35 results about "Nano composites" patented technology

The invention belongs to the technical field of photoacoustic response antibacterial dressings, and discloses PDA (at) Ag (at) Ag2S / SA / F68 / F127 antibacterial temperature-sensitive hydrogel as well as a preparation method and application thereof.The PDA (at) Ag (at) Ag2S / SA / F68 / F127 antibacterial temperature-sensitive hydrogel can complete conversion of gel and sol under the condition of 4-60 DEG C, PDA (at) Ag (at) Ag2S nano-enzyme is constructed by means of an in-situ growth method, a PDA (at) Ag (at) Ag2S nano-composite material can generate electron-hole pairs under photoacoustic combination, then reactive oxygen species (ROS) is generated, and the antibacterial temperature-sensitive hydrogel can be used for preparing antibacterial temperature-sensitive hydrogel. The photoacoustic response antibacterial effect is realized. Meanwhile, PDA (at) Ag (at) Ag2S has peroxidase (POD)-like activity, and the material can catalyze endogenous hydrogen peroxide (H2O2) in a common wound microenvironment with the pH value of 7-8 to generate reactive oxygen species (ROS) with high toxicity, such as hydroxyl free radicals (. OH), so that efficient killing of various bacteria under photoacoustic combination is realized. Synthesis conditions are mild, and the process is simple, economical and feasible. The hydrogel has thermosensitivity, can resist inflammation, stop bleeding and relieve wound pain, does not loosen after absorbing seepage, is free of residues and does not adhere to a wound surface when being removed, and a new way is provided for developing novel medical dressings for treating drug-resistant bacterial infection wounds.

The application discloses a method for treating antibiotic wastewater by using a graphdiyne / ferrous indium sulfide nanocomposite to activate persulfate, and the method is characterized by using the graphdiyne / ferrous indium sulfide nanocomposite as a catalyst to activate persulfate for degrading and treating antibiotic wastewater, wherein the graphdiyne / ferrous indium sulfide nanocomposite comprises ferrous indium sulfide nanoparticles, and the nanoparticles are loaded with graphdiyne nanosheets. The method for treating antibiotic wastewater by using the graphdiyne / ferrous indium sulfide nanocomposite to activate persulfate uses the graphdiyne / ferrous indium sulfide nanocomposite as a catalyst, wherein the nanocomposite has many reactive sites, high catalytic activity and good stability, can efficiently activate persulfate with a smaller amount of catalyst, can efficiently remove antibiotics in wastewater, and has the advantages of low cost, high treatment efficiency, good removal effect, green environmental protection and the like, and therefore, the method has important significance for effectively purifying antibiotic wastewater, has high use value and good application prospect.

The present application provides the use of a nanocomposite with a core-shell structure. Specifically, the present application provides the use of a nanocomposite with a core-shell structure in the preparation of a drug for preventing and / or treating Clostridium difficile infection and recurrent diseases caused thereby, wherein the nanocomposite comprises: ZnO nanoparticles as a core; mesoporous silica as a shell coated on the surface of the ZnO nanoparticles; an antibiotic loaded in the pore channel of the mesoporous silica; hyperbranched polylysine modified on the surface of the mesoporous silica; and a pH-responsive coating material as the outermost layer. The nanocomposite provided by the present application can achieve precise targeted release of the drug in the colon, and through the sequential and synergistic mechanism of "membrane breaking-sterilization-spore inhibition-repair", it can simultaneously solve multiple factors leading to CDI recurrence such as biofilm protection, spore storage, bacterial population destruction, mucosal damage, etc., and improve the treatment effect.

The application discloses a preparation method of a multi-charge electrostatic self-assembled nanocomposite and application thereof, and relates to the technical field of nanomaterials. The method comprises the following steps: (1) synthesizing CAT-Ce6; (2) synthesizing negative electric Ag2S-3MPA QDs; (3) synthesizing positive electric Ag2S-NH2 QDs; and (4) preparing Ag2S@CAT-Ce6@Oxa nanocomposite: ultrasonic mixing of Ag2S-NH2 QDs solution and CAT-Ce6 solution to obtain a mixed solution, dropwise adding Oxa dissolved in a mixture of methanol and DMSO into the mixed solution, stirring in a dark environment at room temperature to obtain Ag2S@CAT-Ce6@Oxa crude product, and purifying the Ag2S@CAT-Ce6@Oxa crude product to obtain Ag2S@CAT-Ce6@Oxa nanoparticle pure product. The application is helpful to realize controllable release of drugs, improve curative effect, effectively relieve tumor hypoxia in vivo, provide a better environment for photodynamic therapy and other treatments, realize accurate positioning and observation of tumors, effectively inhibit tumor growth and prolong survival time, improve curative effect and reduce side effects, and has good biocompatibility and wide application prospect in vivo.

The present disclosure provides a nanocomposite and a preparation method and use thereof. In the present disclosure, the nanocomposite is wrapped with Prussian blue nanoparticles (PB) using a platelet membrane (PM) as a shell; and a surface of the PM is modified with an aptamer of cancer cells and horseradish peroxidase (HRP). An ability of platelets (PLTs) to specifically target cancer cells and inflammatory sites can effectively enhance the accumulation of nanoparticles at tumor sites, and help PB better achieve a desirable photothermal therapy (PTT) under near-infrared light irradiation. In addition, hydrogen peroxide is highly expressed in the tumor microenvironment; the HRP modified on a surface of the nanocomposite can decompose the hydrogen peroxide to generate oxygen bubbles, which drive active transport of the nanocomposite, thereby enhancing the accumulation in cancer cells. Modification with the aptamer of cancer cells on a platelet membrane surface enhances cancer cell targeting.

The invention relates to the technical field of antibacterial materials, in particular to an antibacterial nano composite material and a preparation method thereof. The method comprises the following steps: mixing a cerium source solution and an organic ligand solution for reaction, and adding a buffer solution after the reaction is finished to obtain a cerium metal organic framework; mixing the cerium metal organic framework and vancomycin, and reacting to obtain a composite material; a substrate is soaked in a solution containing a coupling agent and a composite material, and the antibacterial nano composite material is formed on the surface of the substrate through deposition. Through the synergistic effect of the cerium metal organic framework and vancomycin, common pathogenic bacteria can be efficiently inhibited. As a carrier, the organic framework can realize slow release of vancomycin, so that the antibacterial action time is prolonged, and the antibacterial effect reduction caused by too fast release of vancomycin in a short time is also avoided. In addition, the antibacterial nano composite material has good biological safety and corrosion resistance.

The invention relates to the technical field of crossing of bone tissue engineering and intelligent antibacterial materials, in particular to a heterojunction nanocomposite and a preparation method thereof, and a heterojunction stent and a preparation method and application thereof. The preparation method comprises the following steps: by taking pCu-BTC and MoS2 as raw materials, carrying out ball milling in a dispersion medium at room temperature, then carrying out intermittent ultrasonic treatment under an ice bath condition to form a type II heterojunction interface so as to obtain a heterojunction nano composite material, compounding the heterojunction nano composite material with poly-L-lactic acid, and then carrying out high-pressure homogenization-3D printing forming, thereby obtaining the ultrasonic response type MoS2 / pCu-BTC / PLLA heterojunction scaffold. The stent has the sonodynamic / chemical dynamic dual-mode antibacterial and osteogenesis promoting functions, is good in biocompatibility and controllable in degradation, can be widely applied to the field of infectious bone defect repair, and provides a novel material solution for antibacterial-bone regeneration synergistic treatment.

The invention relates to a drug-eluting nanoengineered medical implant / contact device. The device comprises a nanocomposite and a drug, wherein the nanocomposite comprises a hydrophilic polymer domain, a hydrophobic polymer domain, a water pore, and a boundary charged double layer; wherein when the drug is hydrophilic, at least 80% of the drug partition in the boundary charged double layer is formed at the boundary interface of the hydrophilic polymer domain and the water pore, and when the drug is hydrophobic, at least 80% of the drug partition in the boundary charged double layer is formed at the boundary interface of the hydrophobic polymer domain and the water pore. The device is configured to maintain release of the drug with high precision and long duration.

The present invention relates to a drug-eluting nanoengineered medical implant / contact device. The device comprises a nanocomposite and a drug, wherein the nanocomposite comprises hydrophilic polymer domains, hydrophobic polymer domains, water pores, and boundary charged double layers; wherein when the drug is hydrophilic, at least 80% of the drug partitions in the boundary charged double layers formed at the boundary interface of the hydrophilic polymer domains and water pores, and when the drug is hydrophobic, at least 80% of the dmg partitions in the boundary charged double layers formed at the boundary interface of the hydrophobic polymer domains and water pores. The device is configured to sustain the release of the drug at high precision and long duration.

The invention belongs to the technical field of biomedicine, and particularly relates to a diagnosis and treatment integrated nano composite material for targeting tumor blood vessels as well as a preparation method and application of the nano composite material. The invention aims to provide the diagnosis and treatment integrated nano composite material for targeting tumor blood vessels, so that organic integration of multi-mode molecular imaging and targeted therapy is successfully realized, an innovative solution is provided for constructing a novel diagnosis and treatment integrated platform, the technical blank of existing blood vessel targeting drugs is filled, and the application prospect is wide. And meanwhile, the treatment and monitoring functions are innovatively integrated to meet the urgent clinical requirements. According to the present invention, based on the precise evaluation requirement of tumor blood vessel targeting treatment, the MRI imaging agent and the blood vessel targeting drug are grafted and integrated on the POSS through the chemical bond for the first time, such that the treatment-monitoring integration is achieved, the targeting property and the synergistic treatment effect of the nanoparticles are systematically evaluated, the pain point that the action process cannot be evaluated in real time by using the traditional drug is solved, and the application prospect is broad. And a basis is provided for clinical individualized treatment.

The invention discloses a method, a system and a device for screening a conductive network structure of a polymer composite, and relates to the technical field of conductive polymer nano composites.The method comprises the steps that molecular dynamics simulation trajectory data of a polymer composite system of carbon nano tubes with different concentrations is obtained, particle nodes are sequentially coded, and the particle nodes are obtained; carrying out one-hot coding according to particle types and molecule IDs to which the particles belong, generating a node attribute matrix, and meanwhile, generating an adjacent matrix according to a bonding relationship among the particles so as to construct a corresponding graph structure data set; inputting the graph structure data set into a prediction model based on a graph attention network, and training by adopting an incremental learning method; according to the trained prediction model, the optimal polymer composite conductive network structure is screened out, and the method can capture complex multilevel structure information and better predict the polymer properties affected by the complex multilevel structure information.

A system for the synthesis and production of a cermolybdate graphitic carbon nitride (Ce2 (Mo4)3@g-C3N4) nanocomposite for the detection of uric acid in sweat, comprising: a) a cermolybdate synthesis unit for the production of Ce2 (Mo4)3 nanoparticles by hydrothermal treatment, wherein the cermolybdate synthesis unit comprises: • a reaction vessel containing cerium nitrate and ammonium molybdate in a molar ratio of 2:3 in a solvent mixture of ethanol and deionized water, • a surfactant additive system configured to add cetyltrimethylammonium bromide (CTAB) for stabilization, and • a hydrothermal reactor configured to heat the mixture to 180°C for 24 hours; b) a plant for the synthesis of graphitic carbon nitride, configured to produce g-C3N4 by thermal polymerization of melamine under inert atmospheric conditions at temperatures of 400 °C to 600 °C; and c) a nanocomposite formation unit configured to combine Ce2(Mo4)3 and g-C3N4 to form the Ce2(Mo4)3@g-C3N4 nanocomposite, wherein the nanocomposite formation unit comprises: • an ultrasound system configured to disperse the components at the molecular level and allow them to interact with each other, and • a drying system for removing residual solvents.

The application discloses a cell membrane modified nanocomposite as well as a preparation method and application thereof. The nanocomposite comprises, from outside to inside, a membrane structure outer layer, a piezoelectric material middle layer and a magnetostrictive material core structure, wherein the outer surface of the membrane structure contains protein molecules. Under the stimulation of an external magnetic field, the nanocomposite can regulate Th1 / Th2 balance, promote Th2 cell polarization and enhance T cell proliferation, thereby reducing T cell-mediated autoimmune reactions and maintaining host immune homeostasis, and has a wide application prospect in the treatment of arthritis.

The application provides cytosine-rich ssDNA (C-rich ssDNA) and application thereof in improving peroxidase-like activity of Fe3O4@Au, and belongs to the technical field of nanocomposites; the C-rich ssDNA is obtained by connecting 20 continuous cytosine nucleotides to an aptamer; the sequence of the 20 continuous cytosine nucleotides is shown in SEQ ID NO. 1. Fe3O4@Au shows peroxidase-like activity, and after the C-rich ssDNA is used to modify Fe3O4@Au, the peroxidase-like activity is significantly enhanced, and then the detection limit of a sensing method based on Fe3O4@Au is reduced.

An electrochemical immunosensor device for the early detection of Orientia tsutsugamushi-specific TSA antigens, consisting of a carbon screen-printed paper electrode (SPPE) modified with AuNPs@rGO nanocomposites, an antibody immobilization interface and an electrochemical detection circuit.

A biodegradable and biocompatible barrier membrane of piezoelectric nano composites of Metallic Oxide (MO) (e.g., Magnesium oxide, Zinc oxide and iron oxide)-PLLA (Poly-L-lactide), which can be subjected to acoustic pressure from ultrasound, to generate useful electrical charge for enhanced bone regeneration and enhanced antibacterial effects for guided bone regeneration to treat dental diseases, such as periodontitis.

The application discloses a lung-targeted nanocomposite and a preparation method and application thereof, wherein the nanocomposite comprises carbon nitride two-dimensional nanosheets and AIE photosensitizers loaded on surfaces of the carbon nitride two-dimensional nanosheets. The nanocomposite has excellent aggregation-induced emission properties and active oxygen generation capacity, can play a diagnostic role of the photosensitizer, and can produce a better tumor elimination effect, so that the diagnosis and treatment of lung cancer can be simultaneously realized. In addition, the nanocomposite has a suitable size, can enhance the retention of drugs in the lung, prolong the treatment time, and reduce the administration frequency; the nanocomposite can also be administered through tracheal spray, has the advantages of rapid onset, high local drug concentration, small drug dosage, convenient use, less systemic adverse reactions, easy monitoring and adjustment of the dosage, and the like.

The present invention relates to: a cerium oxide nanocomposite in which a shell layer comprising a cationic amino acid and PVP is formed on a core layer of cerium oxide nanoparticles; and a composition comprising same as an active ingredient for improving skin conditions. Employing lysine, which is an optimal amino acid capable of functioning as a multifunctional ligand among various amino acids, the nanocomposite of the present invention exhibits both excellent particle properties and maximized reactive oxygen species scavenging activity within skin tissue. Therefore, it can reduce and alleviate various skin tissue damages caused by oxidative stress including skin aging.

The application discloses a novel dental nanocomposite material and a preparation method and application thereof, and the nanocomposite material comprises the following preparation raw materials in parts by weight: 15-30 parts of eucommia ulmoides derived antibacterial carbon dots-epigallocatechin gallate, 10-25 parts of iron nitrate, 5-7 parts of boric acid, 8-12 parts of metformin hydrochloride, 4-6.6 parts of zinc chloride, 40-60 parts of hyaluronic acid and 4-6 parts of 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid sodium. The application takes eucommia ulmoides derived antibacterial carbon dots-epigallocatechin gallate as a core, and through the o-benzenetriol structure of epigallocatechin gallate, a stable metal-phenol / boric acid ester hybrid network inner shell is cooperatively constructed with iron ions and boric acid, and the effect of synergistically improving anti-inflammatory and long-acting promotion of directional differentiation of dental pulp stem cells is achieved.

The present invention relates to a reduced graphene oxide nanocomposite for targeting multiple drug-resistant cancer cells capable of simultaneously performing enhanced photothermal therapy and photodynamic therapy, and a method for manufacturing the same. The nanocomposite of the present invention comprises reduced graphene, poly(N-isopropylacrylamide)-acrylic acid, and folic acid, thereby exhibiting excellent targeting function for multiple drug-resistant cancer cells. In particular, when an anticancer agent including indocyanine green is encapsulated internally, it exhibits a synergistic effect of photothermal and photodynamic therapy against multiple drug-resistant cancer.

The application discloses a kind of for removing apoptotic cell, inhibiting the mechanical adaptive hydrogel of tissue fibrosis and preparation method and application thereof, and the hydrogel includes interpenetrating network polymer matrix and dynamic nanocomposite embedded in matrix.The hydrogel of the application provides structural support with AAm as the first crosslinking network, CSMA is given softness and high porosity connectivity as the second network, realizes high bearing and self-adaptive deformation to external pulling.The CP@ZV as nanonode, through the network stability of multiple-point non-covalent interaction is enhanced and the pulling energy generated by pre-stretching is dissipated.After pre-stretching attachment, nanonode cooperatively forms reverse mechanical buffer, effectively reduces the abnormal pulling stress perceived by edge cell, inhibits mechanical signal sustained activation, so as to restore macrophage cytophagic-mediated apoptotic cell removal function.

The present disclosure relates to an albumin nanocomposite comprising a phytochemical and a composition for muscle disease comprising the same, and more specifically, to an albumin nanocomposite comprising a phytochemical that exhibits an effect of inhibiting muscle loss caused by oxidative stress or inflammatory response and promoting the differentiation of myoblasts into muscle cells. The albumin nanocomposite comprising the phytochemical effectively delivers the phytochemical by targeting immune cells that induce reactive oxygen species and inflammatory responses. Accordingly, by regulating muscle-loss signaling pathways induced by reactive oxygen species and inflammatory responses, the nanocomposite inhibits muscle cell atrophy and promotes differentiation. Therefore, a composition comprising the albumin nanocomposite comprising the phytochemical according to the present disclosure can be provided as a composition for improving, preventing, or treating muscle diseases.

The invention discloses a preparation method and application of a ZIF-8-EGCG / Co < 2 + >-coated ZnPc nano composite material. A ZIF-8 metal organic framework is used as a main body, EGCG, Co < 2 + > ions and a ZnPc photosensitizer are subjected to functional modification, and the EB virus targeted recognition capability and antibacterial activity of EGCG, the Fenton-like catalytic characteristic of Co < 2 + > and the photodynamic effect of ZnPc are further integrated on the basis of ensuring the remarkable surface area characteristic, the adjustable pore structure and the excellent biocompatibility of the composite material. Through an acid response trigger mechanism, directional enrichment and controllable release of drugs at tumor sites are realized, synergistically enhanced ROS is generated, tumor cell death is effectively induced, microbial colonization closely related to nasopharyngeal carcinoma occurrence and development is inhibited, and the drug effect is improved. An innovative solution is provided for overcoming the clinical challenges that a traditional operation is difficult to eradicate tiny focuses, and normal tissue damage is easily caused.

The invention belongs to the technical field of biological nanomaterials, and particularly relates to an engineered insulin compound with an ultrasonic response characteristic as well as a preparation method and application of the engineered insulin compound. The engineered insulin compound with the ultrasonic response characteristic comprises pancreas islet beta cells and a nano composite material with a fiber net structure, and the nano composite material is loaded on the surfaces of the pancreas islet beta cells through adsorption, the nano composite material of the fiber net structure comprises a carbon nano fiber net wrapping the outer surface of pancreatic beta cells and defective titanium oxide quantum dots which modify the carbon nano fiber net and have acoustic-electric conversion performance. The engineered insulin compound adopts a strategy of constructing nanometer engineered pancreas islet beta cells of an acoustic-electric conversion system, the pancreas islet beta cells are controlled through an external ultrasonic signal, and insulin is controllably released, so that the type 1 diabetes mellitus is simply and conveniently treated.

The invention belongs to the field of preparation of medical materials, and particularly relates to application of acellular matrix loaded Sr-Se coated SiO2 and adipose-derived mesenchymal stem cells in sequential treatment of volumetric muscle defects. On the basis of the Sr-Se-coated SiO2 nano composite material, a composite filling scaffold is developed in combination with a tissue engineering scaffold, and the effect of the composite filling scaffold in the VML treatment process is researched. The filler is composed of three parts, namely a nano material Sr-Se coated SiO2 with multiple functions of resisting inflammatory response, promoting vascularization and the like, ADSCs with myogenic differentiation potential and a dECM composite scaffold used for loading contents, the composite filling scaffold provided by the invention can improve the problem that traditional VML treatment is difficult, and sequential treatment of personalized guide VML is achieved.

The application discloses a method for detecting ochratoxin A by using a competitive colorimetric fluorescent dual-mode immunosensor, and the method uses AuAg NCs-S,P-g-C3N4 nanocomposites as a label of the competitive colorimetric fluorescent dual-mode immunosensor; the S,P-g-C3N4 has the advantages of a large specific surface area and good biocompatibility; the AuAg NCs have an aggregation luminescence effect after being combined with the S,P-g-C3N4 through Au-S bonds, the fluorescence of the AuAg NCs is enhanced, the fluorescence signal is amplified, and the sensitivity of the sensor is improved; the loading of the AuAg NCs greatly enhances the enzyme-like activity of the S,P-g-C3N4; the nanocomposites are used to catalyze TMB into blue oxTMB, so that visual detection is realized. The two signals are mutually verified, so that the sensor is more sensitive, and the method has the characteristics of simple operation, fast reaction speed, low cost, low detection limit and wide linear range.

The invention relates to the technical field of synthesis and anaerobic fermentation of nano composite materials, in particular to a method for enhancing anaerobic fermentation hydrogen production through a calcium oxide loaded ferroferric oxide nano material. Ferroferric oxide nano-particles are loaded on calcium oxide, the loading proportions of ferroferric oxide are respectively 10%, 20%, 30% and 40%, and the calcium oxide loaded ferroferric oxide nano composite material is introduced into a hydrogen production working solution enriched with anaerobic fermentation hydrogen production microorganisms. The material can synchronously realize two core effects: ferroferric oxide strengthens electron transfer to assist microbial enrichment, calcium oxide strengthens hydrolysis of organic matters and regulates and controls pH to relieve excessive acidification of a system, and finally, effective support is provided for improvement of anaerobic fermentation hydrogen production efficiency.

This invention belongs to the field of biomedical materials and wound repair technology, and discloses a photothermal antibacterial hydrogel based on polydopamine-platinum nanocomposite materials, its preparation method, and its applications. The preparation method includes the following steps: S1, preparing polydopamine nanoparticles; S2, loading platinum nanoparticles in situ onto the surface of the polydopamine nanoparticles to prepare a polydopamine-platinum nanocomposite material; S3, dispersing or dissolving the matrix material in water to form a homogeneous colloidal system, then adding the polydopamine-platinum nanocomposite material and mixing evenly, followed by standing to form a gel to obtain the photothermal antibacterial hydrogel. The photothermal antibacterial hydrogel comprises a three-dimensional network structure formed by the matrix material and the polydopamine-platinum nanocomposite material dispersed within the three-dimensional network structure. This photothermal antibacterial hydrogel possesses both near-infrared photothermal response properties and enzyme-like catalytic activity, enabling localized photothermal antibacterial action, reactive oxygen species scavenging, and catalytic oxygen production, and can be used for the repair of infected wounds.

The invention discloses a composite nano material for treating drug resistance of non-small cell lung cancer as well as a preparation method and application of the composite nano material, and belongs to the technical field of biological medicines. The material is of a core-shell structure, zinc / copper double-monatomic nano-enzyme is taken as a core, a mesoporous silica shell layer is coated outside to load YAP-siRNA, and glucose oxidase and an endoplasmic reticulum targeting agent TsG are adsorbed on the outermost layer. According to the application disclosed by the invention, active oxygen outbreak is realized in tumor cells, a YAP drug-resistant pathway is inhibited and strong endoplasmic reticulum stress is induced through the coordination of double-monatomic nano-enzyme catalysis, YAP gene silencing and glucose oxidase mediated metabolism deprivation, so that the EGFR-TKI drug resistance of the non-small cell lung cancer is effectively reversed. The preparation method of the material is mild in condition and good in biocompatibility, shows a remarkable anti-tumor effect in an in-vitro cell experiment and an in-vivo animal model, and provides a new solution for clinically solving the drug resistance problem of non-small cell lung cancer.

The invention provides a novel two-step sintering method for developing a magnesium-based nano composite material for an orthopaedic implant, and relates to the technical field of medical materials.The novel two-step sintering method for developing the magnesium-based nano composite material for the orthopaedic implant comprises the following steps that magnesium, hydroxyapatite and graphene nanosheets are taken to be evenly mixed; pressing into a green body, heating the green body to 250-350 DEG C for presintering, and keeping the temperature for 3-5 hours; and heating to 850-950 DEG C, carrying out high-temperature sintering, and carrying out heat preservation for 1.5-2.5 hours. The elasticity modulus of the prepared magnesium-based nano composite material is about 45 GPa, the magnesium-based nano composite material can be matched with human bones, controllable degradation of 0.2-0.5 mm / year and synchronous bone regeneration are achieved, controllable degradation of the bones in the healing process is guaranteed, perfect balance between the mechanical performance and the degradation speed of implants is kept, complete degradation can be achieved, secondary operation is avoided, and the infection risk is reduced.