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Modified glucan nano-microsphere composite dressing and preparation method thereof

A technology of nano-microspheres and dextran, which is applied in the field of medical materials, can solve the problems of difficult growth factors, achieve the effect of promoting healing, simple operation process, and preventing secondary infection

Pending Publication Date: 2022-08-09
北京恒峰铭成生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Therefore, this application provides a modified dextran nano-microsphere composite dressing and its preparation method to solve the problem that the growth factors in the prior art are difficult to effectively combine with the electrospinning preparation of wound dressing technology

Method used

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  • Modified glucan nano-microsphere composite dressing and preparation method thereof
  • Modified glucan nano-microsphere composite dressing and preparation method thereof
  • Modified glucan nano-microsphere composite dressing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] First, this embodiment provides a modified glucan nano -nano -ball composite dressing 5, which includes active layer 1. Waterproof layer 2. Berbal layer 3 and protective layer 4. Among them The waterproof layer 2 and the bacterial layer 3 are the middle layer, and the protective layer 4 is the outermost layer; the active layer 1 is specifically scattered inside the fiber to modify the sodium alginate-polyvinyl compound fibrous membrane, polyethylene glycol, Modified glucan nano -micro -balls are specifically for the glucose nano -nano -balls with growth factor; waterproof layer 2 is an ordinary polypropylene non -woven fabric, which is mainly to isolate the active layer of absorbing exudate 1 and the bacterial layer 3 , Prevent the bacterial layer 3 in dyeing, and play a certain protective role in the bacterial layer 3; the bacterial layer 3 is a melting spray non -woven non -woven non -woven non -woven non -woven non -woven of polypropylene resin that uses economic practic...

Embodiment 2

[0064] First, this embodiment provides a preparation method for modified glycogen nano -ball composite dressing. The steps are basically the same as the preparation method provided by Example 1. The difference is:

[0065] Step (1), growth factor: glucan: PEG6000 = 1: 800: 1000 (w / w / w);

[0066] Step (2), configure it to 8 % PVA aquatic solution;

[0067] Step (3), configure to be configured to 1.5 % sodium alginate solution;

[0068] Step (4), the mixed ratio of PVA aquatic solution and sodium algina solution is 1.5: 2;

[0069] In the step (5), the amount of modified glucan nano-nano-golf is 10 % of the mass score of sodium algina-polyvinyl alcohol solution;

[0070] Step (7), CACL 2 The concentration of aquatic ethanol solution is 3 %;

[0071] In the step (8), the cross -linking time is 4h.

[0072] Second, this embodiment provides a modified glucan nano -ball composite dressing, which is obtained by the preparation method provided by this embodiment.

Embodiment 3

[0074] First, this embodiment provides a preparation method for modified glycogen nano -ball composite dressing. The steps are basically the same as the preparation method provided by Example 1. The difference is:

[0075] Step (1), growth factor: glucan: PEG6000 = 1: 800: 1000 (w / w / w);

[0076] Step (2), configure to be configured to 13 % PVA aquatic solution;

[0077] Step (3), configure to be configured to 1.2 % sodium alginate solution;

[0078] Step (4), the mixed ratio of PVA aquatic solution and sodium algina solution is 1.5: 1;

[0079] In the step (5), the amount of modified glucan nano-nano-golf is 10 % of the mass score of sodium algina-polyvinyl alcohol solution;

[0080] Step (7), CACL 2 The concentration of aquatic ethanol solution is 5 %;

[0081] In the step (8), the cross -linking time is 1h.

[0082] Second, this embodiment provides a modified glucan nano -ball composite dressing, which is obtained by the preparation method provided by this embodiment.

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Abstract

The modified glucan nano-microsphere composite dressing comprises an active layer, a waterproof layer, a bacteria-isolating layer and a protective layer, the active layer is a skin-friendly layer, the waterproof layer and the bacteria-isolating layer are middle layers, and the protective layer is the outermost layer; the active layer is specifically a sodium alginate-polyvinyl alcohol composite fiber membrane with modified glucan nano-microspheres dispersed in fibers, and the modified glucan nano-microspheres are specifically glucan nano-microspheres wrapped with growth factors.

Description

Technical field [0001] The invention involves the field of medical materials and specifically involves a dressing that promotes the healing of the wound. Background technique [0002] In daily life, the skin is often damaged and ulcerated, such as abrasions, trauma, burns, diabetic feet, old rotten legs, old feet, and sword infection after surgery. Some open wounds are not easy to heal and are easily infected with secondary infections. Patients have suffered great pain for this. Therefore, choosing an ideal wound dressing has important significance and huge market demand. The ideal dressing should have the following characteristics: to ensure the sterile environment of the wound, a certain breathability and water absorption, the anti -adhesiveness of the auxiliary materials and the wound, and a certain mechanical strength. The ideal wound dressing will not only reduce the pain for patients, but also speed up the wound healing speed. [0003] The process of wound healing is a comp...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/24A61L15/28A61L15/32A61L15/42A61L15/44A61L15/46A61L15/60B32B27/32B32B27/02B32B27/12B32B27/08B32B27/30B32B9/00B32B9/04B32B5/06B32B38/00D01F8/10D01F8/18D01F1/10
CPCB32B5/022B32B5/268B32B5/266B32B5/06B32B38/00D01F8/10D01F8/18D01F1/10A61L15/28A61L15/44A61L15/24A61L15/60A61L15/32A61L15/425A61L15/46B32B2038/0076B32B2250/20B32B2262/0223B32B2262/0253B32B2307/7145B32B2307/724B32B2535/00A61L2300/414A61L2300/404A61L2300/236A61L2300/622C08L5/04C08L29/04Y02A50/30
Inventor 郝好杰王雪蒙李梓源易军陈惠华
Owner 北京恒峰铭成生物科技有限公司
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