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Method and use of closed hydrophilic and lipophilic liquid-phase hollow capsules with cores

A self-sealing, water-lipophilic technology, applied in emulsion delivery, microcapsule preparation, microsphere preparation, etc., can solve the problems of expensive freeze-drying equipment, limited dissolved oxygen concentration, and decreased dissolution rate, so as to improve the body's immunity ability, alleviate tissue damage, and reduce the effect of cohesion

Inactive Publication Date: 2005-05-11
WEST CHINA HOSPITAL SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, the domestic invention patent application number 02133720.9 and the phospholipid film-forming material used by Sonovue are consistent with the domestic invention application number 02133720.9, and the cost is expensive
Although the freeze-drying method is beneficial to sub-packaging, the process requirements are high, and the freeze-drying equipment for mass production is also expensive. For example, Sonovue, the price of a Sonovue in China is about 730 yuan
The invention of the gas-filled liposome involved in the invention patent application No. 94192405.X requires special equipment and special technology, and the preparation is more cumbersome and requires a lot of investment.
The development of artificial blood such as fluorocarbons, animal hemoglobin, and synthetic oxygen-carrying complexes (porphyrin compounds), etc., can dissolve high-concentration oxygen substances, but due to various shortcomings and high cost, it has not been promoted.
In recent years, some researchers have used dissolved oxygen tanks or intravenous oxygen delivery devices for hyperoxic liquids to produce a certain concentration of active oxygen through the reciprocating light-transmitting blood bag through multi-spectral light. When injecting, the pressure is lowered, and the dissolution rate is often reduced; therefore, there is currently no better way to achieve intravenous oxygen delivery

Method used

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  • Method and use of closed hydrophilic and lipophilic liquid-phase hollow capsules with cores
  • Method and use of closed hydrophilic and lipophilic liquid-phase hollow capsules with cores
  • Method and use of closed hydrophilic and lipophilic liquid-phase hollow capsules with cores

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Example 1: Preparation of non-ionic surface-active bodies with liquid-phase core cavitation

[0042] First, 1 gram of maltodextrin was ground to micron-sized powder particles, 100 mg of Span 60 and 20 mg of cholesterol were mixed in chloroform organic solution, and loaded into a sprayer. Introduce a 50 ml round-bottomed ground flask, spray on the maltodextrin, connect to a rotary evaporator, vacuumize in a 60-degree water bath, and rotate to evaporate for 30 minutes to form a film on the maltodextrin powder particles. The maltodextrin covered by the film was taken out, and air-dried at room temperature for 12 hours. Dissolve the above-mentioned membrane-wrapped maltodextrin in 10 ml of normal saline quickly, shake it manually for 30 seconds, take the suspension and observe it under a microscope. The distribution is about 90%. At room temperature and without sealing, the microvesicles can remain in the flask for 3 days without disappearing or breaking; in the sealed st...

Embodiment 2

[0043] Example 2: Adjusting the HLB value to prepare liquid-phase core cavitation non-ionic surface-active bodies

[0044]Grind 1 gram of maltodextrin to micron-sized powder particles. The HLB values ​​of Span 80 and Tween 80 are calculated according to the weighted average of the respective HLB values ​​to prepare a composite emulsifier with an HLB value of 6, wherein Span 80 (166 mg) accounts for 83% by weight and Tween 80 (34 mg) accounts for 17% by weight , the above compound emulsifier and 20mg of cholesterol were miscible in chloroform organic solution, and loaded into the sprayer. Introduce a 50 ml round-bottomed ground flask, spray on the maltodextrin, connect to a rotary evaporator, vacuumize in a 60-degree water bath, and rotate to evaporate for 30 minutes to form a film on the maltodextrin powder particles. The maltodextrin covered by the film was taken out, and air-dried at room temperature for 12 hours. The above-mentioned membrane-wrapped maltodextrin was quick...

Embodiment 3

[0045] Example 3: Adjusting the HLB value to prepare liquid-phase core perfluoropropane gas cavitation non-ionic surface-active bodies

[0046] Grind 1 gram of maltodextrin to micron-sized powder particles. The HLB values ​​of Span 80 and Tween 80 are calculated according to the weighted average of the respective HLB values ​​to prepare a composite emulsifier with an HLB value of 6, wherein Span 80 (166 mg) accounts for 83% by weight and Tween 80 (34 mg) accounts for 17% by weight , the above compound emulsifier and 20mg of cholesterol were miscible in chloroform organic solution, and loaded into the sprayer. Introduce a 50 ml round-bottomed ground flask, spray on the maltodextrin, connect to a rotary evaporator, vacuumize in a 60-degree water bath, and rotate to evaporate for 30 minutes to form a film on the maltodextrin powder particles. The maltodextrin covered by the film was taken out, and air-dried at room temperature for 12 hours. The above-mentioned film-wrapped malt...

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PUM

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Abstract

A process for preparing the vesicles in liquid phase used for intravenous oxygen transfer includes such steps as dissolving the filming material in chloroform and / or methanol, vacuumizing, spray drying at the transfer temp from gel state to liquid crystal state to generate film on the biodegradable water-soluble small particles, loading them in container, vacuumizing, sealing, filling gas and water medium at the temp lower than the transfer temp from gel state to liquid crystal state, and manual waving until said small particles are dissolved to form the hydrophilic-lipophilic self-enclosed small vesicles.

Description

technical field [0001] The invention relates to a method for cavitating hydrophilic and lipophilic amphiphilic molecules from the liquid phase core of a closed small body to form vesicle bubbles. The microcapsule bubbles of the present invention are used in medical diagnosis for contrast-enhanced ultrasound imaging, and in clinical treatment for intravenous oxygen infusion to treat hypoxic diseases. Background technique [0002] Micro-vesicles or shell-wrapped micro-bubbles (vesicles) are widely used in the medical field. In recent years, it has been found that intravenous injection of microbubbles or shell-wrapped microbubbles can significantly improve the contrast of ultrasound imaging. Contrast-enhanced ultrasound is a technology that uses ultrasound contrast agents to enhance the reflection or scattering of ultrasound. Compared with the surrounding liquid and tissue, the gas in the microbubbles contained in or generated by the contrast agent used in ultrasound contrast ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/18B01J13/02
Inventor 周翔
Owner WEST CHINA HOSPITAL SICHUAN UNIV
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