213 results about "Natural compound" patented technology

The invention relates to the technical field of compound fertilizers, in particular to a selenium-rich water-soluble compound fertilizer. The selenium-rich water-soluble compound fertilizer comprises the following components in parts by weight: 10-15 parts of selenium sustained-release microspheres, 8-12 parts of a natural compound extract, 1-2 parts of potassium chloride, 1-3 parts of monoammonium phosphate, 0.1-0.2 part of EDTA chelated zinc, 0.05-0.08 part of borax and 300-500 parts of deionized water, and the selenium-rich water-soluble compound fertilizer prepared by the invention can slowly release selenium elements and effectively improve the selenium content of plants.

The invention provides application of a natural compound in prevention and treatment of gray mold of fruits and vegetables. In the invention, botrytis cinerea can be inhibited by using the natural compound kaempferol. Experimental results show that the inhibitor has an inhibition effect on botrytis cinerea, has an IC50 value of 64 [mu] g / mL, has a good prevention and treatment effect on gray mold of cherry tomatoes, delays rotting and deterioration of the cherry tomatoes and prolongs the shelf life. The effect of the natural compound kaempferol in inhibiting the toxicity of botrytis cinerea is expected to become a novel prevention and treatment means for gray mold of fruits and vegetables.

The invention discloses a method for increasing the yield of mesenchymal stem cell exosomes. A main culture medium used in the method is a human umbilical cord mesenchymal stem cell serum-free culture medium, and different natural compounds are respectively added in three main stages of mesenchymal stem cell growth, namely a recovery stage, an amplification stage and a stable stage, so that the characteristics of the mesenchymal stem cells in the stages are pertinently improved; the survival rate of the mesenchymal stem cells is protected in stages, the amplification efficiency of the mesenchymal stem cells is improved, the stability of the mesenchymal stem cells is maintained, and the exosome secretion amount of the mesenchymal stem cells can be remarkably increased through combined use of the three natural compounds. According to the invention, the secretion amount of the exosome of the mesenchymal stem cells can be obviously increased, and the problem of low yield of the mesenchymal stem cells at present is solved.

The invention relates to the technical field of natural compounds, in particular to ganoderma leukemia polysaccharide and a preparation method thereof. The ganoderma leukemia polysaccharide comprises galactose, glucose and mannose, and the molar ratio of the galactose to the mannose to the glucose is (1.5-3.5): (15-30): (65-85); the ganoderma leukemia polysaccharide comprises:-> 6)-Glcp-(1-> dominant residues; (-> 6)-Manp-(1->,-> 4)-Glcp-(1-> residue; and-> 4, 6)-Manp-(1->,-> 3, 6)-Galp-(1->. The ganoderma leukemia polysaccharide has anti-oxidation and detoxification capabilities, can avoid neurodegenerative diseases, reduce lipid accumulation and prolong the service life, and also has high-temperature resistance.

A system and method are herein disclosed. The system and method use a generative AI agent to analyze and identify synergistic blends of natural compounds for combination therapies by leveraging an array of specialized modes to access data from a multitude of sources including patient medical history (including test results, drug history, and imaging) to improve the efficacy of compounds, including traditional medicine, in line with combination therapy principles, aimed at: enhanced efficacy, decreased toxicity, improved dosage, and reduced drug resistance. In this way, the generative AI agent determines cross-therapeutic similarities and / or dissimilarities between pharmaceutical, naturopathic, homeopathic, and nutraceutical compounds along a plurality of compound property vectors such as efficiency, efficacy, toxicity, effects, side-effects, chemistry, pharmacology, pharmacokinetics, mechanisms of action, and pharmacodynamics, thereby enabling the proposition of cross-disciplinary and transdisciplinary therapeutic analyses and the identification of synergistic effects in combination therapies.

The invention provides a composition and an application thereof in tumor anti-lactylation, and belongs to the technical field of biological medicines. The corilagin and the baicalein are combined to be applied to tumor treatment, a stronger glycolysis inhibition effect can be shown, a main energy supply way of tumor cells can be more effectively cut off, and rapid proliferation and growth of the tumor cells are restrained. The combination of corilagin and baicalein provided by the invention provides a new potential molecular combination drug for lung cancer treatment, provides a new treatment choice for patients, develops a new idea for the field of tumor treatment, proves the potential of a natural compound combination in tumor anti-lactic acid treatment, and has a wide application prospect. Reference and reference are provided for subsequent research and development of more tumor treatment drugs and strategies based on natural products.

The invention is applicable to the technical field of biological medicines, provides application of a natural compound of a targeted colon cancer drug resistance related protein, and particularly relates to application in preparation of drugs for preventing or treating colon cancer. According to the invention, a natural small molecule compound neohesperidin dihydrochalcone targeting the colon cancer drug resistance related protein TAGLN is screened out, and a new scheme is provided for reversing colon cancer drug resistance, so that the situation that no drug is available to the target spot is solved. Secondly, the invention also provides a scheme for combined use of neohesperidin dihydrochalcone and oxaliplatin, the scheme can significantly enhance the killing effect of oxaliplatin on drug-resistant colon cancer, and a new choice is provided for clinical treatment of colon cancer.

The invention relates to the technical field of medicines, in particular to a composite nano vaccine and application thereof. The composite nano vaccine is prepared by coupling a natural compound with endoplasmic reticulum stress induction capability on the surface of Ga-MOF nano particles. The composite nano vaccine can significantly enhance the anti-tumor effect through a ferroptosis mechanism, an endoplasmic reticulum stress and immunogenic cell death mechanism and a cryoablation technology synergistic effect mechanism, reverses an immunosuppressed tumor microenvironment, inhibits the growth of primary tumors and distant metastatic tumors, and has a good anti-tumor effect. A brand new strategy is provided for comprehensive treatment of tumors, and the application prospect is wide.

The invention belongs to the technical field of medicines, and particularly relates to application of 1, 2, 3, 4, 6-pentagalloylglucose (PGG) in inhibition of peptidyl arginine deiminase (PAD4). The invention relates to an application of PGG in preparation of a medicine for inhibiting PAD4 in a subject or a biological sample. Experiments show that the moutan bark extract has a definite inhibiting effect on PAD4, and it is confirmed that moutan bark is a traditional Chinese medicine which is hopeful to screen out a natural PAD4 inhibitor. The PGG in the tree peony bark extract is confirmed to be a natural compound with a strong inhibition effect on PAD4 by analyzing bioactive components in the tree peony bark extract, and the PGG can provide support for developing a PDA4 inhibitor and preparing a medicine for treating PAD4-mediated diseases, obstacles or symptoms, and has very important significance.

The invention discloses a key effect and a targeted intervention strategy of YTHDF1 in regulation and control of a hepatocellular carcinoma immunosuppression microenvironment. In the tumor-associated fibroblasts, YTHDF1 enhances the translation efficiency of OTUD5 mRNA through an m6A dependency mechanism, an up-regulated deubiquitination enzyme OTUD5 is directly combined with a tryptophan metabolic rate-limiting enzyme IDO1, ubiquitination degradation of the tryptophan metabolic rate-limiting enzyme IDO1 is inhibited, tryptophan is further driven to catabolism to generate kynurenine, regulatory T cell differentiation is promoted, and an immunosuppression microenvironment is formed. Spatial transcriptomics shows that YTHDF1 + CAFs and Tregs are significantly co-localized in tumor tissues and have metabolic interaction. Based on artificial intelligence virtual screening, it is found that a natural compound hesperidin can be specifically combined with a YTH structural domain of YTHDF1, an OTUD5-IDO1 signal axis mediated by the natural compound hesperidin is blocked, and the KYN level is remarkably reduced. Animal experiments prove that the tumor inhibition rate of combined treatment of hesperidin and anti-PD-1 is increased by 40% or above compared with that of a single drug group, and synergistic interaction is achieved by inhibiting Tregs infiltration and enhancing the activity of cytotoxic T lymphocytes.

The present invention belongs to the field of natural compounds, and specifically relates to a crude extract of frog follicles, the VMO1 protein, and their extraction methods and uses. The specific technical solution is as follows: A crude extract, wherein the crude extract is from frog follicles and does not contain egg grains. The preparation method includes: extracting the follicles of frogs, removing the egg grains under a sterile environment, adding a buffer solution, performing ultrasonic treatment and centrifugation, taking the supernatant, and filtering to obtain the crude extract. The crude extract obtained by the present invention has good maintained activity and can be further developed for subsequent uses. The crude extract obtained by the present invention can significantly reduce the surface tension, and at the same time has good antioxidant activity and good antibacterial ability, such as the ability to inhibit Pseudomonas aeruginosa. Since products derived from natural products have good biocompatibility, therefore, based on the above activities and functions, the crude extract provided by the present invention has good application prospects in multiple fields such as the field of cosmetics water retention, the field of food preservation, and the field of pharmaceuticals.

The invention discloses an application of homocapsaicin II in preparation of an anti-tumor drug, the homocapsaicin II is used in the anti-tumor drug independently or in combination with 5-fluorouracil or in combination with oxaliplatin, and when the homocapsaicin II is used in preparation of an anti-colorectal cancer drug, the drug concentration is 20-200 [mu] M. It is found that high capsaicin II can inhibit growth of intestinal cancer cells in vivo and in vitro, and nude mice have good tolerance to the natural compound. When the compound is used together with a first-line chemotherapeutic drug 5-fluorouracil, the drug concentration of the 5-fluorouracil can be remarkably reduced while the same treatment effect is achieved, a synergistic cancer inhibition effect is achieved, and a new research and development approach is found for anti-colorectal cancer drugs.

The invention relates to the technical field of herbicides, in particular to an allelochemical-based organic herbicide and application thereof. The herbicide is prepared from the following active ingredients: L-menthone, pulegone and beta-caryophyllene. The mass ratio of the L-menthone to the pulegone to the beta-caryophyllene is (1 to 4) to (1 to 4) to 1. The three substances are compounded to generate a synergistic effect of '1 + 1 + 1 gt and' 3 ', the herbicidal activity is far better than that of a single agent, and the use concentration of each component is remarkably reduced. All the components are plant source natural compounds, the degradation path is clear, rapid metabolism can be achieved through microbial decomposition in soil and water, and no complex residual product exists.

A method for treating a gastrointestinal condition includes preparing an aqueous extract of bioactive compound by adding dried green tea material to hot water and filtering the aqueous extract; adding a solution of an iron-containing compound to the filtered aqueous extract to form a complex or chelate of the bioactive compounds with iron; and drying the solution at a temperature between 80 to 150 degrees Fahrenheit to obtain a fine granular or powdered state.

This invention belongs to the field of biomedical technology, specifically relating to a compound extracted from *Acer buergerianum* (a type of shrub), its extraction method, and its application in the preparation of drugs for the prevention or treatment of non-alcoholic fatty liver disease. This invention is the first to obtain a natural compound with a novel structure from *Acer buergerianum*, and provides a method for its preparation. Activity studies were conducted, and experimental data show that the compound exhibits low cytotoxicity and no significant cytotoxicity to normal cells. It can inhibit the expression of fatty acid synthases ACC, ACLY, and FAS, thereby inhibiting de novo fatty acid synthesis in cells, suppressing lipid droplet accumulation, and reducing cellular lipid levels. This compound has broad application prospects in the preparation of drugs for the prevention or treatment of non-alcoholic fatty liver disease.

The application belongs to the technical field of biological medicine, and provides application of a natural compound targeting colon cancer drug resistance related protein, in particular, application in preparation of a drug for preventing or treating colon cancer; the application screens out a natural small-molecule compound hesperetin dihydrochalcone targeting colon cancer drug resistance related protein TAGLN, and provides a new scheme for reversing colon cancer drug resistance, so as to solve the situation that no drug is available for the target point. In addition, the application further provides a scheme in which hesperetin dihydrochalcone is combined with oxaliplatin, and the scheme can significantly enhance the killing effect of oxaliplatin on drug-resistant colon cancer, thereby providing a new choice for clinical treatment of colon cancer.

The application discloses a preparation method of egg yolk phospholipid polypeptide which is helpful for bone growth and improvement of brain health, and comprises the following steps: (1) raw material pretreatment to obtain a reaction substrate solution; (2) primary enzymolysis to prepare a primary enzymolysis solution; (3) secondary enzymolysis to prepare a secondary enzymolysis solution; (4) inactivation, the temperature of the secondary enzymolysis solution prepared in the step (3) is adjusted to 85-95 DEG C, and the enzyme is completely inactivated by keeping for 10-15 min; (5) fermentation; (6) post-treatment, the fermentation liquid after the fermentation is kept at 50-60 DEG C for 10-30 min, and then cooling, centrifugation, collection of supernatant, vacuum freeze drying or spray drying of the supernatant are carried out, so that the egg yolk phospholipid polypeptide powder is obtained. The natural compound rich in specific functional peptide segments and phospholipids is prepared through the two-step enzymolysis coupling fermentation process, can effectively promote the growth and development of the bone, significantly improve the learning, memory and cognitive ability, and can significantly promote the proliferation of osteoblasts.

The invention provides medical application of sanguinarine in preparation of a salmonella flagellum inhibitor, and belongs to the technical field of biological medicine. According to the invention, the flagellum of salmonella is used as a potential target for researching and developing the anti-salmonella toxicity drug, and a natural product capable of inhibiting the flagellum of salmonella is screened through a salmonella sliding motion inhibition test and a real-time fluorescent quantitative PCR test; in combination with tests such as a minimum inhibitory concentration determination test, a growth curve, inhibition of salmonella from adhesion to Caco-2 cells and the like, it is verified that sanguinarine can effectively inhibit the salmonella flagellum-mediated swimming ability on the basis of not influencing normal growth of bacteria, so that the pathogenic potential of salmonella is remarkably reduced, the effect of bacteriostasis instead of sterilization is achieved, and the application prospect is broad. A new research thought and a candidate natural compound are provided for prevention and treatment of salmonella infection, and potential practical application value is achieved.

The invention discloses a phenylboronic acid affinity deoxynojirimycin imprinted polymer nano-material as well as a preparation method and application thereof, and belongs to the fields of nano-material preparation and natural compound extraction and separation. Phenylboronic acid modified nano silica gel is used as a carrier, deoxynojirimycin is used as a template molecule, dopamine is used as a cross-linking agent, a polyethyleneimine hyperbranched strategy is further combined, a deoxynojirimycin molecularly imprinted polymer (MIPs-PEI) with boric acid affinity and pH response characteristics is constructed, and hyperbranched modification remarkably improves hydrophilicity and boric acid affinity sites of the material. The synthesized MIPs-PEI has good adsorption performance on deoxynojirimycin and can effectively enrich deoxynojirimycin in mulberry leaves, and the natural hypoglycemic alkaloid deoxynojirimycin is extracted in a green mode through the method.

The application belongs to the technical field of medicine, and discloses application of SERPINE1 protein or a coding gene thereof as a new target for hepatitis B virus treatment. The application first discloses that SERPINE1 promotes autophagy flux by directly combining PIKfyve protein, thereby significantly inhibiting HBV replication and HBsAg expression. Based on this, the application establishes a multi-dimensional target verification platform, and first discovers that a natural compound, betulinic acid, is a high-affinity agonist (KD=1.46 µM) of SERPINE1. In-vivo and in-vitro experiments prove that betulinic acid can effectively reduce the levels of HBsAg and HBV DNA, and has good safety. In addition, betulinic acid and entecavir show a synergistic antiviral effect (CI<1). The application provides a new target and treatment strategy for realizing functional cure of hepatitis B.

Disclosed is a hair dye base composition comprising an improved basifying agent, which improvement is embodied in the overall reduction of ammonia compounds, thereby advantageously minimizing the problems associated with ammonia compounds. The composition provides a satisfactory hair dyeing covering power without malodors or damage to the scalp that are typically caused by ammonia compounds, while being free of ingredients known to cause skin damage problems, such as ethoxylated compounds, PEG and derivatives thereof, and silicones, since the composition contains a high percentage of natural compounds. Therefore, the composition of the present invention is significantly healthier for customers / consumers and hairstylists using the composition, while maintaining high performance of hair dyeing. Also disclosed are multi-compartment kits comprising the compositions, dyes and oxidizing components, as well as their use in permanent hair dyeing. Also disclosed is a process for producing the hair dye base composition, and a hair dyeing method comprising applying the composition to the hair.

The invention discloses a gallic acid-based cationic photodynamic antibacterial agent with sterilizing, anti-infection and wound healing promoting effects and a preparation method thereof, and belongs to the technical field of antibacterial agent synthetic chemistry. The cationic photodynamic antibacterial agent EY-QEGDM-MG is prepared by taking a natural compound gallic acid as a raw material and carrying out ring opening polymerization and quaternization reaction with photosensitizer eosin EY and ethylene glycol diglycidyl ether (EGDE), and the polymer shows an excellent antibacterial effect on escherichia coli and multi-drug-resistant MRSA germs under the action of illumination, and can be used for preparing a cationic photodynamic antibacterial agent EY-QEGDM-MG. The polymer has good blood compatibility and cell compatibility, in addition, the polymer can kill bacteria around infected wounds and can rapidly promote wound healing, and therefore the polymer can provide a new method for photodynamic antibacterial agents for treating the infected wounds in hospitals.

The invention discloses a ferulic acid derivative and a preparation method and application thereof.The ferulic acid derivative is a compound shown in the formula (I) or pharmaceutically acceptable salt of the compound, and the compound is a natural compound extracted from rubus corchorifolius stems, has anti-inflammatory activity and anti-tumor activity and has the potential of being developed into anti-inflammatory or anti-tumor drugs. Or as a lead compound.

The invention discloses a tetrahydrofuran lignan compound as well as a preparation method and application thereof, the tetrahydrofuran lignan compound is a compound shown as a formula (I) or pharmaceutically acceptable salt thereof, the compound is a natural compound extracted from rubus corchorifolius stems, has anti-inflammatory activity and anti-tumor activity, and can be used for preparing a medicine for treating tumors. The compound has the potential of being developed into anti-inflammatory or anti-tumor drugs and can be used as a lead compound.

The invention belongs to the field of natural compounds, and particularly relates to application of VMO1 protein in toxicity resistance, oxidation resistance, thrombolysis and sperm motility regulation. According to the specific technical scheme, the application of the VMO1 protein in preparation of drugs for inhibiting bacteria, resisting toxicity, resisting oxidation and improving or reducing sperm motility is provided, and the amino acid sequence of the VMO1 protein is shown as SEQ NO ID: 1. It is found for the first time that the VMO1 protein extracted from frog follicles not only can inhibit the activity of pseudomonas aeruginosa, but also can resist toxicity, and meanwhile, the VMO1 protein has a good antioxidant effect, a thrombus dissolving effect and a bidirectional sperm motility adjusting effect. Therefore, the VMO1 protein has huge pharmaceutical potential.

The present invention provides a method for preparing polysubstituted 1,2,3,4-tetrahydroquinoline, which relates to the technical field of the synthesis of chemical intermediates for medicines and natural compounds. In the present invention, o-N-acylphenyl MBH carbonate and an unsaturated olefin are used as raw materials, and under the action of a Lewis base catalyst, a [4+2] cycloaddition reaction occurs in an organic solvent to generate a polysubstituted 1,2,3,4-tetrahydroquinoline compound. The diastereoselectivity and regioselectivity of the product are high. Without the need for a metal catalyst, the reaction product can be obtained in one step. The reaction conditions are mild, and it only needs to be stirred at room temperature in an organic solvent. The raw materials are easily available, the cost is low, the process is stable and the yield is high. The operation and post-treatment are simple. Moreover, the product can be prepared in gram scale and further derivatized and transformed, providing a reference for drug research and development.

The present application relates to the application of ocanin in the preparation of anti-tumor drugs, and the ocanin is used in the anti-tumor drugs alone or in combination with 5-fluorouracil, and the concentration of the ocanin used in the preparation of anti-intestinal cancer drugs is 20-500 uMol. It is found that the ocanin can inhibit the growth of intestinal cancer cells in vivo and in vitro, and the naked mice have good tolerance to the natural compound. The ocanin has better anti-intestinal cancer effect than other extracts of goldeneye and devil's needle, and has better anti-cancer effect and smaller toxicity than the current conventional intestinal cancer drug 5-fluorouracil. Therefore, the ocanin can be developed into a new anti-cancer drug.

The invention belongs to the technical field of medicines, and particularly relates to tripterine-loaded nano-particles as well as a preparation method and application thereof, and the tripterine-loaded nano-particles (Cel-GDNPs) comprise ginger exosome (GDNPs) and tripterine (Cel) encapsulated in the ginger exosome. According to the invention, the Cel is used as a therapeutic drug, and the adopted carrier GDNPs has anti-inflammatory activity, so that when the Cel and the GDNPs are used for treating inflammatory diseases such as colitis and the like, the Cel and the GDNPs can play a multi-component synergistic therapeutic effect, and compared with the single use of the Cel or the GDNPs, the expression of proinflammatory factors (such as TNF-alpha, IL-1beta and IL-6) can be more effectively inhibited, so that the synergistic therapeutic effect is realized; a new strategy is provided for developing a novel natural compound preparation.

The invention belongs to the technical field of biological medicines, and particularly relates to a daphniphyllum calycinum extract compound, an extraction method thereof and application of the daphniphyllum calycinum extract compound in preparation of a medicine for preventing or treating non-alcoholic fatty liver diseases. A natural compound with a novel structure is obtained from daphniphyllum calycinum for the first time, a preparation method of the compound is provided, activity research is carried out on the compound, and experimental data shows that the compound is low in cytotoxicity and has no obvious cytotoxicity to normal cells, and the compound can be used for preparing the compound by inhibiting expression of fatty acid synthetases ACC, ACLY and FAS. The compound inhibits the de novo synthesis of fatty acid in cells, thereby inhibiting the accumulation of lipid droplets in the cells and reducing the lipid level in the cells, and has wide application prospects in the field of preparation of drugs for preventing or treating non-alcoholic fatty liver diseases.

The application discloses a Daphnane type macrocyclic diterpenoid compound with a 4,7-oxygen bridge structure and a preparation method and application thereof. The monomer compound is obtained by repeatedly separating and purifying an ethyl acetate part extract of Daphne giraldii by using various separation fillers and separation technologies. The new compound is subjected to structural identification by using various 1D and 2D nuclear magnetic resonance spectrometry and high resolution mass spectrometry (HR-ESI-MS) and the like, and a molecular formula and a structural formula thereof are deduced. Further in-vitro cell activity researches show that the Daphnane type macrocyclic diterpenoid compound with the 4,7-oxygen bridge structure separated from the Daphne giraldii has good inhibitory activity on melanoma cells. The application is helpful to development and utilization of natural compounds of the Daphne giraldii.