The invention discloses an application of nocardia rubra cell wall skeleton (N-CWS) in preparation of drugs for treating skin lesions, which comprise at least one of eczema, neurodermatitis, non-specific dermatitis, atopic dermatitis, and psoriasis. N-CWS is used to treat skin diseases including eczema, neurodermatitis, non-specific dermatitis, atopic dermatitis, and psoriasis, can effectively relieve the symptoms of lesions such as exudation, swelling, red spots, toughened epidermis, lichenification, scaling, itching, and the like, reduces the skin damage caused by scratching and chronic friction, and finally improves and cures the skin diseases.