14 results about "Oxygen-carrying" patented technology

The utility model provides a portable low-temperature oxygen-carrying organ transfer box which comprises a machine shell and a cover plate, a miniature oxygen generator is installed on the machine shell, two sets of air outlet connectors are arranged on the machine shell, and the miniature oxygen generator is connected with the two sets of air outlet connectors through connecting pipes. The cover plate is rotatably connected with the shell to form a placement cavity, a storage assembly is arranged in the placement cavity, the storage assembly comprises a covering shell, a container bag and an oxygenator are arranged in the covering shell, two groups of oxygen circulation openings are formed in the container bag, one group of air outlet connectors are connected with the oxygenator, and the other group of air outlet connectors are connected with one group of oxygen circulation openings; a control panel is arranged on the machine shell, and a power supply and a main control board are installed on one side of the machine shell. According to the transfer box, the miniature oxygen generator is installed on the machine shell, the miniature oxygen generator is communicated with the oxygenator and the container bag in the storage assembly through the connecting pipe, oxygen can be supplied to organs at low temperature, accumulation of toxic metabolites of the organs is effectively avoided, and the risk of ischemia reperfusion injury is reduced.

The invention discloses a low-oxygen affinity deoxidized hemoglobin spray and application thereof. The invention creatively discovers that the oxygen concentration on the surface of a wound is obviously higher than that of pure deoxidized hemoglobin and high-oxygen-affinity deoxidized hemoglobin with higher oxygen carrying capacity after the low-oxygen-affinity deoxidized hemoglobin with higher oxygen release capacity is used; it is proved that the low-oxygen affinity deoxidized hemoglobin is more beneficial to improvement of the oxygen concentration of the wound surface. According to the specific embodiment of the invention, the RSR-13 is combined with the deoxidized hemoglobin, the conformation of the deoxidized hemoglobin is changed, the oxygen affinity of the deoxidized hemoglobin is reduced, the oxygen release of the deoxidized hemoglobin in the hypoxia tissue is effectively enhanced, the drug has no obvious toxicity to skin cells, the effectiveness and safety of the drug in skin wound treatment are improved, and the application prospect is wide. The method is suitable for treating multiple types of wound surfaces, and has wide application value and market prospect.

The invention relates to a hemoglobin oxygen carrier based on small molecule modification as well as a preparation method and application thereof. The hemoglobin oxygen carrier comprises hemoglobin and N-fluoromethoxycarbonyl diphenylalanine, the hemoglobin forms the hemoglobin oxygen-carrying carrier through the non-covalent bond acting force between the hemoglobin and the N-fluoromethoxycarbonyl diphenylalanine. According to the hemoglobin oxygen carrier disclosed by the invention, a co-assembly strategy of N-fluoromethoxycarbonyl diphenylalanine and hemoglobin is rapidly implemented by taking a non-covalent bond acting force as a driving force. The hemoglobin oxygen-carrying carrier prepared by the process greatly shortens the stabilization time of hemoglobin molecules on the basis of ensuring the stability of molecular chemical groups, has good biocompatibility and injectable application characteristics on the basis of the characteristics of non-covalent acting force, and provides a new foundation for research and development of a new generation of hemoglobin oxygen-carrying carriers. And an engineering design thought and a theoretical basis are provided.

The present application relates to a kind of from starworm separates oxygen-carrying active haemerythrin method, belong to protein separation and purification technical field.This method is first obtained from the body cavity fluid of square starworm pigment cell, obtains crude haemerythrin liquid after lysis, haemerythrin molecule is separated by multistage tangential flow ultrafiltration technology, further by vacuum low-temperature freeze-drying method reaches the purpose of long time keeping active.This application obtains body cavity fluid by cutting short starworm end, and almost does not affect its edible value, is selectively lysed pigment cell by configuring hypotonic lysis solution and protects haemerythrin activity, determines multistage tangential flow ultrafiltration membrane pore size specification and use order and other key parameters, provides freeze-dried powder preparation method to long time maintain activity.The present application discloses a kind of from starworm high-efficiency separation active haemerythrin method complete technical scheme, is suitable for biological medicine field haemerythrin research and development and starworm industry intensive processing.

The invention relates to the field of gas breathing circulation regeneration, and discloses a gas breathing circulation system based on bionic half gills and an underwater respirator, the gas breathing circulation system comprises a respirator, the respirator is used for breathing interaction of a user; the bionic half gill is internally provided with a permeable diaphragm for air-water exchange; the respirator and the bionic half gill are connected in series through a connecting pipeline to form a gas circulation loop; based on the characteristic that the solubility and the mass transfer rate of carbon dioxide in water are far higher than those of oxygen, the scheme realizes that carbon dioxide is efficiently transferred only by a physical diaphragm without a chemical adsorbent, so that not only is the chemical risk thoroughly eliminated, but also the utilization rate of oxygen is increased by several times by recycling residual oxygen in exhaled gas; and finally, the underwater operation time is remarkably prolonged under the same oxygen carrying amount, meanwhile, the breathing comfort is guaranteed through the gas adjusting cavity, intelligent regulation and control of gas components are achieved through the exhaust port, and the system has safety, high efficiency and engineering feasibility.

The invention provides an oxygen-carrying synergist, a preparation method thereof and application of the oxygen-carrying synergist in underground supercritical water coal gasification. The preparation method comprises the following steps: mixing alkali carbonate, hydrogen peroxide and a compound stabilizer to form a first system, and controlling the pH value of the first system to be 7-9; adding the first system into a dispersion liquid containing siloxane, a water-in-oil emulsifier and a dispersant solution, and mixing to form a second system; adding a curing agent into the second system for curing reaction to form a third system; the third system is subjected to freeze-drying treatment, and the oxygen-carrying synergist is obtained. When the obtained oxygen-carrying synergist is subsequently applied to underground supercritical water coal gasification, the effective utilization rate of coal and hydrogen selectivity can be effectively improved, and the metal corrosion risk is reduced.

The invention relates to the technical field of hylocereus undatus moxibustion, in particular to a formula of hylocereus undatus moxibustion as well as a preparation method and application of the hylocereus undatus moxibustion, and the hylocereus undatus moxibustion is prepared from the following raw materials in parts by weight: 35-40 parts of folium artemisiae argyi, 5-10 parts of a modified carbon agent, 4-7 parts of a graphene regulator and 8-12 parts of an auxiliary agent; wherein the adjuvant is prepared from the following raw materials in parts by weight: 15-20 parts of fresh ginger, 5-10 parts of radix angelicae sinensis, 5-10 parts of cortex cinnamomi and 8-12 parts of cortex eucommiae. The hylocereus undatus moxibustion is beneficial to the human body; qi and blood circulation can be quickly recovered, primordial qi can be replenished, Qi and blood running channels (oxygen carrying capacity of red blood cells) can be opened, and anemia can be improved; the self-immune function and the activity of white blood cells are rapidly improved; the tissue blood supply is increased, and the sub-health state is improved.

The invention discloses an organ maintenance liquid for repairing liver functions as well as a preparation method and application of the organ maintenance liquid. The feed additive comprises the following components: an oxygen-carrying component, succinyl gelatin, sodium chloride, sodium hydroxide, sodium bicarbonate, calcium gluconate, magnesium sulfate, chromium chloride, copper chloride, ferric chloride, manganese chloride, sodium molybdate, sodium selenite, zinc chloride, potassium iodide, sodium fluoride, isoleucine, leucine, lysine acetate, methionine, phenylalanine, threonine, tryptophan, serine, valine and histidine. The injection is prepared from arginine, alanine, asparaginic acid, cysteine, glutamic acid, proline, tyrosine, glycine, sodium hydrogen sulfite, heparin, methylprednisolone sodium succinate, broad-spectrum antibiotics, antifungal drugs, FXR agonists and sterilized water for injection. The oxygen-carrying component is washed red blood cells or concentrated red blood cells or artificial blood. The viscosity of the organ maintenance liquid is closer to that of plasma, the influence on the blood coagulation function and the renal function is avoided, and the organ maintenance liquid has higher safety, can treat ischemia reperfusion injury, repair the liver biliary tract function and remarkably reduce various inflammation indexes, and is used for ischemia-free liver transplantation.

The invention belongs to the technical field of biomedical materials, and particularly relates to injectable-oxygen-carrying-antibacterial composite hydrogel as well as a preparation method and application thereof. The method comprises the following steps: dissolving dopamine hydrochloride in a buffer solution, adding bioactive glass, carrying out ultrasonic treatment to obtain BGs (at) PDA, dispersing the BGs (at) PDA in water, dropwise adding perfluorooctanoyl chloride, and carrying out ultrasonic treatment to obtain fluorinated bioactive glass; the preparation method comprises the following steps: dissolving hyaluronic acid in water, adding sodium periodate, reacting in a dark place, adding ethylene glycol, continuously reacting, dialyzing and freeze-drying to obtain an oxidized hyaluronic acid solid; and dispersing the fluorinated bioactive glass into a gelatin solution, and then uniformly mixing with an oxidized hyaluronic acid solution, thereby obtaining the product. The hydrogel provided by the invention has injectability, excellent mechanical property and oxygen carrying effect, has good antibacterial effect and biocompatibility, can effectively promote bone defect repair, and has wide application prospect in the field of bone tissue engineering.

The application belongs to the technical field of biological medicine and photodynamic therapy, and particularly relates to an aggregation-induced emission photosensitizer with tumor hypoxia relief function and a preparation method and application thereof. The photosensitizer is MeTCP-F, which uses methoxy-modified triphenylamine as an electron donor, benzindole as an electron acceptor, and thiophene as a pi bridge to form a D-pi-A structure, and is connected with a perfluorinated compound through an ester bond; and the MeTCP-F NPs are prepared by using CH3-PEG-DSPE through a nano precipitation method. The photosensitizer has near-infrared fluorescence imaging, active oxygen generation and oxygen carrying capacity, can relieve tumor hypoxia, cooperatively realize the generation of type I and type II active oxygen, and improve the photodynamic therapy effect. The MeTCP-F NPs have good water solubility and high biocompatibility, can be enriched in tumor tissues through the EPR effect, can realize efficient tumor killing under the guidance of near-infrared imaging, have low systemic toxicity, and have application value in the preparation of anti-tumor photodynamic therapy drugs.

This invention discloses an ultrasound-responsive Pickering-like emulsion and its application in the preparation of tumor therapeutic agents, relating to the field of tumor therapeutic nanomaterials. The emulsion consists of oxygen-carrying perfluorohexane droplets and copper-coordinated 1 / 4-carboxyphenyl porphyrin nanoparticles, wherein the nanoparticles act as colloidal surfactants, armoring the surface of the perfluorohexane droplets to form a Pickering-like emulsion. The preparation method includes: coordinating 1 / 4-carboxyphenyl porphyrin with copper chloride and co-assembling it with Pluronic F127 to obtain FTC NPs; then emulsifying perfluorohexane with the FTC NPs to obtain PFTC EMs, which can be further oxygen-saturated to obtain an oxygen-carrying emulsion. Under ultrasound, the emulsion undergoes responsive disintegration and simultaneously releases oxygen and FTC NPs, which can both deplete glutathione and alleviate tumor hypoxia, and promote the generation of reactive oxygen species and Cu. + Induced copper death, thereby reshaping the tumor microenvironment and enhancing the synergistic antitumor effect of sonodynamics / copper death.

The invention discloses a polyamino acid-hemoglobin nanosphere artificial oxygen carrier therapeutic agent as well as a preparation method and application thereof. The therapeutic agent is a nanosphere with a specific core-shell structure, wherein an inner core is formed by crosslinking L-phenylalanine and L-cystine copolymerization chain segments through intermolecular disulfide bonds; the middle layer is polyglutamic acid, and hemoglobin is covalently grafted on the surface of the middle layer; and the outer layer is an mPEG chain. The preparation method comprises the following steps: synthesizing an amino acid NCA monomer, initiating sequential ring opening polymerization by mPEG-NH2, performing deprotection, and activating carboxyl grafted hemoglobin. The therapeutic agent can improve hemoglobin stability, prolong in-vivo circulation time, reduce toxic and side effects and increase oxygen carrying capacity, and can be used as an oxygen bridge for hemorrhagic shock resuscitation so as to prolong treatment time.

The invention discloses a preparation method of a complex iron desulfurization solution regeneration reaction additive, and belongs to the technical field of sulfur-containing natural gas desulfurization purification, and the preparation method comprises the following steps: preparing a cobalt-based organic metal framework Co-MOF; modifying the Co-MOF: adding a phenolic compound into the prepared Co-MOF, and carrying out a reaction, so as to obtain the Co-MOF modified by the phenolic compound; the method further comprises an infiltration process, wherein the obtained Co-MOF modified by the phenolic compound is infiltrated into a surfactant aqueous solution with the mass fraction of 1.0 wt.%. According to the invention, the cobalt-based metal organic framework porous material Co-MOF is taken as a support skeleton to cooperate with the phenolic compound and the phenolic modified fragment, so that the oxygen carrying capacity is enhanced, the effects of capturing and removing hydroxyl free radicals. OH are achieved, and the degradation rate of a complexing agent is reduced; the hydrophilicity of CO-MOF is enhanced through infiltration, the utilization rate of oxygen is increased, the regeneration rate is further increased, and recycling of complex iron is promoted.

The invention belongs to the technical field of biology, and particularly relates to application of calcitonin to improvement of hypoxia resistance of fishes. According to the invention, the ferroheme content, hemoglobin expression, erythropoiesis and hypoxia tolerance of the fish model lacking the calcitonin synthesis function are detected by constructing the fish model lacking the calcitonin synthesis function and combining an experiment of treating wild type fish with exogenous calcitonin; it is found that the calcitonin has the promoting effect on zebrafish ferroheme, hemoglobin synthesis and erythropoiesis and has the remarkable enhancing effect on the hypoxia tolerance of zebrafish. Therefore, the calcitonin can improve the oxygen carrying capacity of fish blood and improve the hypoxia resistance of fish.