167 results about "Natural compound" patented technology

The invention relates to the technical field of natural compounds, in particular to ganoderma leukemia polysaccharide and a preparation method thereof. The ganoderma leukemia polysaccharide comprises galactose, glucose and mannose, and the molar ratio of the galactose to the mannose to the glucose is (1.5-3.5): (15-30): (65-85); the ganoderma leukemia polysaccharide comprises:-> 6)-Glcp-(1-> dominant residues; (-> 6)-Manp-(1->,-> 4)-Glcp-(1-> residue; and-> 4, 6)-Manp-(1->,-> 3, 6)-Galp-(1->. The ganoderma leukemia polysaccharide has anti-oxidation and detoxification capabilities, can avoid neurodegenerative diseases, reduce lipid accumulation and prolong the service life, and also has high-temperature resistance.

A system and method are herein disclosed. The system and method use a generative AI agent to analyze and identify synergistic blends of natural compounds for combination therapies by leveraging an array of specialized modes to access data from a multitude of sources including patient medical history (including test results, drug history, and imaging) to improve the efficacy of compounds, including traditional medicine, in line with combination therapy principles, aimed at: enhanced efficacy, decreased toxicity, improved dosage, and reduced drug resistance. In this way, the generative AI agent determines cross-therapeutic similarities and / or dissimilarities between pharmaceutical, naturopathic, homeopathic, and nutraceutical compounds along a plurality of compound property vectors such as efficiency, efficacy, toxicity, effects, side-effects, chemistry, pharmacology, pharmacokinetics, mechanisms of action, and pharmacodynamics, thereby enabling the proposition of cross-disciplinary and transdisciplinary therapeutic analyses and the identification of synergistic effects in combination therapies.

The invention is applicable to the technical field of biological medicines, provides application of a natural compound of a targeted colon cancer drug resistance related protein, and particularly relates to application in preparation of drugs for preventing or treating colon cancer. According to the invention, a natural small molecule compound neohesperidin dihydrochalcone targeting the colon cancer drug resistance related protein TAGLN is screened out, and a new scheme is provided for reversing colon cancer drug resistance, so that the situation that no drug is available to the target spot is solved. Secondly, the invention also provides a scheme for combined use of neohesperidin dihydrochalcone and oxaliplatin, the scheme can significantly enhance the killing effect of oxaliplatin on drug-resistant colon cancer, and a new choice is provided for clinical treatment of colon cancer.

The invention relates to the technical field of medicines, in particular to a composite nano vaccine and application thereof. The composite nano vaccine is prepared by coupling a natural compound with endoplasmic reticulum stress induction capability on the surface of Ga-MOF nano particles. The composite nano vaccine can significantly enhance the anti-tumor effect through a ferroptosis mechanism, an endoplasmic reticulum stress and immunogenic cell death mechanism and a cryoablation technology synergistic effect mechanism, reverses an immunosuppressed tumor microenvironment, inhibits the growth of primary tumors and distant metastatic tumors, and has a good anti-tumor effect. A brand new strategy is provided for comprehensive treatment of tumors, and the application prospect is wide.

The invention relates to the technical field of herbicides, in particular to an allelochemical-based organic herbicide and application thereof. The herbicide is prepared from the following active ingredients: L-menthone, pulegone and beta-caryophyllene. The mass ratio of the L-menthone to the pulegone to the beta-caryophyllene is (1 to 4) to (1 to 4) to 1. The three substances are compounded to generate a synergistic effect of '1 + 1 + 1 gt and' 3 ', the herbicidal activity is far better than that of a single agent, and the use concentration of each component is remarkably reduced. All the components are plant source natural compounds, the degradation path is clear, rapid metabolism can be achieved through microbial decomposition in soil and water, and no complex residual product exists.

A method for treating a gastrointestinal condition includes preparing an aqueous extract of bioactive compound by adding dried green tea material to hot water and filtering the aqueous extract; adding a solution of an iron-containing compound to the filtered aqueous extract to form a complex or chelate of the bioactive compounds with iron; and drying the solution at a temperature between 80 to 150 degrees Fahrenheit to obtain a fine granular or powdered state.

This invention belongs to the field of biomedical technology, specifically relating to a compound extracted from *Acer buergerianum* (a type of shrub), its extraction method, and its application in the preparation of drugs for the prevention or treatment of non-alcoholic fatty liver disease. This invention is the first to obtain a natural compound with a novel structure from *Acer buergerianum*, and provides a method for its preparation. Activity studies were conducted, and experimental data show that the compound exhibits low cytotoxicity and no significant cytotoxicity to normal cells. It can inhibit the expression of fatty acid synthases ACC, ACLY, and FAS, thereby inhibiting de novo fatty acid synthesis in cells, suppressing lipid droplet accumulation, and reducing cellular lipid levels. This compound has broad application prospects in the preparation of drugs for the prevention or treatment of non-alcoholic fatty liver disease.

The application belongs to the technical field of biological medicine, and provides application of a natural compound targeting colon cancer drug resistance related protein, in particular, application in preparation of a drug for preventing or treating colon cancer; the application screens out a natural small-molecule compound hesperetin dihydrochalcone targeting colon cancer drug resistance related protein TAGLN, and provides a new scheme for reversing colon cancer drug resistance, so as to solve the situation that no drug is available for the target point. In addition, the application further provides a scheme in which hesperetin dihydrochalcone is combined with oxaliplatin, and the scheme can significantly enhance the killing effect of oxaliplatin on drug-resistant colon cancer, thereby providing a new choice for clinical treatment of colon cancer.

The application discloses a preparation method of egg yolk phospholipid polypeptide which is helpful for bone growth and improvement of brain health, and comprises the following steps: (1) raw material pretreatment to obtain a reaction substrate solution; (2) primary enzymolysis to prepare a primary enzymolysis solution; (3) secondary enzymolysis to prepare a secondary enzymolysis solution; (4) inactivation, the temperature of the secondary enzymolysis solution prepared in the step (3) is adjusted to 85-95 DEG C, and the enzyme is completely inactivated by keeping for 10-15 min; (5) fermentation; (6) post-treatment, the fermentation liquid after the fermentation is kept at 50-60 DEG C for 10-30 min, and then cooling, centrifugation, collection of supernatant, vacuum freeze drying or spray drying of the supernatant are carried out, so that the egg yolk phospholipid polypeptide powder is obtained. The natural compound rich in specific functional peptide segments and phospholipids is prepared through the two-step enzymolysis coupling fermentation process, can effectively promote the growth and development of the bone, significantly improve the learning, memory and cognitive ability, and can significantly promote the proliferation of osteoblasts.

The invention discloses a phenylboronic acid affinity deoxynojirimycin imprinted polymer nano-material as well as a preparation method and application thereof, and belongs to the fields of nano-material preparation and natural compound extraction and separation. Phenylboronic acid modified nano silica gel is used as a carrier, deoxynojirimycin is used as a template molecule, dopamine is used as a cross-linking agent, a polyethyleneimine hyperbranched strategy is further combined, a deoxynojirimycin molecularly imprinted polymer (MIPs-PEI) with boric acid affinity and pH response characteristics is constructed, and hyperbranched modification remarkably improves hydrophilicity and boric acid affinity sites of the material. The synthesized MIPs-PEI has good adsorption performance on deoxynojirimycin and can effectively enrich deoxynojirimycin in mulberry leaves, and the natural hypoglycemic alkaloid deoxynojirimycin is extracted in a green mode through the method.

The application belongs to the technical field of medicine, and discloses application of SERPINE1 protein or a coding gene thereof as a new target for hepatitis B virus treatment. The application first discloses that SERPINE1 promotes autophagy flux by directly combining PIKfyve protein, thereby significantly inhibiting HBV replication and HBsAg expression. Based on this, the application establishes a multi-dimensional target verification platform, and first discovers that a natural compound, betulinic acid, is a high-affinity agonist (KD=1.46 µM) of SERPINE1. In-vivo and in-vitro experiments prove that betulinic acid can effectively reduce the levels of HBsAg and HBV DNA, and has good safety. In addition, betulinic acid and entecavir show a synergistic antiviral effect (CI<1). The application provides a new target and treatment strategy for realizing functional cure of hepatitis B.

Disclosed is a hair dye base composition comprising an improved basifying agent, which improvement is embodied in the overall reduction of ammonia compounds, thereby advantageously minimizing the problems associated with ammonia compounds. The composition provides a satisfactory hair dyeing covering power without malodors or damage to the scalp that are typically caused by ammonia compounds, while being free of ingredients known to cause skin damage problems, such as ethoxylated compounds, PEG and derivatives thereof, and silicones, since the composition contains a high percentage of natural compounds. Therefore, the composition of the present invention is significantly healthier for customers / consumers and hairstylists using the composition, while maintaining high performance of hair dyeing. Also disclosed are multi-compartment kits comprising the compositions, dyes and oxidizing components, as well as their use in permanent hair dyeing. Also disclosed is a process for producing the hair dye base composition, and a hair dyeing method comprising applying the composition to the hair.

The invention discloses a gallic acid-based cationic photodynamic antibacterial agent with sterilizing, anti-infection and wound healing promoting effects and a preparation method thereof, and belongs to the technical field of antibacterial agent synthetic chemistry. The cationic photodynamic antibacterial agent EY-QEGDM-MG is prepared by taking a natural compound gallic acid as a raw material and carrying out ring opening polymerization and quaternization reaction with photosensitizer eosin EY and ethylene glycol diglycidyl ether (EGDE), and the polymer shows an excellent antibacterial effect on escherichia coli and multi-drug-resistant MRSA germs under the action of illumination, and can be used for preparing a cationic photodynamic antibacterial agent EY-QEGDM-MG. The polymer has good blood compatibility and cell compatibility, in addition, the polymer can kill bacteria around infected wounds and can rapidly promote wound healing, and therefore the polymer can provide a new method for photodynamic antibacterial agents for treating the infected wounds in hospitals.

The invention discloses a ferulic acid derivative and a preparation method and application thereof.The ferulic acid derivative is a compound shown in the formula (I) or pharmaceutically acceptable salt of the compound, and the compound is a natural compound extracted from rubus corchorifolius stems, has anti-inflammatory activity and anti-tumor activity and has the potential of being developed into anti-inflammatory or anti-tumor drugs. Or as a lead compound.

The invention discloses a tetrahydrofuran lignan compound as well as a preparation method and application thereof, the tetrahydrofuran lignan compound is a compound shown as a formula (I) or pharmaceutically acceptable salt thereof, the compound is a natural compound extracted from rubus corchorifolius stems, has anti-inflammatory activity and anti-tumor activity, and can be used for preparing a medicine for treating tumors. The compound has the potential of being developed into anti-inflammatory or anti-tumor drugs and can be used as a lead compound.

The invention belongs to the field of natural compounds, and particularly relates to application of VMO1 protein in toxicity resistance, oxidation resistance, thrombolysis and sperm motility regulation. According to the specific technical scheme, the application of the VMO1 protein in preparation of drugs for inhibiting bacteria, resisting toxicity, resisting oxidation and improving or reducing sperm motility is provided, and the amino acid sequence of the VMO1 protein is shown as SEQ NO ID: 1. It is found for the first time that the VMO1 protein extracted from frog follicles not only can inhibit the activity of pseudomonas aeruginosa, but also can resist toxicity, and meanwhile, the VMO1 protein has a good antioxidant effect, a thrombus dissolving effect and a bidirectional sperm motility adjusting effect. Therefore, the VMO1 protein has huge pharmaceutical potential.

The present application relates to the application of ocanin in the preparation of anti-tumor drugs, and the ocanin is used in the anti-tumor drugs alone or in combination with 5-fluorouracil, and the concentration of the ocanin used in the preparation of anti-intestinal cancer drugs is 20-500 uMol. It is found that the ocanin can inhibit the growth of intestinal cancer cells in vivo and in vitro, and the naked mice have good tolerance to the natural compound. The ocanin has better anti-intestinal cancer effect than other extracts of goldeneye and devil's needle, and has better anti-cancer effect and smaller toxicity than the current conventional intestinal cancer drug 5-fluorouracil. Therefore, the ocanin can be developed into a new anti-cancer drug.

The invention belongs to the technical field of medicines, and particularly relates to tripterine-loaded nano-particles as well as a preparation method and application thereof, and the tripterine-loaded nano-particles (Cel-GDNPs) comprise ginger exosome (GDNPs) and tripterine (Cel) encapsulated in the ginger exosome. According to the invention, the Cel is used as a therapeutic drug, and the adopted carrier GDNPs has anti-inflammatory activity, so that when the Cel and the GDNPs are used for treating inflammatory diseases such as colitis and the like, the Cel and the GDNPs can play a multi-component synergistic therapeutic effect, and compared with the single use of the Cel or the GDNPs, the expression of proinflammatory factors (such as TNF-alpha, IL-1beta and IL-6) can be more effectively inhibited, so that the synergistic therapeutic effect is realized; a new strategy is provided for developing a novel natural compound preparation.

The invention belongs to the technical field of biological medicines, and particularly relates to a daphniphyllum calycinum extract compound, an extraction method thereof and application of the daphniphyllum calycinum extract compound in preparation of a medicine for preventing or treating non-alcoholic fatty liver diseases. A natural compound with a novel structure is obtained from daphniphyllum calycinum for the first time, a preparation method of the compound is provided, activity research is carried out on the compound, and experimental data shows that the compound is low in cytotoxicity and has no obvious cytotoxicity to normal cells, and the compound can be used for preparing the compound by inhibiting expression of fatty acid synthetases ACC, ACLY and FAS. The compound inhibits the de novo synthesis of fatty acid in cells, thereby inhibiting the accumulation of lipid droplets in the cells and reducing the lipid level in the cells, and has wide application prospects in the field of preparation of drugs for preventing or treating non-alcoholic fatty liver diseases.

The application discloses a Daphnane type macrocyclic diterpenoid compound with a 4,7-oxygen bridge structure and a preparation method and application thereof. The monomer compound is obtained by repeatedly separating and purifying an ethyl acetate part extract of Daphne giraldii by using various separation fillers and separation technologies. The new compound is subjected to structural identification by using various 1D and 2D nuclear magnetic resonance spectrometry and high resolution mass spectrometry (HR-ESI-MS) and the like, and a molecular formula and a structural formula thereof are deduced. Further in-vitro cell activity researches show that the Daphnane type macrocyclic diterpenoid compound with the 4,7-oxygen bridge structure separated from the Daphne giraldii has good inhibitory activity on melanoma cells. The application is helpful to development and utilization of natural compounds of the Daphne giraldii.

The invention relates to an antibacterial contact lens silicon hydrogel composite material and a preparation method thereof, and belongs to the technical field of silicon hydrogel materials, and the preparation method comprises the following steps: combining a natural compound with a biocompatible material to obtain a composite material; combining the composite material with a zwitterionic polymer to obtain an antibacterial reinforced material; the preparation method comprises the following steps: mixing a siloxane oligomer, an antibacterial reinforcing material, a hydrophilic monomer, a small molecular silicon monomer, a thermal initiator and a cross-linking agent, and carrying out polymerization reaction to obtain the antibacterial contact lens silicon hydrogel composite material, according to the technical scheme, the natural compound is combined with the biocompatible material, so that the antibacterial property and the stability of the silicon hydrogel composite material can be effectively improved; the composite material is combined with the zwitterionic polymer, so that the hydrophilicity and moisture retention of the silicon hydrogel composite material can be improved, the antibacterial performance of the silicon hydrogel composite material is further improved, and the comprehensive performance of the antibacterial contact lens silicon hydrogel composite material is generally improved.

The present application relates to the technical field of biological control of agricultural pests, and particularly relates to a method for improving pathogenicity of Metarhizium rileyi CQMa421 to Nilaparvata lugens by using carbon-hydrogen compounds on the body surface of the brown planthopper. The method for improving pathogenicity of Metarhizium rileyi to Nilaparvata lugens comprises mixing an effective dose of n-undecane liquid agent with the Metarhizium rileyi. The present application adopts the mixed use of n-undecane and Metarhizium rileyi, shortens the median germination time of Metarhizium rileyi, accelerates the initial process of infection, improves the pathogenicity to Nilaparvata lugens, and is conducive to rapid pest control. The n-undecane is a natural compound carried by insects, and the compound is safe to the environment and non-target organisms, and meets the development needs of green agriculture. The method only needs to simply mix the existing Metarhizium preparation with n-undecane before application, without the need to change the existing application equipment and process, and is easy to popularize and apply.

The invention aims to provide a novel application of a known natural compound. By screening and researching small molecular compounds derived from medicinal and edible substances, the fact that the original aubergine A has the activity of resisting chikungunya virus infection is found. Research results show that the original aubergine A can inhibit the infection process of chikungunya virus in a cellular level and an animal model, and shows relatively low cytotoxicity in an effective dose range. The invention provides the application of the protoaucoside A in preparation of the medicine for resisting chikungunya virus infection, provides a new technical scheme for prevention and treatment of chikungunya virus infection, and has potential application value.

The invention provides application of kestose in preparation of a medicine for treating heart failure related diseases, and belongs to the technical field of biological medicine. The prominent application value of the natural compound kestose in prevention and treatment of heart failure related diseases is disclosed for the first time. The traditional Chinese medicine composition has the direct effects of remarkably improving cardiac insufficiency and relieving myocardial injury; in the aspect of product application, a brand-new choice of a heart failure treatment medicine derived from a natural product is provided for clinic, the medicine has a good myocardial protection effect, a solid foundation is laid for developing a targeted treatment strategy aiming at a specific pathological link of chronic cross-induction, and the application has a wide application prospect. Important theoretical significance and wide clinical application prospects are realized.

The present invention provides methods for controlling gene expression of gene 5 engineered organisms using inducer compounds. The invention also relates to genetically modifying microorganisms by using natural and / or non-natural inducer compounds, such as carbon compounds and / or nitrogen-containing compounds, such as sugars, saccharide analogs, nucleotides, and the like, to develop efficient gene regulatory mechanisms. The present invention also describes gene expression regulation and 10 modulation by the use of a unique natural compound guanidine, alone or in combination with other inducer compounds, thereby achieving efficient gene expression control.

The invention belongs to the technical field of separation methods of new natural compounds, and particularly relates to a separation method of new ginsenoside in ginseng. According to the separation method, ginseng roots serve as raw materials, sample segmentation and targeted enrichment of target compounds are carried out through ultrasonic extraction, normal-pressure and medium-pressure preparation and the like, then enrichment is further carried out through high-pressure semi-preparation, specific parameters are adopted in each step, and therefore the new ginsenoside can be separated from the ginseng roots. The discovery of the new ginsenoside is helpful for deeply exploring the action mechanism of the ginseng, and also possibly provides new active substances for disease treatment, so that the pharmaceutical application of the ginseng is further developed, and the economic value of the ginseng is improved.

The application provides a method for preventing and controlling pear ring rot by using tyrosol, and the pear ring rot is prevented and controlled by spraying tyrosol aqueous solution externally; the concentration of tyrosol in the tyrosol aqueous solution is 1-5 mg / ml. The application takes 'Dangshan' pear as experimental material, and proves that tyrosol has a significant inhibitory effect on pear ring rot fungus through in-vitro antibacterial experiment and ring rot fungus inoculation experiment, can effectively inhibit the development speed of ring rot fungus spots, reduces the occurrence and spread of diseases, and thus reduces the invasion of ring rot fungus on plants. Tyrosol is a natural compound in plants, has low toxicity, and when applied to the prevention and control of pear ring rot, can enhance the defense mechanism of the plants, improve the natural resistance of the plants to ring rot, simultaneously reduces or replaces the use of chemical pesticides, and reduces the potential risks to the environment and human health.

The present invention discloses a method for extracting phenolic ketone compounds from sea buckthorn leaves with an ultrasound-assisted natural low eutectic solvent. The sea buckthorn leaf powder is mixed with a natural low eutectic solution, ultrasonically extracted, and the supernatant is collected by centrifugation. The supernatant is concentrated, frozen, and dried to obtain the phenolic ketone compounds. The phenolic ketone compounds extracted by the present invention are diverse in type and high in content. By optimizing the type of natural low eutectic solvent, the extracted phenolic ketone compounds can have a better inhibitory effect on the activity of related enzymes, making them promising natural compounds for treating and preventing hyperglycemia, hyperlipidemia, hypertension, and gout.

This invention discloses a green and efficient bioreduction method for quinone-structured natural compounds used in textile dyeing. This method utilizes biosensor-regulated electrode microbial communities of *Shewanella putrefactiveis* and *Saccharomyces cerevisiae* as whole-cell biocatalytic reduction staining conditions. It constructs an electron transport system centered on cable bacteria and redox factors, and a dispersed staining system of quinone-structured natural compounds acting as electron acceptors. This provides a green and efficient bioreduction method for quinone-structured natural compounds used in textile dyeing. Electrons generated by biosensor-regulated electrode microbial communities are directly transferred between microbial species to cable bacteria and redox factors, and then efficiently transferred to highly dispersed natural compounds acting as electron acceptors, resulting in novel structures with dyeing properties.

The application discloses a new antibacterial compound and a preparation method and application thereof, and the new antibacterial compound is obtained by fermenting endophytic fungi (Epicoccum latusicollum) under stress of pathogenic fungi (Fusarium oxysporum), filtering, discarding mycelia, enriching the fermentation liquor by using a macroporous adsorption resin, and adopting high performance liquid preparation separation, and the chemical name of the new compound is (6E,8E)-13-acetoxy-3-hydroxy-8,10,12,14-tetramethylhexadeca-6,8-dienoic acid. The new compound obtained by fermenting endophytic fungi under stress of pathogenic fungi has significant antibacterial activity, and the application provides a scientific basis for mining endophytic fungi antibacterial natural compounds based on stress effects.