Biodegradable polymer hpma-gd magnetic resonance imaging probe and preparation method thereof
A magnetic resonance imaging and biodegradable technology, applied in the field of medical imaging, can solve the problems of low sensitivity, non-specificity, and difficulty in achieving satisfactory imaging effects, and achieve the goals of improving aggregation, high-efficiency biocompatibility, and prolonging cycle time Effect
Active Publication Date: 2019-09-06
SICHUAN UNIV
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Problems solved by technology
However, they all belong to small molecular magnetic resonance imaging probes, which have disadvantages such as low sensitivity, non-specificity, and rapid clearance from the body; and they mainly pass passive diffusion into the tumor stroma or tissue stroma, making it difficult to achieve satisfactory results. Imaging effect
Method used
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Embodiment 1
[0042] A biodegradable polymeric HPMA-Gd magnetic resonance imaging probe, the chain structure is as follows:
[0043]
[0044] Among them: m:n:o=35~45:410~450:65~70;
[0045]
[0046] The order of the C, B and A groups in the system is not fixed, and the R group can be connected to any one of C, B and A.
Embodiment 2
[0048] On the basis of embodiment 1:
[0049] Wherein, R1 is SH, m:n:o=35:410:65.
[0050] The average molecular weight of the magnetic resonance imaging probe is 85KDa.
Embodiment 3
[0052] On the basis of embodiment 1:
[0053] Wherein, R1 is not SH, m:n:o=45:450:70.
[0054] The average molecular weight of the magnetic resonance imaging probe is 94KDa.
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Abstract
The invention provides a biodegradable poly-HPMA-Gd magnetic resonance imaging probe, which inserts the enzyme-sensitive polypeptide GFLG into the poly-HPMA main chain structure; the molecular weight of the prepared polymer is basically controllable, and the molecular weight polydispersity coefficient ( PDI) is low; and linearized HPMA-DOTA-Gd is obtained by coupling with Gd(III). The probe is a high-efficiency biocompatible nanoscale MRI magnetic resonance imaging probe, which can be used for clinical tumor diagnosis and adjuvant therapy.
Description
technical field [0001] The invention belongs to the technical field of medical imaging, and relates to a polymer magnetic resonance imaging probe, in particular to a biodegradable polymeric HPMA-Gd magnetic resonance imaging probe. Background technique [0002] Due to the advantages of high spatial resolution, 3D image information and no radioactivity, magnetic resonance imaging (MRI) has become an effective non-invasive diagnosis method for tumors. According to incomplete statistics, more than 50% of clinical MRI tumor diagnosis requires the use of MRI magnetic resonance imaging probes. Commonly used clinical MRI magnetic resonance imaging probes include gadoterate meglumine (Magnevist) and gadoterate meglumine (Dotarem). However, they all belong to small molecular magnetic resonance imaging probes, which have the disadvantages of low sensitivity, non-specificity, and rapid clearance from the body; and they mainly pass passive diffusion into the tumor stroma or tissue stro...
Claims
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IPC IPC(8): A61K49/12A61K49/14A61K49/18
Inventor 罗奎龚启勇
Owner SICHUAN UNIV
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