Method for preparing amorphous calcium carbonate nanospheres

A technology of amorphous calcium carbonate and nanospheres, applied in the directions of calcium carbonate/strontium/barium, nanotechnology, nanotechnology, etc., can solve problems such as poor stability of amorphous calcium carbonate, and achieve good application prospects, convenient operation, and simple process. Effect

Active Publication Date: 2014-03-26
江苏先进无机材料研究院
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Problems solved by technology

[0005] Although there are many methods for artificially synthesizing amorphous calcium carbonate, there are few reports on the direct use of organic molecules in organisms as stabilizers to study their role in the biomineralization process.
In addition, most artificially synthesized amorphous calcium carbonate has poor stability, and few can be kept in aqueous solution at room temperature for more than ten days without biophase transition.

Method used

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  • Method for preparing amorphous calcium carbonate nanospheres
  • Method for preparing amorphous calcium carbonate nanospheres
  • Method for preparing amorphous calcium carbonate nanospheres

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] At room temperature, 0.925 g of CaCl 2 Dissolved in 250 ml of deionized water to form A solution, 1.060 g of Na 2 CO 3 Dissolve in 100 ml of deionized water to form liquid B; take 0.055 g of adenosine triphosphate disodium salt hydrate and dissolve it in 30 ml of solution A and adjust its pH to 9 with 1 mol / L sodium hydroxide solution, then add 10 ml of B dropwise During this process, magnetic stirring was used to keep the pH value at about 9; the dropwise addition was completed, stirred at room temperature for 1 hour, and then centrifuged, and the separated solid was washed 3 times with deionized water, and then washed with absolute ethanol Wash once, and finally dry in air at 60°C.

[0045] The X-ray (XRD) diffraction pattern of the obtained sample is as follows figure 1 Shown in the curve c in: the obtained sample is an amorphous phase.

[0046] The SEM photographs of the obtained samples are as Figure 4 Shown: the obtained sample is a calcium carbonate nanosph...

Embodiment 2

[0048] At room temperature, 0.925 g of CaCl 2 Dissolved in 250 ml of deionized water to form A solution, 1.060 g of Na 2 CO 3Dissolve in 100 ml of deionized water to form liquid B; dissolve 0.088 g of adenosine triphosphate disodium salt hydrate in 30 ml of solution A and adjust the pH to 9 with 1 mol / L sodium hydroxide, then add 10 ml of liquid B dropwise In this process, magnetic stirring is used and the pH value is kept at about 9; the dropwise addition is completed, stirred at room temperature for 1 hour, and then centrifuged, and the separated solid is washed 3 times with deionized water, and then washed with absolute ethanol 1 time, and finally dry in air at 60°C.

[0049] The X-ray (XRD) diffraction pattern of the obtained sample is as follows figure 1 Shown in the curve d in: the obtained sample is an amorphous phase.

[0050] The SEM photographs of the obtained samples are as Figure 5 Shown: the obtained sample is a calcium carbonate nanosphere with a diameter o...

Embodiment 3

[0052] At room temperature, 0.925 g of CaCl 2 Dissolved in 250 ml of deionized water to form A solution, 1.060 g of Na 2 CO 3 Dissolve in 100 ml of deionized water to form liquid B; take 0.110 g of adenosine triphosphate disodium salt hydrate and dissolve it in 30 ml of solution A and adjust its pH to 9 with 1 mol / L sodium hydroxide, then add 10 ml of liquid B dropwise In this process, magnetic stirring is used and the pH value is kept at about 9; the dropwise addition is completed, stirred at room temperature for 1 hour, and then centrifuged, and the separated solid is washed 3 times with deionized water, and then washed with absolute ethanol 1 time, and finally dry in air at 60°C.

[0053] The X-ray (XRD) diffraction pattern of the obtained sample is as follows figure 1 Shown in the curve e in: the obtained sample is an amorphous phase.

[0054] The SEM photographs of the obtained samples are as Image 6 Shown: the obtained sample is a calcium carbonate nanosphere with ...

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Abstract

The invention discloses a method for preparing amorphous calcium carbonate nanospheres. The method comprises the following steps: water soluble calcium salt is dissolved in de-ionized water; then a stabilizing agent is added; the pH value of a solution is adjusted to 7-11 to obtain a solution A; water soluble carbonate is dissolved in the de-ionized water to obtain a solution B; the solution B is dropwise added in the solution A; the pH value of the solution system is controlled to be 7-11; after the dripping is finished, the stirring is conducted at the room temperature for a certain time; then the centrifugal separation, the washing and the drying are conducted to obtain the amorphous calcium carbonate nanospheres. The method has the advantages that the process is simple; the operation is convenient; complex and expensive equipment is not required; industrialization is easy to achieve; raw materials are cheap in cost and easily obtained. The amorphous calcium carbonate nanospheres prepared through the method, as biomedical materials, can be applied to the fields of medicine delivery, protein adsorption, gene transfection, tissue repair and the like, and has good application prospect.

Description

technical field [0001] The invention relates to a method for preparing amorphous calcium carbonate nanospheres, in particular to a method for preparing amorphous calcium carbonate nanospheres by using phosphorus-containing biomolecules as a stabilizer, and belongs to the technical field of biological material preparation. Background technique [0002] Calcium carbonate is the main component of rocks in nature and one of the most important minerals in nature and industry. At the same time, calcium carbonate is also one of the main components of biomineralization products in the biological world, plays an important role in organisms, and widely exists in the exoskeleton of crustaceans, the shell of marine organisms, the eggshells of birds and the shells of plants. Among the leaves. In the field of biomineralization, calcium carbonate has become one of the important simulation objects due to its relatively simple structure, which greatly reduces the difficulty of research. In...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01F11/18B82Y30/00
Inventor 朱英杰漆超陈峰
Owner 江苏先进无机材料研究院
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