The invention discloses tranquilization and brain tonifying epimedium herb oral liquid, which comprises the following raw medicaments in parts by weight: 10 to 50 parts of epimedium herb, 10 to 20 parts of yerbadetajo herb, 10 to 20 parts of schisandra chinensis, 10 to 20 parts of wolfiporia extensa, 10 to 20 parts of radix polygonum multiflorum preparata, 10 to 20 parts of glossy privet fruits, 10 to 20 parts of radix paeoniae alba, 10 to 20 parts of acorus gramineus, 10 to 20 parts of platycladi seeds, 10 to 20 parts of mulberries, 10 to 20 parts of nacres, 10 to 20 parts of polygala tenuifolia, 10 to 20 parts of cortex albiziae, 10 to 20 parts of ophiopogon japonicus, 10 to 20 parts of semen ziziphi spinosae, 10 to 20 parts of tuber fleeceflower stems, 10 to 20 parts of coptis chinensis, 10 to 20 parts of polygonatum odoratum, 10 to 20 parts of cortex moutan and 10 to 20 parts of curcuma aromatica. The tranquilization and brain tonifying epimedium herb oral liquid has the effects of engendering essence, supplementing marrow, reinforcing qi, nourishing blood, tonifying the brain and tranquilization, is used for dizziness, weakness, amnesia, insomnia and neurasthenia, which are caused by deficiency of kidney essence, qi and blood, is scientific in compatibility and high in efficacy, is a pure traditional Chinese medicinal preparation, does not have any toxic or side effect, has good mouth-feel, and can be taken for a long time; epimedium herb serves as a main material, and natural traditional Chinese medicine with the effects of tonifying the brain, tranquilization, promoting blood circulation, removing blood stasis, reinforcing qi, soothing the liver, relieving depression, calming the liver, suppressing yang, enriching yin, nourishing the kidney, clearing heat, removing toxicity and discharging fire is added, so that the metabolism of a human body can be regulated.