73 results about "Amorphous calcium carbonate" patented technology

Compositions and methods for forming, in an aqueous environment, a nanoaggregate of calcium fluoride and amorphous calcium phosphate-containing compound, such as amorphous calcium phosphate fluoride or amorphous calcium carbonate phosphate fluoride are described. The nanoaggregate (or nanocomposite) can release calcium, phosphate, and fluoride, and ultimately convert to the tooth mineral, fluorapatite. One method for forming such a nanoaggregate involves applying a non-aqueous (e.g., varnish-based) composition (e.g., a suspension), containing solid particles of water soluble salts of calcium, phosphate, and fluoride, to the aqueous environment of the mouth. This results in rapid solubilization of the salts, precipitation of the nanoaggregate, and tooth remineralization. Tooth fluoridation and remineralization may also be carried out by applying to the tooth a non-aqueous carrier containing the nanoaggregate. Whitening agents can also be added to these compositions and methods.

The invention discloses a composite calcium sulfonate grease lubricant and a preparation method thereof. The grease lubricant has the following ingredients by proportion: A) base oil which accounts for 40-80% of the gross weight of the grease lubricant, with kinematic viscosity of 40-1600mm2/s at temperature of 40 DEG C; B) high base number synthesized calcium sulfonate which accounts for 10-50% of the gross weight of the grease lubricant, with total alkali value of 380-420mgKOH/g; and C) a composite densifier comprising C12-C22 hydroxy fatty acid, boric acid, phosphoric acid and calcium hydroxide, accounting for 0.5-5%, 0.5-3%, 0.5-3% and 0.5-2% of the gross weight of the grease lubricant respectively. The preparation method comprises the following steps: mixing, stirring, heating, heating up, homogenizing, degassing, etc. In the invention, no transforming agents are used, amorphous calcium carbonate can be thoroughly converted into calcite crystal form calcium carbonate merely by adding water, and phosphoric acid and boric acid are used in the composite technology formula to improve the technology of composite calcium sulfonate grease lubricant. The method has the advantages of simple method and easy control and the product has stable performances.

The invention relates to a novel technology for large-scale, simple and economical production of ultra-micro amorphous calcium carbonate in an alcohol-water system. The invention provides a common novel technological method for rapidly preparing the amorphous calcium carbonate in an alcohol-water system by taking carbide slag, calcium hydroxide and calcium chloride as calcium sources. According tothe method provided by the invention, the difficulties of industrial synthesis and stable preservation of the amorphous ultra-micro calcium carbonate are overcome very well and industrial wastes including the carbide slag, the calcium chloride, flue gas and the like are utilized very well. The novel technology provided by the invention has remarkable environment, economic and social benefits.

The invention belongs to the technical field of functional materials, and particularly relates to a self-healing capacitive intelligent skin with high sensitivity and a preparation method thereof. According to the invention, amorphous calcium carbonate and sodium alginate are crossly linked with polyacrylic acid to obtain polyelectrolyte gel which is easy to deform and has the self-healing capability, and the gel can be further designed into the bionic intelligent skin which has high sensitivity and the self-healing capability and can be recycled. The raw materials involved in the invention are natural high polymer sodium alginate, calcium carbonate and polyacrylic acid with good biocompatibility, the solvent used is water, the preparation process is green and pollution-free, the operation is simple and convenient, the production cost is low, and the large-scale industrial production is expected to be realized. Compared with the currently reported intelligent skin material, the bionic intelligent skin designed by the invention achieves high sensitivity and complete self-healing effect and has the potential of large-scale preparation and a wide commercial application prospect.

The invention provides a construction method of a core-shell structure. The method comprises the following steps of (A) mixing an ethanol solution containing calcium ions and water and a core material to obtain a mixed solution, and reacting the mixed solution with a decomposition product of ammonium bicarbonate to obtain nanoparticles coated with calcium carbonate layers; and (B) mixing the nanoparticles coated with the calcium carbonate layers, ethanol, tetraethyl orthosilicate, ammonia water, water and ethylenediaminetetraacetic acid and then reacting to obtain the nanoparticles coated with silicon dioxide layers. By using layer-by-layer coating of amorphous calcium carbonate and silicon dioxide, the nano multi-layer core-shell structure is successfully prepared; for example, the core material as a drug-loaded core can be applied to drug loading and controlled release of the nanoparticles. By virtue of the novel technology, flexible control on the interlayer property of the amorphous calcium carbonate or the silicon dioxide can be achieved.

The invention relates to a calcite phase spherical porous calcium carbonate granule and a preparation method thereof, and the calcite phase spherical porous calcium carbonate granule is a calcite phase solid core spherical calcium carbonate granule with multipe nano pores, and comprises accumulated crystal particles. A NH3 and CO2 mixed gas is used for diffusion and reaction with calcium ions in a water and ethanol mixed solution of a soluble calcium salt. The NH3 dissolved in the water /ethanol mixed solution produces a weak alkaline solution to promote the reaction of the CO2 and the calcium ions to produce amorphous calcium carbonate, and further the amorphous calcium carbonate is gradually self-assembled and partially crystallized to produce white precipitate E. After centrifugal drying, the white precipitate E is soaked in water / ethanol mixed solution F, after mutual fusion growth and crystallization of the calcium carbonate, accumulation pores in the range of 10-400nm are formed, and further the calcite phase spherical porous calcium carbonate granule with a high degree of crystallinity is formed.

The invention discloses a method for reinforcing soil by using a soil solidification solution. The method for reinforcing the soil by using the soil solidification solution includes the steps of putting calcium carbonate powder in a high pressure resistant container, adding water and then continuously introducing carbon dioxide gas thereto to form a saturated aqueous solution of calcium bicarbonate under the action of stirring, continuously spraying or pouring the obtained aqueous solution of the calcium bicarbonate on the surface or inside of the soil, allowing the calcium bicarbonate to decompose and form amorphous calcium carbonate with cementation function when water infiltrates into the soil for migration, and cementing soil particles into a whole to improve engineering properties such as strength, water stability and durability of the soil and meet the needs of engineering construction. The method for reinforcing the soil by using the soil solidification solution has the advantage of being suitable for various fields such as rock and soil reinforcement, dam and soil structures for anti-seepage and plugging, sand liquefaction prevention, heavy metal pollution soil treatment, earth and stone brick heritage building restoration, and concrete crack repair.

A facile method to synthesize stable calcium carbonate microstructures is demonstrated which allows in situ encapsulation of sensitive molecules like drugs. The methodology involves a macromolecular assembly of anionic polypeptide with cationic peptide oligomer to concurrently template and hold to stabilize the mineralized structure. The heterogeneously distributed mixture of anionic and cationic residues in the macromolecular assembly, similar to that is found in natural systems assists in recognizing and coassembling Ca²⁺ and CO₃²⁻ ionic clusters, especially for formation of a disordered precursor phase such as amorphous calcium carbonate (ACC) and further crystallization to form a metastable vaterite phase. The assembly also facilitates encapsulation of a guest molecule such as tetracycline at ambient conditions without affecting the mineralization process. The tetracycline-loaded microstructures show excellent antibacterial activities against many Gram-positive and Gram-negative bacterial strains and hence together with the fluorescence property of tetracycline and appropriate drug release profile, they can be used as multifunctional materials for therapeutic and imaging applications.

The invention provides an amorphous calcium carbonate nanosheet material and a preparation method thereof. Tellurium nanowires are washed, and washed tellurium nanowires are obtained; then a tellurium nanowire solution is prepared from the washed tellurium nanowires, the tellurium nanowire solution, a carbon source and a calcium source have a reaction, and the amorphous calcium carbonate nanosheet material is obtained; the zeta potential of the washed tellurium nanowires is controlled to be smaller than or equal to minus 14 mV, the volume ratio of the tellurium nanowires to a first solvent is controlled to be (0.2-10):1, so that one-dimensional tellurium nanowire materials used as formworks can induce the calcium source to react with the carbon source, amorphous calcium carbonate is obtained, and the nanosheet material can be further assembled. Meanwhile, according to the preparation method, materials of the formworks are simple and easy to obtain, the preparation method is simple and controllable, and batch production is facilitated.

The invention discloses an amorphous calcium carbonate-gadolinium (ACC-Gd) multifunctional nano material obtained by stabilizing ACC through Gd and a preparation method and an application thereof. The invention further discloses an ACC-Gd-polymer multifunctional nano material obtained by introducing appropriate polymer or biomacromolecule to the ACC-Gd nano material and a preparation method and an application thereof. A novel multifunctional nano material is obtained by stabilizing ACC through Gd, the Gd is located in crystal lattices of ACC, toxicity of the Gd is greatly reduced, simultaneously the Gd which is a magnetic element has an excellent radiography effect, and thereby the multifunctional nano material can be used in magnetic resonance imaging (MRI) contrast media.

The invention discloses a synthesis method of amorphous calcium carbonate, which comprises the following steps: (1) preparing a solution A: dissolving a water-soluble calcium salt in deionized water,and adding an ionic surfactant to form the solution A, with the molar ratio of the water-soluble calcium salt to the ionic surfactant being 1:1-100:1; (2) preparing a solution B: dissolving water-soluble carbonate or bicarbonate in deionized water, and adjusting the pH value of the solution to 11-13 to form the solution B; (3) refrigerating the solution A in the step (1) and the solution B in thestep (2) at -5 DEG C to 5 DEG C for 40 to 60 minutes, then quickly mixing the refrigerated solution A and the solution B, stirring the mixture for 5-60 seconds, and carrying out centrifugal separation, washing and drying to obtain the amorphous calcium carbonate. The synthesis method provided by the invention has the advantages of simple operation, cheap and easily available raw materials, high reaction rate, no need of complex expensive instruments or devices, and the like.

A preparation method for high-base-number crystalline calcium sulfonate comprises the following steps: adopting amorphous high-base-number calcium sulfonate as a raw material, adding a transforming agent under the existence of lower alcohol and water, heating, uniformly mixture, introducing carbon dioxide to enable all amorphous calcium carbonate micelles in the amorphous high-base-number calcium sulfonate to be converted into crystalline calcite micelles to obtain a product (high-base-number crystalline calcium sulfonate). The preparation method has the advantages that the process is simple, the operation is convenient, the applicability is high, the requirements on the raw material of the amorphous high-base-number calcium sulfonate is not high, the preparation method is suitable for any high-base-number calcium sulfonate, and the problem in selectivity of different conversion systems to conversion of calcium sulfonate is solved; the product structure adopts the calcite crystallization form, and is stable; the product is high in extreme pressure property and thickening capability; all indexes of the product can meet the requirements.

The invention provides a method of preparing linoleate isomerase micro-capsules on the basis of a polyelectrolyte layer-by-layer self-assembly technology and can solve a problem that free linoleate isomerase is poor in tolerance, is poor in stability and cannot be recycled in industrial production. The method of the invention includes the following steps: with an amorphous calcium carbonate crystal, which is obtained through co-precipitation of calcium carbonate and the linoleate isomerase, as a template and with polyallylamine hydrochloride and sodium polystyrenesulfonate as coating materials, preparing the linoleate isomerase micro-capsules through the polyelectrolyte layer-by-layer self-assembly technology. The micro-capsule is high in activity, excellent in stability and long in half life.

The invention relates to an amorphous calcium carbonate composite nano-medicine with an effect of inducing ferroptosis of tumor cells and a preparation method of the amorphous calcium carbonate composite nano-medicine, and belongs to the technical field of medicines. After the composite nano-medicine enters the tumor cells, the degradation of nanoparticles is promoted by means of the acidic environment of lysosomes, meanwhile, the lysosomes are subjected to permeabilization to release doxorubicin and ferrous ions through the protonation of dendrimers, wherein ferrous ions can promote the conversion of polyunsaturated fatty acids of cell membranes to lipid peroxides and induce ferroptosis of the tumor cells, and DOX can promote oxidative stress to increase the content of hydrogen peroxide in the cells while inducing apoptosis, so that iron-dependent ferroptosis caused by lipid peroxidation induced by the ferrous irons is further enhanced. The composite nanoparticles can not only increase the therapeutic effect of tumors, but also reduce the side effects caused by chemotherapy.

The invention discloses a method for preparing a beta-tricalcium phosphate crystal material under a low temperature condition, and belongs to the technical field of biomaterials. The method comprises the following steps: preparing amorphous calcium carbonate doped with different contents of Mg and amorphous apatite doped with different contents of Mg and Sr through a rapid precipitation technology, and converting the Mg-containing calcite and the amorphous apatite containing Mg and Sr into Mg-doped or Mg and Sr codoped beta-TCP crystal material through using a hydrothermal synthesis technology. Compared with present high temperature calcining or solid phase reaction methods for preparing the beta-TCP crystal material, the method disclosed in the invention has the advantages of low reaction temperature, production cost reduction, and solving of the problem of preparation of beta-TCP crystal nanomaterial through a high temperature reaction. Mg and Sr element doping also can improve the bioactivity of the beta-TCP material, is in favor of promoting bone restoration, and has great values in the fields of bone restoration and bone transplantation.

The invention discloses an underwater super-oleophobic material and a preparation method thereof. The underwater super-oleophobic material has high transparency and mechanical stability. The preparation method is based on a nacreous layer biomimetic mineralization strategy, and acidic macromolecules are used for regulating mineralization of amorphous calcium carbonate (ACC) on the surface of an organic membrane in order to prepare an organic/inorganic composite nacreous layer biomimetic mineralized film. Compared with traditional underwater super-oleophobic materials such as a hydrogel base, the underwater super-oleophobic material prepared through biomimetic mineralization not only has high transparency, but also has good mechanical stability and excellent underwater super-oleophobicity and ultralow oil adhesion. The mineralized film can be expanded to a series of transparent support materials, and has wide application prospects in many fields, such as diving goggles, underwater optical equipment and underwater vehicles.

The present invention provides stable amorphous calcium carbonate (ACC) compositions, and food articles comprising said compositions.

The invention relates to an aqueous mineral binder for a silicon negative electrode of a lithium ion battery, a preparation method and an application thereof, wherein the binder is a hydrogel obtainedby forming a physical crosslinking network through polyacrylic acid and amorphous calcium carbonate nanoparticles. The hydrogel obtained by the invention has high specific capacity, excellent cycle stability and rate performance when used as a binder material for a silicon negative electrode of a lithium ion battery. Adopting one-step mixing method to form gel has the advantages of simple operation, low production cost, low environmental pollution, easy batch production and large-scale production. It has a good industrial production foundation and broad application prospects.

The present invention provides a method for accelerating bone growth in a subject having a bone condition, selected from the group consisting of a fracture by external force, pathological fracture, fatigue fracture, distraction osteogenesis, osteotomy, osseointegration and combinations thereof, the method employing the administration of a composition containing stable amorphous calcium carbonate, comprising at least one stabilizer. Further provided are the orally-administrable pharmaceutical compositions for use in accelerating bone growth in said bone conditions.