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78results about How to "Improve radiosensitivity" patented technology

Albumin nanoparticles capable of double-stage oxygen carrying and preparation method and application thereof

The invention belongs to the field of radiotherapy sensibilization medicines, and relates to albumin nanoparticles capable of double-stage oxygen carrying and a preparation method and application thereof. The albumin nanoparticles are mainly prepared from albumin, perfluoro-carbon and catalase, the particle size of the albumin nanoparticles is even, the property is stable, the biosecurity is good,and the problem of radiotherapy resisting of solid tumors can be solved. Experimental results show that the nanoparticles can target the tumors and improve tumor hypoxia by means of double-stage oxygen carrying, for specific performance of double-stage oxygen carrying of the nanoparticles, the high-oxygen-carrying perfluoro-carbon directly supplies oxygen (first stage oxygen carrying) to the hypoxic tumors directly through oxygen concentration gradient difference, meanwhile, the catalase conducts catalytic hydrolysis on high-concentration hydrogen peroxide on the tumor portions to generate oxygen for indirect oxygen carrying (second stage oxygen carrying), through synergism of first stage oxygen carrying and second stage oxygen carrying, a tumor hypoxia microenvironment is reversed, and effective sensibilization is conducted on oxygen-dependent tumor radiotherapy.
Owner:南京从一医药科技有限公司

Application of total glucosides of paeonia in preparation of medicament for treating thyroid cancer and improving tumor radiotherapy synergy

ActiveCN110327389ASignificantly against thyroid cancerEnhance iodine uptakeAntineoplastic agentsPlant ingredientsCancer cellBULK ACTIVE INGREDIENT
The invention relates to new application of a traditional Chinese medicine, in particular to application of total glycoside of paeonia in preparation of a medicament for treating thyroid cancer and improving tumor radiotherapy synergy, and belongs to the technical field of traditional Chinese medicines. The invention relates to the application of total glycoside of paeonia in preparation of a medicament for treating thyroid cancer and improving tumor radiotherapy synergy. The total glucosides of paeonia can be used as an active ingredient, are added with pharmaceutically-acceptable pharmaceutical excipients or carriers, and are prepared into a preparation according to a method recorded in pharmacy. The total glycosides of paeonia of the invention can also be used as one of the active ingredients, also contain other medicines, are added with pharmaceutically-acceptable pharmaceutical excipients or carriers, and are prepared into a preparation according to the method recorded in pharmacy. Through research, the inventor discovers that: the total glucosides of paeonia have obvious functions of resisting thyroid cancer and enhancing iodine uptake of cancer cells, and can improve the sensitivity of radiotherapy, can be prepared into a medicament for treating thyroid cancer, and can be prepared into a medicament for improving tumor radiotherapy synergy.
Owner:ZHEJIANG CANCER HOSPITAL
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