Traditional Chinese medicine composition for treating superficial thrombophlebitis and preparation method thereof

Abstract

The invention relates to the technical field of traditional Chinese medicine formulas, and discloses a traditional Chinese medicine composition for treating superficial thrombophlebitis and a preparation method thereof, and the traditional Chinese medicine composition comprises the following components in parts by weight: 40-60 parts of rhizoma anemarrhenae, 40-60 parts of bulbus fritillariae cirrhosae, 60-80 parts of radix trichosanthis, 40-60 parts of rhizoma pinelliae preparata, 20-30 parts of rhizoma bletillae, 40-60 parts of spina gleditsiae, 80-100 parts of honeysuckle, 30-60 parts of turtle shell, 30-60 parts of frankincense, 30-60 parts of turmeric and 10-20 parts of borneol. According to the traditional Chinese medicine composition for treating superficial thrombophlebitis and the preparation method thereof disclosed by the invention, the obtained traditional Chinese medicine composition can be used for improving superficial thrombophlebitis (blood stasis and stagnated heat type) caused by dark purple skin, high skin temperature and severe walking pain of an affected limb or insleep at night, and has a very good treatment effect; red and swollen local skin and pain symptoms of a patient disappear, thrombus-type nodules are dissipated and diminished, and varicose blood vessel repair is improved.

Description

Technical Field

[0001] The invention relates to the technical field of traditional Chinese medicine formulas, and in particular to a traditional Chinese medicine composition for treating superficial thrombophlebitis and a preparation method thereof. Background Art

[0002] For thrombophlebitis, Western medicine uses oral new anticoagulants or subcutaneous injections of anticoagulants to treat thromboembolism and improve blood circulation. Aspirin is an anti-inflammatory and analgesic method to eliminate local inflammation and its anti-platelet aggregation effect relieves pain, but the effect is often slow. Traditional Chinese medicine divides thrombophlebitis into three types: 1. Yang deficiency and cold stagnation type (equivalent to the first stage). The affected limb is cold and numb, and the local skin turns pale and is cold to the touch. There are paroxysmal cramps, but the patient's pain is not obvious and is often easily ignored or misdiagnosed, so there is little desire to seek medical treatment; 2. Blood stasis and heat type (equivalent to the second stage). The skin of the affected limb turns purple and dark, and there is severe pain when walking, or sleepless nights. The condition is more serious; 3. Yin deficiency and dampness type (equivalent to the third stage). The affected limb has severe pain or burning pain, and the appearance is withered, or even charred and necrotic, or the flesh is rotten and the tendons are rotten, and the knuckles of the fingers and toes fall off. In Western medicine treatment, most patients are given oral anticoagulants, antiplatelets, and severe surgical thrombectomy after admission. It is impossible to reduce the frequency of surgical thrombectomy and achieve the effect of non-invasiveness and reducing the economic burden of patients by applying it like traditional Chinese medicine. Therefore, we propose a Chinese medicine composition for treating superficial thrombophlebitis and its preparation method. Summary of the invention

[0003] The main purpose of the present invention is to provide a Chinese medicine composition for treating superficial thrombophlebitis and a preparation method thereof, which can effectively solve the problems in the background technology.

[0004] To achieve the above object, the technical solution adopted by the present invention is: A traditional Chinese medicine composition for treating superficial thrombophlebitis comprises, by weight, 40-60 parts of Rhizoma Anemarrhenae, 40-60 parts of Fritillariae Chuanxiong, 60-80 parts of Radix Trichosanthis, 40-60 parts of Rhizoma Pinelliae, 20-30 parts of Rhizoma Bletillae, 40-60 parts of Spina Gleditsiae, 80-100 parts of Flos Lonicerae, 30-60 parts of Carapace of Trionycis, 30-60 parts of Olibanum, 30-60 parts of Curcuma Longa and 10-20 parts of Borneol.

[0005] Preferably, it comprises the following components in parts by weight: 40 parts of Anemarrhena asphodeloides, 40 parts of Fritillaria cirrhosae, 60 parts of Radix Trichosanthis, 40 parts of Rhizoma Pinelliae, 20 parts of Bletilla striata, 40 parts of Gleditsia sinensis, 80 parts of Flos Lonicerae, 30 parts of Carapace of Trionycis, 30 parts of Olibanum, 30 parts of Curcuma longa, and 10 parts of Borneol.

[0006] Preferably, it comprises the following components in parts by weight: 60 parts of Anemarrhena asphodeloides, 60 parts of Fritillaria cirrhosae, 80 parts of Radix Trichosanthis, 60 parts of Rhizoma Pinelliae, 30 parts of Bletilla striata, 60 parts of Gleditsia sinensis, 100 parts of Flos Lonicerae, 60 parts of Carapace of Trionycis, 60 parts of Olibanum, 60 parts of Curcuma longa, and 20 parts of Borneol.

[0007] Its drug mechanism is as follows: The Chinese medicine composition of the present application is an empirical prescription summarized by clinical practice for many years, which is obtained by modifying the ancient prescription for internal dissipation. The drug composition includes Anemarrhena, Fritillaria, Radix Trichosanthis, Rhizoma Pinelliae, Radix Bletillae, Spinosa Lonicerae, Flos Lonicerae, Carapace of Bie, Olibanum, and Rhizoma Curcumae, which is from Volume 1 of "The Authentic Surgery": Internal dissipation, treatment of carbuncle and back, oral furuncle, nameless swelling and poison, and all sores. The main drug in the prescription, Flos Lonicerae, is sweet and cold in nature, can clear away heat and detoxify, carbuncle, swelling and poison, scrofula, and Li Zhongzi of "The Explanation of the Properties of Leigong's Preparations": Flos Lonicerae "detoxifies the skin, so it enters the lung meridian and is an important medicine for sores". Modern research shows that Flos Lonicerae 1. can resist pathogenic microorganisms, and has a certain inhibitory effect on various pathogenic bacteria such as Staphylococcus aureus, hemolytic Streptococcus Escherichia coli, Salmonella typhi, etc.; 2. Anti-inflammatory and antipyretic effects; 3. Strengthening defense function; 4. Blood lipid lowering effect; 5. Anti-endotoxin effect. The adjuvant drugs include Anemarrhena, pollen, Fritillaria, Pinellia, Bletilla, Gleditsia, and Frankincense to resolve phlegm and resolve stagnation, break stasis, dissipate hard masses and detoxify. The pangolin in the original prescription is replaced with turtle shell and turmeric to enhance its effect of softening hard masses, dissipating stagnation, activating blood circulation and removing stasis. According to the Ben Jing, Anemarrhena "treats thirst, heat, and eliminates edema of limbs due to pathogenic factors". Tao Hongjing said that "it is very effective in treating heat accumulation, and also treats malaria and heat and restlessness". Modern pharmacological research: 1. Antipyretic, analgesic, anti-inflammatory; 2. Anti-platelet aggregation; 3. Anti-pathogenic microorganisms. "Leigong's Explanation of the Properties of Medicinal Materials" Chuanbei "is used for stranguria, hernia, throat paralysis, wounds on the face, goiter and other malignant ulcers. Remove the core and grind it for use." Modern pharmacological research: 1. Antibacterial effect; 2. Anti-vasoconstriction effect; "Leigong's Explanation of the Properties of Medicinal Materials" "grows muscles, discharges pus and reduces swelling" Modern pharmacological research: 1. Anti-ulcer effect; 2. Antibacterial and antiviral; "Ben Cao Chong Yuan" Sophora japonica thorn "removes wind and resolves phlegm, eliminates toxins and attacks poisons" "Ben Cao Hui Yan" "Sophora japonica thorn, removes toxins and dispels wind, can lead carbuncle that has not yet formed to dissipate, can lead those that are about to burst to come out, can lead those that have already ulcerated to discharge pus, it is the most important agent among poison-injury medicines, modern pharmacological research Sophora japonica thorn can inhibit and eliminate a variety of bacteria; 2. Regulate the immune system; 3. Treat a variety of neurological diseases Pain. According to Compendium of Materia Medica, frankincense "eliminates all kinds of toxins from carbuncles and swellings, protects the heart, promotes blood circulation and relieves pain, and stretches the tendons." Modern research shows that it has 1. Analgesic effect; 2. Anti-inflammatory and antiseptic effects. According to Depei Materia Medica, Bletilla striata "treats malignant sores, carbuncle toxins, ulcers and dead muscles, and removes rot and regenerates new ones." Current research shows that it has 1. Hemostatic effect, which can significantly shorten the time of hemostasis. According to Yuzhuo Yaojie, turmeric "breaks blood and resolves tumors, eliminates swelling and eliminates toxins, breaks up blood stasis and old tumors, and eliminates carbuncles and ulcers." Modern research shows that the components of turmeric have anti-platelet aggregation, anti-inflammatory and analgesic effects. According to Changsha Yaojie, turtle shell "breaks up tumors and eliminates blood stasis, regulates carbuncles and discharges pus and blood." Modern research shows that Chinese soft-shell turtle has anti-fatigue effects, and is an adjuvant of borneol, and has the functions of clearing away heat and relieving pain. According to Huiyue Yijing, "pain in limbs" helps the monarch to improve pain.

[0008] A method for preparing a Chinese medicine composition for treating superficial thrombophlebitis comprises the following steps: S1. Weigh a specified amount of Rhizoma Anemarrhenae, Fritillariae Chuanxiong, Radix Trichosanthis, Rhizoma Pinelliae, Rhizoma Bletillae, Spina Gleditsiae, Flos Lonicerae, Carapace of Trionycis, Olibanum, and Rhizoma Curcumae, and crush the above drugs to obtain powder for later use; S2, take an equal amount of vaseline as the powder, heat the vaseline on an induction cooker to melt it, add the reserved powder and stir; S3. Stir and boil for 10 minutes, then gradually cool for 10 minutes; boil again for 10 minutes and gradually cool; repeat 3 times.

[0009] S4. After the boiling is completed, the mixture is cooled for 3 hours to obtain the Chinese medicine composition.

[0010] Compared with the prior art, the present invention has the following beneficial effects: The Chinese medicine composition of the present application can improve thrombophlebitis (blood stasis and heat type) caused by dark purple skin, high skin temperature, severe pain when walking, or sleeplessness at night, and has a good therapeutic effect. It can make the patient's local skin redness, swelling and pain symptoms disappear, thrombotic nodules dissipate and become smaller, and improve the repair of varicose blood vessels. The Chinese medicine composition of the present application is reasonable and scientific in compatibility, has excellent therapeutic effect, meets clinical treatment requirements, and improves the quality of life of patients. DETAILED DESCRIPTION

[0011] In order to make the technical means, creative features, objectives and effects achieved by the present invention easy to understand, the present invention is further explained below in conjunction with specific implementation methods.

[0012] Embodiment 1 A Chinese medicine composition for treating superficial thrombotic phlebitis comprises the following components by weight: 40 parts of Rhizoma Anemarrhenae, 40 parts of Fritillariae Chuanxiong, 60 parts of Radix Trichosanthis, 40 parts of Rhizoma Pinelliae, 20 parts of Rhizoma Bletillae, 40 parts of Spina Gleditsiae, 80 parts of Flos Lonicerae, 30 parts of Carapax Trichosanthis, 30 parts of Olibanum, 30 parts of Curcuma Longa, and 10 parts of Borneol. A preparation method of a Chinese medicine composition for treating superficial thrombotic phlebitis comprises the following steps: S1. Take 40g of Rhizoma Anemarrhenae, 40g of Fritillariae Chuanxiong, 60g of Radix Trichosanthis, 55g of Rhizoma Pinelliae, 25g of Rhizoma Bletillae, 50g of Spina Gleditsiae, 100g of Flos Lonicerae, 35g of Carapax Trichosanthis, 30g of Olibanum, 40g of Rhizoma Curcumae, and 10g of Borneol according to weight, and crush the above drugs to obtain powder for later use; S2, take an equal amount of vaseline as the powder, heat the vaseline on an induction cooker to melt it, add the reserved powder and stir; S3, stir and boil for 10 minutes, gradually cool for 10 minutes; boil again for 10 minutes and gradually cool; repeat 3 times; S4. After the boiling is completed, the mixture is cooled for 3 hours to obtain the Chinese medicine composition.

[0013] The obtained Chinese medicine composition is applied to the deformed blood vessels and the red, swollen, painful and hardened areas of the patient's area, and then wiped off after 40 minutes.

[0014] Embodiment 2 A Chinese medicine composition for treating superficial thrombotic phlebitis comprises the following components by weight: 55 parts of Rhizoma Anemarrhenae, 50 parts of Fritillariae Chuanxiong, 75 parts of Radix Trichosanthis, 40 parts of Rhizoma Pinelliae, 20 parts of Rhizoma Bletillae, 40 parts of Spina Gleditsiae, 80 parts of Flos Lonicerae, 30 parts of Carapax Trichosanthis, 40 parts of Olibanum, 30 parts of Curcuma Longa, and 18 parts of Borneol. A method for preparing a Chinese medicine composition for treating superficial thrombotic phlebitis comprises the following steps: S1. Take 55g of Rhizoma Anemarrhenae, 50g of Fritillariae Chuanxiong, 75g of Radix Trichosanthis, 40g of Rhizoma Pinelliae, 20g of Rhizoma Bletillae, 40g of Spina Gleditsiae, 80g of Flos Lonicerae, 30g of Carapax Trichosanthis, 40g of Olibanum, 30g of Rhizoma Curcumae, and 18g of Borneol according to weight 100g, and crush the above drugs to obtain powder for later use; S2, take an equal amount of vaseline as the powder, heat the vaseline on an induction cooker to melt it, add the reserved powder and stir; S3, stir and boil for 10 minutes, gradually cool for 10 minutes; boil again for 10 minutes and gradually cool; repeat 3 times; S4. After the boiling is completed, the mixture is cooled for 3 hours to obtain the Chinese medicine composition.

[0015] The obtained Chinese medicine composition is applied to the deformed blood vessels and the red, swollen, painful and hardened areas of the patient's area, and then wiped off after 40 minutes.

[0016] Embodiment 3 A Chinese medicine composition for treating superficial thrombotic phlebitis comprises the following components in parts by weight: 60 parts of Rhizoma Anemarrhenae, 60 parts of Fritillariae Chuanxiong, 80 parts of Radix Trichosanthis, 60 parts of Rhizoma Pinelliae, 30 parts of Rhizoma Bletillae, 60 parts of Spina Gleditsiae, 100 parts of Flos Lonicerae, 60 parts of Carapax Trichosanthis, 60 parts of Olibanum, 60 parts of Curcuma Longa, and 20 parts of Borneol. A preparation method of a Chinese medicine composition for treating superficial thrombotic phlebitis comprises the following steps: S1. Take 60g of Rhizoma Anemarrhenae, 60g of Fritillariae Chuanbei, 80g of Radix Trichosanthis, 60g of Rhizoma Pinelliae, 30g of Rhizoma Bletillae, 60g of Spina Gleditsiae, 100g of Flos Lonicerae, 60g of Carapax Trichosanthis, 60g of Olibanum, 60g of Curcuma Longa, and 20g of Borneol by weight, and crush the above drugs to obtain powder for later use; S2, take an equal amount of vaseline as the powder, heat the vaseline on an induction cooker to melt it, add the reserved powder and stir; S3, stir and boil for 10 minutes, gradually cool for 10 minutes; boil again for 10 minutes and gradually cool; repeat 3 times; S4. After the boiling is completed, the mixture is cooled for 3 hours to obtain the Chinese medicine composition.

[0017] The obtained Chinese medicine composition is applied to the deformed blood vessels and the red, swollen, painful and hardened areas of the patient's area, and then wiped off after 40 minutes.

[0018] The Chinese medicine preparation prepared in Example 1 of the present application was used to treat 150 subjects, and 60 cases of thrombophlebitis (blood stasis and heat type) were cured, 50 cases were significantly effective, 25 cases were effective, 15 cases were ineffective, and the effective rate was 90%.

[0019] Clinical trials The cases were from 150 patients diagnosed with thrombophlebitis (blood stasis and heat type) in the Department of Peripheral Vascular Diseases of our hospital from September 2022 to June 2024. According to the principle of randomization and control, random numbers were generated and grouped by SPSS 21.0, with 150 cases in each group. The serial number, random number, grouping and treatment plan were written on paper and sealed in a numbered envelope. When the patient was included in the study, the envelope was opened in sequence and the treatment was strictly carried out according to the corresponding plan.

[0020] The treatment group (using the Chinese medicine preparation prepared in Example 3 of the present application) included 80 males and 70 females; aged 38 to 89 years old, with an average age of (68.95±12.48) years old; thrombophlebitis (blood stasis and heat type); basic diseases: 75 cases of hypertension, 69 cases of coronary heart disease, 6 cases of type 2 diabetes and its complications, 13 cases of sequelae of cerebral infarction, and 2 cases of heart failure. The control group (not using any drugs) included 78 males and 72 females; aged 42 to 90 years old, with an average age of (70.45±11.36) years old. There was no significant difference in the basic conditions between the two groups before intervention (P>0.05), and they were comparable.

[0021] In summary: The Chinese medicine composition of the present application can improve thrombophlebitis (blood stasis and heat type) caused by dark purple skin, high skin temperature, severe pain when walking, or sleepless nights on the affected limbs, and has a good therapeutic effect. It can make the patient's local skin redness, swelling and pain symptoms disappear, the thrombus nodules dissipate and shrink, and improve the repair of varicose blood vessels.

[0022] The above shows and describes the basic principles and main features of the present invention and the advantages of the present invention. It should be understood by those skilled in the art that the present invention is not limited to the above embodiments. The above embodiments and descriptions are only for explaining the principles of the present invention. Without departing from the spirit and scope of the present invention, the present invention may have various changes and improvements, which fall within the scope of the present invention to be protected. The scope of protection of the present invention is defined by the attached claims and their equivalents.

Claims

1. A Chinese medicine composition for treating superficial thrombophlebitis, characterized in that: The invention comprises, by weight, 40-60 parts of Anemarrhena asphodeloides, 40-60 parts of Fritillaria cirrhosae, 60-80 parts of Radix Trichosanthis, 40-60 parts of Rhizoma Pinelliae, 20-30 parts of Bletilla striatae, 40-60 parts of Gleditsia sinensis, 80-100 parts of Flos Lonicerae, 30-60 parts of Carapace of Trionycis, 30-60 parts of Olibanum, 30-60 parts of Curcuma longa and 10-20 parts of Borneol.

2. A Chinese medicine composition for treating superficial thrombophlebitis according to claim 1, characterized in that: The invention comprises the following components in parts by weight: 40 parts of rhizoma anemarrhenae, 40 parts of fritillariae cirrhosae, 60 parts of root of trichosanthes, 40 parts of rhizoma pinelliae, 20 parts of bletillae striata, 40 parts of spina gleditsiae, 80 parts of honeysuckle, 30 parts of turtle shell, 30 parts of frankincense, 30 parts of turmeric and 10 parts of borneol.

3. A Chinese medicine composition for treating superficial thrombophlebitis according to claim 1, characterized in that: The invention comprises the following components in parts by weight: 55 parts of rhizoma anemarrhenae, 50 parts of fritillariae cirrhosae, 75 parts of root of trichosanthes, 40 parts of rhizoma pinelliae, 20 parts of bletillae striatae, 40 parts of thorns of gleditsiae, 80 parts of honeysuckle, 30 parts of turtle shell, 40 parts of frankincense, 30 parts of turmeric and 18 parts of borneol.

4. A Chinese medicine composition for treating superficial thrombophlebitis according to claim 1, characterized in that: The invention comprises the following components in parts by weight: 60 parts of rhizoma anemarrhenae, 60 parts of fritillariae cirrhosae, 80 parts of root of trichosanthes, 60 parts of rhizoma pinelliae, 30 parts of bletillae striatae, 60 parts of thorns of gleditsiae, 100 parts of honeysuckle, 60 parts of turtle shell, 60 parts of frankincense, 60 parts of turmeric and 20 parts of borneol.

5. A method for preparing a Chinese medicine composition for treating superficial thrombophlebitis according to claims 1-3, characterized in that: The following steps are involved: S1. Weigh a specified amount of Rhizoma Anemarrhenae, Fritillariae Chuanxiong, Radix Trichosanthis, Rhizoma Pinelliae, Rhizoma Bletillae, Spina Gleditsiae, Flos Lonicerae, Carapace of Trionycis, Olibanum, and Rhizoma Curcumae, and crush the above drugs to obtain powder for later use; S2, take an equal amount of vaseline as the powder, heat the vaseline on an induction cooker to melt it, add the reserved powder and stir; S3, stir and boil for 10 minutes, gradually cool for 10 minutes; boil again for 10 minutes and gradually cool; repeat 3 times; S4. After the boiling is completed, the mixture is cooled for 3 hours to obtain the Chinese medicine composition.