Method for preparing gadolinium-containing nano particles

Abstract

The invention relates to a method for preparing gadolinium-containing nano particles, belonging to the field of biomedicines. Liver-targeting compound and amido polymer are used to prepare polymer containing a liver-targeting group, which has ion crosslinking reaction with gadolinium brine solution to prepare the gadolinium-containing nano particles. The gadolinium-containing nano particles are used for MRI magnetic resonance imaging, and can evidently increase relaxivity and improve the imaging effect.

Description

technical field

[0001] The invention belongs to the field of biomedicine, in particular to a method for preparing gadolinium-containing nanoparticles. Background technique

[0002] According to the 2004-2010 "China Cancer Prevention and Control Program Outline", 8 cancer deaths including lung cancer, liver cancer, and gastric cancer accounted for more than 80% of the total cancer deaths in China. my country is an area with a high incidence of liver cancer, the incidence of primary liver cancer accounts for 45% of the world, the mortality rate ranks second in malignant tumors, and the 5-year survival rate is only 5%. The total course of liver cancer is about 2 and a half years, of which 2 years are in the early stage without symptoms. Once symptoms appear, most patients only have half a year to survive. If the small lesions can be detected in time in the early stage and surgically removed in time, the 5-year survival rate can reach 60%-70%. In imaging diagnosis of the liver...