The invention discloses the production formula of a Huoxuezhitong ointment and the preparation method thereof, wherein the Huoxuezhitong ointment is composed of two parts of a Huoxuehuayu powder and an ointment. The Huoxuehuayu powder comprises the components of muskiness, dragon's blood and ground cinnamon; and the ointment comprises the following components: Chinese angelica root, rhizoma ligustici wallichii, radix sileris, ramulus mori, processed frankincense, processed myrrh, cassia twig, rhizoma curcumae longae, gentiana macrophylla, red flower, monkshood, dried ginger, sargentgloryvine stem, sabia japonica, angelica dahurica, peach kernel, achyranthes, notopterygium root, heracleum hemsleyanum michaux, caulis Spatholobi, processed rhizoma corydalis, calcined pyrite, Chinese polyphaga, sapanwood, dipsacus asperoides, teasel root, giant knotweed, trogopterus dung, radix notoginseng, cattail pollen, rhizoma gastrodiae, monkshood, kusnezoff monkshood, root-bark of tree peony, nutgrass galingale rhizome, cortex acanthopanacis radicis, long-nosed pit viper, zaocys dhumnade, lead tetraoxide and bean oil. The Huoxuehuayu powder is separately packaged into a small glass tube, and can be doped into the ointment for administration, (the ointment can also be used independently). The Huoxuezhitong ointment has the unique curative effects on various arthralgia, shoulder sore, hyperosteogeny, lumbar pain, cervical spondylosis, paraesthesia of extremity, wind cold damp impediment and injuries from falls, fractures, contusions and strains.