12 results about "Growth inhibitory" patented technology

Novel compositions are described, each comprising at least one active constituent that has a 12-carbon atom backbone as a 12-carbon chain base structure having at least a sub-terminal nitrogen and no terminal amino group. One of the active constituents is Boc-12-Ado-OH (BOA) and / or N,N-dimethyldodecylamine N-oxide (LO). Novel particle or liposomal compositions comprising at least BOA and / or LO may be prepared with an emulsifier and / or lipid and optionally a biopolymer, and may be formulated into pharmaceutically acceptable formulations and / or medicaments with or without one or more pharmaceutically acceptable carriers or excipients for utilization as an antimicrobial against one or more microbial pathogens. The novel antimicrobial compositions have broad-spectrum growth inhibitory or other destructive activity against microbial pathogens, biofilms produced by one or more pathogens, and biofilm infections.

The application discloses methyl phenolic compounds, a preparation method and application thereof. Six new methyl phenolic compounds are separated from the skin of eleocharis tuberosa, and the compounds all show good inhibitory activity on alpha-glucosidase, and are stronger than the clinical first-line drug acarbose. The inhibitory activity of compound 3 is the best, enzyme kinetics research shows that the compound 3 plays a role as a reversible mixed inhibitor, ADME predicts that the compound 3 has good drug properties, including high gastrointestinal absorption and no CYP450 enzyme inhibition. The cytotoxicity experiment shows that the six compounds have no obvious growth inhibition on human embryonic kidney cells HEK293 at a concentration of 100 muM, and have good safety. The compounds can be combined with a pharmaceutically acceptable carrier to form a pharmaceutical composition, and are used for preparing a health care product for reducing blood sugar or a drug for treating diabetes. The preparation method is simple, easy to operate, suitable for industrial production, and is helpful to the high-value reuse of the skin of eleocharis tuberosa.

This invention belongs to the field of plant genetic engineering and plant stress resistance biotechnology, and discloses... ZmCYP81Q32 Application of genes in improving nicosulfuron resistance in plants. This invention provides... ZmCYP81Q32 The nucleotide sequence of the gene, as shown in SEQ ID NO:1, encodes a cytochrome P450 enzyme that can directly bind to sulfonylurea herbicides and promote their hydroxylation metabolism. This reduces the accumulation of the parent herbicide in the plant, alleviates herbicide-induced growth inhibition, leaf chlorosis, and oxidative damage, and significantly improves plant tolerance to sulfonylurea herbicides, especially enhancing plant resistance to nicosulfuron. This invention can be widely used for crop herbicide resistance improvement, herbicide-tolerant germplasm creation, and related molecular breeding.

This invention discloses a kit for constructing an iron-dependent growth environment for Acinetobacter baumannii and its application method, belonging to the field of biotechnology. The kit is specifically designed for Acinetobacter baumannii, and its core components include a 50 mmol / L sterile stock solution tube of 2,2′-bipyridine, a 2000 μmol / L sterile stock solution tube of FeCl3, and a user manual. It does not include general-purpose LB medium, thus avoiding the problem of high-temperature and high-pressure deterioration of core reagents and highlighting the innovative combination of dedicated reagents. This invention also provides the application method of the kit. By adding the kit stock solution to the autoclaved and cooled LB medium in a specific ratio, standardized growth environments with normal iron, iron deficiency, and iron enrichment can be rapidly constructed. Dynamic monitoring and verification of the reversibility of growth inhibition-recovery ensure that the iron environment is precise and controllable. The kit is easy to operate, has good reproducibility, and can achieve standardized construction of the iron environment for Acinetobacter baumannii. It is suitable for iron metabolism-related research such as functional analysis of iron uptake-related proteins, development of iron deprivation antibacterial strategies, and screening of iron-deficient strains.

The application belongs to the technical field of natural compound application, and particularly relates to application of globulol in preparation of lysine-deficient Staphylococcus aureus. The application provides, for the first time, application of globulol in preparation of lysine-deficient Staphylococcus aureus. Globulol in the application is a natural monomer component in eucalyptus, and is a natural sesquiterpene compound. After endogenous lysine is consumed by pre-treatment according to the application, S. aureus Globulol has obvious growth inhibition effect on Staphylococcus aureus in a lysine-deficient culture system, and the growth inhibition phenomenon is obviously recovered after exogenous lysine is supplemented under the same control.

This invention belongs to the field of biotechnology, specifically relating to the cassava transcription factor MeWRKY30 and its applications. This invention cloned the transcription factor gene of MeWRKY30 from cassava. Overexpression of this gene in cassava can improve the resistance of transgenic cassava plants to low-temperature and drought stress. The effects of qRT-PCR on cassava... MeWRKY30 Gene expression was significantly upregulated after drought and treatment with the plant hormone abscisic acid (ABA). After recovery from low temperature treatment, the malondialdehyde content of the overexpressing cassava lines decreased, wilting was reduced, root growth inhibition was lessened, and the number of cortical cells in the root tip meristem was significantly increased.

The present application relates to a kind of harmless physical method and reagent for treating corn borer.The reagent includes the following mass percentage components: colloid 0.2%-0.6%, diatomite 1%-2%, Bacillus thuringiensis 0.2%-0.3%, Beauveria bassiana 0.1%-0.15%, azadirachtin 0.03%-0.1%, and the balance is water.The present application uses the viscous colloid formed by colloid to effectively occupy corn bell mouth and stick to the corn borer that crawls out to feed, achieving physical control;At the same time, Bacillus thuringiensis and Beauveria bassiana biological components are used to infect and kill the corn borer, azadirachtin plays a role in repelling and growth inhibition, and diatomite can physically pierce the insect skin, enhancing the control effect, and through the synergistic effect of multiple components, biological control is achieved.The present application creatively uses harmless physical method combined with biological components to control corn borer, not only avoiding pesticide residues, but also being more environmentally friendly and safe, and synergistically enhancing the control effect, reducing the worm boring rate.

The compound represented by Chemical Formula 1 or 2 of the present invention, or a pharma- ceutically acceptable salt thereof, can be usefully used for the prevention or treatment of cancer or tumor.

This invention discloses the application of purified lignin and oxygen-alkali treated lignin in alleviating salt stress in plants. The purified lignin and oxygen-alkali treated lignin were prepared into aqueous solutions of appropriate concentrations and applied to plants under salt stress through hydroponics or soil cultivation systems. Results showed that exogenous application of both lignins alleviated the growth inhibition caused by salt stress to a certain extent, effectively improving the growth status of plants in saline environments. This was mainly manifested in the recovery of apparent biomass, improvement in leaf photosynthetic pigment content and photosynthetic rate, and increased antioxidant enzyme activity. This invention uses low-cost, high-activity, and environmentally friendly purified lignin as a novel plant growth regulator, providing an economical, green, and scalable new approach for the efficient cultivation of crops in saline soils.

The application relates to the field of medicinal chemistry and discloses a pyrimidine diamine compound and application thereof. The pyrimidine diamine compound is shown as formula I: The pyrimidine diamine compound of the application can be applied to preparing a product for promoting hair growth and / or preventing hair loss, can promote the hair in the resting phase to enter the growth phase, can stimulate hair growth, can inhibit the hair loss caused by a chemotherapy agent, can resist the chemotherapy toxicity and prevent the hair loss caused by chemotherapy, can inhibit androgen, thereby preventing androgen-induced hair loss, can accelerate the natural growth speed of the hair, can increase the growth weight and length of newly-added hair or the remaining hair after hair loss, and the effect is better than that of minoxidil approved by the FDA.

This invention discloses the application of zanthoxylin in the preparation of plant-based herbicides and the resulting herbicides, relating to the field of herbicide technology. The concentration of zanthoxylin in the plant-based herbicides is ≥20 μg / mL. By using zanthoxylin as the active ingredient in plant-based herbicides, it exhibits significant growth inhibition against various common farmland weeds at a concentration ≥20 μg / mL. Furthermore, this active ingredient is derived from natural plants and is a biodegradable secondary metabolite, making it less likely to leave residues in the environment and causing no soil degradation or water pollution. Compared to chemically synthesized herbicides, it is more ecologically safe. This not only provides a new option for developing efficient, broad-spectrum, and environmentally friendly bio-based herbicides but also expands the application prospects of zanthoxylin in the agricultural field.

The application discloses a plant growth regulator and application thereof in promoting growth and coloring of eggplants under high-temperature stress, and belongs to the technical field of plant growth regulators. Methyl jasmonate and rhamnolipid are combined as active components of the plant growth regulator, which can effectively relieve the growth inhibition of eggplants under high-temperature stress, and synergistically improve the anthocyanin content in the pericarp of eggplants, significantly improve the coloring effect of eggplant fruits under high-temperature stress, and improve the fruit quality. The application adds a synergistic component on the basis of the active components; the synergistic component comprises potassium dihydrogen phosphate, calcium chloride, zinc sulfate and boric acid, and can further strengthen the active components from the aspects of energy and osmotic regulation, calcium signal and membrane stability, antioxidant enzyme activity and photosynthetic protection, cell wall integrity and sugar transport, so as to synergistically improve the heat tolerance of plants, promote anthocyanin accumulation of fruits and improve the coloring performance of fruit surfaces.