8 results about "Umbelliferone" patented technology

The invention discloses laurel essential oil with anti-aging activity and application of the laurel essential oil. According to the method, laurel essential oil is used for acting on caenorhabditis elegans to verify the aging delaying effect of the caenorhabditis elegans, after the caenorhabditis elegans are counted and subjected to synchronization treatment, a life determination test of the caenorhabditis elegans is carried out, a blank control group, a DMSO solvent group, a positive drug group and a laurel essential oil experimental group are set respectively, a survival curve is drawn, and statistical analysis is carried out. Results show that the lifetime of nematodes in a laurel essential oil treatment group is remarkably prolonged, and the anti-aging effect of the laurel essential oil treatment group is superior to that of a Meanwhile, target function analysis on the laurel essential oil shows that the essential oil regulates and controls senescence-related pathways. The further determination of the effect of monomer components in the laurel essential oil on delaying caenorhabditis elegans aging shows that p-cymene, methyleugenol, ocimene, linalool, sabinene, 4-terpene alcohol, terpinene and linalyl acetate show significant anti-aging activity.

The application discloses a kind of nanomedicine for tumor hypoxia, which is prepared by mPEG-SS-PLGA wrapping drug IR-1048, PFOB and 4-MU.The nanomedicine of the application is constructed by wrapping perfluorooctyl bromide (PFOB), 4-methyl umbelliferone (4-MU) and IR-1048 in tumor microenvironment-responsive amphiphilic polymer mPEG-SS-PLGA, and in response to high GSH in tumor area, 4-MU, PFOB and IR-1048 are released; 4-MU makes the dense tumor extracellular matrix loose, so that tumor vessels are normalized, which is conducive to PFOB carrying oxygen into the tumor interior, long-term solution of tumor hypoxia, remodeling of tumor microenvironment, and reduction of myeloid-derived suppressor cell (MDSC) infiltration; and under the action of 980nm laser in vitro, IR-1048 responds, and the effect of photothermal therapy of tumor is improved.

The application relates to the technical field of pharmaceutical preparations, and provides an ivermectin external pharmaceutical composition, a preparation method and application.The ivermectin external pharmaceutical composition is mainly composed of ivermectin, a permeation enhancer combination, oil ingredients, an emulsifier, a viscosity regulator and a carrier; the ivermectin content is 0.60%-1.00% w / w; the permeation enhancer combination is a combination of diethylene glycol monoethyl ether, decyl umbelliferrone polyoxyethylene ether 8 and farnesol, and the content is 10%-15% w / w.The application overcomes the defects of the prior art, the composition not only has improved skin permeability and retention, but also is stable and non-greasy, and meanwhile, the production process has scalability, and can ensure uniform dispersion of active ingredients and auxiliary materials.

The application belongs to the field of genetic engineering, enzyme engineering and natural product biosynthesis, and particularly relates to a coumarin O-methyltransferase, a coding gene thereof and application. The natural product O-methyltransferase is selected from one or more of PcOMT1, PcOMT2, PcOMT7 and PcOMT10, and the amino acid sequences thereof are SEQ ID NO:1-4 in sequence; specifically, the PcOMT1 can catalyze umbelliferone to generate 7-methoxycoumarin, catalyze bergaptan to generate bergapten, and catalyze xanthotoxol to generate xanthotoxin; any one of the PcOMT2, the PcOMT7 and the PcOMT10 can catalyze bergaptan to generate bergapten, and catalyze xanthotoxol to generate xanthotoxin.

A composition is disclosed comprising a coumarin or a derivative thereof for use in a method of treating a disease or disorder associated with cell senescence. Alternatively or additionally, the composition may comprise a plant extract comprising a coumarin or a derivative thereof . Also disclosed is a cosmetic method for preventing, minimising or reducing cell senescence, comprising contacting the skin of an individual with said composition. Preferred coumarin compounds used in the composition include osthole, xanthotoxin, bergapten, isopimpinellin, umbelliferone and imperatorin. The compounds may be sourced from extracts of Umbelliferae, in particular Angelica or Cnidium. The compounds are especially useful in the treatment of skin aging where they preserve, maintain or improve epidermal thickness, function and / or quality.

The invention relates to an anhydrous scalp repair base solution and a preparation method thereof. Three leading-edge skin care concepts of'micro-ecological management ', 'barrier repair' and'cell defense 'are systematically integrated in the scalp care field for the first time, the three systems cooperate with one another to jointly construct a complete scalp health management closed loop, and the limitation of a single technical path is solved. Micro-ecology is managed in an intelligent adjusting mode, and barrier repair is combined, so that the health basis of scalp is fundamentally improved, and the recurrence rate of problems is effectively reduced. Wherein anti-light aging and anti-pollution components such as phytosterol, cholesterol, cymene-5-ol, inulin, hydrated silica and the like which are verified in skin care products are introduced, active intervention on scalp aging factors is realized in wash-off products for the first time, anhydrous formula design is matched with a simple mixing preparation process, the activity of functional components is ensured, and the skin care product has good skin care effect. The market requirements are effectively met.

The present application relates to a kind of methods for extracting active ingredients of Saussurea, including anisodine and umbelliferone, characterized in that, the extraction method includes the following steps: (1) obtain Saussurea paste; (2) 3-10% mass of ammonium bicarbonate is added in Saussurea paste, and the extract is obtained under the condition of ultrasonic power 200-400W, ultrasonic frequency 30-50kHz, room temperature for 30-50 minutes; (3) the extract is concentrated to relative density 1.1-1.3g / ml under reduced pressure to obtain extract infusion; (4) 0.8-1.5 times volume of cyclohexane is added in extract infusion for extraction, and the supernatant is concentrated under reduced pressure to obtain the final Saussurea extract. By using the method of the present application, the content of anisodine and umbelliferone in Saussurea extract can be effectively improved.

To remove senescent cells, and / or to prevent, suppress, or improve skin aging phenomena such as age spots, wrinkles, sagging, dullness, thinning of the skin, weakening of the skin, decreased skin barrier function, and dryness by removing senescent cells. [Solution] A composition containing lactic acid, indole lactic acid, phenyl lactic acid, catechin, caffeic acid, umbelliferone, parthenolide, pyridoxine hydrochloride, arbutin, hinokitiol, oxaloacetate, tocotrienol, tocopherol, γ-oryzanol, retinol acetate, retinyl palmitate, riboflavin, and pantothenyl ethyl ether, as well as chemically possible salts thereof, and at least one selected from the group consisting of Enterococcus bacteria and Lactobacillus bacteria.