74 results about "Amorphous calcium carbonate" patented technology

Provided are compositions containing amorphous calcium carbonate (ACC), and at least one phosphorylated amino acid which stabilizes the amorphous form of said calcium carbonate. The compositions are useful in pharmaceutical and nutraceutical formulations.

The invention provides a construction method of a core-shell structure. The method comprises the following steps of (A) mixing an ethanol solution containing calcium ions and water and a core material to obtain a mixed solution, and reacting the mixed solution with a decomposition product of ammonium bicarbonate to obtain nanoparticles coated with calcium carbonate layers; and (B) mixing the nanoparticles coated with the calcium carbonate layers, ethanol, tetraethyl orthosilicate, ammonia water, water and ethylenediaminetetraacetic acid and then reacting to obtain the nanoparticles coated with silicon dioxide layers. By using layer-by-layer coating of amorphous calcium carbonate and silicon dioxide, the nano multi-layer core-shell structure is successfully prepared; for example, the core material as a drug-loaded core can be applied to drug loading and controlled release of the nanoparticles. By virtue of the novel technology, flexible control on the interlayer property of the amorphous calcium carbonate or the silicon dioxide can be achieved.

The invention relates to monodisperse non-crystal calcium carbonate nano-particles with uniform particle size ranging from 10 nm to 300 nm. The invention further discloses a method for preparing the monodisperse non-crystal calcium carbonate nano-particles. The method comprises steps as follows: a, an ethanol solution A of calcium chloride is prepared; b, water is added into the solution A, and a reaction liquid B is obtained; c, the reaction liquid B is placed into a container C, an opening of the container C is sealed, and a small hole is performed in a sealing film; d, ammonium bicarbonate solids are loaded into a container D, an opening of the container D is sealed, and a small hole is performed in a sealing film; e, the container C and the container D are jointly placed in a sealed dryer for standing, and a liquid in the container C becomes a suspension liquid E; and f, the suspension liquid E is subjected to centrifugal separation to obtain the calcium carbonate nano-particles.

Provided is a method for preparing a stable amorphous calcium carbonate (ACC), which can be obtained either in suspension or as a powder. The method comprises stepwise combination of a soluble calcium salt, a soluble carbonate, a first and second stabilizer, and a water miscible organic solvent as described herein. The present invention further relates to stable ACC suspensions and dry powders produced by the method of the present invention.

The invention discloses a method for preparing amorphous calcium carbonate nanospheres. The method comprises the following steps: water soluble calcium salt is dissolved in de-ionized water; then a stabilizing agent is added; the pH value of a solution is adjusted to 7-11 to obtain a solution A; water soluble carbonate is dissolved in the de-ionized water to obtain a solution B; the solution B is dropwise added in the solution A; the pH value of the solution system is controlled to be 7-11; after the dripping is finished, the stirring is conducted at the room temperature for a certain time; then the centrifugal separation, the washing and the drying are conducted to obtain the amorphous calcium carbonate nanospheres. The method has the advantages that the process is simple; the operation is convenient; complex and expensive equipment is not required; industrialization is easy to achieve; raw materials are cheap in cost and easily obtained. The amorphous calcium carbonate nanospheres prepared through the method, as biomedical materials, can be applied to the fields of medicine delivery, protein adsorption, gene transfection, tissue repair and the like, and has good application prospect.

The invention relates to a novel technology for large-scale, simple and economical production of ultra-micro amorphous calcium carbonate in an alcohol-water system. The invention provides a common novel technological method for rapidly preparing the amorphous calcium carbonate in an alcohol-water system by taking carbide slag, calcium hydroxide and calcium chloride as calcium sources. According tothe method provided by the invention, the difficulties of industrial synthesis and stable preservation of the amorphous ultra-micro calcium carbonate are overcome very well and industrial wastes including the carbide slag, the calcium chloride, flue gas and the like are utilized very well. The novel technology provided by the invention has remarkable environment, economic and social benefits.