14results about How to "Reduce distribution" patented technology

This invention relates to the field of biopharmaceutical technology, providing a self-assembled peptide-rhein conjugate, its formulation, preparation method, and applications. The MMP-9-responsive self-assembled peptide-rhein conjugate of this invention, with the sequence Rhein-GFFPLGLAGACE, can respond to abnormally activated MMP-9 in atherosclerotic plaques, self-assembling in situ into a stable nanofiber structure at the lesion site. The rhein in this conjugate exhibits significant anti-inflammatory and antioxidant functions, but its water solubility and oral bioavailability are low. These are significantly improved after conjugation with the peptide, achieving targeted delivery and prolonging retention time. The introduction of the tripeptide ACE, which mimics the function of glutathione, further enhances the conjugate's ability to resist oxidative stress. Furthermore, this conjugate exhibits excellent anti-inflammatory and antioxidant effects, scavenging ROS, inhibiting inflammatory pathways, regulating macrophage phenotype, and inhibiting apoptosis, providing a new strategy for the treatment of atherosclerosis.

This invention discloses a low-temperature start-stop control method for a hydrogen fuel cell vehicle, comprising: during the startup of the on-board fuel cell system, performing a self-check to determine whether the ambient temperature is below 0°C; when the ambient temperature is below 0°C, detecting the operating status of the hydrogen fuel cell vehicle and executing different cold-start strategies according to the operating status; during the shutdown of the on-board fuel cell system, detecting the ambient temperature, and when the ambient temperature is below 0°C, executing a shutdown strategy to reduce cooling circuit heat dissipation. The shutdown strategy to reduce cooling circuit heat dissipation includes: reducing the cooling circuit temperature to a first preset temperature, where the first preset temperature is greater than 30°C. This invention's low-temperature start-stop control method for hydrogen fuel cell vehicles adopts a self-starting approach, avoiding multiple cold starts due to energy allocation during operation in low-temperature environments. It optimizes the fuel cell system shutdown purging strategy during vehicle operation, increases the shutdown temperature, slows down system temperature drop, improves insulation, reduces the risk of low-temperature cold start failure, improves fuel cell stack lifespan, reduces the additional heating space of the fuel cell, and reduces additional consumption of the fuel cell system.

The invention relates to a method for observing and quantitatively analyzing microscopic displacement of water-displacing oil, and belongs to the technical field of oilfield development. The method specifically comprises the following steps: preparing a core sample into a visual rock slice assembly; injecting fluid into the visual rock slice assembly to carry out a displacement experiment, recording a video of the distribution condition of the fluid in the slice, intercepting a picture, and establishing fluorescent picture standard samples of the rock slice in different states; oil-bearing areas before and after displacement are analyzed from the pictures; and analyzing the occurrence state of the residual oil. The defects that a glass etching model cannot reflect a real core pore structure and the definition of a recorded displacement video or picture is low are overcome.

The application provides a dsHpAGO1 for preventing and controlling holotrichia larvae and application thereof, and belongs to the field of biotechnology and agricultural application. The dsHpAGO1 in the application is synthesized by an HpAGO1 gene with a nucleotide sequence as shown in SEQ ID NO. 1 and dsRNA primers with nucleotide sequences as shown in SEQ ID NO. 3 to SEQ ID NO. 4. After the holotrichia larvae are injected with the dsHpAGO1 in the application, the expression amount of the HpAGO1 gene is significantly reduced compared with a control group, the interference efficiency is 95.53%, the holotrichia larvae grow and develop abnormally, and a large number of holotrichia larvae die, the mortality rate is 91.7%, and the silencing efficiency of the HpVAA gene is reduced by 42.6%. Therefore, the dsHpAGO1 in the application has great significance in the prevention and control of holotrichia larvae.

The application discloses an electrowetting display device structure and a method for preparing the same. The electrowetting display device structure comprises a first substrate, a second substrate, a sealing frame and a pixel wall. The second substrate is arranged in parallel with the first substrate, and has a first conductive layer on one side close to the first substrate. A hydrophobic insulating layer is arranged on the first conductive layer. The sealing frame is arranged between the first substrate and the second substrate, and a sealed cavity is formed between the first substrate, the sealing frame and the second substrate. The sealed cavity is filled with a polar liquid. The pixel wall is arranged on the hydrophobic insulating layer in the sealed cavity, and defines a pixel grid. The pixel grid is filled with a non-polar liquid which is immiscible with the polar liquid. The pixel wall comprises a second conductive layer, and the second conductive layer and the first conductive layer form a positive electrode and a negative electrode, respectively. The electrowetting display device structure can improve the response time and the conductive efficiency of the electrowetting display device.

The application discloses a gaze estimation method based on a hybrid pulse neural network and joint sparsity optimization, and belongs to the field of computer vision and human-computer interaction. The asymmetric hybrid network architecture with a front-end lightness and a rear-end self-adaptation is adopted, and the full-connection calculation of the front-end redundancy is removed. The structure effectively realizes the lightness of the network parameters while guaranteeing the modeling ability of the time sequence characteristics, effectively reduces the total energy consumption of the single-step system, and improves the deployment cost-effectiveness in the edge computing scene. The pulse sparsity joint optimization strategy is introduced, the MFR regularization penalty term is added in the loss function, and the accumulation speed of the membrane potential of the hidden layer neurons is effectively inhibited through the alternative gradient back propagation. The method reduces the overall pulse firing quantity at the physical level, reduces the redundant pulse firing irrelevant to the prediction accuracy, effectively reduces the synaptic operation number (SOPs) in the reasoning stage, and maintains good feature expression robustness under high sparsity.

The invention discloses a CO2 flooding asphaltene blocking degree quantitative calculation method, and relates to the technical field of oil and gas field development. According to the technical scheme, the method comprises the following steps: executing on-line core in-situ condition nuclear magnetic testing: preparing a solution for saturating a core, preparing a saturated rock sample, determining a static pore throat nuclear magnetic T2 spectrum, determining a CO2 displacement process nuclear magnetic T2 spectrum, and determining a CO2 displacement post-nuclear magnetic T2 spectrum; the permeability damage rate and the porosity damage rate of the rock core are calculated by respectively obtaining static pore throat nuclear magnetic T2 spectrums and CO2 displacement process nuclear magnetic T2 spectrums of different rock cores, so that the CO2 displacement asphaltene blockage index is obtained. The method has the beneficial effects that the core in-situ condition on-line nuclear magnetic experiment is adopted, the micro-pore structure characteristics of the reservoir core are classified and researched, the CO2 displacement micro-dynamic process is observed by using the representative real core, the asphaltene and wax blocking degree of each stage can be quantitatively analyzed, the observation and operation are simple, the cost is low, and the method is suitable for large-scale popularization and application. And the support is provided for improving the recovery efficiency and reducing the residual oil distribution in the later-stage work of the oil field.

The application provides a method for preparing an aluminum-bronze-based composite material by remelting dilution and the aluminum-bronze-based composite material, and the method comprises the following steps: putting an aluminum-based composite material into a copper melt to obtain the aluminum-bronze-based composite material. The mass ratio of the aluminum-based composite material to the copper melt is 2-8:98-92. The aluminum-based composite material comprises 2-10 wt% TiB2 particles and the balance of aluminum. Compared with the in-situ self-formation method in the copper melt, the method for preparing the aluminum-bronze-based composite material by remelting dilution can greatly reduce the agglomeration of the particles, so that the tensile strength and elongation of the prepared aluminum-bronze-based composite material are significantly improved. In addition, the application simplifies the smelting process, has the advantages of energy saving, high efficiency, green and no pollution.

This invention relates to the fields of biomedical engineering and drug delivery technology, specifically disclosing a novel targeted drug delivery system based on rosehip extracellular vesicles, comprising: preparing rosehip-derived extracellular vesicles; preparing drug-loaded vesicles; and preparing targeted modified drug-loaded vesicles. This invention utilizes the specific downregulation of stem cell-related pathways by rosehip components, while simultaneously leveraging doxorubicin to kill conventional tumor cells, forming a complementary therapeutic mechanism to fundamentally reduce the risk of tumor recurrence. The phenylboronic acid group of DSPE-PEG-PBA specifically recognizes sialic acid overexpressed on the surface of tumor cells, significantly increasing drug accumulation in tumor tissues while reducing distribution in normal tissues. By leveraging the natural biocompatibility and low immunogenicity of RHNVs, combined with the long-circulating properties of the PEG chain, systemic toxicity is minimized while ensuring delivery efficiency, particularly reducing the cardiotoxicity and bone marrow suppression of doxorubicin.

This invention provides an aptamer targeting the growth hormone receptor and its uses, the nucleotide sequence of which is shown in SEQ ID NO.1 or SEQ ID NO.2. This invention utilizes a modified SELEX technique to perform multiple rounds of screening targeting recombinant GHR protein, obtaining specific nucleic acid aptamers with high affinity for GHR (KD values ​​at the micromolar level). In vivo distribution experiments show that the fluorescently labeled aptamer can efficiently and specifically accumulate in white adipose tissue (including inguinal and gonadal fat) at the in vivo level, exhibiting excellent tissue targeting. The nucleic acid aptamer and its derivatives of this invention can be used to prepare drugs or diagnostic reagents targeting adipose tissue, for example, for the prevention or treatment of metabolic diseases such as obesity, type 2 diabetes, fatty liver, hyperlipidemia, or cardiovascular disease.

This invention provides a pharmaceutical composition for the prevention or treatment of atrial fibrillation and its application. Composed of herbs such as Astragalus membranaceus and Angelica sinensis, this invention is based on the theory of collaterals and the principle of invigorating qi and lifting sunken qi, guided by the theory of collaterals. It uses warming and dispersing wind-dispelling herbs as adjuvants, supplemented with herbs that promote blood circulation and remove blood stasis, and regulate qi flow. The entire formula has the effects of tonifying and lifting, nourishing the collaterals, and extinguishing internal and external wind.

This utility model belongs to the field of lithium-ion battery technology and discloses a composite current collector and battery electrode. The composite current collector includes a base film and a first conductive layer disposed on a first surface and a second conductive layer disposed on a second surface of the base film. The first and second surfaces are disposed opposite to each other. Along the width direction of the base film, the thickness of the base film decreases from the middle position in the width direction to both sides of the width direction. The base film is axially symmetrically disposed in the width direction. The total thickness of the composite current collector remains consistent throughout the entire composite current collector. When the polymer film is electroplated in an electroplating bath, it can avoid the surface undulation of the base film along the width direction caused by the difference in current density in the electroplating solution. This avoids the situation where the surface of the base film wrinkles or slips and cannot be rolled up, thus reducing the difficulty of subsequent application of the current collector inside the lithium-ion battery.

The application discloses an antibacterial and wound healing promoting nanocomposite film as well as a preparation method and application thereof. The nanocomposite film is obtained by repeatedly freezing and thawing a mixed solution of polyvinyl alcohol, lignin and MXene to form a crosslinked network. The mass ratio of the polyvinyl alcohol, the lignin and the MXene is 1:4:(0.0025-0.04). The application introduces MXene and LS into a PVA hydrogel system, endows the composite film with good mechanical properties, biocompatibility and antibacterial activity, and the composite film has moderate swelling performance and conductivity. The nanocomposite film of the application is non-toxic and has good chemical stability. The nanocomposite film can promote wound healing, significantly reduce inflammatory response, promote the formation of new blood vessels, strengthen nutrient transport, and can be combined with electric stimulation to further promote wound healing, and has a broad application prospect in the field of wound dressings.

The utility model discloses an electromagnetic descaling device for high-hardness industrial circulating water, which relates to the field of descaling and comprises a pipeline, and a plurality of annular grooves are equidistantly formed in the surface of the pipeline along the axial direction of the pipeline; the pipeline is fixedly connected with an electromagnetic generation assembly, the electromagnetic generation assembly is provided with a plurality of coils, the surface of the pipeline is fixedly connected with a plurality of permanent magnet rings, and the coils and the permanent magnet rings are alternately arranged in the annular grooves. The device has the beneficial effects that a plurality of annular grooves are formed in the pipeline, so that an area of which the inner diameter is continuously and alternately changed can be formed in the pipeline, when circulating water flows in the pipeline, turbulent flow can be generated, meanwhile, the coil is mounted in the annular grooves, and the corresponding area of the circulating water and the coil can be increased; the distance between the coils and circulating water in the center of the pipeline is reduced, the electromagnetic action range and the descaling effect are improved on the premise that the number of the coils is not increased, and the electromagnetic descaling effect is further improved.