64 results about "HPMA polymer" patented technology

The invention provides a composite low-phosphorus corrosion and scale inhibitor and application thereof. The composite low-phosphorus corrosion and scale inhibitor is prepared from a corrosion and scale inhibitor A and a corrosion and scale inhibitor B, wherein the corrosion and scale inhibitor A is prepared from 20-40 parts of polyepoxysuccinic acid (PESA), 20-40 parts of sodium gluconate and 20-60 parts of water; and the corrosion and scale inhibitor B is prepared from 10-25 parts of hydroxypropyl methacrylate (HPMA), 10-25 parts of acrylic acid / 2-acrylamido-2-methylacrylsulfonic acid copolymer (AA / AMPS), 5-10 parts of 2-phosphonobutyl-1,2,4-tricarboxylic acid (PBTCA), 10-25 parts of zinc salt, 1-2 parts of fluorescent tracer and 13-64 parts of water. The technical scheme is as follows: the corrosion and scale inhibitor A and the corrosion and scale inhibitor B in a weight ratio of 1:2 are compounded with water. The composite low-phosphorus corrosion and scale inhibitor has excellent corrosion and scale inhibition effects, and thus, the phosphorus content in the product is low, thereby reducing the phosphorus discharge and having favorable environmental protection performance.

The invention provides a composite phosphorus-free corrosion and scale inhibitor and its application. The composite phosphorus-free corrosion and scale inhibitor is composed of a corrosion and scale inhibitor A and a corrosion and scale inhibitor B, wherein the corrosion and scale inhibitor A is obtained through mixing polyepoxysuccinic acid (PESA), sodium gluconate and water; and the corrosion and scale inhibitor B is obtained through mixing hydrolytic polymaleic anhydride (HPMA), an acrylic acid / 2-acrylamide-2-methylpropanesulfonic acid copolymer (AA / AMPS), a zinc salt, a fluorescent tracer and water. The composite phosphorus-free corrosion and scale inhibitor, which compounds the corrosion and scale inhibitor A and the corrosion and scale inhibitor B according to a weight ratio of the corrosion and scale inhibitor A to the corrosion and scale inhibitor B of 1:2, has the advantages of excellent corrosion and scale inhibition effects, avoiding of a water eutrophication problem caused by phosphorus discharge, environmental pollution mitigation, and good environmental protection property.

The present invention provides bone-targeting polymeric drug delivery systems based on HPMA and related copolymers and methods of making thereof. The water-soluble bone-targeting polymeric conjugates of the present invention comprise water-soluble copolymer backbones (P) which are linked, via a first spacer (S1), with a bone-related therapeutic agents or drug (D) and, via a second spacer (S2), with a bone-targeting moiety (T).

Methods of making room temperature-curable polymers. Reactants include siloxane-terminated polymers and silanols. The reactants are mixed, and the polymerization allowed to proceed in air at room temperature. The polymers are exceptionally useful because they allow for the incorporation into the polymers themselves of one or more therapeutic compounds. Thus, medical devices from which controlled drug release is desirable (for either local or systemic delivery) can be coated with therapeutic compound-containing polymers of the invention. In a preferred embodiment, a polymer of poly(MPCw:LAMx:HPMAy:TSMAz) where w, x, y, and z represent the molar ratios of monomers used in the feed for preparing the polymer; MPC represents the unit 2-methacryoyloxyethylphosphorylcholine, LMA represents the unit lauryl methacrylate, HPMA represents the unit 2-hydroxypropyl methacrylate, and TSMA represents the unit 3-trimethoxysilylpropyl methacrylate is reacted with polydimethylsiloxane. In another preferred embodiment, a therapeutic compound is incorporated into the polymer, such as dexamethasone.

The inventions provide compositions and methods for nucleic acid delivery comprising IIPMA conjugated to a polyamine. These compositions have the benefit of the steric hindrance of HPMA and the nucleic acid binding capability of a polyamine. Useful polyamines for this purpose include spermine, spermidine and their analogues, and DFMO. These polyamines have the ability not only to bind nucleic acids, but also have anti-cancer effects themselves. The compounds provided can also include ligand binding domains, such as vascular endothelial growth factors, somatostatin and somatostatin analogs, transferring, melanotropin, ApoE and ApoE peptides, von Willebrand's factor and von Willebrand's factor peptides, adenoviral fiber protein and adenoviral fiber protein peptides, PD 1 and PD 1 peptides, EGF and EGF peptides, RGD peptides, CCK peptides, antibody and antibody fragments, folate, pyridoxyl and sialyl-LewisX and chemical analogs. Methods for using these compositions to achieve a therapeutic effect, including for vaccination, are also provided.

The invention discloses a chromate-free passivation agent for an aluminum alloy. Per liter of chromate-free passivation agent is composed of, by mass, 10 mg to 300 mg of amino silane or / and epoxy silane, 1 mg-100 mg of dispersible nano particles, 10 mg-500 mg of a zirconium compound or / and a titanium compound, 1 mg-150 mg of metal ions, 10 mg-150 mg of fluoride, 1 mg-20 mg of a complexing agent, 75 mg-100 mg of organic phosphoric acid and the balance water; and the organic phosphoric acid is at least two of HEDP, HPMA, EDTMP, DTPMP, ATMP and PBTCA. According to the passivation agent, multiple kinds of organic phosphoric acid, multiple kinds of metal ions and multiple kinds of nano particles are chelated to the different degrees; on one aspect, the thickness and the compactness of a passivation film layer can be strengthened; and meanwhile, the passivation film layer (inorganic film layer) formed after chelation can show a color to a certain degree on the surface of the aluminum alloy.

The invention discloses a water-based working liquid for electrical discharge wire cutting, which comprises the following components by weight percent: triethanolamine, boric acid, oleic acid, polyethyleneglycol PEG-600, petroleum sodium sulfonate, petroleum barium sulfonate, sodium dodecyl sulfate, nonylphenol ethoxylate OP-10, fatty alcohol-polyoxyethylene ether MOA-15, Span S-80, detergent 6501, sodium alcohol ether sulphate AES, hydrolytic polymaleic anhydride HPMA, 1-hydroxy ethylidene-1,1-diphosphonic acid HEDP, glycerol, ethanol, sodium benzoate and water. The invention further relates to a preparation method of the water-based working liquid for electrical discharge wire cutting. The water-based working liquid with the pH ranging from 7.5 to 8.0 is yellowish and transparent, free from toxicity and irritating odor, and easy for biodegradation, and BOD (Biochemical Oxygen Demand), COD (Chemical Oxygen Demand) and other indexes in discharged sewage are in compliancy with the emission standards for environmental protection. The water-based working liquid disclosed by the invention can ensure the bright processed surface of workpiece even when being used in hard water regions.

The invention belongs to the field of a medicine slow release carrier material and specifically discloses a preparing method for slow release hydrogel carrier material with a semi-interpenetrating structure modified by a polyelectrolyte membrane and an application thereof. The slow release hydrogel material is comprised of HPMC and SA as raw materials, firstly an HPMC-SA semi-interpenetrating composite gel is prepared by a Ca2+ physical crosslinking method and polyelectrolyte membrane modification is performed on the HPMC-SA hydrogel with low molecular weight CS so as to increase the stabilityof the HPMA-SA hydrogel, so that the HPMA-SA-CS hydrogel is obtained. The hydrogel has advantages of mild preparing condition, simple method, less reagent and no violent reactions. BSA and micromolecule indissolvable IDM are regarded as model medicine and the slow release effect of the HMPC-SA-CS composite hydrogel material on macro-molecule medicine and micromolecule medicine is investigated. The result shows that the gel system continuously swell for 50 hours, the swellability reaches above 52 times and the slow release effect of the protein medicine and IDM is increased.

The present invention discloses gemcitabine and docetaxel water soluble compositions formed by conjugating gemcitabine or docetaxel to a water soluble polymer such as N-2-hydroxypropylmethacrylamide (HPMA). The invention also discloses a method of treating cancer using the composition of the invention.

The invention relates to a circulating water scale inhibitor, which comprises the following components by weight portion: 2. 5 to 2.8 portions of PASP (polyaspartic acid), 1 to 1.2 portions of ATMP (amino trimethylene phosphonic acid), 2.4 to 2.6 portions of HPMA (hydrolyzed polymaleic anhydride), 1.2 to 1.4 portions of AA / AMPS (acrylic acid and 2-acrylamide-2-methyl propane sulfonic acid copolymer), 1.1 to 1.3 portions of PAA (polyacrylic acid), and 0.7 to 1.8 portions of water. The scale inhibitor prepared by the formulation is environment-friendly, has the characteristics of safety and reliability, easy preparation, convenient use and the like, and is suitable to be used as medicaments for preventing scale on circulating water systems in the fields of electric power, chemical engineering, medicine, petroleum, and the like.

The invention discloses an anti-tumor targeting drug carrier and a preparation method thereof. The carrier is a high polymer copolymerized by PEG, HPMA and MAGG. A polymerization method of reversible addition-fragmentation transfer (RAFT) is used to obtain copolymerizing components and copolymer with controllable molecular weight and narrow molecular weight distribution (the molecular weight distribution d being less than 1.4), a general formula of the copolymer being PEG-b-P (HPMA-co-MAGG). By adjusting a PEG chain length of the polymer, a composition ratio of the HPMA and the MAGG and the molecular weight of the polymer, the anti-tumor targeting drug carrier with substantially increased circulation time in body is obtained. The polymer can be used for targeting transportation of the antitumor drugs; not only is high in targeting and good in biocompatibility, but also can prevent nonspecific protein adsorption and prolong the circulation time in body; and is the excellent anti-tumor targeting drug carrier.

The invention relates to a corrosion and scale inhibitor applicable to circulating cooling water high in chlorine content and bromine content. The corrosion and scale inhibitor is prepared from 4-8 parts of high explosive-dual purpose (HEDP), 1-5 parts of hydroxypropyl methacrylate (HPMA), 0.3-1.2 parts of acrylic acid-2-acrylamide-2-methyl propanesulfonic acid copolymer (AA-AMPS), 1-5 parts of zinc sulfate (ZnSO<4>) and 1-5 parts of benzotriazole (BTA). The corrosion and scale inhibitor is little in toxicity and influence on the environment, and good scale inhibition and corrosion mitigation performances in the circulating water high in chloride ion content and bromine ion content are exhibited.

The invention provides a tumor microenvironment stimulation degradable amphiphilic block HPMA (hydroxypropyl methacrylate) polymer delivery system which is a conjugate of HPMA polymer, cathepsin B substrate GFLG, and small-molecular drug gemcitabine; the nano delivery system formed by self-assembly of the amphiphilic block conjugate has enzyme responsive degrading capacity and drug release capacity, gemcitabine is delivered by being conjugated to the amphiphilic block HPMA polymer skeleton, the molecular weight of the system is relatively high, the system may effectively collect at a tumor part, has good biocompatibility and antitumor effect, and by introducing near-infrared fluorescent probe Cy5.5, self-tracing capacity is imparted to the system.

The invention relates to a preparing method of a PDLC (polymer dispersed liquid crystal) dimming glass film. The method particularly comprises the following steps that in a light shading environment, resin, photoinitiators, HPMA (hydroxypropyl methacrylate), OPPEA (ortho-phenyl phenoxyl ethyl acrylate) and LMA (lauryl methacrylate) are proportionally mixed; after the mixing, the materials are uniformly stirred for about 30 minutes at the room temperature being about 25 DEG C; a mixture A is obtained; 35 percent of the mixture A is mixed with 65 percent of liquid crystals, and the mixture is uniformly stored for about 30 minutes at the room temperature about 25 DEG C; a mixture B is obtained; 0.5-percent 20um nanometer materials are added to be mixed with the mixture B, and the mixture is uniformly stirred for about 30 minutes at the room temperature being about 25 DEG C; finally, PDLC raw materials are obtained; coating and pressing are carried out; the curing process is carried out. The method provided by the invention includes the PDLC raw material preparation and a film production method. The production cost of the PDLC film is greatly reduced.

The invention discloses a novel efficient anti-tumor targeting drug carrier and a preparation method thereof. The carrier is a diblock copolymer consisting of a chain segment A and a chain segment B, wherein the chain segment A is PEG, and the chain segment B is a random copolymer formed by the following three monomers: HPMA, MAGG and BHMAGG. By adoption of a reversible addition fragmentation chain transfer polymerization method, the copolymer with controllable copolymerization components and molecular weight, and narrow molecular weight distribution (with the molecular weight distribution PDI being less than 1.4) is obtained. By modification of side chain functional groups of the MAGG and the BHMAGG in the polymer, a water-soluble polymer drug carrying system with significant targeting and controlled drug release functions is obtained. The polymer drug carrying system can be used for efficient transportation of anti-tumor drugs, has advantages of high targeting property, good biocompatibility, adjustable drug carrying amount, and drug release with pH responsiveness, and is an anti-tumor targeting drug carrier with excellent performances.

The invention discloses a PEG modified PHPMA material and a preparation method thereof. The PEG modified PHPMA material which is provided by the invention is N-(2'-hydroxyl) propyl methyl acrylamide (HPMA) and / or a copolymer of the derivative of the N-(2'-hydroxyl) propyl methyl acrylamide and polyethylene glycol (PEG). The PEG modified PHPMA material of the invention is a polymer which is formed by the copolymerization of the polyethylene glycol (PEG), poly-N-(2'-hydroxyl) propyl methyl acrylamide (PHPMA) and the derivative of the PHPMA, the copolymer can be obtained by adopting the reversible addition-fragmentation chain transfer (RAFT), the composition and the molecular weight are controllable, and the molecular weight distribution is narrow (the molecular weight distribution d is less than 1, 4). Such polymers can be applied in the targeting drug delivery, which can not only have high targeting property and good biocompatibility, but can also have the function of preventing the protein non-specific absorption after the PEG modification, so the PEG modified PHPMA material is a good drug targeting carrier with the good performance, in particular to the drug targeting carrier of an anti-tumor drug.

The invention discloses a photocurable maleic anhydride tung oil acrylic resin and a preparation method thereof. The technical scheme is as follows: the photocurable maleic anhydride tung oil acrylic resin comprises the following components: 1 mol of elacostearic acid, 2 mol of maleic anhydride (fumaric acid) and 4-5 mol of hydroxy acrylic monomer. The preparation method comprises the following steps: hydrolyzing tung oil at high pressure so as to obtain alfa-elacostearic acid, carrying out addition reaction on the maleic anhydride or the fumaric acid and a conjugated double bond of the alfa-elacostearic acid to generate a maleic / fumaric elacostearic acid, and then carrying out esterification reaction on hydroxyethyl acrylate (HEA), hydroxypropyl acrylate (HPA), hydroxyethyl methacrylate (HEMA) or hydroxypropyl methacrylate (HPMA) and the maleic / fumaric elacostearic acid to obtain various high-activity photocurable maleic anhydride tung oil penta-acrylic resins with 4-5 functionalities. The photocurable maleic anhydride tung oil acrylic resin has the characteristics of environment friendliness, no solvent, hydrolysis resistance and the like; and the paint film has excellent hardness and flexibility; as renewable resources are used for replacing a part of petrochemical products, and after the workpieces painted with the resin are discarded, the paint film is easy to degrade, and the harm of the pure chemical coating film to the environment is avoided; and after the resin is added with a photoinitiator, various photocureable coatings, printing ink and the like can be prepared.

The invention discloses an antibacterial wet-wiping-resistant interior wall coating. The coating comprises the following raw materials in parts by mass: 40-50 parts of styrene-acrylic emulsion, 0.5-1 part of acrylic emulsion, 12-18 parts of silica powder, 7-12 parts of titanium dioxide, 0.1-0.2 part of ethyl vanillin, 1-2 parts of Texanol ester alcohol, 0.2-0.5 parts of dispersant, 5-6 parts of polyethylene glycol 200, 0.1-0.2 part of antifoaming agent and 80-90 parts of deionized water, wherein the dispersant is one or two of HPMA (Hydroxypropyl Methacrylate) and zinc stearate, and the antifoaming agent is polyoxyethylene octylphenol ether. The interior wall coating disclosed by the invention is good in bacterial resistance, wet-wiping resistance and adhesion, and can be widely applied to various indoor coatings.

The invention discloses a method for preventing salt-manufacturing equipment from scale deposition. The method comprises the following steps: during a production process of salt-manufacturing equipment, inputting an anti-deposition agent and brine in the salt-manufacturing equipment; and when the pH value of a salt-manufacturing equipment liquid is greater than 11, adding an anti-deposition agent containing a carboxylate-sulfonate-nonion terpolymer, HPMA and PAA. A salt-manufacturing anti-deposition agent is composed of polymaleic acid, the carboxylate-sulfonate-nonion terpolymer and PAA or composed of PASP, polymaleic acid, the carboxylate-sulfonate-nonion terpolymer and PAA. The method and the salt-manufacturing anti-deposition agent disclosed by the invention have the following advantages: the proper anti-deposition agent for preventing the salt-manufacturing equipment from scale deposition is separated by selecting scale inhibitors for circulation cooling water, and the continuous production of the salt-manufacturing equipment can be guaranteed, the prolonging the scale reduction period of the equipment.

A polymeric drug in the form of a conjugate of a copolymer of N-(2-hydroxypropyl)-methacrylamide (HPMA) with doxorubicin bound to the polymer via spacers containing hydrolytically cleavable hydrazone bonds, of formula (I), wherein SP1 represents an aminoacyl spacer, x=40 to 335, y=1 to 25, consisting of from 90 to 99.5 mol. % of units of HPMA and 10 to 0.5 mol. % of doxorubicin-containing comonomeric units. The conjugate is prepared via direct copolymerization of the doxorubicin-containing monomer of formula (II) with HPMA.

The invention discloses a gambogic acid-galactose-HPMA (N-(2-hydroxypropyl)methacrylamide) high-molecular copolymer. The structural formula is shown as (I) in the specification. In the formula, x=5-10 mol%, y=5-10 mol%, z=80-90 mol%, Mn=2.2*10<4>, and Mw / Mn=1.45. A preparation method comprises the following steps: preparing a galactose derivative C by taking D-galactose as a preparation raw material; reacting gambogic acid oxalamide and methylacryloyl to prepare a gambogic acid derivative D; and finally, performing condensation on the galactose derivative C, the gambogic acid derivative D and HPMA to obtain the gambogic acid-galactose-HPMA high-molecular copolymer. After being used in a drug for treating a neoplastic disease, the copolymer has a targeted intelligent drug release functional and achieves a favorable inhibition effect for liver cancer, lung cancer and colon cancer.

The present invention relates to water-soluble high-molecular-weight polymer drug carriers and their conjugates with drugs, derived from dendrimers of the amidoamine and 2,2-bis(hydroxymethyl)propanoic types, the amino and hydroxy end groups of which are attached to semitelechelic copolymers of N-(2 hydroxypropyl)methacrylamide (HPMA) through biodegradable spacers. The polymer carriers and conjugates enable targeted transport notably of anticancer drugs into solid tumors in which biodegradation, the associated controlled drug release and subsequent elimination of polymer carrier from the organism are provided. The polymer carrier conjugated with a cancerostatic for use in targeted therapy of human tumors.

The invention relates to a novel graphene aerogel material and a preparation method thereof. The novel graphene aerogel material is prepared from, by weight, 40-60 parts of graphene oxide, 5-10 partsof HPMA, 100-150 parts of ammonium hydroxide, 10-20 parts of polytetrafluoroethylene, 8-10 parts of China wood oil, 6-10 parts of m-aminophenol and 50-80 parts of deionized water. The novel graphene aerogel material is easy to obtain, simple in preparation method, little in consumed time, high in mechanical strength, low in energy consumption, pollution-free, good in absorption and catalyzing effect and good in self-lubricating effect, does not easily crack or scale, and is good in dispersion effect and high in oxidation resistance, the service life of the novel graphene aerogel material is prolonged, the graphene aerogel material can be recycled and used repeatedly, the cost is lowered, and the comprehensive economic benefits are improved.

The invention discloses a novel preparing method for a scale inhibitor special for an iron-pollution-resistant film, and relates to a preparing method for a film-special scale inhibiting-dispersing agent. The scale inhibitor is prepared from 10%-30% of polyepoxysuccinic acid (PESA), 10%-30% of 2-phosphonobutane-1,2,4-tricarboxylic acid (PBTCA), 5%-15% of an allyl sulfonic acid salt copolymer (AA / AMPS), 1%-5% of styrene sulfonic acid (SS), 2%-8% of hydrolytic polymaleic anhydride (HPMA) and the balance distilled water. According to the scale inhibitor, under the condition of high-alkali, high-hardness and high-pH-value water quality and existence of iron ions, calcium carbonate scale inhibition and calcium sulfate scale inhibition reach 100%, and the scale inhibition performance for silicon dioxide scale, barium sulfate scale, strontium sulfate scale and the like is improved.

The invention provides a D-galactose / benzaldehyde nitrogen mustard / N-(2-hydroxypropyl) methacrylamide copolymer, and belongs to the field of high polymer chemistry and application. The D-galactose / benzaldehyde nitrogen mustard / N-(2-hydroxypropyl) methacrylamide copolymer is a macromolecular copolymer which has good biocompatibility and is formed in the way that D-galactose and benzaldehyde nitrogen mustard are linked to N-(2-hydroxypropyl) methacrylamide (HPMA) through covalent bonds. An experiment proves that the D-galactose / benzaldehyde nitrogen mustard / N-(2-hydroxypropyl) methacrylamide copolymer has the function of intelligently releasing drugs in a targeting manner, and has excellent inhibiting effect on a liver cancer HepG2 tumor cell; besides the macromolecular copolymer is an effective drug delivery system; therefore, the copolymer has excellent prospect as being used as an inhibitor for the HepG2 tumor cell and the like to be applied to the preparation of anti-tumor drugs.

The invention discloses a biodegradable core-crosslinked gadolinium complex-containing polymer and a preparation method and a purpose thereof. The invention also discloses a biodegradable linear HPMA copolymer and a preparation method and a purpose thereof. The biodegradable core-crosslinked gadolinium complex-containing polymer has high relaxation rate, has excellent effect as a magnetic resonance imaging contrast medium, has the advantages of degradable performance, no toxicity, good biological compatibility, and has good clinic application prospect.

The invention discloses a novel efficient anti-tumor targeting drug carrier and a preparation method thereof. The carrier is a diblock copolymer consisting of a chain segment A and a chain segment B, wherein the chain segment A is PEG, and the chain segment B is a random copolymer formed by the following three monomers: HPMA, MAGG and BHMAGG. By adoption of a reversible addition fragmentation chain transfer polymerization method, the copolymer with controllable copolymerization components and molecular weight, and narrow molecular weight distribution (with the molecular weight distribution PDI being less than 1.4) is obtained. By modification of side chain functional groups of the MAGG and the BHMAGG in the polymer, a water-soluble polymer drug carrying system with significant targeting and controlled drug release functions is obtained. The polymer drug carrying system can be used for efficient transportation of anti-tumor drugs, has advantages of high targeting property, good biocompatibility, adjustable drug carrying amount, and drug release with pH responsiveness, and is an anti-tumor targeting drug carrier with excellent performances.