Application of nocardia rubra cell wall skeleton (N-CWS) in preparation of drugs for treating skin lesions

A technology of Nocardia rubrum and skin lesions, applied in the field of medicine, can solve the problems of many side effects, easy recurrence, drug dependence, etc., and achieve the effect of alleviating exudation

Pending Publication Date: 2018-12-07
FUJIAN SHANHE PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The traditional medicine for the treatment of such skin lesions is external use of glucocorticoids, but there are many side effects, and it is easy to relapse after discontinuation, and it is easy to become dependent on the drug after long-term use

Method used

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  • Application of nocardia rubra cell wall skeleton (N-CWS) in preparation of drugs for treating skin lesions

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] The pharmaceutical composition is prepared through the following steps: firstly mix the cell wall skeleton of Nocardia rubra, benzoic acid, ethylparaben, white petrolatum, stearic acid, glycerin and part of purified water, use 0.1M and pH The pH is adjusted to 7 by the phosphate buffer solution with a value of 7.2, and the remaining purified water is added. The feeding amount of the above-mentioned materials makes the mixed material contain 0.005% by weight of Nocardia rubra cell wall skeleton, 0.1% by weight of benzoic acid, 0.1% by weight ethylparaben, 25% by weight white petrolatum, 25% by weight stearic acid and 15% by weight glycerin. The above mixed material was stirred at a rate of 50 rpm for 10 minutes to prepare a 0.005% by weight Nocardia rubra cell wall skeleton emulsion.

Embodiment 2

[0036] The pharmaceutical composition is prepared through the following steps: firstly mix the cell wall skeleton of Nocardia rubra, benzoic acid, sodium sulfite, carbomer, Tween-80, glycerin and part of purified water, use 0.1M, pH value The phosphate buffer solution of 7.2 adjusts the pH to 7, adds the remaining purified water, and the feeding amount of each of the above materials makes the mixed material contain 0.2% by weight of Nocardia rubra cell wall skeleton, 1.5% by weight of Carbomer, 0.1% by weight Tween-80 in wt%, benzoic acid in 0.1 wt%, sodium sulfite in 0.2 wt%, glycerol in 5 wt%. The above mixed material was stirred at a rate of 50 rpm for 10 minutes to prepare a 0.2% by weight Nocardia rubrum cell wall skeleton gel.

Embodiment 3

[0038]The pharmaceutical composition is prepared through the following steps: first, the Nocardia rubra cell wall skeleton, white petrolatum, cetyl alcohol, stearyl alcohol, Tween-60, glycerin, squalene, stearic acid, monostearyl Glycerides, isopropyl myristate and part of purified water were evenly mixed, and the pH was adjusted to 7 using a 0.1M phosphate buffer solution with a pH value of 7.2, and the remaining purified water was added to obtain a mixed material, and the above mixed material was mixed with 50 Stir at a speed of rev / min for 10 minutes, and press tetrafluoroethane into the medicament. The feeding amount of the above-mentioned materials makes the medicament contain 0.05% by weight of Nocardia rubra cell wall skeleton, 10% by weight of white Vaseline, 1% by weight of cetyl alcohol, 1% by weight of stearyl alcohol, 2% by weight of Tween-60, 4% by weight of glycerin, 0.1% by weight of squalene, 1% by weight of stearic acid, 1 % by weight of glyceryl monostearate,...

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PUM

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Abstract

The invention discloses an application of nocardia rubra cell wall skeleton (N-CWS) in preparation of drugs for treating skin lesions, which comprise at least one of eczema, neurodermatitis, non-specific dermatitis, atopic dermatitis, and psoriasis. N-CWS is used to treat skin diseases including eczema, neurodermatitis, non-specific dermatitis, atopic dermatitis, and psoriasis, can effectively relieve the symptoms of lesions such as exudation, swelling, red spots, toughened epidermis, lichenification, scaling, itching, and the like, reduces the skin damage caused by scratching and chronic friction, and finally improves and cures the skin diseases.

Description

technical field [0001] The invention relates to the field of medicines, in particular to the use of the cell wall skeleton of Nocardia rubrum in the preparation of medicines for treating skin lesions. Background technique [0002] Eczema, neurodermatitis, psoriasis, and nonspecific or atopic dermatitis are common skin lesions. Patients often experience unbearable itching and pain. The condition is prone to relapse and persists for many years, which brings great mental pressure to patients. and economic burden. The traditional medicine for the treatment of such skin lesions is external use of glucocorticoids, but there are many side effects, and it is easy to relapse after stopping the use, and it is easy to become dependent on the medicine for long-term use. [0003] Therefore, there is an urgent need to develop a new drug for the treatment of skin lesions, which can effectively relieve the exudation, swelling, erythema, thickened and rough epidermis, lichenification, scale...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/74A61P17/00A61P17/06A61P25/00A61P17/04
CPCA61K35/74
Inventor 徐镜王骥飞李戈
Owner FUJIAN SHANHE PHARMA
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