111results about How to "Good contrast effect" patented technology

The invention discloses a preparation method of RGD-modified ultra-small magnetic iron oxide nanoparticles. The preparation method comprises the following steps: preparing ultra-small magnetic iron oxide nanoparticles by taking ferric acetylacetonate as a reaction raw material and a precursor, taking oleylamine as a surfactant and a reducing agent and taking dibenzyl ether as a solvent; replacing oleylamine molecules wrapped on the surfaces of the nanoparticles by utilizing dopamine-modified HOOC-PEG-COOH to realize PEG-modification of the surfaces of the nanoparticles; and finally, chemically coupling RGD cyclic peptide by virtue of free carboxyl at the tail end of the PEG to obtain the RGD-modified ultra-small magnetic iron oxide nanoparticles. The method of synthesizing the ultra-small magnetic iron oxide nanoparticles has the characteristics of a simple process, a high raw material conversion ratio, strong repeatability and the like. The synthesized magnetic iron oxide nanoparticles have the characteristics of a regular morphology, an ultra-small dimension, good stability, good monodispersity, high biocompatibility, and tumor specific targeting, and the like, and can be used as a T1-weighted imaging high-performance magnetic resonance imaging contrast agent with a tumor active targeting function.

The invention relates to a preparation method of ferric oxide nanoparticle supported sodium alginate nanogel. The preparation method comprises steps as follows: (1), PEI (polyethylenimine) coated Fe3O4 nano-particles (Fe3O4-PEI) are synthesized with a hydrothermal method; (2), an aqueous solution of sodium alginate is firstly activated by EDC (carbodiimide) and has a double emulsion reaction to form a W / O / W polymer emulsion; (3), Fe3O4-PEI in the step (1) is taken as a crosslinking agent and added into the polymer emulsion in the step (2) to have a crosslinking reaction, and the ferric oxide nanoparticle supported sodium alginate nanogel is obtained after an organic solvent and a surface active agent are removed. The method is very simple, and operation and separation are easy; meanwhile, sources of raw materials are extensive; the prepared sodium alginate nanogel has a smaller grain diameter, is uniformly distributed, high in relaxation rate and low in cost, has a remarkable radiography effect, simultaneously has excellent water solubility, gel stability, biocompatibility and blood compatibility, doesn't have a harmful effect on a living body, and has potential application value in the magnetic resonance imaging diagnosis field.

The invention relates to a rare earth-based nanoparticle magnetic resonance contrast agent and a preparation method thereof. The rare earth-based nanoparticle magnetic resonance contrast agent are rare earth-based inorganic nanoparticles having the surface coated with a hydrophilic ligand, firstly rare earth-based nanoparticles are obtained through a high-temperature oil phase reaction, and then the surface is coated with hydrophilic molecules to obtain the rare earth-based nanoparticle magnetic resonance contrast agent. Compared with a conventional clinical contrast agent, the magnetic resonance contrast agent has the relaxation rate greatly improved, is good in imaging effect, low in required injection dose, and relatively long in time staying in a body. In addition, a rigid structure of the inorganic nanoparticles can effectively reduce the free possibility of gadolinium ions. The rare earth-based nanoparticle magnetic resonance contrast agent has the advantages of simple preparation method, good repeatability and stable property, and easily realizes clinical commercial applications.

The invention belongs to the technical field of medical apparatus and instruments, and in particular relates to a multi-purpose nasal biliary drainage tube. The multi-purpose nasal biliary drainage tube comprises a drainage tube section I, a drainage tube section II, a drainage tube section III, a drainage tube section IV, a drainage tube section V and a drainage tube section VI, wherein the drainage tube section I is of straight line type, the drainage tube section II is spiral, and a channel I in the drainage tube section II communicates with the drainage tube section I; the center of the drainage tube section III is bent, the formed angle alpha is 30-45 degrees, a channel III in the drainage tube section III communicates with the channel I, and a channel IV in the drainage tube sectionIII communicates with a channel II; the center of the drainage tube section IV is bent, the formed angle beta is 60-90 degrees, and the drainage tube section IV communicates with the channel III; thecenter of the drainage tube section V is bent, the formed angle gamma is 60-120 degrees, and a channel V of the drainage tube section V communicates with the channel III; the drainage tube section VIis of straight line type, a channel VII in the drainage tube section VI communicates with the channel V, and a channel VIII in the drainage tube section VI communicates with the channel VI. The multi-purpose nasal biliary drainage tube can be widely popularized and applied in the fields including endoscope treatment for the diseases including hepatobiliary and pancreatic diseases.

The invention discloses a method for preparing a supermolecule capsule with multiple drug release stimulation and MRI radiography ability. A ferroferric oxide microcapsule is prepared as a novel multifunctional magnetic resonance noise and drug therapy medicament through a layer-by-layer self-assembly technology. Through the host-guest interaction and the Coulomb interaction of different supramolecular polymers, the medicine molecule is controllably released through the non-invasive ultraviolet radiation distributed azobenzene isomerism and the acid response Schiff base. Additionally the magnetic-targeted MRI contrast agent is obtained by encapsulating the superparamagnetic ferroferric oxide granule. The r2 relaxation rate of the microcapsule is increased by 37% to reach 125.71 mM-1S-1 compared with that of the neutral condition (92.02mM-1S-1) through the stimulation of subacidity (pH=5.6).

A process for preparing the ultrasonic contrast medium by mechanical oscillation is disclosed. Said ultrasonic contrast medium may be conventional one, target one, nano-foam one, and therapeutic one. A process for preparing aliphatic ultrasonic contrast medium is also disclosed.

The invention relates to a method for preparing gadolinium-containing nano particles, belonging to the field of biomedicines. Liver-targeting compound and amido polymer are used to prepare polymer containing a liver-targeting group, which has ion crosslinking reaction with gadolinium brine solution to prepare the gadolinium-containing nano particles. The gadolinium-containing nano particles are used for MRI magnetic resonance imaging, and can evidently increase relaxivity and improve the imaging effect.

The invention discloses a degradable dendritic macromolecule magnetic resonance contrast agent and a preparation method thereof. The degradable dendritic macromolecule magnetic resonance contrast agent is characterized in that a degradable dendritic macromolecule is used as a skeleton and micromolecular gadolinium chelates are connected to the degradable dendritic macromolecule so that the degradable dendritic macromolecule magnetic resonance contrast agent is formed. The degradable dendritic macromolecule magnetic resonance contrast agent has a relaxation rate of 17.4mM<-1>.s<-1> obviously higher than a relaxation rate of the common contrast agent, has a better MRI contrast effect, can be enriched in tumor tissue by enhanced permeation and retention effects of the degradable dendritic macromolecule magnetic resonance contrast agent, and improves MRI sensitivity and an early diagnosis level of cancers. The degradable dendritic macromolecule magnetic resonance contrast agent can be hydrolyzed by internal esterase catalysis and then is gradually discharged out of a human body so that the toxicity accumulation of gadolinium in a human body is avoided. The preparation method has simple processes, can be controlled easily and is suitable for industrial large-scale production.

A preparation method of a micro bubble ultrasound contrast agent coated by a microcapsule relates to a preparation method of a micro bubble ultrasound contrast agent. The invention solves the problems of the instability of a micro bubble contrast agent and the disappearance of acoustic characteristic of a modified micro bubble. The preparation method of the micro bubble ultrasound contrast agent is that: absorbing, standing or centrifuging, cleaning, absorbing once again, standing or centrifuging and cleaning once more; finally the micro bubble ultrasound contrast agent is available. The invention has simple process, mild reaction condition, simple operation, good reproducibility, wild range of application and environment-friendliness, and is applicable to the surface modification of various ultrasound contrast agents and can be easily implemented.

The invention relates to a nanometer magnetic resonance contrast material, a nanometer magnetic resonance contrast agent and a preparation method of the nanometer magnetic resonance contrast agent. The nanometer magnetic resonance contrast material comprises a core having the chemical formula of A3x[GdyFeIII1-y](4-x)[FeII(CN)6]3.nH2O, and a casing which is composed of auxiliary materials and coats the core. In the chemical formula, A represents Li<+>, Na<+>, K<+> or NH4<+>, x is greater than 0 and less than or equal to 1, y is in a range of 0-1, and n is in a range of 1-16. The nanometer magnetic resonance contrast agent prepared from the nanometer magnetic resonance contrast material has stable properties, is decomposed and ionized difficultly, has low toxicity and is suitable for injection and oral administration.

The invention discloses a contrast medium for fluorescent-magnetic resonance dual-mode targeting biological imaging and a preparation method thereof. The method comprises the following steps that 1, a chelating agent and a compound containing Gd3+ react in water to obtain a Gd3+ chelate solution; 2, citric acid and polyethyleneimine are dissolved into water, and then the Gd3+ chelate solution is added to be mixed; 3, the mixture obtained in the step 2 is dissolved and evaporated to dryness repeatedly, centrifuging is performed on the dissolved and dried products, a supernate is taken for dialysis in water to obtain a dialysis solution, and a dialysis solution is subjected to freeze-drying, and Gd doped carbon dots are obtained. Meanwhile, the invention further discloses a contrast medium for fluorescent-magnetic resonance dual-mode targeting biological imaging. The contrast medium is synthetized in an environment-friendly mode, is low in gadolinium content, promotes surface functionalization, and has the quite high longitudinal relaxation rate and the fluorescence quantum yield, and the good biological compatibility and blood compatibility.

The invention relates to a functionalized dendrimer-based SPECT-CT bimodal imaging contrast agent and a preparation method thereof. The functionalized dendrimer-based SPECT-CT bimodal imaging contrast agent is obtained by pegylation modified fifth polyamide-amine dendrimer as a polymer carrier material; connecting diethylenetriaminepentaacetic acid on the dendrimer surface through covalent grafting; coating gold nanoparticles through an in-situ synthesis method; carrying out acetylation or hydroxylation on residual surface amino groups; and marking <99m>Tc. The functionalized dendrimer-based SPECT-CT bimodal imaging contrast agent has a very good SPECT / CT imaging effect, realizes SPECT / CT imaging of different in-vivo tissue sites of a mouse, lays good foundation for development of multi-functional tissue specific contrast agent, and has wide application prospects.

The application discloses a magnetic nano composite material, and a preparation method and application of the material, and belongs to the field of medical materials. The magnetic nano composite material comprises magnetic nanoparticles and a hydrophilic compound layer coated outside the magnetic nanoparticles, the magnetic nanoparticles are iron oxides, the particle size of the magnetic nanoparticles is 0.1-20 nm, the particle size of the magnetic nano composite material is 0.5-300 nm, and the longitudinal relaxation rate r1 of the magnetic nano composite is >= 20 mM-1s-1. The provided magnetic nano composite material can be used as a contrast material, and can be used in the aspects of magnetic resonance imaging contrast agents, targeted drugs, cell separation, etc.

The invention discloses a preparation method of a zeolite imidazole framework structure material. According to the method, a zeolite imidazole framework structure is subjected to ion exchange to become a composite of two metal ions, wherein post-exchanged particles have a nuclear magnetic resonance effect. The method is mild in reaction condition, easy to operate and low in raw material cost and comprises simple steps. The zeolite imidazole framework structure contrast medium prepared with the method has good water solubility, improved application safety, small toxicity to normal cells and efficient contrast effects.

The invention provides a biological membrane-wrapped multi-mode tumor contrast agent as well as a preparation method and application thereof. The biological membrane-wrapped multi-mode tumor contrastagent comprises a biological membrane, a ferritin nanometer cage (M-HFn) of superparamagnetic ferroferric oxide and a fluorescent dye, wherein the ferritin nanometer cage (M-HFn) of the superparamagnetic ferroferric oxide and the fluorescent dye are wrapped with the biological membrane and are connected with each other to form a fluorescent dye-M-HFn compound, a bionic nanometer biological membrane vector delivery system in vivo is constructed, in vivo long circulation can be realized, targeting to a tumor is strengthened, non-specific accumulation is reduced, damages on normal tissues are reduced, and the contrast effect is strengthened at the same time. The invention also provides a preparation method of the biological membrane-wrapped multi-mode tumor contrast agent, and the preparationmethod has important application prospect and study value in the field of clinic oncology early diagnosis and treatment and the like.

The invention relates to a magnetic resonance imaging (MRI)-oriented high intensity focused ultrasound (HIFU) synergist and a preparation method thereof. The MRI-oriented HIFU synergist comprises mesoporous nano particles, manganese oxide nano particles dispersed in the mesoporous nano particles, and guest molecules which are loaded in the mesoporous nano particles and are used for HIFU synergism. Manganese oxides and mesoporous hollow nano materials are combined, so that tumor parts are accurately positioned by manganese-based MRI and by using an imaging function of the materials, and high biocompatibility is achieved. Moreover, a large-cavity structure of the mesoporous material can be loaded on HIFU synergistic perfluorohexane, so that the treatment effect if HIFU can be improved.

Since the commonly used nuclear magnetic resonance contrast agent containing gadolinium (Gd<3+>) element shall leaks metal gadolinium under certain conditions to bring toxicity to human body, the toxicity may can be fatal to patients with renal failure in particular, so that the problem of developing a new generation of stable and non-toxic contrast agents is urgent to be solved by pharmaceutical enterprises in the whole world. A Prussian blue nanometer material contrast agent containing gadolinium (Gd<3+>) element is synthesized in the invention through the latest development of nanotechnology, which comprises a synthesis method, material characteristics, contrast effect, and the like; and compared with the commonly used contrast agent containing gadolinium (Gd<3+>) element, the novel nanometer material contrast agent provided by the invention has the advantages of non-toxicity, high efficiency, low cost, and the like, thereby having a broad application prospect.

A process for preparing the vesicles in liquid phase used for intravenous oxygen transfer includes such steps as dissolving the filming material in chloroform and / or methanol, vacuumizing, spray drying at the transfer temp from gel state to liquid crystal state to generate film on the biodegradable water-soluble small particles, loading them in container, vacuumizing, sealing, filling gas and water medium at the temp lower than the transfer temp from gel state to liquid crystal state, and manual waving until said small particles are dissolved to form the hydrophilic-lipophilic self-enclosed small vesicles.

The invention relates to a preparation method of γ-PGA hydrogel loaded with Au nanoparticles, comprising: adding PEI solution to activated mPEG-COOH solution to obtain PEI·NH 2 -mPEG, add chloroauric acid after being dissolved in ultrapure water, stir, add sodium borohydride aqueous solution, get (Au 0 ) 200 -PEI·NH 2 -mPEG; Add sodium bicarbonate to the activated γ-PGA solution, then add it to the DCM solution of AOT to get a W / O emulsion, add it to the PVA solution to get a W / O / W polymer emulsion; ( Au 0 ) 200 -PEI·NH 2 - Add the ultrapure aqueous solution of mPEG into the polymer emulsion drop by drop, and stir to obtain it. The invention has simple process and low cost; the prepared hydrocoagulation has good X-ray attenuation performance, remarkable imaging effect, good water solubility, colloidal stability, cell compatibility and biocompatibility.

The invention provides a single-cylinder double-chamber injector needle cylinder; the needle cylinder is provided with two pistons which divide the needle cylinder into a front chamber and a back chamber; the two pistons are connected with each other by a flexible connecting piece; the front chamber piston is provided with a through hole and a sealing device, thus realizing double drug administration of CT and MR contrast agent and physiological saline; remaining contrast agent in the cylinder is injected into human body by a physiological saline washing pipe and enters vein after being driven, so that the contrast agent reaches the target organ rapidly, thus increasing contrast of pathological changes with surrounding tissues and improving checkout of the pathological changes; meanwhile, blood supply information of nidus is increased, which facilitates diagnosis and differential diagnosis and increases certainty factor of diagnosis by the doctors; when CT and MR angiogram is carried out, contrast between the blood vessel and surrounding tissues is increased, which improves the angiogram effect; perfusion imaging is carried out on CT and MR, so that the contrast agent which enters the targeted organ has more constant rate and more accurate data is obtained; on the basis, more abundant information is expected to be obtained with the same amount of contrast agent used or the use amount of the contrast agent is expected to be reduced.

The invention discloses a multifunctional probe and a preparation method and application thereof. The nano diagnosis and treatment probe with the two functions of magnetic resonance imaging and thermal therapy is formed in the mode that nano gold bars are formed by adding surfactant, chloroauric acid, a reduction agent and silver nitrate, target macromolecules are inoculated, and gadolinium ions are adsorbed. The preparation method is simple, the probe is good in dispersity in an aqueous solution, good in stability and capable of meeting requirements of clinical application and combining radiography and thermal therapy, and the dual functions of lymphoma diagnosis and treatment are achieved.

The invention relates to a preparation method of Gd–Zn–Cu–In–S@ZnS core-shell quantum dots with adjustable emission wavelength; Gd–Zn–Cu–In–S@ZnS core-shell quantum dots were synthesized by high-temperature oil-phase synthesis to prepare near-infrared fluorescence and magnetic resonance imaging dual-modal probes for in vivo diagnostics. The characteristics of the present invention are: the combination of fluorescence imaging and magnetic resonance imaging greatly improves the sensitivity of diagnosis; the Gd–Zn–Cu–In–S@ZnS core-shell quantum dots can be made by adjusting the Zn / Cu molar ratio The emission wavelength is controlled at 570-735nm; Gd 3+ The introduction of Gd–Zn–Cu–In–S@ZnS core-shell quantum dots has little effect on the quantum yield, and the quantum yield is as high as about 40%.

The invention discloses a two-dimensional metal-organic framework structure nano-sheet, a preparation method and applications thereof. The preparation method comprises the following steps: providing amixed solution containing tetraphenylporphyrin, gadolinium metal ions, an organic solvent and water, adjusting the ratio of the organic solvent to the water in the mixed solution, and carrying out asolvothermal reaction to obtain a two-dimensional metal-organic framework structure nano-sheet with uniform size distribution; and carrying out hydrogen protonation treatment on the nano-sheet to obtain the protonated nano-sheet with the two-dimensional metal-organic framework structure. According to the invention, the obtained two-dimensional metal-organic framework structure nano-sheet can be used for magnetic resonance imaging analysis or photodynamic therapy of tumors; and the nano-sheet with uniform size distribution is obtained by adjusting the proportion of the mixed solution and carrying out solvothermal treatment, and the ultraviolet and visible absorption intensity and the ultraviolet and visible absorption intensity range of the nano-sheet are improved through hydrogen protonation treatment, so that the nano-sheet generates sensitive magnetic resonance imaging and photodynamic treatment effects on tumors.

The invention discloses a high-molecular MRI contrast agent based on lysine. The contrast agent has a structure shown as a formula I, wherein n represents an integer between 10-100. The high-molecular MRI contrast agent has simple structure, good biocompatibility, no toxic or side effect, easiness for clinic conversion, relaxation rate of 7.32 mM<-1>.s<-1>, which is obviously higher than that of a micro-molecular contrast agent, and better MRI radiography effect. The invention also discloses a preparation method of the high-molecular MRI contrast agent based on lysine. An amino acid of lysine required by human body is used as a unit for constructing the high-molecular agent; and esterification derivatives of lysine and diethylene triamine pentacetic acid dianhydride are subjected to polycondensation, hydrolysis and gadolinium chelating to obtain the high-molecular MRI contrast agent. The preparation method is simple, easy to control and suitable for industrialized large-scale production.

The invention discloses iodine-containing polysaccharide, which is characterized in that the molecular structure of the iodine-containing polysaccharide takes hydrophilic natural polysaccharide as a skeleton, and the structure general formula is shown in the description, wherein R is selected from hydrogen or derived triiodo benzoyl and is not all hydrogen; the structural formula of the derived triiodo benzoyl is shown in a description, wherein R minute is selected from one or two of hydrogen, methyl, methylamino, acetamido, N minute-methyl carbamoyl, methoxyl acetamido, N-methyl acetamido or alkyl. The high-substituted iodine-containing polysaccharide provided by the invention has the outstanding advantages, relative to iodine-containing micromolecule, that after the iodine-containing micromolecule is polymerized, cytotoxicity is greatly reduced, and the problem of micromolecule leakage caused by diffusion is avoided; in addition, a CT contrast agent provided by the invention is high in iodide content, good in contrast effect, low in cytotoxicity, and capable of being used as a blood vessel X-ray CT contrast agent for clinical CT examination and diagnosis.

The invention relates to a digestive tract contrast agent having the effect of treating gastrointestinal ulcer and good smearing effect. The digestive tract contrast agent disclosed by the invention comprises barium sulphate dry suspension or compound meglumine diatrizoate, sea-buckthorn oil, the root of three-nerved spicebush, patrinia, scutellaria baicalensis, cassia twig, rhizoma corydalis, liquorice, curcuma aromatic, tangerine leaf, Chinese angelica, poria cocos, thunberg fritillary bulb, radix pseudostellariae, pseudo-ginseng and pearl powder. The digestive tract contrast agent provided by the invention is scientific in composition; the preparation method of the digestive tract contrast agent in various dosage forms is simple; the prepared digestive tract contrast agent is convenient to take and can be applied to patients suffering from different cases; and the digestive tract contrast agent has good contrast effect.

The invention relates to a gold nanoparticle doped fluorocarbon liposome and a preparation method and application thereof. The method comprises the steps of: (1) preparation of hydrophobic gold nanoparticles; and (2) preparation of gold nanoparticle doped fluorocarbon liposome by using the hydrophobic gold nanoparticles obtained in the step (1) as the reactant. The preparation method provided by the invention is simple, has strong operability and can further satisfy the needs of production and application. The prepared CT contrast agent has good physical and chemical stability, can be used as a double-element CT imaging system, and has collaborative reinforcement imaging effect, and the contrast effect better than that of a pure fluorocarbon contrast agent.

The invention discloses a gadolinium coordination polymer network microsphere and application thereof to magnetic resonance imaging and belongs to the field of material science and biomedical application. The coordination polymer network microsphere is of a net-shaped crosslinking structure; specifically, after an acrylic monomer is coordinated with gadolinium ions, the net-shaped cross-linked gadolinium coordination polymer network microsphere is formed through coordination and free radical polymerization. A preparation method of the polymer microsphere is simple and the cost is low; the polymer microsphere has a stable structure and has a relatively high relaxation rate, a relatively good T1 imaging effect and long blood circulation time; the polymer microsphere has extremely great potential application value in the aspects of diagnosis and treatment of cancers and tumors.

The invention provides a percutaneous T-tube cholangiography agent bolus injection device.The percutaneous T-tube cholangiography agent bolus injection device comprises patient side equipment and physician side equipment.The patient side equipment comprises an injector clamping groove, a bolus injection rod and a supporting table.The injector clamping groove is composed of a groove body, an injector jacket clamping groove, a jacket hemming clamping groove and a bolus injection rod clamping groove, wherein the injector jacket clamping groove, the jacket hemming clamping groove and the bolus injection rod clamping groove are formed in the groove body.The injector jacket clamping groove and the jacket hemming clamping groove are used for fixing an injector.The bolus injection rod is used for pushing and pulling the injector and comprises a rod body matched with the injector jacket clamping groove.The rod body is provided with a bolus injection rod boss for being matched with the bolus injection rod clamping groove.The tail end of the rod body is connected with a motor with a remote control receiving device.The supporting table comprises a bevel edge for containing the injector clamping groove.The physician side equipment comprises a remote controller matched with the remote control receiving device of the motor.The tele-medicine technology and the cholangiography technology are combined, and the percutaneous T-tube cholangiography agent bolus injection device is specially designed for cholangiography, can be remotely controlled and can achieve speed change and control.On one hand, a physician is protected against radiation injuries; on the other hand, the radiography speed can be controlled or changed, and postoperative complications of a patient are reduced.

The present invention relates to one device for automatically conveying X-ray contrast medium into root canal in contrast examination of root canal. The device consists of a sliding vane rotary vacuum pump, a filter element to avoid the sucking of liquid into the vacuum pump, a transparent hard plastic connecting pipe, a valve with switch, a contrast medium feeding head, a injector for storing contrast medium and a vacuum meter. By means of negative pressure and special conveying head, the device leads X-ray contrast medium to the whole root canal system with less bubbles so as to reach excellent root canal contrast examination effect.