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781results about How to "Reduce distribution" patented technology

Lung-targeted medicine carrying precursor liposome for injection and method of use thereof

The invention relates to the technical field of medicament delivery by a carrier, in particular to a lung targeting medicament carried proliposome used for injection and an application method thereof. Solid dispersion technology is adopted to obtain solution A by dissolving active medicament, phospholipid liposome, cholesterol liposome, surface active agent and acid type carrier in absolute ethyl alcohol or the mixed solvent of absolute ethyl alcohol and absolute ether; active carbon which is used for injection and has the volume being 0.1-1% of the volume of the solution A is added into the solution A; stirring, standing and filtering of the solution by a millipore filter are carried; therefore, aseptic solution B free of pyrogen is obtained; aseptic additives are added into the solution B under an aseptic condition; organic solvent is removed; and solid granular medicament carried proliposome or powdered medicament carried proliposome are obtained. The invention has the advantages that the preparation process is simple; the cost is low; the quality is controllable; the stability is good; and the invention is suitable for industrial production. The medicament carried proliposome prepared by effervescency dispersion technology has small and uniform particle diameter, the electric charge ranges from -10mv to -30mv, the proliposome can deliver over 90% medicament to a lung, and remarkable lung targeting effect is achieved, and thus being the best preparation delivering medicament by a carrier for treating lung diseases.
Owner:CHONGQING MEDICAL UNIVERSITY +1

Serum-free fibroblast cell culture medium and preparation method thereof

The invention relates to a serum-free fibroblast cell culture medium and a preparation method thereof, wherein the base culture medium is a DMEM culture medium or a mixture of the DMEM culture medium and a F12 culture medium, and the exogenous additives comprise hormones, a metal transporter, glutamine, a lipid concentration agent, an antioxidant, purine, saccharide and a cell growth factor. Compared with the culture medium in the prior art, the serum-free fibroblast cell culture medium of the present invention has the following advantages that: animal origin or recombinant albumin is not added so as to avoid the possibly-carried safe hidden danger and reduce the culture medium cost; the culture medium is suitable for primary culture and subculture of fibroblast cells, the good cell morphology is maintained, and the status and the function of the cultured cells are similar to the status and the function of the serum group cells; adherence factor coating is not required, the primary 24 h adherence rate is more than 60%, the passage 24 h adherence rate is more than 80%, no difference exists between the cells cultured with the culture medium of the present invention and the serum group cells; requirements of multiple passages can met, and the growth conditions of the cells after 15 passages are similar to the growth conditions of the serum group cells; and after the fibroblast cells are directly transferred into the culture of the present invention from the serum-containing culture, the cells can successfully adhere and extend without the gradual adaptation process.
Owner:西安博鸿生物技术有限公司

Evaluation testing device for anti-sand screen tube blockage characteristic in exploitation process of natural gas hydrate and method thereof

The invention discloses an evaluation testing device for an anti-sand screen tube blockage characteristic in an exploitation process of natural gas hydrate and a method thereof. The device comprises atesting device body, a supporting seat, a liquid supplying system, an air supplying system and a fluid leading-out acquisition system. The testing device body is longitudinally mounted on the supporting seat and can longitudinally rotate on the supporting seat. The testing device body comprises a reaction kettle, a constant-temperature clamping jacket, an anti-sand sieve tube module, a pressure sensor, a temperature sensor, a resistivity sensor, etc. The circumferential wall of the reaction kettle is provided with a kettle body interface. The circumferential wall of the constant-temperature jacket is provided with an external interface at a position which corresponds with the kettle body interface. According to the evaluation testing device, the anti-sand screen tube blockage condition indifferent stratum conditions and exploitation conditions and the influence of the stratum factor to screen tube blockage in a sand outlet process can be simulated through experiments; and the screentube blockage characteristic change caused by sand outlet in a hydrate exploitation process can be analyzed through analyzing particle size distribution characteristic, a screen tube sand-blocking medium unit pressure, unit and permeability change.
Owner:CHINA UNIV OF PETROLEUM (EAST CHINA)

Processing method and processing system for highly-concurrent requests

The invention discloses a processing method and a processing system for highly-concurrent requests. A server receives hyper text transport protocol (HTTP) requests sent by clients in a batch mode, and the HTTP requests are directly subjected to reverse proxy and forwarded to an HTTP proxy by means of the server; the HTTP proxy receives the HTTP requests, converts the HTTP requests to a database language and then sends the data language to a database; the database establishes corresponding relationships between the clients and the requests of the clients and returns relevant data to the HTTP proxy according to the HTTP requests and the corresponding relationships; the HTTP proxy performs reverse conversion to the received data and then returns the data to the server; and the server receives the data returned by the HTTP proxy, converts the data to a light weight data exchange format and then returns the light weight data exchange format to the corresponding clients. According to the processing method and the processing system for the highly-concurrent requests, an efficient message polling structure is achieved, and a stable message pushing service is provided for a message pushing system which has a large amount of login users.
Owner:BEIJING QIHOO TECH CO LTD +1
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