115 results about "Low temperature treatment" patented technology

The invention belongs to the technical field of preparation of nano silicon materials, and particularly relates to a method for preparing nano silicon by etching a silicon-aluminum alloy and a nano silicon material thereof. Comprising the following steps: placing a pretreated silicon-aluminum alloy sample wafer in an etching tank containing a main etching solution, etching under the action of an alternating pulse electric field and ultrasonic-megasonic coupling, and adjusting the pH value to 2.5-3.0 by using acetic acid; quickly washing the silicon-aluminum alloy sample wafer subjected to main etching, putting the silicon-aluminum alloy sample wafer into an electrolytic cell containing a composite buffer solution of oxalic acid and sulfuric acid, and performing electrochemical fine etching under a direct-current constant-voltage electric field; and when the etching current density is reduced to 10% of the initial value, the reaction is terminated, and after low-temperature treatment and low-temperature vacuum drying, the nano silicon material with the residual Al content of 8-12 wt% and the O / Si atomic ratio of 0.15-0.25 is obtained. According to the invention, the problems of out-of-control components, structural damage and serious pollution in the prior art are solved, and the nano silicon material with controllable residual aluminum element and low oxygen-silica ratio can be stably prepared.

The invention relates to the field of fermentation product extraction methods, in particular to a method for efficiently extracting intracellular products. According to the method, staged extraction and ultrasound are combined to be applied to intracellular product extraction, and the extraction rate can be obviously increased. After thalli in fermentation liquor are crushed, a non-polar solvent is adopted for first extraction, and ultrasonic short-time low-temperature treatment is adopted in the extraction process, so that the extraction efficiency of a target product can be obviously improved, a polar solvent is added into an extraction phase of the first extraction in second extraction, and ultrasonic short-time low-temperature treatment is performed again, so that the extraction amount of intracellular products is increased; the process does not need complex equipment, is short in operation time consumption and high in extraction efficiency, and is suitable for large-scale industrial production.

This invention relates to the technical field of cryogenic natural gas separation and discloses a pollution-free cryogenic natural gas separation and treatment device, including a treatment tank. A cryogenic tank is fixedly installed at the bottom of the inlet tank. A condenser pipe is installed on the inner wall of the installation groove. A liquid nitrogen pipe is inserted and connected to the upper part of one side of the outer wall of the treatment tank. A pressure sensor is installed on the upper part of one side of the treatment tank, and a temperature sensor is installed in the middle of one side of the treatment tank. In this invention, natural gas is introduced into the inlet tank for accumulation and cryogenic separation. Then, the liquefied liquid and natural gas fall directly into the cryogenic tank below. The condenser pipe is controlled by the compressor to start cooling, so that the cryogenic natural gas is further cryogenically processed. After the temperature sensor detects that the temperature remains constant on the outside, it controls the first and second electromagnetic sealing valves through wires to open them and perform gas-liquid separation, thereby improving the overall effect of natural gas separation of the equipment.

The invention relates to the technical field of sewage treatment, and particularly discloses a sewage treatment agent as well as a preparation method and application thereof. The sewage treatment agent comprises modified polyaluminum chloride, a low-temperature flocculant and a plurality of auxiliary components, the modified polyaluminum chloride is obtained by doping nano boron nitride and modifying with a low-temperature modifier, and the low-temperature flocculant is obtained by copolymerization of polyacrylamide and 2-acrylamide-2-methylpropanesulfonic acid; the preparation method mainly comprises the steps of raw material dissolution, mixing reaction, flocculation compounding and the like. The sewage treatment agent can be used for domestic sewage treatment in a low-temperature environment of 0-5 DEG C, has the advantages of excellent low-temperature resistance, high hydrolysis speed, high pollutant removal rate and good stability, and can effectively overcome the defect of poor low-temperature treatment effect of an existing agent.

The application provides a method for improving the adenosine content of Ophiocordyceps sinensis based on metabolic regulation and synergistic induction, wherein a metabolic intervention is performed on the larva and strain complex using a regulating agent during the infection period before low-temperature treatment to form the infected larva; first, deep low-temperature immobilization treatment is performed at 2-5 DEG C for 30-50 days, then culture is performed using a variable-temperature cycle with diurnal temperature difference during the stroma induction period, and mannitol is sprayed onto the surface of the culture medium at the beginning of the step; after harvesting, rapid temperature rising enzyme inactivation and drying treatment is performed on the harvested Ophiocordyceps sinensis, the rapid temperature rising enzyme inactivation and drying treatment comprises increasing the drying temperature from 40-45 DEG C to 60-70 DEG C within 30-45 minutes and maintaining the temperature until the moisture content is less than 10%. The application can solve the problem that the adenosine content is generally low in the existing full artificial cultivation technology, and can make the adenosine content of the full artificial cultivation Ophiocordyceps sinensis reach more than 0.020% (w / v), which is significantly better than the existing artificial cultivation level, and the product morphology is complete and the reproducibility is high.

This invention provides a method for synergistically preparing sterile liquid formulations using high-energy fluid milling and plant components, relating to the field of traditional Chinese medicine technology. The method involves subjecting medicinal plant raw materials to a first low-temperature treatment using high-energy fluid milling to obtain highly active functional components. These functional components are then mixed with a liquid formulation matrix and subjected to a second low-temperature treatment using high-energy fluid milling, simultaneously achieving homogenization and sterilization. This invention reveals for the first time a significant synergistic sterilization effect between the medicinal plant functional components prepared by a specific process and the high-energy fluid milling treatment. Complete microbial inactivation can be achieved under mild conditions of 120 MPa and below 50°C, with effects far exceeding the simple superposition of a single component and a single physical treatment. This invention provides an integrated homogenization-sterilization method for external preparations and natural beverages that eliminates the need for chemical preservatives and high-temperature sterilization, and has broad applicability in the fields of traditional Chinese medicine and food.

The invention discloses a rapid propagation rooting culture medium for peony seed tissue culture and a culture method, and belongs to the technical field of plant tissue culture. The rapid propagation rooting culture medium takes 1 / 2 MS as a basic culture medium, and further comprises the following components: ammonium nitrate, potassium nitrate, calcium chloride, magnesium sulfate, monopotassium phosphate, a carbon source, kinetin and a curing agent. By adding kinetin into the culture medium, dependence of peony seed tissue culture seedlings on low-temperature treatment is broken, low-temperature pretreatment necessary in a traditional method is avoided, the peony seed tissue culture process is greatly simplified, the culture period is shortened, the rooting rate and the root strengthening rate are increased, the rooting rate is stabilized to be 95% or above, and the rooting rate is stabilized to be more than 95%. Technical support is provided for establishment of a new peony seed tissue culture and rapid propagation technology, and a material foundation is laid for promotion of peony seed tissue culture and rapid propagation factorization.

The invention relates to the technical field of low-temperature carbonization, in particular to a low-temperature energy-saving environment-friendly carbonization furnace for carbon fiber textiles. Comprising a supporting platform, two supporting plates are oppositely arranged at the top of the supporting platform, a treatment tank is rotationally arranged between the two supporting plates, the treatment tank is provided with a treatment cavity used for containing treatment liquid, and a plurality of stirring plates are arranged on the inner wall of the treatment cavity in the circumferential direction at equal intervals; driving gear blocks are arranged on the outer wall of the treatment tank in the circumferential direction, a driving rod is rotationally arranged on the supporting platform and located at the bottom of the treatment tank, a driving gear meshed with the driving gear blocks is arranged on the outer wall of the driving rod, and one end of the driving rod is fixedly connected with a driving motor installed on one side of the supporting platform; compared with the prior art, the waste gas is in full contact with the treatment liquid, the contact area of HCN and NH3 in the waste gas of the tank body and the treatment liquid is increased, so that the waste gas treatment efficiency is improved, and a good environment-friendly effect is achieved; in addition, due to the adoption of a low-temperature treatment process, a certain energy-saving effect is achieved.

The present application relates to the technical field of plant tissue culture, and specifically discloses a method for establishing a tissue culture sterile system of peach rootstock dormancy material, which comprises the following steps: S1, selecting one-year-old branches with leaf buds in the dormancy period, removing flower buds and cleaning; S2, performing low-temperature treatment on the branches, then performing water culture and bud breaking to obtain sprouting branches; S3, performing surface sterilization treatment on the sprouting branches, and then washing with sterile water; S4, peeling the sprouting buds from the branches under sterile conditions, removing the external wrapping tissues of the bud bodies, and exposing the internal tender tissues; S5, performing secondary sterilization treatment on the exposed tender tissues, and then washing with sterile water; and S6, inoculating the bud bodies subjected to the secondary sterilization treatment into a culture medium for culture, and establishing a sterile system; according to the above method, in the process of establishing the sterile system of Zhongtao Kangzhen No. 1 material, the sterilization survival rate of 100 bud heads is as high as 80% or more, and the work efficiency and the utilization efficiency of the material are greatly improved.

The application discloses a preparation method of a cactus and orchid seed composite beverage and belongs to the technical field of health food processing. The method is designed according to a standardized industrial formula with cactus and orchid seed as core raw materials, and is matched with Dendrobium candidum, white granulated sugar, erythritol and other auxiliary materials. Pure oxygen-free water is used as a solvent throughout the process. A pH 3.5 stable buffer system is constructed by compounding sodium citrate and citric acid. The fine filtration after low-temperature centrifugation is replaced by industrial filtration with an 80-100 mesh filter screen. The finished product is prepared by combining the whole low-temperature treatment and HPP ultra-high pressure cold sterilization process. The oxygen-free pure water effectively avoids the oxidation loss of active ingredients, and the whole low-temperature and HPP process realizes the efficient retention of active ingredients such as cactus SOD, flavonoids and polysaccharides. Meanwhile, the problems of unstable pH, low industrial filtration efficiency and easy stratification and precipitation of the traditional cactus beverage are solved. The finished beverage has a refreshing taste, a sweet and sour coordination and strong stability.

This invention discloses a method for preparing and applying elastic ceramic nanofiber flocs. Precursor coiled nanofibers are dynamically assembled using a periodically arranged spinneret module to form three-dimensional interwoven precursor nanofiber flocs. These flocs are then calcined at high temperature to obtain elastic ceramic nanofiber flocs. The flocs are cut into pre-formed sheets, conveyed by a conveying device, and wound onto the main mold of a self-rotating forming device under the action of auxiliary forming rollers. Adhesive is sprayed from the pre-formed sheets to achieve interlayer bonding, producing preforms. The main mold and preforms are placed into a matching mold to form a forming module. The preforms are then impregnated by an ultrasonic impregnation and homogenization device, followed by low-temperature treatment to form ice crystals in the impregnation solution perpendicular to the fiber direction, achieving inter-sheet stitching. Finally, the preforms are dried and demolded to obtain the finished product. This invention preserves the intrinsic elasticity and three-dimensional network structure of the fibers without damaging their structure and morphology, enabling short-process, high-efficiency, and continuous preparation of floc products.

The application relates to the technical field of paint, and discloses a preparation method of a low-temperature-resistant paint for natural gas metal pipelines, which comprises 85-95 parts by weight of an acrylate monomer, 5-15 parts by weight of a methyl methacrylate hydroxyl perfluoroalkane, 1.1-1.2 parts by weight of an initiator, 28-40 parts by weight of a filler and 12-30 parts by weight of an isocyanate-terminated polyurethane prepolymer. The isocyanate-terminated polyurethane is chemically bonded to the acrylic resin matrix, plays a good toughening role, and can improve the adhesion, toughness and impact resistance of the paint film. After low-temperature treatment, the acrylic resin molecular chain and the isocyanate-terminated polyurethane still maintain a stable crosslinking system, the adhesion grade and the impact resistance have a very small decline, the paint film is not easy to crack and fall off at low temperature, and good low-temperature resistance is shown.

The invention discloses a preparation method of liquid compound edible oil, which comprises the following steps: scientifically proportioning refined lard oil and vegetable oil, adding a proper amount of natural antioxidant, mixing, blending and performing low-temperature treatment under specific process conditions to promote high-melting-point saturated triglyceride in the lard oil to preferentially crystallize and separate out, and keeping at constant temperature for a period of time, thereby obtaining the liquid compound edible oil. Then tiny solid fat crystals are removed in a filter pressing or centrifugation mode, and the edible oil which is kept in a clear liquid state at the normal temperature, is good in stability and has the mellow flavor of animal fat and the refreshing taste of vegetable fat is obtained, so that the problems that existing lard oil is in a solid state at the normal temperature and is inconvenient to take and use, negative effects are easily caused to health when lard oil is independently used, and the use cost is low are solved. The flavor is insufficient when the vegetable oil is independently used for cooking and frying the green vegetables.

The invention relates to the technical field of breeding, and discloses a character screening method of an instantaneous cold-resistant plant, which is used for carrying out instantaneous low-temperature treatment on the plant and screening the instantaneous cold-resistant plant by comparing the shrinkage degree of the plant before and after the low-temperature treatment, and also discloses a screening device of the character screening of the instantaneous cold-resistant plant. According to the invention, automatic grading and screening of plants are realized, the screening precision is high, subsequent screening of characters of experimental bodies is not needed, and the screening rhythm is accelerated.

The invention relates to the technical field of heat treatment, in particular to an ultralow-temperature top-mounted ball valve material heat treatment device which comprises a liquid nitrogen subzero treatment box and an intercepting mechanism, the bottom of the rear side of the liquid nitrogen subzero treatment box communicates with a low-temperature pump, the top of the low-temperature pump communicates with a low-temperature pipe, and the side, away from the low-temperature pump, of the low-temperature pipe communicates with a liquid nitrogen tank; the intercepting mechanism is arranged on the inner side of the liquid nitrogen subzero treatment box, the liquid nitrogen subzero treatment box comprises a liquid nitrogen pool, a controller, hydraulic cylinders, a cover plate, a separation frame and a positioning net, the controller is installed on the left side of the liquid nitrogen pool, and the two hydraulic cylinders are connected to the two sides of the rear side of the liquid nitrogen pool through bolts correspondingly. The heat treatment device for the ultralow-temperature top-mounted ball valve material has the advantages that the structure for independently placing the ball valve material is provided, so that the ball valve material can be independently and separately placed, mutual transfer and influence of the temperature of a ball valve cannot be caused, and the stability of the ball valve during ultralow-temperature treatment is improved.

The present application relates to a kind of pressure-ultrasonic-microwave processing preparation baking-free phosphogypsum building material method, comprising the following steps: 1) phosphogypsum is added with calcium sulfate supersaturated liquid, rubber powder, calcium stearate, liquid paraffin, aluminate, succinic acid, graphene oxide in high-speed mixer in turn, and mixed uniformly to obtain modified phosphogypsum;2) modified phosphogypsum is simultaneously treated with ultrasonic and pressing, and modified phosphogypsum block is obtained;3) modified phosphogypsum block is treated with microwave, and baking-free phosphogypsum building material is obtained.The present application has high waste rate, and low carbon emission, and the phosphogypsum ratio in the final baking-free phosphogypsum product of the present application can reach more than 90%, and compared with the traditional baking-free brick needing to be treated by autoclave curing, the present application uses normal temperature forming, low-temperature treatment, and the carbon emission generated in the product preparation process is lower, and the baking-free phosphogypsum building material prepared by the method of the present application has good economic benefits.

The application provides an in-vitro seed embryo culture method of peony hybrid seeds, which comprises the following steps: 1) taking Chuan-shao No.1 or Chuan-shao No.2 as the female parent, Bozhou peony as the male parent to cross, collecting hybrid seeds, cleaning and disinfecting, taking embryos to obtain seed embryos; 2) taking the seed embryos, connecting into seed embryo starting seedling culture medium to culture, after the F1 generation seed embryo sprouts, first low-temperature treatment and then constant-temperature culture to obtain tissue culture seedlings; 3) taking the tissue culture seedlings to harden and transplant, which can be used. Under the culture of the specific culture medium, the double dormancy problem of the peony hybrid seeds is solved, and the low germination rate, high rot rate and embryo abortion of the peony hybrid seeds are overcome, so that the difficulty of the hybrid peony seedling quantity and quality is solved.

The production method of the double-flange thin-walled irregular part of the present invention involves removing the original window end process clamps and openings on the mold, reducing the wax temperature and increasing the mold shell strength during the wax molding process, increasing the liquid stirring speed during argon refining in the melting process, using steel wire mesh for anti-collision isolation on the product surface during solution treatment, and three rounds of high and low temperature treatment. This ensures that the local wall thickness of the window processing is sufficient during processing, the intersection point of the outer circle surface and the four window surfaces is concentric, the inner opening size is stable, and the flange surfaces at both ends are perpendicular to the center line. During the machining process, the product size remains stable as the wall thickness decreases, and the overall pass rate of the cylinder frame reaches 90%.

The application relates to the technical field of electroplating, and discloses a chromium electroplating process for improving the hardness of a connector terminal, which comprises the following steps: performing surface pretreatment on the connector terminal, removing surface impurities through ultrasonic cleaning and micro-etching treatment; performing heating treatment on the connector terminal; performing electroplating treatment on the connector terminal by using an electroplating solution comprising trivalent chromium salt, boron nitride nanoparticles, ferroferric oxide nanoparticles, nickel ions, sodium dichromate and chromium alloy additives, so as to form a chromium plating layer; performing passivation treatment on the plating layer; performing low-temperature treatment on the plating layer; and spraying a protective layer on the chromium plating layer. Through the trivalent chromium salt and the sodium dichromate, the trivalent chromium salt is used to reduce hexavalent chromium ions into trivalent chromium, the toxicity of the hexavalent chromium is reduced, the sodium dichromate is used to provide a stable chromium source, the deposition of chromium elements in the electroplating process is ensured, the pollution of hexavalent chromium to the environment and the harm of hexavalent chromium to the health of operators are solved, and the environmental protection and safety of the electroplating process are improved.

The present application relates to a kind of precision micro stepping motor wax removal methods, comprising the following steps: 1) after organic solvent water bath is heated to constant temperature, stator is immersed in organic solvent ≥30min;2) take new organic solvent water bath and heat to constant temperature, use circulating pump to flush the inner hole of stator, and each stator flushing time ≥1min;3) using anhydrous ethanol along the inner hole of stator axial reciprocating wash ≥20 times, then room temperature is placed ≥10min;4) stator is placed into high-low temperature test chamber and is treated at high-low temperature, first at high temperature and is kept ≥20min, then temperature is changed to low temperature and is kept ≥10min, repeat high-low temperature treatment at least 4 times, low temperature recovers to normal temperature and is taken out;5) repeat step 1) to step 3) or step 2) to step 3);The present application improves the effect of paraffin wax cleaning under the stator winding structure, improves production efficiency, and reduces the amount of solvent used.

The invention belongs to the technical field of marine product fresh-keeping, and particularly relates to a marine product processing low-temperature fresh-keeping technology and equipment, and the technology comprises the following steps: S1, capturing and transporting: boxing fresh caught marine products in a manner of overlapping dry ice layers and products, and transporting, S2, pretreating fish catches, S3, storing, and immediately performing low-temperature treatment on the marine products after processing. The method generally comprises a cooling seawater fresh-keeping mode and an equipment fresh-keeping mode, S4, temperature control, S5, packaging, selection of appropriate packaging materials such as a refrigeration carton and a freezing bag, and sealed packaging, so that external air and moisture are effectively isolated, seafood decay is prevented, the shelf life of the seafood can be effectively prolonged through the fresh-keeping technology, and the seafood quality guarantee period can be effectively prolonged. The freshness and the quality of the product are kept, the market competitiveness and the additional value of the product are improved, pre-storage is carried out in a fresh-keeping storage mode after supplement and attack, and the freshness of the fish obtained in the boxing process can be guaranteed.

The application provides a high-cold-tolerance Gastrodia elata breeding method suitable for planting in high-altitude areas and relates to the technical field of Gastrodia elata breeding. Wild Gastrodia elata in high-altitude areas above 2000 m and Gastrodia elata planted in large scale in high-altitude areas below 1500 m are selected for hybridization breeding. The obtained seeds are treated by combining chitosan solution soaking with low-temperature treatment, and the germination and growth of the seeds are promoted by using domesticated germination bacteria and Armillaria mellea, so that the seed germination rate of the high-cold-tolerance Gastrodia elata in high-altitude areas is greatly improved, the yield and quality of the Gastrodia elata are improved, and the growth cycle and the breeding cycle of the high-cold-tolerance Gastrodia elata are shortened.

The application relates to a soluble silk fibroin pellet quick-freezing, separating and collecting device. The device comprises a low-temperature treatment tank, an external heat preservation tank, a feeding assembly, a separating assembly and an electric control system. The low-temperature treatment tank is nested in the external heat preservation tank and is adiabatic; the feeding assembly is arranged between a top cover plate and an adiabatic plate and comprises a material feeding pipe, a liquid nitrogen feeding pipe and a recovery pipe; a liquid drop pipe is arranged in the material pipe and is provided with a heating device arranged inside the liquid drop pipe to prevent freezing; liquid drops fall through the adiabatic plate into liquid nitrogen to be quickly frozen into small balls. The parameters of a stirring paddle can be adjusted to control the particle diameter, and a peristaltic pump and the specification of the drop pipe are used to control the size. The quick-frozen mixture flows into a separating tank through a low-temperature electromagnetic valve, small balls are intercepted by a screen, and liquid nitrogen is recycled. The electric control system is used for regulating and controlling stirring, the electromagnetic valve and heating power. The device can ensure resolubility through low shear quick freezing, the quick-frozen mixture can be freeze-dried in less than 24 hours due to the high specific surface area of the small balls, the cost is reduced through liquid nitrogen circulation, and the flux and particle diameter can be controlled through multi-parameter adjustment, so that the device is suitable for the preparation of silk fibroin and composite materials.

The invention relates to the technical field of stock breeding. The invention provides a high-cold-resistance grape rootstock breeding method, which comprises the following steps: (1) carrying out cross breeding by taking river bank grapes as female parents and 5BB grapes as male parents, and collecting seeds of filial generation fruits; (2) pre-treating the seeds in the step (1), and sowing to obtain seedlings; and (3) screening high-quality seedlings from the seedlings in the step (2), hardening the seedlings, and then carrying out low-temperature treatment. By the adoption of the technical scheme, the grape stock with good cold resistance can be effectively bred, it is better guaranteed that grape varieties safely overwinter in cold regions, reliable guarantee is provided for growth of grapes, and the method has wide application prospects and popularization value.

The application relates to a sewage treatment system and method. The sewage treatment system comprises a sewage bin, a heater, a sewage treatment device and a heat exchange assembly. The heater is connected downstream of the sewage bin and is used for heating sewage. The sewage treatment device is connected downstream of the heater. The sewage treatment device performs sewage treatment on the sewage. The sewage treatment device is provided with a water outlet. One end of the heat exchange assembly is connected to the water outlet. High-temperature treatment water exchanges heat with the heat exchange assembly. The heat exchange assembly collects heat of the high-temperature treatment water and discharges low-temperature treatment water. The other end of the heat exchange assembly is connected between the sewage bin and the heater. The heat exchange assembly preheats sewage discharged from the sewage bin through heat. The heat exchange assembly collects heat of the high-temperature treatment water and preheats the sewage in the sewage bin, reduces the dependence on the heater, reduces the heating power of the heater, reduces the waste of heat, makes the treatment water discharged from the sewage treatment system be low-temperature treatment water, and reduces the temperature influence on the surrounding environment.

The application discloses a high-efficiency creating method and application of a limited inflorescence retention line and a corresponding sterile line of Brassica napus, and the method comprises the following steps: crossing a Polima CMS sterile line 1658A and a limited inflorescence resource 732 to obtain F1; continuously backcrossing the F1 and an unlimited inflorescence retention line C, performing foreground selection on limited inflorescence genes Bnsdt1 / Bnsdt2 by using a codominant molecular marker in each generation, and reserving a completely sterile single plant BC3F1; giving a low-temperature treatment at a budding stage of the BC3F1 generation to induce trace pollen, continuously backcrossing, and obtaining RBC4F1 and BC4F1; and self-crossing after foreground and background selection is performed again. The application solves the problems of a long period of breeding the limited inflorescence retention line and the sterile line in the prior art, and the problem that breeding of the sterile line must wait for completion of the retention line transformation, and the problem of low efficiency, and a limited inflorescence retention line and a corresponding sterile line of Brassica napus are efficiently created.

The invention relates to the technical field of pharmaceutical engineering and powder, and discloses a low-temperature granulation method and system based on a cut spraying type fluidized bed, and the method comprises the following steps: carrying out low-temperature treatment on inlet air of the fluidized bed through an inlet air pre-cooling module, and controlling the working temperature within-5 DEG C to 25 DEG C; the air inlet temperature and humidity are adjusted in real time through a dynamic temperature compensation algorithm; the low-temperature adhesive is atomized based on an ultrasonic-assisted atomization technology, atomization particle size distribution is optimized, and the coefficient of variation is reduced; parameters in the granulation process are monitored in real time through a multi-parameter coupling model, wherein the parameters comprise the retention rate of active ingredients of materials, the porosity of particles and the fluidization state; and when the monitored parameters deviate from the preset range, optimization strategies such as adjustment of the air inlet temperature, change of the adhesive spraying rate and reconstruction of an atomization model are automatically triggered. According to the invention, the problem of activity loss of the heat-sensitive material in the granulating process is effectively solved, and the granulating efficiency and the product quality stability are improved.

This invention discloses a herbal compound-based hair growth and anti-hair loss conditioning cream and its low-temperature preparation process, relating to the fields of cosmetics and scalp care technology. Specifically, it is a herbal compound-based hair growth and anti-hair loss conditioning cream and its low-temperature preparation process. The conditioning cream contains, by weight, herbal active ingredients such as ginseng, arborvitae leaf, duckweed, soapberry, angelica, chuanxiong, rosemary, ginger, asarum, and mulberry bark, as well as functional and matrix excipients such as sodium hyaluronate, cocoyl glucoside, carbomer 940, phenoxyethanol, and ethylhexylglycerin. Its preparation process employs low-temperature treatment throughout, including low-temperature extraction at room temperature to 50℃ and ultrasonic extraction at 200-800W, as well as low-temperature blending with low-speed stirring at 25-40℃, effectively preserving the active herbal ingredients. This product can improve scalp microcirculation, repair hair follicles, and regulate sebum secretion, suitable for various types of hair loss, while also relieving scalp itching and repairing damaged hair.

The invention discloses a photo-thermal self-healing drug-loaded microneedle patch and a preparation method and application thereof, and belongs to the technical field of transdermal drug delivery. Firstly, an initial needle body is prepared from a synthetic high polymer material, photo-thermal nano-particles and a first solvent, after the initial needle body and a substrate prepared from a curable material are combined and cured, low-temperature treatment is conducted, and a drug-loaded microneedle patch is obtained; the preparation method comprises the following steps: preparing a first solvent and a second solvent, demolding to obtain a preformed micro-needle patch, immersing the preformed micro-needle patch into the second solvent, carrying out solvent replacement on the first solvent and the second solvent, drying to obtain a porous micro-needle patch, dropwise adding a vaccine solution or a drug solution to the surface of a needle body of the porous micro-needle patch, and enabling a vaccine or a drug to enter the needle body in a vacuum-assisted manner to obtain the porous micro-needle patch. And after drying, applying near-infrared light to irradiate, and accelerating the closing of the holes of the needle body based on a photothermal effect to obtain the photothermal self-healing drug-loaded microneedle patch. The invention provides an efficient, stable and controllable novel delivery platform for the fields of vaccine delivery, immunotherapy, transdermal delivery of biological agents and the like.