External gel used for treating diabetic foot, and preparation method and application thereof

A gel for external use, a technology for diabetic foot, which can be applied to medical preparations containing active ingredients, metabolic diseases, skin diseases, etc., and can solve the problem of lack of bacteriostatic and tissue growth promotion, lack of diabetic foot composition, and increased wound oxygenation. In order to achieve the effect of long-lasting drug effect, convenient use, and promoting skin tissue healing

Active Publication Date: 2013-03-06
ZHANGJIAGANG IND TECH RES INST CO LTD DALIAN INST OF CHEM PHYSICS CHINESE ACADEMY OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chinese patent CN101053657A, an external preparation for treating refractory skin ulcers, which contains epidermal growth factor, antibacterial drugs and insulin, which can promote skin healing and inhibit bacterial growth, but there is no oxygen-carrying material to increase the oxygen content of the wound
2) The application of oxygen-carrying materials has been mentioned in the existing patents, the world patent WO/2010/065059, PERFLUOROCARBON GEL FORMULATIONS, which uses perfluorocarbons to increase the oxygen content of skin tissue, but this patent is mainly used in cosmetics, No antibacterial and tiss...

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Preparation of perfluorocarbon emulsion

[0037] The composition of perfluorocarbon and surfactant of the present invention is made up of the following raw materials by weight ratio: perfluorotributylamine: poloxamer=5: 1, magnetic stirring and mixing, and ultrasonic mixing to make emulsion.

Embodiment 2

[0039] Preparation of perfluorocarbon emulsion

[0040] The composition of perfluorocarbon and surfactant of the present invention is made up of following raw material by weight ratio: perfluorodecalin: poloxamer: water=10: 1: 89, magnetic stirring and mixing, in ultrasonic mixing , made into an emulsion.

Embodiment 3

[0042] Preparation of perfluorocarbon emulsion

[0043] The composition of perfluorocarbon and surfactant of the present invention is made up of following raw material by weight ratio: perfluorotributylamine: poloxamer: water=20: 1: 79, magnetic stirring and mixing, in ultrasonic mixing Mix well to make emulsion.

[0044] Implementation 4

[0045] Prescription: chitosan 2g; rhEGF80mg; perfluorodecalin 1g; poloxamer 0.1g; glycerin 5g; polyvinyl alcohol 7g; azone 2g; ethylparaben 4g; lysine 5g; 10% NaOH amount ;Add distilled water to 100g

[0046] Preparation method: mix perfluorodecalin, poloxamer and water at a ratio of 10:1:9, and mix well to prepare a stable milk, which is liquid A.

[0047] Take chitosan, add 80ml deionized water and magnetically stir to disperse chitosan, add 0.8ml acetic acid to dissolve. Add an appropriate amount of 10% NaOH pH regulator dropwise to make the pH of the glue solution reach about 6.0, and filter. Heat the glue solution in a water bath to...

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PUM

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Abstract

The invention relates to an external gel used for treating diabetic foot, and a preparation method and an application thereof. Specifically, the invention relates to an external gel preparation with oxygen-carrying and antibacterial materials, and containing recombinant human epidermal growth factor (rhEGF). The preparation basically comprises: a medicine component recombinant human epidermal growth factor (rhEGF), an oxygen-carrying material, an antibacterial material, a gel substrate, a stabilizing agent, a humectant, a penetration enhancing agent, a surfactant, and a pH regulation agent.

Description

technical field [0001] The invention relates to an external gel preparation for treating diabetic foot, in particular to an external preparation for treating diabetic foot which has oxygen-carrying and antibacterial materials and contains recombinant human epidermal growth factor (rhEGF). Background technique [0002] Diabetes is one of the most common diseases in the world. According to a report by the World Health Organization, diabetes has become the fourth leading cause of death. By 2025, the number of diabetic patients in the world will reach 300 million. 10% to 15% of diabetic patients suffer from foot complications, so diabetic foot is one of the main chronic complications of diabetes. Its pathogenesis involves peripheral neuropathy, vasculopathy, and infection. The most common clinical manifestation is skin ulcer of the lower extremities, and severe cases may be amputated due to gangrene of the lower extremities, or even die. The basic characteristics of diabetic f...

Claims

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Application Information

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IPC IPC(8): A61K38/18A61K9/06A61P3/10A61P17/02A61P25/02A61P9/14A61K31/025A61K31/131A61K31/722
Inventor 马小军李微微吕国军于炜婷谢威扬赵姗
Owner ZHANGJIAGANG IND TECH RES INST CO LTD DALIAN INST OF CHEM PHYSICS CHINESE ACADEMY OF SCI
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