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Gadolinium stabilizing amorphous calcium carbonate nanocomposite material and preparation method

A technology of amorphous calcium carbonate and nanomaterials, applied in calcium carbonate/strontium/barium, nanotechnology for materials and surface science, nanotechnology, etc., can solve short stability time, large ACC particle size, no calcium carbonate Combination of applications and other issues to achieve strong adsorption capacity, reduce toxicity, and broad application prospects

Inactive Publication Date: 2013-01-30
UNIV OF SCI & TECH OF CHINA
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Problems solved by technology

However, the particle size of the obtained ACC is too large, which can only be limited to the research on the mineralization mechanism, and is not suitable for biological applications.
[0005] The Netherlands (Journal of Crystal Growth (Journal of Crystal Growth), 2008, Volume 310, pages 3779 to 3787) reported the stabilization of polymer polyacrylic acid (PAA) and polystyrene sodium sulfonate (PSS) to ACC, and in alcohol The stability time in the water system has only done some simple mechanism research, and no applied research has been done, and the stability time of this method in the alcohol-water system is relatively short, which cannot be adapted to many biological applications
[0006] All of the above ACC studies have focused on the mineralization mechanism, and have not combined the traditional mineralization material of calcium carbonate with biomedical applications. In particular, they have not mentioned the use of the magnetic element gadolinium (Gd) to stabilize ACC for multifunctional nanomaterials with broad biomedical applications

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  • Gadolinium stabilizing amorphous calcium carbonate nanocomposite material and preparation method
  • Gadolinium stabilizing amorphous calcium carbonate nanocomposite material and preparation method
  • Gadolinium stabilizing amorphous calcium carbonate nanocomposite material and preparation method

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[0029] In the preparation method of the ACC-Gd nano material of the present invention, the ACC is stabilized by doping the element Gd into the ACC, thereby obtaining a stabilized ACC, that is, the ACC-Gd nano material. In a preferred embodiment, first calcium (Ca) salt solution and gadolinium (Gd) salt solution are mixed, then carbonate solution is added, reacted under vigorous stirring, after filtering and drying, the ACC-Gd multifunctional nano Material. Preferably, equal volumes and equal concentrations of the Ca salt solution and the carbonate solution can be used.

[0030] In a preferred embodiment, the concentrations of the Ca salt solution and the carbonate solution used are both in the range of 0.1M-0.5M. Preferably, the Ca salt solution is CaCl 2 solution, but other Ca salt solutions such as Ca(NO 3 ) 2 solution; the Gd salt solution is GdCl 3 solution, but other Gd salt solutions such as Gd(NO 3 ) 3 solution; the carbonate solution is Na 2 CO 3 solution, but...

Embodiment 1

[0039] Preparation of ACC-Gd 1 / 3 (The subscript 1 / 3 here means [Gd 3+ ] / [Ca 2+ ] molar ratio is 1 / 3) nanomaterials: 25ml 0.1M CaCl 2 solution and 5ml of 0.167M GdCl 3 The solution was mixed in a 100ml Erlenmeyer flask, and then 25ml 0.1M Na was added 2 CO 3 Solution, stirred vigorously to obtain a white precipitate, and quickly washed the precipitate with ethanol (4000r / min, 3min) three times to obtain ACC-Gd 1 / 3 Solid precipitation, drying at room temperature in a vacuum oven for 24 hours to obtain ACC-Gd 1 / 3 solid powder. Such as figure 1 As shown, the X-ray diffraction analysis figure shows that the obtained ACC-Gd 1 / 3 The calcium carbonate in the powder is in the amorphous phase, namely ACC.

Embodiment 2

[0041] Preparation of ACC-Gd 1 / 4 (The subscript 1 / 4 here means [Gd 3+ ] / [Ca 2+ ] the molar ratio is 1 / 4) nanomaterials: similar to Example 1, 25ml 0.1M CaCl 2 solution and 5ml of 0.125M GdCl 3 The solution was mixed, and 25ml of 0.1M Na 2 CO 3 solution, vigorously stirred evenly, and quickly washed the precipitate with ethanol for three times, and dried to obtain ACC-Gd 1 / 4 solid powder. Such as figure 1 As shown, the X-ray diffraction analysis figure shows that the obtained ACC-Gd 1 / 4 The calcium carbonate in the powder is in the amorphous phase, namely ACC.

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Abstract

The invention discloses an amorphous calcium carbonate-gadolinium (ACC-Gd) multifunctional nano material obtained by stabilizing ACC through Gd and a preparation method and an application thereof. The invention further discloses an ACC-Gd-polymer multifunctional nano material obtained by introducing appropriate polymer or biomacromolecule to the ACC-Gd nano material and a preparation method and an application thereof. A novel multifunctional nano material is obtained by stabilizing ACC through Gd, the Gd is located in crystal lattices of ACC, toxicity of the Gd is greatly reduced, simultaneously the Gd which is a magnetic element has an excellent radiography effect, and thereby the multifunctional nano material can be used in magnetic resonance imaging (MRI) contrast media.

Description

technical field [0001] The invention relates to multifunctional nanomaterials, more particularly to a novel stabilized amorphous calcium carbonate (ACC) multifunctional nanomaterial. Background technique [0002] At present, the following research reports on stable ACC can be seen: [0003] The United Kingdom (CrystEngComm (Crystal Engineering Communication), 2011, Volume 13, pages 952-956) reported a method for Mg to stabilize ACC, and did related research on the mineralization of ACC induced by Mg. [0004] Germany (Advanced Materials (Advanced Materials), 1996, Volume 8, pages 222 to 226) discovered the stabilizing effect of biological macromolecules on ACC, studied the content of various amino acids in natural ACC, and the content of glycine and serine in ACC Accounting for a large proportion, however, aspartic acid accounts for the largest proportion in crystalline calcium carbonate. The journal reported on page 2217 of volume 17 in 2005 that ACC was stabilized with p...

Claims

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Application Information

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IPC IPC(8): A61K47/32A61K47/02A61K49/08A61K49/12C08L33/02C08L25/18C08K3/08C08K3/26C01F11/18B82Y30/00
Inventor 俞书宏隋聪陆杨
Owner UNIV OF SCI & TECH OF CHINA
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