Gambogic acid-galactose-HPMA (N-(2-hydroxypropyl)methacrylamide) high-molecular copolymer, and preparation method and application thereof

A high molecular copolymer, galactose technology, applied in the field of gambogic acid-galactose-HPMA high molecular copolymer and its preparation, can solve the problems of hematopoietic system and immune function, limited clinical research, large toxic and side effects, etc. Achieve good biocompatibility, prolong residence time, and enhance targeting
CN106822909AInactive Publication Date: 2017-06-13LIAONING UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
LIAONING UNIVERSITY
Publication Date
2017-06-13
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a gambogic acid-galactose-HPMA (N-(2-hydroxypropyl)methacrylamide) high-molecular copolymer. The structural formula is shown as (I) in the specification. In the formula, x=5-10 mol%, y=5-10 mol%, z=80-90 mol%, Mn=2.2*10<4>, and Mw / Mn=1.45. A preparation method comprises the following steps: preparing a galactose derivative C by taking D-galactose as a preparation raw material; reacting gambogic acid oxalamide and methylacryloyl to prepare a gambogic acid derivative D; and finally, performing condensation on the galactose derivative C, the gambogic acid derivative D and HPMA to obtain the gambogic acid-galactose-HPMA high-molecular copolymer. After being used in a drug for treating a neoplastic disease, the copolymer has a targeted intelligent drug release functional and achieves a favorable inhibition effect for liver cancer, lung cancer and colon cancer.
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Description

technical field

[0001] The invention belongs to the field of macromolecule anti-tumor targeted drugs, and in particular relates to a gambogic acid-galactose-HPMA polymer copolymer and its preparation method and application. Background technique

[0002] Gambogic Acid (Gambogic Acid, GA, C38H4408) is one of the active ingredients in the traditional Chinese medicine Gambogic. In the past 20 years, scholars at home and abroad have carried out a lot of in-depth and systematic research on Garcinia Cambogia. Garcinia Cambogia and its active ingredient, Gambogic Acid, have a wide range of pharmacological activities, mainly including anti-tumor, anti-bacterial, anti-inflammatory, anti-viral, and anti-inflammatory. It has strong anti-tumor activity on various tumors and has become a hotspot in the anti-tumor research of natural products in recent years. It has large toxic and side effects and low selectivity. Function will also have an impact, which limits the current clinical resea...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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