128results about How to "Has an immunomodulatory effect" patented technology

The present invention relates to a method for extracting ganoderic spore polysaccharide. It is characterized by that firstly, it uses CO2 supercritical extraction method to extract ganoderic spore oil for another application, and makes the residue obtained after the ganoderic spore oil is extracted undergo the processes of removing fat, water extraction, alcohol precipitation, filtration and drying so as to obtain the invented ganoderic spore polysaccharide.

The invention provides a medicated diet for improving functions of spleen and stomach and enhancing the immunoregulation capability and a preparation method of the medicated diet. The medicated diet comprises the following components: fructus jujubae, radix astragali preparata, ginseng, fried bighead atractylodes rhizome, poria cocos, fried semen coicis, agastache rugosus, radix paeoniae alba, fructus citrus sarcodactylis, fructus citri, Chinese yam, paederia scandens, caulis bambusae in taeniam, scorched medicated leaven, scorched malt, scorched hawthorn fruit, platycodon grandiflorum, radix aucklandiae, fructus aurantii, fructus amomi, pericarpium citri reticulatae, cassia twig, ginger, semen allii tuberose, radix saposhnikoviae, angelica sinensis, wolfberry fruit, rhizoma polygonati, lingzhi mushroom, rhodiola rosea, walnut meat, taraxacum, radix tinosporae, liquorice, brown granulated sugar and starch syrup. The medicated diet takes natural food materials, materials used as medicines and foods and materials used as health foods as the main raw materials, has the functions of invigorating spleen-stomach and replenishing qi, fortifying spleen and nourishing stomach, supporing Yang for consolidating superficies, reinforcing deficiency and strength, regulating qi function of human body, improving sub-health habitus and the like, can be used for improving functions of spleen and stomach and enhancing immunoregulation capability and has a good effect.

The invention discloses a method for extracting porcine blood antibacterial peptide, which comprises following steps: firstly, dissolving porcine blood powder in buffer solution, then, adding papain into mixture to carry out enzymatic hydrolysis, adjusting the pH value of enzymolysis liquid to be 3.5-4.5, secondly, adding chloroform and sodium bisulfite into the enzymolysis liquid to decolorize, and then adjusting the pH value of the sodium bisulfite which is decolorized to be 6.0-7.0 and to form crude extracts of the porcine blood antibacterial peptide. Aiming at obtaining finished goods of the porcine blood antibacterial peptide, following purification steps are carried out to the crude extracts: firstly, freezing and drying the crude extracts of the porcine blood antibacterial peptide, enabling the crude extracts to pass through a gel-type cation exchange column, eluting the exchange column, collecting eluent, and secondly, freezing and drying the eluent in vacuum to form porcine blood antibacterial peptide. The method of the invention provides a new approach and a new method for producing antibacterial peptide. The method of the invention has the characteristics of simple operation, high separation extraction rate and low cost, and is suitable for separating and purifying the antibacterial peptide from porcine blood with comparatively large amount.

The invention relates to a special food for pet cats. The special food consists of the following raw materials in parts by weight: 3-5 parts of rice flour, 20-25 parts of whole grain wheat flour, 15-20 parts of salmon meat paste, 5-10 parts of chicken meat paste, 2-5 parts of animals' livers, 5-10 parts of soybean flour, 0.5-0.8 part of radix salviae miltiorrhizae, 15-20 parts of angelica keiskei, 6-10 parts of haws, 3-8 parts of sunset abelmoschus flowers, 0.02-0.1 part of composite vitamins, 0.1-0.5 part of probiotics microorganisms, 1-2 parts of a malt extract, 5-8 parts of milk, 2-5 parts of puffed powder, 2-5 parts of taurine, 3-10 parts of corn flour, 1-3 parts of butter, 5-10 parts of nanoscale shrimp shell powder, 5-8 parts of eggs, 0.5-2 parts of edible oil, 5-10 parts of dried marine algae powder, 0.02-0.05 part of citric acid, 0.1-0.2 part of L-lysine, 0.05-0.1 part of pantothenic acid and 0.01-0.05 part of folic acid. According to the special food disclosed by the invention, the nutrition is balanced, and besides, the selection of feeds in the daily raising process is considered, so that the immunity of the cats is enhanced; the radix salviae miltiorrhizae, the angelica keiskei, the haws and the sunset abelmoschus flowers are added for comprehensive compatibility, then the probiotics microorganisms, the taurine and the like are matched for use, so that the special food has the efficacy of coordinating the intestines and the stomach and strengthening disease resistance.

The invention relates to a pectin-5-fluorouracil colon cancer two-targeting prodrug and the preparation method thereof, and mainly synthesizes a two-targeting prodrug for colon cancer by utilizing an anti-cancer drug, 5-fluorouracil (5-FU), and pectin. The two-targeting prodrug for colon cancer is used for treating colon cancer and is characterized in that the 6-digit carboxyl is utilized to be combined with 5-FU directly or through different bridging groups to synthesize a series of two-targeting prodrugs for colon cancer. The prodrug first targets 5-FU to the colon by utilizing pectin to realize colon positioned release, and then 5-FU-galactose is identified through high expression of colon cancer galactin-3, and then 5-Fu is targeted to the colon cancer cells to realize two-targeting of colon cancer to treat colon cancer. The prodrug improves the selectivity of 5-FU greatly, enhances the curative effect and reduces adverse reactions. In addition, the hydrolysis fragments of pectin play a role in resisting tumor metastasis and can have a synergic action with 5-FU. The pectin-5-fluorouracil two-targeting prodrug for colon cancer focuses on the drug design ideas of drug delivery, targeting and coordination; therefore, the prodrug achieves the goal of high selectivity, high efficiency and low toxicity.

The invention discloses a medicine which is externally used for treating rheumatic coldness and pains. The invention is characterized in that the invention is prepared by the following medicines by weight: spatholobus stem of 65 to 90g, clematis chinensis of 30 to 50g, brassica alba boiss of 36 to 76g, phellodendron amurense of 28 to 47g, caulis sinomenii of 20 to 50g, raw wild aconite of 37 to 68g, raw radix aconite of 37 to 68g, large centipede of 10 to 20 in quantity, honeylocust thorn of 60 to 80g, thunder god vine of 50 to 70g, salicylic acid of 30 to 50g, phryma leptostachya of 65 to 100g, menispermaceae of 40 to 60g, ephedra of 45 to 80g, parsnip of 35 to 60g, cinnamon of 20 to 40g, notopterygium root of 20 to 40g, heracleum hemsleyanum michaux of 20 to 45g, toad venom of 18 to 25g, himalayan teasel root of 50 to 80g, angelica of 30 to 54g, radix astragali of 30 to 54g, franklincense of 41 to 59g, myrrh of 41 to 59g, rhizona gastrodiae of 25 to 35g, pilose antler of 30 to 50g, borneol of 30 to 40g, muskiness of 8 to 15g, chili of 70 to 110g, radix aconiti brachypodi of 60 to 70g and mandragora of 40 to 68g.

The invention relates to a Chinese herbal medicine preparation against chicken heat shock, which is an oral liquid comprising the following components in parts by weight: 2-4 parts of plaster, 2-4 parts of ageratum, 1-3 parts of rhizoma atractylodis, 2-4 parts of hawthorn, 2-4 parts of pine needle, 0.5-1.5 parts of gynostemma pentaphylla and 0.5-1.5 parts of liquorice. The raw materials are crushed, mixed, boiled with water, extracted, concentrated and packaged to obtain the Chinese herbal medicine preparation against chicken heat shock. The invention has sound effect against chicken heat shock.

The invention provides a medicated diet for conditioning the constitution of qi stagnation and a preparation method thereof. The medicated diet comprises Chinese jujube, radix astragali preparata, ginseng, atractylodes macrocephala, rhizoma atractylodis, poria cocos, roasted malt, radix bupleuri, cassia twig, rhizoma cyperi, radix curcumae, fingered citron, fructus citri, mint, cortex albiziae, rose, radix glycyrrhizae preparata, salvia miltiorrhiza, radix paeoniae alba, Chinese angelica, ligusticum wallichii, lily, platycodon grandiflorum, radix aucklandiae, fructus aurantii immaturus, fructus amomi, rhizoma corydalis, the fruit of Chinese wolfberry, eucommia ulmoides, raspberry, fried coix seeds, radix achyranthis bidentatae, cape jasmine, fermented soybean, caulis bambusae in taeniam, herba lycopi, fresh ginger, cumin, fructus cannabis, brown granulated sugar and starch syrup. The product adopts the natural food materials, edible and medicinal substances, and substances capable of being used as heal food as the main raw materials, has the effects of invigorating spleen-stomach, replenishing qi, soothing liver-qi stagnation, regulating qi, strengthening spleen, replenishing blood, nourishing heart, tonifying lung, liver and kidney, clearing heat, removing toxicity and the like, and has good effect on conditioning of the constitution of qi stagnation and improvement of the immune adjustment.

The invention discloses a method for preparing an ABP (antibacterial peptide) from porcine hemoglobin. The method comprises steps as follows: porcine blood corpuscles are obtained through separation of porcine whole blood and then subjected to hemolysis, enzymolysis, decoloration, ultrafiltration, vacuum concentration and freeze-drying, and the ABP is obtained; the dosage of trypsin is 3000 U/g, and the enzymolysis reaction time is 4-6 h under conditions that the pH is 8 and the temperature ranges from 45 DEG C to 55 DEG C. The method for preparing the ABP from the porcine hemoglobin is low in cost and good in effect.

The invention discloses a feed for piglets with reduced serum lipopolysaccharide level and its preparation method and application, which solves the problem that the disease resistance and immunity of piglets cannot be improved in the prior art. The invention is made of the following components according to a certain weight ratio: corn, puffed corn, broken rice, puffed soybean, fermented soybean meal, fish meal, soybean meal, soybean oil, stone powder, calcium hydrogen phosphate, sodium chloride, choline chloride, betaine , lysine, methionine, threonine, tryptophan, benzoic acid, phytase, compound enzyme, trace element premix, vitamin premix, enramycin premix, arginine, glutamine Amide, proline, astragalus polysaccharide, eleuthero polysaccharide, curcumin, chitosan oligosaccharide, probiotics, yeast cell wall extract. The composition of the invention is scientific, the compatibility is reasonable, each component acts together, can provide balanced and easily digestible nutrients for the growth and development of piglets, and effectively reduce the level of serum lipopolysaccharide of piglets.

The invention discloses a bacterial strain for preparing highly effective capsula glucoprotein immuno-modulatory agent, its selection and use thereof, which relates to a strain of K. peneumoniae and its screen selecting method, and the method for preparing capsula glucoprotein by using the strain, wherein the K. peneumoniae capsula glucoprotein immuno-modulatory agent is prepared through the steps of strain screening, culture, cracking, crude extracting and purification, thus overcoming the problem of drug tolerance for antibiotics when used for treating infection.

The invention provides a cordyceps and ganoderma lucidum polysaccharides compound preparation with immune synergism, which is a compound preparation consisting of polysaccharides from cordyceps and ganoderma lucidum polysaccharides. Dosage forms prepared from the polysaccharides compound have the immunoregulation function, can obviously improve the activity of NK cells, the phagocytic activity of macrophage of organisms, and cellular immunity and humoral immunity functions of the organisms, and have immunoregulation function on the organisms. The cordyceps and ganoderma lucidum polysaccharides compound preparation solves the problem that active ingredients cannot take effect fully because cordyceps, and mycelium or encarpium of ganoderma are directly used as medicaments.

The invention discloses a red mycelium protein feed and a preparation method thereof. The red mycelium protein feed is a product obtained by batching, puffing, inoculating, solid culturing, drying and pulverizing raw materials. The preparation method comprises the following steps: culturing microorganisms producing haematochrome so as to breed mycelium by applying a biotechnology; inoculating the microorganisms producing the haematochrome on a culture medium; promoting the growth and the breeding of the microorganisms by manually controlling the culture medium and the conditions of the temperature, the humidity, and the like of surroundings; and converting nutritive materials of the culture medium into the mycelium and the haematochrome so as to prepare the red mycelium protein feed. The red mycelium protein feed can be directly added to animal feeds and aquatic feeds and used for producing red yolk eggs and tender chickens, enable the color of pork to be bright red, improve the milk yield of dams, promote the oestrus of the dams, improve the production performance of animals, the breeding rate and the number born, promote the fishes to quickly grow and meet the requirement on pigment feeds of the industry.

The invention provides medicated food for conditioning blood-stasis constitution and improving immune adjustment capability and a preparation method of the medicated food. The medicated food is prepared from Chinese-dates, astragalus root, ginseng, roasted rhizoma atractylodis macrocephalae, radix bupleuri, cassia twig, ginger, salvia miltiorrhiza, rhizoma curcumae longae, radix curcumae, peach kernel, cattail pollen, safflower carthamus, amber, platycodon grandiflorum, radix aucklandiae, immature bitter orange, fructus amomi, dried orange peel, earthworm, loofah sponge, prepared rehmannia root, angelica, ligusticum wallichii, caulis spatholobi, ophiopogon root, dried rehamnnia root, roots of common peonies, moutan barks, achyranthes, tuckahoe, alisma orientale, liquorice, brown granulated sugar and starch syrup. The medicated food takes natural ingredients, medicinal and edible materials and materials for health foods as main raw materials, has the efficacies of tonifying middle-Jiao and Qi, promoting blood circulation to remove blood stasis, relieving liver for smoothing Qi, replenishing qi to invigorate spleen, replenishing vital essence and blood, warming and activating meridians, clearing heat, expelling dampness and the like, and has good effects on conditioning the blood-stasis constitution and improving the immune adjustment capability.

The invention provides a Chinese medicament for lowering blood fat and its preparing process, wherein the medicament is prepared from root of red rooted saliva 140g, campanumaea pilosula 70g, Chinese angelica root 70g, notoginseng 47g, gastrodia tuber 90g, earthworm 70g,cassia seed 70g, haw 70g, Siberian solomonseal rhizome 70g, fleece-flower root 70g, dodder seed 70g, dried orange peel 90g, pinellia tuber 70g and bupleurum root 70g.

The invention discloses a drug for removing toxins from the livestock body and improving immunity of the organism and a preparation method of the drug, and belongs to the technical field of livestockdrugs. The traditional Chinese medicine composition is prepared from radix astragali, herba taraxaci, flos chrysanthemi indici, folium eucommiae, rhizoma acori tatarinowii, gizzard membrane, bulbus lilii and poria cocos in the weight ratio being (10-20):(2-5):(4-10):(3-8):(2-8):(1-4):(2-6):(1-4):(2-5). The traditional Chinese medicine composition can regulate functions of an immune system comprehensively, relieve immunosuppression and improve disease resistance of livestock, has no toxic or side effects and is applicable to the livestock for a long time.

The invention relates to a high-efficiency anti-inflammatory natural composition for preventing and treating infant eczema and enhancing barrier function and a preparation process of cream thereof. Bysimulating the molar ratio 1:1:1 of three main components including fatty acid, cholesterol and ceramide in a bilayer membrane in skin corneum, the skin barrier damage caused by environment is reshaped, and by matching with oat beta glucan, ectoine and other ingredients, the skin is effectively repaired and skin resistance is enhanced. At the same time, a variety of antibacterial, anti-viral andanti-inflammatory natural Chinese medicine ingredients such as radix scutellariae, radix glycyrrhizae and radix sophorae flavescentis are selected to exert effects in the initial stage, delivery stageand eczema effect stage of eczema so as to effectively inhibit the release and transmission of inflammatory factors and effectively treat eczema, and the ingredients are synergistic, safe and non-irritating, and capable of preventing recurrence of eczema.

The invention belongs to the field of biological medicine, and relates to application of algal polysaccharides to a vaccine adjuvant. The invention aims at solving the technical problem that the ideal adjuvant for vaccine preparation, particularly for tumor vaccine preparation is difficult to obtain. In order to solve the technical scheme, the invention provides a new purpose of Lambda-carrageenans to preparation of an immunologic adjuvant. The Lambda-carrageenans are disaccharide units formed by connecting 2-sulfated galactose and 2, 6-sulfated galactose through beta-1, 4 keys, and each disaccharide unit is provided with polysaccharides of three sulfating sites. The tumor vaccine prepared by using the Lambda-carrageenans as the adjuvant can obviously enhance the serum antibody titers of the antigen, and can reduce the tumor formation rate of mice, the obvious anti-tumor effect is achieved, and the new selection is provided for the development and the application of the vaccine.

The invention provides a medicated diet for conditioning the specific endowment constitution and a preparation method thereof. The medicated diet comprises Chinese jujube, radix astragali preparata, red ginseng, fried atractylodes macrocephala, rhizoma atractylodis, Chinese yam, cassia twig, saposhnikovia divaricata, fructus psoraleae, ganoderma lucidum, radix puerariae, purple perilla, herba schizonepetae, radix rehmanniae preparata, radix paeoniae alba, Chinese angelica, ligusticum wallichii, fingered citron, rhizoma cyperi, platycodon grandiflorum, radix aucklandiae, fructus aurantii, the fruit of Chinese wolfberry, prepared radix polygoni multiflori, eucommia ulmoides, glossy privet fruit, polygonatum kingianum, semen euryales, deer horn glue, tortoise shell glue, fried coix seeds, honeysuckle, cortex moutan, radix achyranthis bidentatae, poria cocos, rhizoma alismatis, fresh ginger, fructus cannabis, brown granulated sugar and starch syrup. The product adopts natural food materials, edible and medicinal substances, and substances capable of being used as heal food as the main raw materials, has the effects of invigorating spleen-stomach, replenishing qi, strengthening spleen, tonifying lung, supporting yang, consolidating defensive qi, dispelling wind to relieve exogenous syndrome, regulating qi, replenishing blood, nourishing liver and kidney, nourishing and suppressing yang, clearing heat, removing toxicity and the like, and has good effect on conditioning of the specific endowment constitution and improvement of the immune adjustment.

The invention relates to a Chinese herbal medicine composition for treating common bacterial diseases of chickens. The Chinese herbal medicine composition is a powder prepared from the following raw materials in parts by weight: 4-6 parts of cordate houttuynia, 4-6 parts of folium isatidis, 3-4 parts of oregano, 3-4 parts of juncus roemerianus, 2-4 parts of abrus cantoniensis hance, 1-2 parts of centella asiatica, and 1-2 parts of licorice root. The Chinese herbal medicine composition is used for treating common bacterial diseases of chickens, such as colibacillosis, the chronic respiratory disease, acute gastroenteritis and salmonellosis, and has the characteristics of high cure rate, good effect, safety, no toxic or side effect, and good convenience in use.

The invention relates to a medicament for treating febrile bronchial asthma and chronic bronchitis. A solid oral preparation, such as a capsule, is prepared by the steps of mixing 1700-1900 parts of fructus forsythiae, 1400-1600 parts of plaster stone, 800-1000 parts of peach kernel, 200-240 parts of earthworm and 55-65 parts of thunberg fritillary bulb, soaking with cold water, reheating and decocting, filtering and concentrating as well as drying, and then crushing with 85-95 parts of prepared rheum officinale and 25-35 parts of platycodon grandiflorum into granular sensation free fine powder, and preparing the granular sensation free fine powder into solid oral preparation according to the conventional procedures. The medicament can be used for treating the febrile bronchial asthma and the chronic bronchitis, has double efficacy of clearing heat and reducing phlegm, descending qi and relieving asthma, resisting inflammation and relieving spasm (expanding bronchus), and has immunoregulation function to the asthma.

The invention relates to an adipose tissue composite preparation, and a preparation method and an application thereof. The adipose tissue composite preparation includes PDGF, umbilical cord mesenchymal stem cells, SVF and adipose tissues. The preparation method comprises the following steps: preparing a cell suspension from the SVF, the umbilical cord mesenchymal stem cells and the PDGF, and uniformly mixing the adipose tissues with the cell suspension according to a volume ratio of 20:1 in order to prepare the adipose tissue composite preparation. The adipose tissue composite preparation can be applied in plastic surgery or beauty treatment as a filling preparation. The composite biological preparation has the advantages of easiness in revascularization after being injected, and increased survival rate, is safe and reliable, allows the adipose tissues to be pale yellow, soft and bright and to be only wrapped with few fibers after being transplanted for 2-3 months; and the density of capillary tubes in the center position of transplanted fats is normal, and the blood vessel revascularization is obvious.

The invention relates to the field of feed additives and discloses a feed addition material, a preparation method thereof and a feed additive. The feed addition material comprises the ingredients in parts by weight: 1 to 20 parts of beta-cyclodextrin, 10 to 80 parts of monensin and 1 to 10 parts of glycyrrhizic acid. The invention also provides the feed additive, which comprises the feed additionmaterial, a filling agent, a bonding agent and a disintegrating agent. The feed addition material uses the beta-cyclodextrin as coating materials, the influence on the animal palatability caused by the monensin is avoided, in addition, the glycyrrhizic acid is added for prompting the absorption of the monensin in animal bodies and the persistent medicine effect taking, the animal growth can be more perfectly promoted, the coccidiosis is prevented and treated, and the feed addition material can be applied to the preparation process of feed additives.