Novel application of hsa-miR-185

A molecular and product technology, applied in the new application field of hsa-miR-185, can solve the problems such as the unclear function of miR-185
CN102102102AActive Publication Date: 2011-06-22INST OF MODERN PHYSICS CHINESE ACADEMY OF SCI
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
INST OF MODERN PHYSICS CHINESE ACADEMY OF SCI
Publication Date
2011-06-22

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Abstract

The invention relates to novel application of hsa-miR-185. The novel application is application of miR-185 in preparing products with function of enhancing the sensitivity of cells and / or tissues and / or organisms to radiation, or preparing products with function of treating and / or preventing tumors, or preparing products inhibiting signal channels activated or mediated by ATR genes, products inhibiting signal channels activated or mediated by ATR proteins, products inhibiting the ATR genes and / or products for inhibiting the ATR proteins. Experiments prove that: the miR-185 can directly inhibit tumor growth and enhance the sensitivity of cells to the radiation. Further experiments prove that: the functions of the miR-185 are realized by inhibiting the expression of the ATR genes in the cells. Therefore, the miR-185 is used for preparing medicines for treating tumors and radiosensitizers, and has important significance for treating the tumors and wide application prospect.
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Description

technical field

[0001] The present invention relates to a new application of hsa-miR-185. Background technique

[0002] Tumor is a common and frequently-occurring disease that seriously threatens human life and health. It accounts for the top three disease-related mortality in many countries and regions, and its morbidity and mortality are still increasing year by year. The current main treatment methods include surgery, radiotherapy and chemotherapy. According to the data of the World Health Organization (WHO) in 1998, the total cure rate of tumors is about 45%, and 80% of patients have received radiotherapy to varying degrees, but the radiation resistance of tumors seriously affects the therapeutic effect of radiotherapy.

[0003] Radiation therapy is one of the very important tumor treatment methods, but the cure rate is still low. In addition, the current radiotherapy devices mainly include γ-rays, X-rays, and the like. The mechanism of action of these conventional ra...

Claims

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