737 results about "Signal Pathways" patented technology

The invention discloses application of an AI-driven target screening technology in anti-obesity treatment of a drug delivery system, and belongs to the field of cross fusion of biological medicine and artificial intelligence. The screening method provided by the invention comprises the following steps: selecting a signal channel target and active small molecules related to lipid metabolism; processing the signal channel target and the active small molecules through the data set to obtain an input matrix; and inputting the input matrix into a deep learning model to obtain the interaction intensity between the active small molecules and the signal path target. According to the method, an artificial intelligence technology is introduced, a deep learning model is constructed to efficiently predict the affinity between a drug and a protein target, the problems that a traditional target screening method depends on experience and is low in efficiency are solved, and target expression is subjected to experimental verification through a molecular biology method, so that the target screening efficiency is improved. A verification closed loop from calculation prediction to molecular demonstration is realized, and the biological credibility of a target screening result is proved.

The invention relates to the technical field of biology, in particular to application of a rice OsPBL8 gene in enhancing resistance of rice to magnaporthe oryzae. The rice OsPBL8 gene is a rice endogenous gene participating in the processes of plant growth and development, abiotic stress response, hormone signal channel regulation and control and the like. The invention provides application of the OsPBL8 gene in the field of disease resistance, the OsPBL8 gene is overexpressed through gene editing, and the expression quantity of receptor-like cytoplasm kinase OsPBL8 in plants is increased, so that a plurality of signal channels are regulated and controlled, and the germ resistance of the plants is synergistically improved. By adjusting key hub nodes of plant targeted immune signal transduction, more lasting broad-spectrum disease resistance can be provided, good universality is achieved, disease resistance and growth can be balanced, good practicability is achieved, and improvement of disease resistance of various rice varieties is facilitated.

The invention discloses a chimera for degrading a CARD structural domain protein aggregate and application of the chimera. The chimera is prepared from light-operated targeting protein and light-operated degradation protein, the light-operated targeting protein is sequentially connected by an MAVS CARD structural domain, a flexible connecting peptide and a photosensitive protein pMag; the light-controlled degradation protein is sequentially connected by a photosensitive protein nMag, a flexible connecting peptide and an RING structural domain of TRIM21. According to the application, a light-operated activated CARD-RING chimera is constructed, and when the CARTAC generates toxic and side effects or in cells with RIG-I / MDA5 signal channels abnormally activated, the activity of the CARTAC can be effectively controlled or autoimmune diseases caused by RIG-I / MDA5 abnormity can be inhibited.

The invention relates to the technical field of strategy optimization, in particular to an ASIC (Application Specific Integrated Circuit) layout optimization method based on hybrid shaping programming, which comprises the following steps of: analyzing a circuit netlist, and establishing a signal path physical model containing static topological connectivity; a candidate layout scheme is generated based on the model, and layout state data describing the state of the candidate layout scheme is generated through physical effect simulation; based on the layout state data, calculating a signal processing performance index and a wiring cost value, and generating a group of dynamic shaping constraints for guiding subsequent layout according to the index and the cost value, the dynamic shaping constraints being quantitative adjustment of a path congestion perception graph in a signal path physical model; and updating the model through the constraint, evaluating the stability of a Pareto optimal boundary formed by the performance index and the cost value so as to judge convergence, and finally outputting a layout scheme associated with a stable state. According to the method, dynamic shaping constraints are generated through a strategy optimization algorithm, and global collaborative optimization of multiple targets such as time sequence and wiring performance is achieved.

The invention belongs to the technical field of protein, and relates to a peptide with liver protection activity and a preparation method and application thereof, and the amino acid sequence of the peptide is PFPRPQP. The active peptide can be used for activating a Keap1 / Nrf2 signal channel by reducing the liver enzyme level and inhibiting CYP2E1 expression so as to play a role in protecting HepG2 damaged cells. The invention also provides a preparation method and application of the liver-protecting active peptide.

The invention relates to the technical field of biology, and particularly discloses a polypeptide and application thereof in enhancing immunity and / or resisting inflammation. The invention provides a polypeptide. The amino acid sequence of the polypeptide is shown as SEQ ID NO. 1. The compound has the dual functions of regulating immunity and resisting inflammation, on one hand, the immune function of cells under the normal condition can be enhanced, and on the other hand, cell inflammation can be relieved by reducing the phosphorylation level of key protein in an LTR4-NF-kappa B signal channel in the inflammatory state. The polypeptide is low in cytotoxicity, high in safety, simple in preparation method and low in cost, can be used as an ideal immune and anti-inflammatory regulator, and has good application potential and value.

The invention discloses a DCS system IO module channel testing device, and relates to the technical field of industrial automation equipment detection. The device comprises an IO module point inspection instrument and an upper computer, the IO module point inspection instrument is in communication connection with the upper computer, a plurality of sets of independent test modules capable of running in parallel are arranged in the IO module point inspection instrument, and each test module comprises a controller, an excitation source circuit, a signal acquisition circuit and a matrix switch circuit and corresponds to one slot. And the test module establishes a signal path with the IO module connected to the slot through the matrix switch circuit. Wherein a controller in the test module can automatically identify the type of the IO module to be tested, dynamically configure an excitation source circuit and a signal acquisition circuit which are matched with the IO module to be tested, and realize automatic and high-precision detection of various types of IO modules. According to the device, the point inspection efficiency of the IO module of the DCS system can be greatly improved by integrating a multi-channel signal output function and a signal detection function.

The invention discloses a non-reflection band-pass filter chip based on a novel topological structure, which is characterized by comprising a dielectric substrate, a filter circuit arranged on the dielectric substrate, an input port and an output port, a topological structure of the filter circuit is in bilateral symmetry, a main signal path of the filter circuit is of a five-order band-pass filter structure, and the filter circuit comprises a first series resonator, a third series resonator and another first series resonator which are sequentially connected between an input port and an output port in series; one ends of the two second parallel resonators are respectively connected between the first first series resonator and the third series resonator and between the third series resonator and the second first series resonator, and the other ends of the two second parallel resonators are grounded; the two ends of each first series resonator are connected with an absorption branch in parallel, each absorption branch is formed by sequentially connecting a fourth parallel resonator, a resistor and a fifth parallel resonator in series, and out-of-band energy absorption is achieved through the two branches of the same structure. An absorption circuit and a main filter circuit are organically fused, the problem of out-of-band reflection of a traditional filter is solved, and meanwhile the filter has the advantages of being compact in structure, small in size and high in integration degree.

The invention discloses a mouse lung organ and fibroblast co-culture method, which comprises the following steps of: performing in-vitro mouse lung organ culture on mouse lung tissue primary epithelial stem cell spheres (pneumospheroids) in a Transwell upper chamber, and after the lung organs in the Transwell upper chamber are differentiated, replacing with a lower chamber paved with mouse lung fibroblasts, therefore, a gas-liquid interface co-culture system of the mouse lung organ (upper chamber) and the fibroblast (lower chamber) is formed, and the hierarchical structure, morphological characteristics and regeneration function of the upper chamber organ and the phenotype, function and related signal path activation level of the lower chamber fibroblast can be dynamically researched.

The invention discloses a communication protocol switching system, method and device, computer equipment and a storage medium, and the system comprises a main control module, a plurality of communication protocol switching chips, and a plurality of dual-path power switch chips which are in one-to-one correspondence with the plurality of communication protocol switching chips, each communication protocol switching chip is used for converting a non-target communication protocol different from a target communication protocol into a target communication protocol which can be processed by the main control module; the control end of each two-way power switch chip is electrically connected with the main control module and is used for receiving a control signal from the main control module and controlling the on-off of a power supply of the corresponding communication protocol switching chip and the on-off of a signal path between the communication protocol switching chip and the main control module under the control of the control signal; when a communication protocol switching chip is not selected, power supply disconnection and signal path isolation are realized, and signal interference among different communication protocols is avoided. The communication stability can be effectively improved.

The invention discloses application of a tea tree CsNAC25 gene in negative regulation of cold resistance of plants, the gene belongs to a tea tree NAC transcription factor family, and the nucleotide sequence of the gene is shown as SEQ ID NO.1. The tea tree CsNAC25 gene negatively regulates the cold resistance of the tea tree, and the gene expression is reduced under low temperature induction. The over-expression of the gene in tobacco weakens the cold resistance of a transgenic plant, and the expression of CsNAC25 is silenced by adopting a VIGS technology in a tea tree, so that the cold resistance of the tea tree is remarkably improved. Silencing CsNAC25 effectively reduces the wilting degree and the ion leakage rate of tea seedling leaves under low temperature stress, activates a key CBF signal channel and promotes accumulation of osmoregulation substances. The application of the application is expected to effectively improve the cold resistance when low-temperature disasters such as late spring coldness occur, and has important theoretical significance and wide application prospects for guaranteeing the stable yield and quality of the tea industry.

The invention discloses an application of costunolide in preparation of a medicine for treating and / or preventing a non-alcoholic fatty liver disease. It is found that costunolide can activate an Nrf2-ARE signal channel of a body, liver cell lipid metabolism abnormality is effectively improved from the molecular level, and meanwhile the pathological influence of oxidative damage on liver tissue is remarkably relieved. Experimental data show that the compound has a remarkable intervention effect on NAFLD, a scientific basis is provided for development of a novel liver disease treatment agent due to the unique dual regulation and control mechanism of the compound, particularly, the compound shows an important development prospect in the field of clinical intervention of metabolism-related liver injury, and an innovative solution is provided for NAFLD lacking a special-effect therapy at present.

The application provides application of a TT2-SCT1 / SCT2-WR2 regulation channel in plant heat stress tolerance. The application first discloses a new signal channel involved in plant heat tolerance: a TT2-SCT1 / SCT2-WR2 signal channel; wherein, TT2 is a negative regulation factor for regulating the heat tolerance of plants or protecting (maintaining) the yield of plants in Gramineae under high temperature, SCT1 / SCT2 are also negative regulation factors for regulating the heat tolerance of plants or protecting (maintaining) the yield of plants in Gramineae under high temperature, and WR2 is a positive regulation factor for playing a role, which is beneficial to maintaining the homeostasis in plants. The application has important theoretical significance for genetic improvement of plant traits.

The invention discloses application of gentiopicroside in preparation of a medicine for improving liver fatty degeneration and ferroptosis of type 2 diabetes mellitus, and belongs to the technical field of medicines. A C57BL / 6J mouse T2DM model induced by combination of high-fat feed and streptozotocin is taken as a research object, gentiopicroside is given for 8 weeks through oral administration and intragastric administration, metabolic indexes such as blood sugar, body weight, food intake and water intake of the mouse are dynamically monitored, serum and liver tissue are reserved after the mouse is killed, and the mouse can be used for preparing the gentiopicroside-gentiopicroside-gentiopicroside-gentiopicroside-gentiopicroside-gentiopicroside. Through liver pathological staining, serum and liver tissue oxidative stress index detection and PI3K / AKT / Nrf2 signal channel and ferroptosis related protein expression analysis, the pharmacological action of the gentiopicroside on T2DM is systematically evaluated, the regulation effect of the gentiopicroside on T2DM liver fatty degeneration and ferroptosis is determined for the first time, the research blank of the action mechanism of the gentiopicroside in T2DM liver complications is filled, and the application prospect of the gentiopicroside in T2DM liver complications is broadened. An experimental basis is provided for developing a novel medicine for improving T2DM liver fatty degeneration and ferroptosis.

The invention provides an application of polyphyllin VII in preparation of an Akt signaling pathway inhibitor targeting GRB2, the invention reveals that PPVII is specifically combined with GRB2 protein and regulates and controls the function of the GRB2 protein for the first time, the Akt pathway inhibition effect is exerted, and the molecular mechanism of PPVII is specifically shown as follows: molecular docking and dynamic simulation confirms that PPVII and an SH3 structural domain of GRB2 form a stable compound, and the stable compound is used for inhibiting the Akt pathway of the GRB2. And the key amino acid binding sites are Ile65, Gln157, Tyr160 and Phe182. Cell thermal transfer experiments (CETSA) show that PPVII can significantly enhance the thermal stability of GRB2 protein, surface plasmon resonance (SPR) determines the direct binding affinity KD = 58.5 [mu] M, functional research proves that PPVII inhibits an Akt signal channel through a GRB2 dependency mode, the polyphyllin VII is used as a GRB2 targeted inhibitor, and by specifically binding with an SH3 structural domain of GRB2 and inhibiting a downstream Akt signal channel, the polyphyllin VII can be used for inhibiting the Akt signal channel in the GRB2 targeted inhibitor. And a new strategy and a candidate compound are provided for intervention of related diseases.

The invention relates to an SR-B1 targeted polypeptide compound and application thereof in preparation of antitumor drugs, and belongs to the technical field of biological drug manufacturing. In order to solve the problems that the existing PDT photosensitizer is insufficient in targeting property and the treatment effect is limited due to the action of intracellular cholesterol, the invention provides an SR-B1 targeting polypeptide compound which is composed of an SR-B1 targeting polypeptide and an AS1411 aptamer. The SR-B1 targeting polypeptide comprises an SR-B1 targeting peptide fragment, a self-assembly peptide fragment, a response enzyme digestion peptide fragment and a photosensitizer TCPP which are connected in sequence. The invention constructs a polypeptide targeting system based on a dual self-assembly strategy, which not only can target SR-B1, inhibit a cholesterol-mediated tumor for a long time to promote a signal channel and interfere the ROS steady state, but also can target TCPP to a cell nucleus, improve the photosensitivity of PDT, and further improve the killing effect on tumor cells by improving the yield of ROS to cause the damage to the cell nucleus.

The invention provides a chicken PGC reporter gene cell strain for detecting the biological activity of FGF2 as well as a construction method and application of the chicken PGC reporter gene cell strain, and belongs to the technical field of biological activity detection. The cell strain is a recombinant cell which is stably integrated with a reporter gene expression cassette responding to an FGF signal channel in a chicken PGC genome; the expression cassette comprises a serum response element (SRE), a minimum promoter and a reporter gene (such as a luciferase gene). The construction method comprises the following steps: introducing a donor vector containing the elements into chicken PGC by utilizing a PiggyBac transposon system, and screening to obtain a stably expressed cell strain. The cell strain provided by the invention retains endogenous signal channel characteristics of chicken PGC, and can specifically and highly sensitively respond to FGF2 stimulation. The method can be used for biological activity quantitative determination and thermal stability evaluation of the FGF2 protein and the mutant thereof, quality control of culture medium components and screening of an FGF signal channel regulator.

The invention provides an anti-PD-1 antibody, a CAR-T cell, and a preparation method and application thereof. The anti-PD-1 antibody comprises LCDR-1-3 as shown in SEQ ID NO: 1-3 and HCDR-1-3 as shown in SEQ ID NO: 4-6, respectively. The CAR-T cell expresses a novel element for efficiently blocking the PD-1, and the element is a single-chain antibody for targeting the PD-1 in a cell membrane anchoring manner. And the chimeric antigen receptor and the cell membrane anchored anti-PD-1 scFv are connected by a 2A cleavage protein. The membrane anchor type anti-PD-1 scFv expressed by the CAR-T cell can almost completely block the expression of PD-1 on the surface of a T cell membrane, and further block a signal channel combined with PD-1 / PD-L1, so that the capability of T cell depletion caused by antagonism tumor of the CAR-T cell is enhanced, and the purpose of enhancing the anti-tumor effect of the CAR-T cell is achieved.

The invention relates to the technical field of plant genetic engineering, and particularly provides cloning of a GbGELP25D gene of gossypium barbadense and application of the GbGELP25D gene of gossypium barbadense. According to the invention, the GbGELP25D gene with a full length of 1092 bp is cloned from the sea island cotton variety Xinhai No. 7 for the first time, and the gene encodes a secretory lipase protein with a signal peptide and is positioned in an extracellular gap. Through bioinformatics analysis, phylogenetic classification, protein structure modeling and signal peptide function verification, it is clear that the gene belongs to a plant GELP family. Furthermore, a virus-induced gene silencing technology is utilized to prove that the silent GbGELP25D can obviously enhance the resistance of cotton to verticillium wilt, and the mechanism of the silent GbGELP25D is closely related to activation of ethylene synthesis and signal channels and induction of expression of disease-resistant related genes. The resistance gene provided by the invention enriches gene resources of cotton verticillium wilt resistance breeding, and has important theoretical significance and application value.

The invention discloses a regulation mechanism research method of depleted precursor CD8T cells, and relates to the field of immunology and molecular biology. Comprising the following steps: detecting the expression level of the ARHGAP9 gene in a chronic virus infection model; constructing a T cell specific ARHGAP9 gene knockout animal model; the influence of ARHGAP9 deletion on the frequency, phenotype and function of the Tpex cell is analyzed; a single cell transcriptome sequencing technology reveals that ARHGAP9 regulates and controls a downstream signal channel of a Tpex cell. By constructing a chronic virus infection model, detecting the expression dynamic state of the ARHGAP9 gene, knocking out an animal model by utilizing T cell specificity ARHGAP9, and combining flow cytometry, qPCR, single cell transcriptome sequencing and other technologies, the invention discloses the effect of the ARHGAP9 as a novel immune checkpoint molecule, and provides a theoretical basis for developing Tpex cell targeting immunotherapy.

The invention discloses an application of silibinin in enhancing the immunomodulatory function of stem cells, and relates to the technical field of biological medicines. The silybin is applied to the composition for enhancing the immunoregulation function of the stem cells, the composition comprises the silybin and umbilical cord-derived mesenchymal stem cells, and the immunoregulation function of UC-MSCs is enhanced by adjusting the interaction of ICOS / ICOSL axes based on the combined action of the silybin and the umbilical cord-derived mesenchymal stem cells. The silybin disclosed by the invention is competitively combined with the ICOS, so that the interaction of the ICOS / ICOSL is blocked, and the immune regulation function of the umbilical cord-derived mesenchymal stem cells is remarkably enhanced; therefore, the UC-MSCs show a stronger immunosuppression effect in both in-vitro and in-vivo experiments; silybin not only acts on an ICOS / ICOSL axis, but also inhibits secretion of inflammatory factors through a PI3K / AKT signal channel, so that a multi-mechanism synergistic treatment effect is achieved.

The present application relates to the technical field of medicine, in particular to the application of gansix triol A in the preparation of a drug for treating gastric cancer and / or non-small cell lung cancer, gansix triol A plays an anti-gastric cancer role by selectively inhibiting the proliferation of gastric cancer MGC-803 cells and inhibiting angiogenesis, the mechanism involves inhibiting the VEGF / VEGFR2 signal pathway and inducing cell apoptosis; the mechanism of gansix triol A in inhibiting the VEGF / VEGFR2 signal pathway is similar to that of bevacizumab; gansix triol A plays an anti-non-small cell lung cancer role by selectively inhibiting the proliferation of non-small cell lung cancer A549 cells, the mechanism involves inhibiting the MAPK / ERK signal pathway and inducing cell apoptosis. The present application finds that the cytotoxic activity of gansix triol A on MGC-803 cells and A549 cells is significantly stronger than that of tanshinone IIA; gansix triol A has an anti-tumor effect of "one drug with double targets, double inhibition" and "high efficiency and low toxicity".

The invention discloses application of 4-isopropyltoluene to improvement of depression-like behaviors of mice. An experiment adopts a chronic constraint stress method to construct a depression model, through behavioral detection such as a sucrose preference test, a tail suspension test and a novel inhibition ingestion test, and in combination with molecular biology means such as immunofluorescent staining and Western blot, the anti-depression effect and potential mechanism of 4-isopropyltoluene are systematically evaluated, and the anti-depression effect and potential mechanism of 4-isopropyltoluene are evaluated. Results show that 4-isopropyltoluene plays a significant anti-depression role by inhibiting neuroinflammation, enhancing glial cell support function and activating AKT signal pathway, and has the potential of being developed into a novel anti-depression candidate drug.

This application provides a cable anti-theft device for construction sites, comprising: a transmitting module; and a receiving module, which, along with the transmitting module, is respectively disposed within cable end caps at both ends of the cable and connected to the same conductor within the cable via conductive connectors to form an electrical signal path. The receiving module includes a loop detection unit and an alarm unit for signal connection. The loop detection unit detects the continuity of the electrical signal path; the alarm unit triggers a first alarm upon interruption of the electrical signal path. This device, through the transmitting and receiving modules and the conductive connectors, forms an electrical signal path with the same conductor within the cable. The formation of this path is independent of whether the cable is energized; even if the cable is not energized, as long as the conductor is intact, the electrical signal path remains unobstructed. When the cable is cut, the conductor breaks, and the electrical signal path is interrupted. The loop detection unit detects this promptly, and the alarm unit issues an alarm, thus solving the problem of dependence on the cable being energized.

The invention discloses an ultralow-temperature quantum controller applied to a low-temperature superconducting quantum computer, which comprises an analog circuit part and a digital circuit part, and is characterized in that the analog circuit part comprises two XY channels and three Z channels, each XY channel comprises two signal paths and an on-chip balun; each signal path comprises a nonlinear digital-to-analog converter NLDAC, an intermediate-frequency filter, an adjustable gain amplifier VGA, a quadrature mixer and a quadrature local oscillator signal generator, the input end of the quadrature mixer is connected with the output end of the quadrature local oscillator signal generator, and the output ends of the two signal paths of the XY channel generate XY channel control signals of the XY channel through on-chip balun combination. Each of the three Z channels includes three independent, independently adjustable digital-to-analog converters (DACs) for generating Z channel control signals for the three Z channels. The invention aims to shorten the distance between the controller and the quantum chip, improve the fidelity of the quantum computer and reduce the expense of quantum error correction.

The invention provides an application of M1 as an affinity of human source PD-L1 and / or mouse source PD-L1, and relates to the technical field of biological medicine. The invention proves that M1 can be used as a PD-L1 affinity for human / mouse cross reaction, and has low nanomole affinity for two targets. In cell-based function detection, M1 has similar affinity with mPDL1 and hPD-L1 expressed on the surface of a cell, and signal transduction is inhibited through a PD-L1: PD1 axis at a low micromolar concentration. The M1 disclosed by the invention can be used as a non-antibody treatment method to damage a PD-L1: PD1 signal channel, and the M1 shows high tumor permeability compared with an antibody, and particularly has a remarkable advantage in tumors (such as pancreatic tumors) with high fiber hyperplasia; the M1 shows selective uptake in the tumor for expressing the PD-L1.

The utility model provides an LKJ locomotive signal equipment nondestructive failure setting training room, which comprises a vehicle-mounted LKJ, a locomotive signal device and a locomotive wireless comprehensive communication device, and is characterized by further comprising an upper control machine and a lower relay circuit board, the upper control machine is electrically connected with the lower relay circuit board, and the lower relay circuit board is electrically connected with the locomotive signal device. The lower relay circuit board is used for outputting a control instruction to the lower relay circuit board and controlling the action of a relay on the lower relay circuit board, the lower relay circuit board is electrically connected with the vehicle-mounted LKJ, the locomotive signal device and the locomotive wireless comprehensive communication device, and the lower relay circuit board is used for executing the control instruction of the upper control machine and controlling the action of a relay on the lower relay circuit board. And then on-off operation is carried out on signal channels of the vehicle-mounted LKJ, the locomotive signal device and the locomotive wireless integrated communication device, so that nondestructive fault setting is realized. According to the utility model, on the premise that equipment hardware is not damaged, practical teaching and fault demonstration of LKJ locomotive signal equipment are realized, so that the cost is reduced, and the stability and the safety of the equipment are improved.

The present application provides a kind of debugging system and debugging method for mechanical and electrical engineering, the system includes oscillation generator, for sending oscillation signal, in the passage confirmation stage, it is arranged at the pre-installation position of the element to be detected;Field transceiver digital-analog circuit processing unit for receiving the oscillation signal sent by oscillation generator and carrying out signal type conversion, controller unit, including digital-analog circuit processing unit and signal oscillation generator unit;Digital-analog circuit processing unit, in the passage confirmation stage, for signal type conversion and output analog signal;Signal oscillation generator unit, in the debugging stage, for receiving the debugging instruction sent by the electronic model of control unit in system platform unit, corresponding to the electronic model of the element to be detected, and output analog oscillation signal to IO module connector docking unit and the element to be detected;System platform unit, including design drawing.The present application can realize automatic debugging, and debugging and drawing modification are carried out synchronously.

This invention relates to the field of wireless communication technology and discloses a radio frequency front-end ASDIV switching system and electronic device, including a physical antenna group comprising a first antenna and a second antenna; a power amplifier front-end module including a first port and a second port, the first port being directly connected to the first antenna and the second port being directly connected to the second antenna; a transceiver having a main receiver and a diversity receiver; and a switching circuit internally within the power amplifier front-end module. The switching circuit is configured to form four signal paths between the first port, the second port, and the main receiver and diversity receiver, including: a first path from the first port to the main receiver, a second path from the first port to the diversity receiver, a third path from the second port to the main receiver, and a fourth path from the second port to the diversity receiver. By dynamically reconstructing the signal paths through the internal switching circuit to replace an external switch, hardware simplification, performance improvement, and cost reduction are achieved.

The invention belongs to the field of medicinal chemistry, and relates to an indole allylamine amide derivative as well as a preparation method and application thereof. Functional activity screening of G protein dependent signaling pathways is carried out on all the synthesized compounds, and it is found that the new derivatives can be used for preparing beta2-adrenergic receptor allosteric antagonism regulator drugs. Trans-indole allylamine is used as a raw material, amide coupling is performed to obtain the novel indole allylamine amide derivative, and R1 is any one of phenyl, m-methylbenzene, m-methoxyphenyl, m-bromophenyl, m-chlorphenyl, m-fluorophenyl, o-methoxyphenyl, p-methoxyphenyl, naphthalene ring, oxazole, cyclohexyl, cyclopentyl, methyl, ethyl and isopropyl. A biological activity test result shows that the indole allylamine amide derivative disclosed by the invention has relatively good antagonistic activity on beta2AR and can be used for carrying out negative allosteric regulation on the functional activity of isoproterenol.