56 results about "Radiosensitizer" patented technology

The invention belongs to the technical field of biological medicine, and particularly relates to a manganese-doped zeolite imidazole framework and application thereof in tumor radiotherapy. According to the present invention, the new use of the manganese-doped zeolite imidazole framework as the tumor radiosensitizer is found, Mn-ZIF-8 has ray responsiveness, can continuously release Mn < 2 + > ions under X-ray irradiation, and can enhance the activation of a cGAS-STING signal channel so as to promote DCs maturation and antigen presentation, and enhance the T cell mediated immune response, such that the tumor treatment effect is enhanced. Furthermore, the invention provides the Mn-ZIF-8 microneedle, the microneedle has the characteristics of rapid dissolution and controlled release, ensures accurate delivery and continuous action of drugs at tumor sites, reduces systemic toxicity, and can significantly amplify local and systemic immune effects caused by radiotherapy and improve the therapeutic effect when used in combination with an immune checkpoint inhibitor.

The present invention relates to the nanoparticles (NP) of the invention, compositions thereof and their use as therapeutic agents, in particular in the field of oncology and / or as imaging agents. The NPs consist of first nanoparticles of at least one high-Z metal oxide material, to which smaller second nanoparticles are covalently bonded at the surface of the first nanoparticles. The second nanoparticles consist of a) at least one noble metal or at least one metal oxide, metal sulfide, metal selenide or metal sulfide / selenide as a Fenton or Fenton-like reaction catalyst. The NPs of the invention produce a surprising therapeutic effect when exposed to ionizing radiation such as X-rays, gamma-rays, protons, neutrons, radioisotopes and / or electron beams. Therefore, these NPs can be used as radiosensitizers in the field of oncology. These nanoparticles can also be used as contrast agents.

The present invention relates to intracellular copper zinc superoxide dismutase inhibitors for protecting a subject from damage caused by radiation outbreak. The invention also relates to kits comprising SOD1 inhibitors and radiosensitizers for cancer cells, to the in vitro use of SOD1 inhibitors for protecting non-cancer cells from ionizing radiation, and to methods, compositions and uses related thereto.

The invention belongs to the technical field of radiotherapy sensitizers, and relates to a hafnium-titanium composite nano radiosensitizer as well as a preparation method and application thereof. The invention discloses a preparation method of a hafnium-titanium composite nano radiosensitizer, which comprises the following steps: (1) mixing a titanium-based metal frame compound Ti-MOF and hafnium-based oxide HfO2 with water according to a mass ratio of 2: 1-1: 2, putting the mixture into a reaction kettle, and carrying out hydrothermal reaction at 80-130 DEG C for 6-48 hours to obtain hafnium-titanium nanoparticles; and (2) dispersing the hafnium-titanium nanoparticles in the hydrophilic modification material solution, and stirring at room temperature for 6-48 hours to obtain the hafnium-titanium composite nano radiosensitizer. The invention also discloses application of the hafnium-titanium composite nano radiosensitizer in the field of imaging and preparation of medicines for treating colorectal cancer.

The present application relates to a kind of radiotherapy sensitization microneedle and its preparation method and application, belong to biological medicine technical field.The radiotherapy sensitization microneedle of the present application includes hyaluronic acid and nano radiosensitizer;The radiotherapy sensitization microneedle is obtained by drying after hyaluronic acid and nano radiosensitizer solution are mixed;The nano radiosensitizer solution is prepared by the following method: hafnium salt, 1,1'-ferrocene dicarboxylic acid and benzoic acid are mixed in organic solvent and stirred, centrifugal;The supernatant obtained is dialyzed, extracted, and the liquid phase obtained after solid-liquid separation is nano radiosensitizer solution.The radiotherapy sensitization microneedle of the present application is applied to the growth inhibition and radiotherapy sensitization of mouse melanoma cell B16F10 cell, can fully play the role of radiotherapy sensitization while overcoming the limitation of prior art, and preparation route is simple, and have certain conversion prospect.

The invention belongs to the field of medicinal chemistry, and particularly discloses a preparation method and application of a nitroimidazole derivative serving as an anti-tumor radiosensitizer. According to the invention, nitroimidazole is used as a lead compound, and a framework of nitroimidazole is modified through a series of reactions to obtain the novel nitroimidazole derivative. The compound can target a tumor hypoxia region, is reduced by a specific enzyme highly expressed in a hypoxia tumor tissue, and is combined with nucleophilic biological macromolecular free radicals generated by radiation to accelerate cancer cell death. As an anti-tumor radiosensitizer, the compound disclosed by the invention is expected to improve the tumor cell selectivity of the compound and reduce toxic and side effects, and is used for subsequent anti-tumor activity research.

The invention discloses an absorbable particle cannula loaded with double radiosensitizers, and aims to effectively improve the internal radiation radiotherapy effect and facilitate implantation of radioactive particles, and the whole material can be degraded and absorbed in vivo and does not need to be taken out through a secondary operation. The absorbable particle sleeve mainly comprises an absorbable particle sleeve body for packaging radioactive particles, a spacer which is arranged in the sleeve body and is used for spacing the radioactive particles, and a polydopamine coating which is loaded with a double radiosensitizer of metal nanoparticles and aromatic ring structure drugs. In the polydopamine coating, the metal nanoparticles are nanoparticles formed by reducing metal ions on the surface of the coating in situ through catechol groups of polydopamine; and the medicine is loaded on the surface of the coating through non-covalent acting force (pi-pi stacking action, hydrophobic interaction and / or electrostatic attraction).

The present disclosure relates to methods of treating tumors. In particular, the present disclosure relates to a method of treating a tumor in a subject in need thereof by ionizing radiation, the method comprising: (i) injecting a first therapeutically effective amount of nanoparticles containing a high Z element as a radiosensitizer into the subject in need thereof for a period of 2-10 days prior to a first irradiation of the tumor, (ii) within 1-12 hours prior to the first irradiation of the tumor, injecting a second therapeutically effective amount of identical or different nanoparticles containing high Z element, and (iii) irradiating the tumor of the subject with a therapeutically effective amount of radiation; wherein the nanoparticles containing high element Z are nanoparticles containing an element having an atomic Z number higher than 40, and the nanoparticles have an average hydrodynamic diameter lower than 10 nm.

The application of poly(D-lactic acid) and poly(D-lactic acid-glycolic acid) copolymers in constructing micro / nanocarriers for antitumor drugs belongs to the field of biomedical polymer materials and nanomedicine. The antitumor drugs are small-molecule chemotherapeutic agents, small-molecule photosensitizers, small-molecule immunotherapeutic agents, and small-molecule radiosensitizers. The particle size of the poly(D-lactic acid) and poly(D-lactic acid-glycolic acid) copolymers is 10–5000 nm. The effective concentration of the poly(D-lactic acid) and poly(D-lactic acid-glycolic acid) copolymers is 1–500 mg / kg. The antitumor mechanism of the poly(D-lactic acid) and poly(D-lactic acid-glycolic acid) copolymers includes increasing the activity of effector T cells in the tumor microenvironment and increasing the concentration of cytokines such as IFN-γ at the tumor site. In the field of tumor therapy, PLA and PLGA materials composed of D-lactic acid have shown good effects in inhibiting tumor growth, prolonging the survival period of tumor-bearing mice, and activating antitumor immune responses.

The invention belongs to the field of biological medicine, and particularly relates to a high-selectivity sensitizer for solid tumor radiotherapy and a preparation method thereof.The sensitizer comprises two newly-designed modified compounds: a derivative based on a diamino-anthraquinone structure and capable of enhancing radiation energy deposition and relieving tumor hypoxia; and the other one is a cystamine derivative containing a diselenide bond, and can effectively consume overexpressed glutathione in tumor cells and enhance the generation of active oxygen. The preparation method comprises the following steps: dissolving the two modified compounds and the biodegradable polymer in an organic solvent to form an organic phase, dissolving phospholipid polyethylene glycol amino in warm water, blending with a stabilizer in a buffer solution to form a water phase, dropwise adding the organic phase into the water phase through a nano-precipitation method, self-assembling to form nano-particles, and filtering and purifying to obtain a final product. The sensitizer can specifically target tumor tissues, the radiotherapy effect is remarkably improved through a multiple synergistic mechanism, meanwhile, the damage to normal tissues is reduced, the preparation process is simple and convenient, and the reproducibility is good.

The present invention discloses a radiosensitizer and its preparation method and application. In the present invention, a PARP inhibitor (PARPi) and a nitro derivative are covalently bonded to obtain a radiosensitizer. During radiotherapy, the radiosensitizer can not only fix DNA damage in tumor cells through the action principle of nitroimidazole drugs, but also inhibit the repair function of PARP, further amplifying the cell damage caused by radiation, thereby achieving the effect of radiotherapy sensitization and improving the efficacy of radiotherapy.

Systems and methods for radiation therapy for cancerous tumors using biocompatible quantum dots to provide radiation dose enhancement and resistance to metastasis are described. In an aspect, a method for radiation therapy treatment of cancer cells, includes, but is not limited to, preparing a radiosensitizer fluid, the radiosensitizer fluid including a plurality of biocompatible quantum dots; introducing the radiosensitizer fluid to cancer cells; and irradiating the cancer cells with the radiosensitizer fluid to promote generation of reactive oxygen species and inhibit radiation-induced enhancement of cell-migration.

The invention discloses a radiosensitization functional probiotic hybrid material as well as a preparation method and application thereof, and belongs to the technical field of medical preparations. The preparation method comprises the following steps: firstly, preparing black phosphorus nanosheets and bismuth nanoparticles; then, in an aqueous solution environment, blending the bismuth nanoparticles with the black phosphorus nanosheets, adding NH2-PEG2000-MAL and MMP-2 enzyme response polypeptide, and carrying out a reaction, so as to obtain the black phosphorus-based radiosensitizer; finally, clostridium butyricum and the black phosphorus based radiosensitizer are blended, then N-hydroxysuccinimide and 1-ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride are added, incubation is carried out, and the radiosensitization functionalized probiotic hybrid material is obtained. The method has the advantages of simple process and high operability. The prepared radiosensitizing functional probiotic hybrid material can be driven by anaerobic probiotics to effectively improve the targeting accuracy of a radiosensitizer and reduce off-target toxic and side effects, has the characteristic of high tumor inhibition efficiency, and has wide application prospects in the anti-tumor field.

Disclosed herein is a radio-afterglow nanoparticle (RANP) comprising ABCD, wherein: A represents a radioabsorber; B represents a radiosensitizer; C represents a luminescent component; and D represents an amphiphilic polymeric matrix. Also disclosed herein are a method for the detection of cancer in vivo, a method of treating cancer, a method of treating cancer in a patient by administering the aforementioned radio-afterglow nanoparticle, uses of the aforementioned radio-afterglow nanoparticle, and a drug comprising the aforementioned radio-afterglow nanoparticle.

The invention discloses a sensitizing drug for resisting breast cancer by radiotherapy and a screening method and application thereof, and belongs to the field of biomedicine.The method comprises the steps that an in-vitro radiotherapy resistance model is constructed, a clinical segmentation radiotherapy dose increasing mode is simulated, stable acquired radiotherapy resistance is induced to be generated, and a carrier is provided for drug screening; natural plant small molecule compounds are used for treatment, and through concentration and time gradient dual control, the reversion ability of the natural plant small molecule compounds to radiotherapy resistance phenotypes is investigated; a multi-dimensional joint detection system is established, multi-level comprehensive evaluation is performed from cell survival and the like, the limitation of a single index is broken through, and the screening accuracy and reliability are improved; dNA damage repair is dynamically monitored through immunofluorescence, comet electrophoresis and the like, and the drug action mechanism is revealed. The medicine screened by the method is suitable for primary and acquired radiotherapy resistance patients, can effectively improve the radiotherapy curative effect, provides a new medicine source and scheme for clinical problems, and opens up the application of the compound in preparation of radiosensitizers or adjuvant therapy medicines.

A gold nanocluster of the formula Au22(Lys-Cys-Lys)16, wherein Lys-Cys-Lys is lysine-cysteine-lysine, and methods for synthesis, are provided. The gold nanocluster effectively produces Type I ROS and functions as photosensitizer, and has utility in applications such as, but not limited to, biomedical applications and photocatalysis. The gold nanocluster may be useful in photodynamic therapy (PDT) and as a radiosensitizer in cells and tissues for treating diseases such as certain cancers.

The invention relates to an application of suramine in promoting tumor radiotherapy sensitization. The invention fully proves that suramin can effectively prepare tumor cells in a state highly sensitive to ferroptosis through a novel metabolic reprogramming mechanism of inhibiting IPPK, reducing IP6 and releasing Fe < 2 + > chelated with an iron pool in cells, thereby creating necessary biochemical conditions for ferroptosis; and the sensitivity of cells to ferroptosis induced stimulation is fundamentally changed. Therefore, the compound can be used as a ferroptosis inducer and a potent sensitizer for radiotherapy at the same time. The discovery not only provides a new combined strategy for overcoming tumor treatment resistance, but also perfectly explains the transformation medicine concept of new use of old medicines, and provides a new active ingredient for human tumor treatment, thereby providing a new direction for subsequent medicine research and development, clinical treatment and the like, and having extremely high social value and market application prospects.

The application provides a preparation method of selenium-doped Prussian blue nanoparticles modified by a targeting polypeptide, and comprises the following steps: (1) synthesizing Prussian blue nanoparticles by a microwave method; (2) synthesizing selenium-containing Prussian blue by a gas-phase atomic deposition method; and (3) preparing selenium-doped Prussian blue nanoparticles modified by a targeting polypeptide: dissolving a tumor-targeting RGD cyclic peptide in ultrapure water, adding a catalyst N-hydroxysuccinimide and 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride and then stirring, then performing dialysis, adding the selenium-containing Prussian blue into the dialysate, stirring, centrifuging, resuspending and obtaining the selenium-doped Prussian blue nanoparticles modified by the targeting polypeptide. According to the preparation method, the selenium is naturally deposited on the surface of the Prussian blue by the gas-phase atomic deposition method, monodisperse selenium with controllable doping amount is formed, and the selenium-doped Prussian blue modified by the targeting polypeptide is prepared.

The subject of the application is a 2'-deoxyadenosine derivative in the form of 8-(4-trifluorothio)benzylamino-2'-deoxyadenosine of formula 1 and its use as a radiosensitizer of DNA damage, which sensitizes cancer cells to ionizing radiation. The application also covers a method for obtaining 8-(4-trifluorothio)benzylamino-2'-deoxyadenosine of formula 1, characterized in that 8-bromo-2'-deoxyadenosine of formula 2 is mixed with 4-trifluorothiobenzylamine of formula 3 in a molar ratio of 1:8, in the presence of methanol, and then the mixture is heated to reflux and stirred for 72 h.

The present invention relates to an inhibitor of intracellular copper-zinc superoxide dismutase for use in protecting subjects from radiation burst injury. The present invention also relates to a kit comprising an SOD1 inhibitor and a radiosensitizer for cancer cells, the in vitro use of an SOD1 inhibitor for protecting non-cancer cells from ionizing radiation, and methods, compositions, and uses relating thereto.

A conjugate of formula T-L-A in which T is a ligand that targets prostate-specific membrane antigen (PSMA), L is a linker, and A is radiosensitizer; a pharmaceutical composition comprising the conjugate and a pharmaceutically acceptable carrier; and a method of treating a patient for prostate cancer or metastasis thereof with radiotherapy. Conjugates of formula T-L-A can be administered before or after the administration of conjugates of the formula T-L-X, wherein X is or comprises a radiotherapeutic or (radio)imaging agent. A conjugate of the formula T-L-(X)A, a pharmaceutical composition comprising same, and a method of use are also disclosed.

The invention belongs to the technical field of biological catalytic materials, and particularly relates to a gold monatomic radiosensitizer with multienzyme activity as well as a preparation method and application of the gold monatomic radiosensitizer. The gold monatomic radiosensitizer is a coordination complex formed by a gold source containing tetrachloro gold (III) acid radical ions and 2, 4, 6-tri (4-pyridyl)-1, 3, 5-triazine through a coordination substitution reaction of Au and pyridine nitrogen. The gold monatomic radiosensitizer disclosed by the invention is a biocatalyst which is newly designed, has multi-enzyme activity biological catalysis performance and can be activated by radiation, and can be used as a polymer artificial enzyme for efficient and controllable tumor treatment.

Radiosensitizer prodrugs and formulations and methods of use thereof are provided. Typically, the radiosensitizer prodrug is an analog of a radiosensitizer parent compound having one or more S-nitrosothiol moieties. Typically, the S—N bond of the S-nitrosothiol moiety can be cleaved by radiation during radiotherapy, releasing the parent compound and nitric oxide. One or preferably both the parent compound and the nitric oxide can contribute to death of tumor cells exposed to radiotherapy. Nanoparticle formulations for delivery of the prodrug, and methods of using them in combination with radiotherapy to treat tumors and cancer are also provided.

Conjugates of the formula T-L-A wherein T is a ligand targeting prostate specific membrane antigen (PSMA), L is a linker, and A is a radiosensitizer; a pharmaceutical composition comprising the conjugate and a pharmaceutically acceptable carrier; and methods of treating prostate cancer or metastases thereof in a patient using radiotherapy. A conjugate of formula T-L-A can be administered prior to or after administration of a conjugate of formula T-L-X, wherein X is or comprises a radiotherapy or (radiation) imaging agent. Conjugates of formula T-L-(X) A, pharmaceutical compositions comprising the same, and methods of use are also disclosed.

The invention discloses application of USP15 in preparation of a bladder cancer radiotherapy sensitizer, and belongs to the technical field of biological medicine. The objective of the invention is to improve the radiotherapy sensitivity of bladder cancer. The invention relates to an application of USP15 in preparation of a bladder cancer radiotherapy sensitizer. The USP15 is used for preparing the bladder cancer radiotherapy sensitizer. The radiotherapy sensitivity of the bladder cancer is improved by overexpressing the USP15. The USP15 can regulate and control the stability of FIS1 protein through ubiquitination modification so as to inhibit the mitochondrial function, and the activation of the regulation and control pathway is the core mechanism of the USP15 for exerting the radiotherapy sensitization effect. In conclusion, the invention not only provides a new thought for molecular mechanism research of bladder cancer radiotherapy sensitization, but also provides a potential strategy for treatment of clinical radiotherapy resistant bladder cancer patients, and has important drug development value and clinical application prospect.

This invention discloses the application of disulfiram or its pharmaceutical salt in the preparation of radiosensitizers, wherein the radiosensitizer refers to a radiosensitizer for malignant tumors, specifically osteosarcoma. The radiation involved in the radiosensitizer is selected from alpha, beta, gamma, or X-ray radiation. This invention is the first to discover and confirm a novel use of disulfiram in enhancing the radiosensitivity of malignant tumors, significantly inhibiting the proliferation of osteosarcoma cells after radiotherapy and promoting cell death in vitro. It also demonstrates outstanding efficacy in inhibiting the growth of subcutaneously implanted osteosarcoma in mice after radiotherapy.

The invention relates to the technical field of radiotherapy drugs. The invention provides an application of frankincense diene alcohol acid in preparation of a tumor radiosensitizer. According to the application disclosed by the invention, the frankincense dienol acid can promote apoptosis induced by radioactive rays, so that the radiotherapy sensitivity is remarkably enhanced.

The present invention provides a radiosensitizer or anti-cancer chemotherapy sensitizer including a combination of (a) hydrogen peroxide and (b) hyaluronic acid or a salt thereof, wherein the hydrogen peroxide content in a final formulation is 0.1 to 3.5 weight percent.

To provide a radiation sensitizer containing fullerene in which the radiation sensitizing effect is high.SOLUTION: A radiation sensitizer contains fullerene modified with polyether.SELECTED DRAWING: None

Radiosensitizer prodrugs, and formulations and methods of use thereof are provided. Typically, the radiosensitizer prodrugs are analogs of a radiosensitizer parent compound having one or more S-nitrosothiol moieties. Typically, the S-N bond of the S-nitrosothiol moiety can be radiocleaved during radiation therapy, releasing the parent compound and nitric oxide. One, or preferably both, of the parent compound and nitric oxide can promote death of tumor cells exposed to radiation therapy. Also provided are nanoparticle formulations for delivery of the prodrugs, and methods of using them in combination with radiation therapy to treat tumors and cancers.