Method and use of closed hydrophilic and lipophilic liquid-phase hollow capsules with cores

A self-sealing, water-lipophilic technology, applied in emulsion delivery, microcapsule preparation, microsphere preparation, etc., can solve the problems of expensive freeze-drying equipment, limited dissolved oxygen concentration, and decreased dissolution rate, so as to improve the body's immunity ability, alleviate tissue damage, and reduce the effect of cohesion

A self-sealing, water-lipophilic technology, applied in emulsion delivery, microcapsule preparation, microsphere preparation, etc., can solve the problems of expensive freeze-drying equipment, limited dissolved oxygen concentration, and decreased dissolution rate, so as to improve the body's immunity ability, alleviate tissue damage, and reduce the effect of cohesion

CN1285383CInactive Publication Date: 2006-11-22WEST CHINA HOSPITAL SICHUAN UNIV
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  • Method and use of closed hydrophilic and lipophilic liquid-phase hollow capsules with cores
  • Method and use of closed hydrophilic and lipophilic liquid-phase hollow capsules with cores
  • Method and use of closed hydrophilic and lipophilic liquid-phase hollow capsules with cores

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Example 1: Preparation of non-ionic surface-active bodies with liquid-phase core cavitation

[0042] First, 1 gram of maltodextrin was ground to micron-sized powder particles, 100 mg of Span 60 and 20 mg of cholesterol were mixed in chloroform organic solution, and filled into a sprayer. Introduce a 50 ml round-bottomed ground flask, spray on the maltodextrin, connect to a rotary evaporator, vacuumize in a 60-degree water bath, and rotate to evaporate for 30 minutes to form a film on the maltodextrin powder particles. The maltodextrin covered by the film was taken out, and air-dried at room temperature for 12 hours. Dissolve the above-mentioned membrane-wrapped maltodextrin in 10 ml of normal saline quickly, shake it manually for 30 seconds, take the suspension and observe it under a microscope. The distribution is about 90%. At room temperature and without sealing, the microvesicles can remain in the flask for 3 days without disappearing or breaking; in the sealed st...

Embodiment 2

[0043] Example 2: Adjusting the HLB value to prepare liquid-phase core cavitation non-ionic surface-active bodies

[0044]Grind 1 gram of maltodextrin to micron-sized powder particles. The HLB values ​​of Span 80 and Tween 80 are calculated according to the weighted average of the respective HLB values ​​to prepare a composite emulsifier with an HLB value of 6, wherein Span 80 (166 mg) accounts for 83% by weight and Tween 80 (34 mg) accounts for 17% by weight , the above compound emulsifier and 20mg of cholesterol were miscible in chloroform organic solution, and loaded into the sprayer. Introduce a 50 ml round-bottomed ground flask, spray on the maltodextrin, connect to a rotary evaporator, vacuumize in a 60-degree water bath, and rotate to evaporate for 30 minutes to form a film on the maltodextrin powder particles. The maltodextrin covered by the film was taken out, and air-dried at room temperature for 12 hours. The above-mentioned membrane-wrapped maltodextrin was quick...

Embodiment 3

[0045] Example 3: Adjusting the HLB value to prepare liquid-phase core perfluoropropane gas cavitation non-ionic surface-active bodies

[0046] Grind 1 gram of maltodextrin to micron-sized powder particles. The HLB values ​​of Span 80 and Tween 80 are calculated according to the weighted average of the respective HLB values ​​to prepare a composite emulsifier with an HLB value of 6, wherein Span 80 (166 mg) accounts for 83% by weight and Tween 80 (34 mg) accounts for 17% by weight , the above compound emulsifier and 20mg of cholesterol were miscible in chloroform organic solution, and loaded into the sprayer. Introduce a 50 ml round-bottomed ground flask, spray on the maltodextrin, connect to a rotary evaporator, vacuumize in a 60-degree water bath, and rotate to evaporate for 30 minutes to form a film on the maltodextrin powder particles. The maltodextrin covered by the film was taken out, and air-dried at room temperature for 12 hours. The above-mentioned film-wrapped malt...

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Abstract

Hydrophilic lipophilic self-closed body liquid phase core cavitation method into vesicles, which is to dissolve the film-forming material in chloroform and / or methanol, in a vacuum state, at the phase transition temperature from the gel state to the liquid crystal state Spray drying to form a film on a biodegradable water-soluble micro-powder particle carrier; put the water-soluble micro-powder particles in a container, vacuum and seal it, and inject it successively at a temperature lower than the phase transition temperature from the gel state to the liquid crystal state A certain volume of gas and water-based medium is shaken manually until the water-soluble tiny powdery particles dissolve, forming a self-closing vesicle of hydrophilic-lipophilic amphiphilic molecules in the liquid phase core and cavitation. The invention has the advantages of low cost, safety and non-toxicity, easy preparation and sub-packaging by adopting dry powder dosage form, and best application effect; as clinical treatment application, it can be used for intravenous oxygen transfusion.

Description

technical field [0001] The invention relates to a method for cavitating hydrophilic and lipophilic amphiphilic molecules from the liquid phase core of a closed small body to form vesicle bubbles. The microcapsule bubbles of the present invention are used in medical diagnosis for contrast-enhanced ultrasound imaging, and in clinical treatment for intravenous oxygen infusion to treat hypoxic diseases. Background technique [0002] Micro-vesicles or shell-wrapped micro-bubbles (vesicles) are widely used in the medical field. In recent years, it has been found that intravenous injection of microbubbles or shell-wrapped microbubbles can significantly improve the contrast of ultrasound imaging. Contrast-enhanced ultrasound is a technology that uses ultrasound contrast agents to enhance the reflection or scattering of ultrasound. The gas in the microbubbles contained or generated by the contrast agents used in ultrasound contrast agents is compared with the surrounding liquid and ...

Claims

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Application Information

Patent Timeline
22 Nov 2006
Publication
CN1285383C
IPC
A61K49/18; B01J13/02
Inventors
周翔