of health maintenance tea processing. The radix peucedani health tea is obtained by processing raw materials including tea leaves, radix peucedani, white mulberry root-bark, fritillaria and radix glycyrrhizae through the eight steps of radix peucedani leaf picking, fresh tea leaf picking, radix peucedani root processing, blending and soaking, rolling, fermentation, stir-frying and packaging. The tea leaves and radix peucedani are used as main materials, radix peucedani leaves containing beneficial components such as nodakenin, decursitin and umbelliferone are soaked in radix peucedani root wine decocted liquid together with fresh tea leaves, functional components in radix peucedani are fully absorbed, and therefore slight enzymatic reaction is achieved, the effective components of radix peucedani are reasonably blended in the tea leaves, and the prepared health tea has the effects of removing wind, releasing heat, depressing qi and reducing phlegm.

The invention relates to a cooling agent and a synthesis method thereof. The synthesis method of the cooling agent comprises the following steps of 1, cleaning up a reactor by an ethanol solution, and removing air in the reactor, 2, adding an ethanol solution as a reaction solvent, umbelliferone and a Pd/C catalyst into the reactor, feeding hydrogen into the reactor, and heating for a reaction lasting for 6 to 8 hours, and 3, removing the Pd/C catalyst, adding NaBH4 into the product obtained by the step 2 for a sequential reaction, acidizing the reacted mixture obtained by the sequential reaction, carrying out extraction by ether to obtain extract, and carrying out reduced pressure distillation of the extract to obtain the cooling agent, wherein the cooling agent comprises four 1-isopropyl-4-methylbicyclo[3.1.0]-hexyl-2-alcohol structural isomers. The cooling agent has a gentle cool taste, long time of duration, obviously low irritation on the laryngeal, an obviously slight dry sensation, and a very strong moistening feel.

The invention discloses an application of umbelliferone in preparing an anti-eimeria tenella medicine. The umbelliferone and an acceptable auxiliary material are prepared as powder which is added into feed and uniformly mixed and is used for feeding chicken according daily feed amount. Or, the umbelliferone is prepared as umbelliferone water soluble powder which is dissolved in water and is used for feeding chicken according to daily water consumption. Animal infection experiments verify that the anticoccidial index (ACI) of the umbelliferone can reach over 165, and the umbelliferone has a better anti-eimeria tenella effect.

The invention provides tobacco flavor capable of reducing hazardous substance in smoke and a preparation method thereof. The invention further provides application of tobacco flavor in bobbin paper. Adopted celery seeds have pleasant strong fragrance and acrid and bitter taste, and can cover up the woodiness and scorch smell in bobbin paper made in China and improve smoking flavor of cigarettes after being combined with vitexin, umbelliferone and maltol; meanwhile, by adopting the specific production technology, the content of nitrosamine in smoke can be reduced, and therefore harm of smoke to the human body is reduced. Compared with the prior art, after bobbin paper is sprayed with the tobacco flavor, the woodiness and scorch smell in bobbin paper made in China are covered, simulation of the bobbin paper made in China is reduced, and the smoking flavor of the cigarettes is good. The content of the harmful ingredient nitrosamine in smoke can be reduced, and harm of smoke to the human body is reduced.

The invention relates to the technical field of application of umbelliferone, and in particular relates to application of umbelliferone in preparing a composition for resisting skin photoaging. The invention discloses application of umbelliferone in preparing the composition for resisting skin photoaging. According to the invention, experiments prove that the umbelliferone can significantly improve the cell activity after UVB irradiation; cell apoptosis induced by UVB and secretion of cell inflammatory factors are inhibited; the expression of MMP-1 and MMP-9 induced by the UVB is reduced; and inhibition of apoptosis and activation of NF-kappa B and MAPK signal channels proves that umbelliferone is an effective substance for resisting skin photoaging.

The invention discloses a fluorescent chromogenic culture medium for detecting staphylococcus aureus. The fluorescent chromogenic culture medium is prepared from a nitrogen source, a carbon source, sodium chloride and an infectious microbe growth inhibitor. The fluorescent chromogenic culture medium is characterized by further being prepared from staphylococcus aureus chromogenic substrate 4-methyl umbelliferone-p-nitro beta-D-glucoside and beta-D-glucoside, non staphylococcus aureus chromogenic substrate paranitrophenol-alpha-D-galactopyranose and non staphylococcus aureus chromogenic substrate p-nitrophenol beta-D-glucuronide. The fluorescent chromogenic culture medium disclosed by the invention can provide a more convenient chromogenic scheme for distinguishing the staphylococcus aureusfrom other staphylococcus under the situation without color developing aid existence, can effectively distinguish the staphylococcus aureus from a part of non staphylococcus aureus and other infectious microbes and has a better selectivity to the staphylococcus aureus.

The present invention discloses a method to determine whether a warning sign will occur in a subject with the Flavivirus infectious illness, and a pharmaceutical composition. The method includes steps of measuring the level of serum hyaluronan of the subject, and determining that the warning sign will occur in his/her illness course when the level is higher than or equal to 70 ng/mL. It is identified in the invention that the level of the serum hyaluronan is an excellent predicator for the severity of the Flavivirus infectious illness. The pharmaceutical composition is used for blocking the serum hyaluronan of the Flavivirus-infected subjects to prevent inflammation, and includes a therapeutically effective amount of a 4-methyl umbelliferone sodium salt, a CD44 siRNA, an anti-CD44 antibody or a hyaluronidase, wherein the therapeutically effective amount is an effective blood concentration of the 4-methyl umbelliferone sodium salt, the CD44 siRNA, the anti-CD44 antibody, and the hyaluronidase of the subject being in a range from 0.05 mM to 5 mM, 1 nM to 100 nM, 5 μg/ml to 500 μg/ml and 0.5 unit/mL to 50 units/mL, respectively.

The invention discloses a method for detecting effective components of girald daphne bark. The method includes the steps of firstly, preparing a reference substance solution, wherein a mixed solution containing daphnetin and umbelliferone is prepared from daphnetin and umbelliferone reference substances; secondly, preparing a test article solution, wherein girald daphne bark tablets are taken to be fine ground, solvent is added, ultrasonic treatment is conducted, and then filtering is conducted to obtain subsequent filtrate; thirdly, conducting detecting, wherein the reference substance solution and the test article solution are taken to be injected into a liquid chromatograph, a chromatogram is obtained, and the contents of the corresponding components in a test article are calculated according to the chromatogram.

The invention discloses a composite for preventing and treating gray mold of cucurbita pepo and a bactericide prepared by the composite. The composite is prepared from, by mass, 50-80% of difenoconazole, 10-40% of umbelliferone and 1-15% of oxidized graphene. According to the composite for preventing and treating gray mold of cucurbita pepo, difenoconazole, a plant extract (umbelliferone) and oxidized graphene are mixed, and the three components achieve synergism within a specific proportion range; the mixed composite reduces the dosage of difenoconazole and meanwhile has great inhibition activity on gray mold of cucurbita pepo, wherein the inhibition activity is equivalent to that of a single agent (difenoconazole). After the mixed composite is made into the bactericide for use, gray moldof cucurbita pepo can be effectively prevented and treated, the dosage of difenoconazole can also be reduced at the same time, and the situation is slowed down and/or avoided that pathogenic bacteriaof gray mold of cucurbita pepo has resistance to difenoconazole.

The invention relates to a drug combination and belongs to the field of medicines. The drug combination comprises, by weight, 5-30 parts of umbelliferone, 5-20 parts of 7-hydroxy-8-methoxycoumarin, 2-20 parts of 8-hydroxy-7-methoxycoumarin, 5-20 parts of luteolin, and 5-20 parts of 4', 7-dyhydroxy-5-methoxyflavone. The drug combination is used for preparing anti-inflammatory, analgesic and antiviral drugs. Dosage of active substances of the anti-inflammatory, analgesic and antiviral drug combination can be changed according to age and weight of patients, disease severity and other like factors, and 50mg-100mg is taken orally for twice a day.

The invention discloses a composition for prevention and control of actinidia chinensis gray mold and a fungicide prepared therefrom. The composition comprises the following components by mass percentage: 40%-80% of difenoconazole, 15%-50% of umbelliferone, and 1%-15% of graphene oxide. According to the composition for prevention and control of actinidia chinensis gray mold provided by the invention, difenoconazole, the plant extract umbelliferone and graphene oxide are compounded, within a specific proportion range, the three components play a synergistic role cooperatively, while the dosageof difenoconazole is lowered, good inhibitory activity of the composition on strawberry gray mold can be guaranteed, and the inhibiting effect is equivalent to that of the single agent difenoconazole.The mixed composition can be prepared into a fungicide for use, and the fungicide can effectively prevent and control actinidia chinensis gray mold, at the same time can reduce the dosage of difenoconazole, and slow down and/or prevent the actinidia chinensis gray mold pathogens from producing resistance to difenoconazole.

The invention provides a medicine for treating tropical theileriosis. The effective component of the medicine is 4-methyl umbelliferone. The medicine disclosed by the invention has a good treatment effect on the tropical theileriosis, the recovery rate reaches 92.3% and is superior to that of the existing medicine triazamidine, the loss of farmers is reduced, and the economic benefits of the sheepfarmers are improved.

The invention discloses a composite for preventing and treating gray mold of tobacco and a bactericide prepared by the composite. The composite is prepared from, by mass, 50-75% of difenoconazole, 10-40% of umbelliferone and 0.1-20% of oxidized graphene. According to the composite for preventing and treating gray mold of tobacco, difenoconazole, a plant extract (umbelliferone) and oxidized graphene are mixed, and the three components achieve synergism within a specific proportion range; the mixed composite reduces the dosage of difenoconazole and meanwhile has great inhibition activity on graymold of tobacco, wherein the inhibition activity is equivalent to that of a single agent (difenoconazole). After the mixed composite is made into the bactericide for use, gray mold of tobacco can beeffectively prevented and treated, the dosage of difenoconazole can also be reduced at the same time, and the situation is slowed down and/or avoided that pathogenic bacteria of gray mold of tobacco has resistance to difenoconazole.

The invention discloses application of umbelliferone in preparation of a medicine for treating vaginitis, and experiments prove that umbelliferone has an inhibition effect on fungi and bacteria causing vaginitis.

The invention discloses a preparation method of Ainsliaea lactone substances. The lactone substances mainly comprise umbelliferone, Ainsliaea terpene, ainsliadimer A, gochatiolide A and the like. The invention particularly discloses the method for obtaining the Ainsliaea lactone substances by separating from Ainsliaea plants. The method comprises the following steps of raw material grinding, supercritical extraction, activated carbon decolorization, solvent extraction, dehydration, drying and the like so that the Ainsliaea lactone substances are finally obtained, wherein the total content of the umbelliferone, the Ainsliaea terpene, the ainsliadimer A and the gochatiolide A reaches above 60%.