45 results about "Growth inhibitory" patented technology

This invention discloses a stress-resistant and yield-increasing plant growth regulator, its preparation method, and its application, belonging to the field of plant growth regulators. The stress-resistant and yield-increasing plant growth regulator of this invention comprises the following raw materials: *Suaeda salsa* extract, a stress-resistant biostimulant, propionyl brassinolide, styracil, polyaspartic acid, γ-aminobutyric acid, emulsifier, penetrant, co-emulsifier, pH buffer, and deionized water; wherein the stress-resistant biostimulant is perilla lactone. This invention significantly improves the tolerance of wheat to salt-alkali stress by strengthening the antioxidant system and osmotic regulation capacity, ensuring its basic survival and normal physiological functions; and effectively reverses stress-induced growth inhibition through mechanisms such as promoting root development, enhancing photosynthesis, and driving product translocation to grains, thereby achieving a significant yield increase under adverse conditions.

The application discloses application of MdERF77 gene in plant resistance to saline-alkali stress, and belongs to the technical field of biotechnology. The application overexpresses the MdERF77 gene in an apple plant through transgenic technology, significantly enhances the tolerance of the plant to saline-alkali stress, and has outstanding technical effects. The method can effectively improve the growth adaptability of the apple in a saline-alkali environment, so that the transgenic plant shows stronger antioxidant capacity, higher photosynthetic efficiency and more stable membrane system under the saline-alkali stress, thereby guaranteeing normal development and quality improvement of fruits, and reducing growth inhibition and yield loss caused by stress. The application provides a reference for improvement of stress resistance of fruit trees, and has a wide agricultural application prospect.

The invention discloses a cyclic iridium-ester tin imidazo phenanthroline complex with an aggregation-induced emission (AIE) characteristic as well as a preparation method and an anti-cancer application of the cyclic iridium-ester tin imidazo phenanthroline complex. The structural formula is as shown in formula (I), R1 is phenyl or 3-pyridyl, and R2 is hydrogen or fluorine. By testing the growth inhibition rate of the target compound on human alveolar basal epithelial cancer cells (A549) and comparing, the target compound shows potential A549 cell proliferation inhibition activity. In addition, the target complex shows a unique AIE luminescence characteristic, and is accumulated in lysosome of A549 cells, resulting in lysosome damage and apoptosis.

Novel compositions are described, each comprising at least one active constituent that has a 12-carbon atom backbone as a 12-carbon chain base structure having at least a sub-terminal nitrogen and no terminal amino group. One of the active constituents is Boc-12-Ado-OH (BOA) and / or N,N-dimethyldodecylamine N-oxide (LO). Novel particle or liposomal compositions comprising at least BOA and / or LO may be prepared with an emulsifier and / or lipid and optionally a biopolymer, and may be formulated into pharmaceutically acceptable formulations and / or medicaments with or without one or more pharmaceutically acceptable carriers or excipients for utilization as an antimicrobial against one or more microbial pathogens. The novel antimicrobial compositions have broad-spectrum growth inhibitory or other destructive activity against microbial pathogens, biofilms produced by one or more pathogens, and biofilm infections.

The invention discloses application of a traditional Chinese medicine composition in preparation of a medicine for preventing and treating bacterial liver injury of chicks. The traditional Chinese medicine composition is prepared from herba artemisiae scopariae and radix scutellariae. For bacterial infection and immunological liver injury triggered by endotoxin, through compatibility and synergy of'one clearing and one benefiting 'of two medicines, pathogen stimulation and immune overresponse links are intervened at the same time, and growth inhibition caused by liver injury is blocked. The traditional Chinese medicine composition is extracted and prepared into oral liquid, powder and other dosage forms, and then is applied to chicks at the age of 6-12 days. Experiments prove that the traditional Chinese medicine composition can significantly reduce the activity of liver injury markers such as serum ALT and AST, alleviate liver inflammatory infiltration and necrosis, can reverse the decrease of average daily gain caused by liver injury, synchronously realizes liver injury repair and growth performance guarantee, adapts to resistance reduction / forbidden resistance trends, and has a broad application prospect. And a safe and effective solution is provided for preventing and treating bacterial liver injury in the early brooding stage of broilers.

The application discloses methyl phenolic compounds, a preparation method and application thereof. Six new methyl phenolic compounds are separated from the skin of eleocharis tuberosa, and the compounds all show good inhibitory activity on alpha-glucosidase, and are stronger than the clinical first-line drug acarbose. The inhibitory activity of compound 3 is the best, enzyme kinetics research shows that the compound 3 plays a role as a reversible mixed inhibitor, ADME predicts that the compound 3 has good drug properties, including high gastrointestinal absorption and no CYP450 enzyme inhibition. The cytotoxicity experiment shows that the six compounds have no obvious growth inhibition on human embryonic kidney cells HEK293 at a concentration of 100 muM, and have good safety. The compounds can be combined with a pharmaceutically acceptable carrier to form a pharmaceutical composition, and are used for preparing a health care product for reducing blood sugar or a drug for treating diabetes. The preparation method is simple, easy to operate, suitable for industrial production, and is helpful to the high-value reuse of the skin of eleocharis tuberosa.

This invention belongs to the field of plant genetic engineering and plant stress resistance biotechnology, and discloses... ZmCYP81Q32 Application of genes in improving nicosulfuron resistance in plants. This invention provides... ZmCYP81Q32 The nucleotide sequence of the gene, as shown in SEQ ID NO:1, encodes a cytochrome P450 enzyme that can directly bind to sulfonylurea herbicides and promote their hydroxylation metabolism. This reduces the accumulation of the parent herbicide in the plant, alleviates herbicide-induced growth inhibition, leaf chlorosis, and oxidative damage, and significantly improves plant tolerance to sulfonylurea herbicides, especially enhancing plant resistance to nicosulfuron. This invention can be widely used for crop herbicide resistance improvement, herbicide-tolerant germplasm creation, and related molecular breeding.

The invention discloses a windmill-shaped alpha-Fe2O3 / Ag nano hybrid material and a preparation method and application thereof in relieving plant salt stress, and the method comprises the following steps: mixing fusiform alpha-Fe2O3 prepared by a forced hydrolysis method with silver acetate, then carrying out ball milling treatment, and then carrying out a high-temperature calcination process to obtain the windmill-shaped alpha-Fe2O3 / Ag nano hybrid material. And the windmill-shaped alpha-Fe2O3 / Ag hybrid structure formed by assembling the fusiform alpha-Fe2O3 and the Ag nanoparticles is obtained. The nano hybrid material has high specific surface area, excellent dispersity and remarkable leaf surface adhesion performance, when the nano hybrid material is applied to plant cultivation, the material can effectively relieve growth inhibition caused by salt stress, can regulate and control plant hormone signals, terpene and carbohydrate metabolism, sulfur metabolism, protein homeostasis and the like, realizes multi-channel comprehensive regulation, and has a wide application prospect. Therefore, the plant stress resistance and quality are improved.

The present invention addresses the problem of providing a highly safe and continuously ingestible agent for: preventing or ameliorating diseases attributed to microorganisms belonging to the family Peptostreptococcaceae by inhibiting the growth of these microorganisms in the intestine; or for preventing or ameliorating diseases potentially preventable or ameliorable by a substance produced from microorganisms belonging to the genus Slackia by promoting the growth of these microorganisms in the intestine.　The problem of the present invention has been solved by a growth inhibitor of microorganisms belonging to the family Peptostreptococcaceae or a growth promotor of microorganisms belonging to the genus Slackia, each containing a galactooligosaccharide as an active ingredient.

The invention discloses a programmed function switching-based calcium sulfate whisker length-diameter ratio accurate regulation and control method, and belongs to the technical field of inorganic functional crystal material preparation. The traditional static regulation and control limitation is broken through, and a new mechanism of programmed adsorption-desorption function switching is created for the first time. The preparation method comprises the following steps: constructing an initial growth inhibition template by using amino trimethylene phosphonic acid (ATMP) as a crystal face adsorbent; in different stages of crystal growth, desorption agents with complementary functions are introduced in stages: sodium citrate is introduced in a competitive growth period, and radial growth inhibition is partially relieved; polyvinyl alcohol (PVA) is introduced in the length-diameter ratio curing period, and material transmission at the axial growth end is specifically promoted. The function switching process is precisely coupled with a gradient temperature change process, and sequential dynamic reconstruction of a crystal growth interface is realized. According to the invention, the length-diameter ratio of the calcium sulfate whisker is regulated and controlled in an ultra-wide range of 50-500, the product uniformity is improved, and a raw material with better performance is provided for the fields of high-end composite materials and the like.

This invention discloses a kit for constructing an iron-dependent growth environment for Acinetobacter baumannii and its application method, belonging to the field of biotechnology. The kit is specifically designed for Acinetobacter baumannii, and its core components include a 50 mmol / L sterile stock solution tube of 2,2′-bipyridine, a 2000 μmol / L sterile stock solution tube of FeCl3, and a user manual. It does not include general-purpose LB medium, thus avoiding the problem of high-temperature and high-pressure deterioration of core reagents and highlighting the innovative combination of dedicated reagents. This invention also provides the application method of the kit. By adding the kit stock solution to the autoclaved and cooled LB medium in a specific ratio, standardized growth environments with normal iron, iron deficiency, and iron enrichment can be rapidly constructed. Dynamic monitoring and verification of the reversibility of growth inhibition-recovery ensure that the iron environment is precise and controllable. The kit is easy to operate, has good reproducibility, and can achieve standardized construction of the iron environment for Acinetobacter baumannii. It is suitable for iron metabolism-related research such as functional analysis of iron uptake-related proteins, development of iron deprivation antibacterial strategies, and screening of iron-deficient strains.

The application belongs to the technical field of natural compound application, and particularly relates to application of globulol in preparation of lysine-deficient Staphylococcus aureus. The application provides, for the first time, application of globulol in preparation of lysine-deficient Staphylococcus aureus. Globulol in the application is a natural monomer component in eucalyptus, and is a natural sesquiterpene compound. After endogenous lysine is consumed by pre-treatment according to the application, S. aureus Globulol has obvious growth inhibition effect on Staphylococcus aureus in a lysine-deficient culture system, and the growth inhibition phenomenon is obviously recovered after exogenous lysine is supplemented under the same control.

This invention belongs to the field of biotechnology, specifically relating to the cassava transcription factor MeWRKY30 and its applications. This invention cloned the transcription factor gene of MeWRKY30 from cassava. Overexpression of this gene in cassava can improve the resistance of transgenic cassava plants to low-temperature and drought stress. The effects of qRT-PCR on cassava... MeWRKY30 Gene expression was significantly upregulated after drought and treatment with the plant hormone abscisic acid (ABA). After recovery from low temperature treatment, the malondialdehyde content of the overexpressing cassava lines decreased, wilting was reduced, root growth inhibition was lessened, and the number of cortical cells in the root tip meristem was significantly increased.

A method and kit for inhibiting microbial proliferation in a fuel container are disclosed. The method involves introducing antimicrobial particles designed to be trapped at the fuel-water interface by interfacial tension, thereby concentrating antimicrobial agents at a primary site of microbial growth. These particles release antimicrobial ions into the water phase, creating a growth inhibition zone that can extend into the sludge zone. A kit is also provided, including at least two separate containers of particles being a denser type that settles and remains at the tank bottom and a lighter type that settles but is subsequently lifted to the interface upon water accumulation.

A method and kit for inhibiting microbial proliferation in a fuel container are disclosed. The method involves introducing antimicrobial particles designed to be trapped at the fuel-water interface by interfacial tension, thereby concentrating antimicrobial agents at a primary site of microbial growth. These particles release antimicrobial ions into the water phase, creating a growth inhibition zone that can extend into the sludge zone. A kit is also provided, including at least two separate containers of particles being a denser type that settles and remains at the tank bottom and a lighter type that settles but is subsequently lifted to the interface upon water accumulation.

The invention belongs to the technical field of tea tree pest control, and relates to an application of linalool in control of ectropis grisescens, the linalool plays a role in a mode of directly feeding the ectropis grisescens or a mode of treating the ectropis grisescens through gaseous exposure, the linalool is used as a unique inhibiting or lethal component, and the linalool can be used for preventing and treating the ectropis grisescens. The compound has a remarkable growth inhibition or lethal effect on ectropis grisescens. When the concentration of the linalool is 5-20 [mu] l / mL, the linalool can generate a remarkable lethal effect on larvae of ectropis grisescens; when the concentration of linalool is 0.2-2 [mu] l / mL, the growth rate of the linalool can be obviously inhibited, and the weight of the linalool can be reduced. When the ectropis grisescens is treated in a gaseous exposure mode, the exposure concentration is 70-90 ng / h, the treatment time is 4-6 days, and the control effect is remarkable. The linalool is used for preventing and controlling tea tree ectropis grisescens, and the method has the advantages of being efficient, safe, high in feasibility and the like and can be applied to comprehensive prevention and control of tea garden insect pests.

The invention discloses a foliage spraying agent as well as a preparation method and application thereof, and relates to the technical field of agricultural planting. The foliage spraying agent provided by the invention comprises the following raw materials: polyethyleneimine and a water-soluble silicon fertilizer, wherein the addition amount of the polyethyleneimine in the foliage spraying agent is 0.0005 g / L to 0.008 g / L, and the addition amount of the water-soluble silicon fertilizer in the foliage spraying agent is 0.5 mL / L to 5 mL / L; the water-soluble silicon fertilizer is a liquid fertilizer containing nano silicon. And correspondingly. The invention also discloses application of the foliar spraying agent in relieving cadmium toxicity of plants in a cadmium stress environment. The foliage spraying agent provided by the invention can relieve the toxicity of heavy metal cadmium toxicity to plants such as rice, Chinese cabbage and the like, so that the growth inhibition effect of cadmium stress on the plants is reduced, and the biomass and yield of the plants under cadmium toxicity growth are improved.

The invention relates to the technical field of environmental microbiological technology and agricultural bioremediation, and discloses a rhodococcus bacterium X-20 and application thereof. The Rhodococcus sp. X-20 can efficiently degrade various pesticides in liquid and soil environments, including carbendazim, dinotefuran, atrazine, pendimethalin and cyhalothrin, and especially shows specific efficient degradation ability to carbendazim. In addition, the strain has various plant probiotic functions: the strain can secrete indole-3-acetic acid (IAA), generate iron carriers, dissolve inorganic phosphorus and antagonize phytophthora nicotianae, and the growth of tobacco seedlings can be remarkably promoted. Field experiments show that the strain can relieve growth inhibition of compound pesticide pollution on tobacco, and the strain can be used for preparing microbial agents and applied to bioremediation of pesticide-polluted soil and green agriculture.

The invention relates to an aporphine-benzylisoquinoline alkaloid dimer as well as a preparation method and application thereof, and belongs to the field of natural medicines and biological medicines. The aporphine-benzylisoquinoline alkaloid dimer has a structural general formula shown in the specification, in the formula, R1, R2, R3, R4, R5, R6, R7 and R8 are independently selected from hydrogen, methoxyl, hydroxyl or two adjacent substituent groups are methylenedioxy, so that a five-membered ring is formed; and R9 is selected from hydrogen, methoxyl or hydroxyl. Six novel aporphine-benzylisoquinoline alkaloid dimers are extracted and separated from roots of thalictrum omeiensis, and through detection, the aporphine-benzylisoquinoline alkaloid dimers have obvious growth inhibition effects on human acute promyelocytic leukemia cells HL-60 and human prostate cancer cells PC-3, and have the prospect of preparing medicines for preventing and treating tumors.

The present application relates to a kind of harmless physical method and reagent for treating corn borer.The reagent includes the following mass percentage components: colloid 0.2%-0.6%, diatomite 1%-2%, Bacillus thuringiensis 0.2%-0.3%, Beauveria bassiana 0.1%-0.15%, azadirachtin 0.03%-0.1%, and the balance is water.The present application uses the viscous colloid formed by colloid to effectively occupy corn bell mouth and stick to the corn borer that crawls out to feed, achieving physical control;At the same time, Bacillus thuringiensis and Beauveria bassiana biological components are used to infect and kill the corn borer, azadirachtin plays a role in repelling and growth inhibition, and diatomite can physically pierce the insect skin, enhancing the control effect, and through the synergistic effect of multiple components, biological control is achieved.The present application creatively uses harmless physical method combined with biological components to control corn borer, not only avoiding pesticide residues, but also being more environmentally friendly and safe, and synergistically enhancing the control effect, reducing the worm boring rate.

The present invention relates to the use of a specific strain of Streptococcus thermophilus in reducing the negative effects arising from the presence of a disaccharide sugar alcohol during fermentation of a milk-based product, as well as to a method for identifying a specific strain of Streptococcus thermophilus, to a method for preparing a fermented milk-based product comprising a disaccharide sugar alcohol, to a method for identifying a specific strain of Streptococcus thermophilus, to a method for preparing a fermented milk-based product comprising a disaccharide sugar alcohol, and to a method for preparing a fermented milk-based product comprising a disaccharide sugar alcohol. And a method for reducing the negative effects resulting from the presence of a disaccharide sugar alcohol during fermentation of a milk-based product.

The invention relates to the technical field of herbicides, in particular to a photosensitive herbicide and a preparation method and application thereof, the general formula structure of the photosensitive herbicide is A-L-B. A is a coumarin herbicidal active group; b is a growth inhibition regulating group and is an abscisic acid analogue or a salicylic acid derivative; l is a light-sensitive connecting arm, and the light-sensitive connecting arm comprises an azobenzene group or an o-nitrobenzyl group and is cracked under the irradiation of light with the wavelength of 365-450 nm. According to the invention, a light-sensitive connecting arm is introduced between a weeding active group and a growth inhibition regulating group, so that the pesticide keeps a stable structure and is in a low-activity state after being sprayed at night, and the exposure risk and environmental load of non-target organisms are reduced from the source. Under the condition of natural illumination or specific wavelength illumination, the photosensitive connecting arm is subjected to controllable splitting decomposition, weeding active ingredients are accurately released, space-time matching of pesticide effect release and the weed photosynthesis active period is achieved, and therefore the pesticide absorption efficiency and the action intensity are remarkably improved.

The invention discloses a giant strong aeromonas hydrophila bacteriophage and application thereof, and belongs to the technical field of microorganisms. According to the invention, aeromonas hydrophila is taken as host bacteria, the phage is enriched from a collected lake water sample, and is separated and purified by adopting a double-layer agar plate method, so that a strain of phage is successfully obtained, the strain of phage is named as aeromonas hydrophila phage Cgtyf, the preservation number is CCTCC NO: M 2026099, and the titer of the phage can reach 1.0 * 10 < 10 > PFU / mL; the genome size of the phage is about 237 kb, and the phage belongs to a giant phage. In an in-vitro bacteriostasis experiment, the bacteriophage Cgtyf shows a remarkable bactericidal effect and a relatively strong growth inhibition capability on host bacteria, and shows a relatively high temperature tolerance range in a temperature stability test. Therefore, the bacteriophage Cgtyf provided by the invention can be effectively used for preventing and controlling aeromonas hydrophila in aquatic products, has a potential application value as an antibacterial drug substitute, is beneficial to reducing or avoiding the use of antibacterial drugs in aquaculture, and has a good application prospect.

The compound represented by Chemical Formula 1 or 2 of the present invention, or a pharma- ceutically acceptable salt thereof, can be usefully used for the prevention or treatment of cancer or tumor.

This invention discloses the application of purified lignin and oxygen-alkali treated lignin in alleviating salt stress in plants. The purified lignin and oxygen-alkali treated lignin were prepared into aqueous solutions of appropriate concentrations and applied to plants under salt stress through hydroponics or soil cultivation systems. Results showed that exogenous application of both lignins alleviated the growth inhibition caused by salt stress to a certain extent, effectively improving the growth status of plants in saline environments. This was mainly manifested in the recovery of apparent biomass, improvement in leaf photosynthetic pigment content and photosynthetic rate, and increased antioxidant enzyme activity. This invention uses low-cost, high-activity, and environmentally friendly purified lignin as a novel plant growth regulator, providing an economical, green, and scalable new approach for the efficient cultivation of crops in saline soils.

The application relates to the field of medicinal chemistry and discloses a pyrimidine diamine compound and application thereof. The pyrimidine diamine compound is shown as formula I: The pyrimidine diamine compound of the application can be applied to preparing a product for promoting hair growth and / or preventing hair loss, can promote the hair in the resting phase to enter the growth phase, can stimulate hair growth, can inhibit the hair loss caused by a chemotherapy agent, can resist the chemotherapy toxicity and prevent the hair loss caused by chemotherapy, can inhibit androgen, thereby preventing androgen-induced hair loss, can accelerate the natural growth speed of the hair, can increase the growth weight and length of newly-added hair or the remaining hair after hair loss, and the effect is better than that of minoxidil approved by the FDA.

The present invention relates to an antimicrobial adjuvant containing a biphenyl derivative compound as an active ingredient, and a technology of various uses thereof. The compound of the present invention reduces the dosage of polymyxin antibiotics, which are administered to inhibit the proliferation of gram-negative bacteria, by enhancing the sensitivity of the gram-negative bacteria with respect to the polymyxin antibiotics, is concomitantly administered with the polymyxin antibiotics to show gram-negative bacteria growth inhibitory and killing effects, may notably reduce side effects such as nephrotoxicity, and may prevent or treat sepsis and septic shock due to antibiotic overuse.

The invention relates to the technical field of biology, in particular to application of a yeast culture in relieving growth inhibition and liver and intestine injury of pseudobagrus ussuriensis induced by vegetable protein feed. The feed formula disclosed by the invention comprises 48% of vegetable protein (soybean meal, cottonseed meal and corn protein powder), 1-3% of yeast culture and the like. 1-2% of yeast culture is added into the feed containing 30% of soybean meal, 11% of cottonseed meal and 7% of corn protein powder, so that the growth performance of the pseudobagrus ussuriensis can be remarkably improved, and through mechanisms such as a TLR2-MyD88-NF-kappa B pathway and the like, the oxidation resistance is improved, and inflammatory response and liver and intestine injury induced by plant protein antinutritional factors are relieved. The feed disclosed by the invention is simple in formula components, easily available in raw materials, safe and harmless, and beneficial to development of novel green additives and promotion of healthy breeding of the pseudobagrus ussuriensis.

The invention discloses design and synthesis of a novel lipophilic Fe (III) complex. The chemical formula of the complex is [Fe-5NO2-8HQ]. The Fe (III) complex shows strong in-vitro anticancer activity on various human tumor cells (including cis-platinum sensitive type and cis-platinum resistant type ovarian cancer cells); particularly, the compound still has a remarkable growth inhibition effect on platinum-resistant tumor cells, and shows the advantage of overcoming the drug resistance of cis-platinum. In addition, the [Fe-5NO2-8HQ] shows effective antibacterial activity on different strains of gram-positive pathogenic bacteria such as staphylococcus aureus and the like. Compared with a free ligand, the complex has the advantages that the antibacterial effect is greatly improved, and the complex is also applicable to drug-resistant strains. The preparation method of the complex is simple and efficient, and the product is stable and easy to separate. The complex can be used as an active pharmaceutical ingredient for preparing anti-cancer drugs and antibacterial drugs, and has potential application value in the aspects of anti-tumor treatment (especially aiming at drug-resistant tumors) and drug-resistant bacterial infection resistance.

The invention discloses application of exogenous nitric oxide in relieving inhibition of strontium stress on tomato seedling growth, and belongs to the technical field of plant stress resistance. Under the strontium stress condition induced by 10 mmol / L SrCl2, key growth indexes such as plant height, root length, stem diameter, leaf area, fresh weight and dry weight of tomato seedlings can be remarkably improved by spraying 100 mmol / L SNP solution on leaf surfaces, oxidative damage and growth inhibition caused by strontium stress are effectively relieved, and the stress resistance of the seedlings is enhanced. According to the method disclosed by the invention, the condition that the exogenous NO relieves the strontium stress of the tomato seedlings and the concentration dependence is clear for the first time, a new technical approach is provided for high-quality cultivation of the tomatoes in the metal-polluted soil, and a theoretical support is also provided for research and development of a relieving technology for plants to deal with the abiotic stress of metal poison.