75 results about "Sulfonylurea" patented technology

The present disclosure relates to herbicidal combinations, compositions and methods for controlling weeds comprising the carbamate herbicide asulam and an additional herbicide selected from the group comprising cyclohexanedione oxime herbicides, pyrimidinylsulfonyhirea herbicides, triazolopyrimidine herbicides, imidazolinone herbicides, alkylazine herbicides, triketone herbicides, N-phenylimide herbicides or chloroacetamide herbicides. Specifically, the additional herbicide may be one of clethodim, chlorimuron, diclosulam, imazamox, imazethapyr, indaziflam, mesotrione, saflufenacil, tiafenacil or S-metolachlor.

The invention discloses a preparation method and application of a sulfonylurea structure thermosensitive color developing agent, and relates to the technical field of color developing agents. The core of the thermosensitive color developing agent is a # imgabs0 # compound in a formula 1 containing a sulfonylurea structure. The preparation method comprises the following three steps: synthesizing an intermediate 1 through esterification of raw materials, obtaining an intermediate 2 through boric acidification, and synthesizing a target compound through Suzuki reaction. Through the synergistic effect of sulfonyl and ureido, hydrogen bond network regulation and electron transfer efficiency optimization are realized, and the technical bottlenecks of high-temperature activation requirements and insufficient color development stability of a traditional thermosensitive color developing agent are solved.

Oil dispersion compositions comprising sulfonylurea-florpyrauxifen-benzyl mixtures, having improved stability, are disclosed.

To provide an adjuvant that can maintain the therapeutic effect while reducing the dose of the SU drugs since sulfonylurea drugs (hereinafter also referred to as "SU drugs"'), which are antidiabetic drugs, induce pancreatic β cell exhaustion when used long-term in addition to the side effects of hypoglycemia and weight gain and have side effects of reduced efficacy (hypoglycemic effect) and renal damage.SOLUTION: If D-allulose is administered before or simultaneously with SU drug administration, the hypoglycemic effect of SU drugs will be enhanced. As a result, the above-mentioned problem is solved because the dose of SU drugs can be significantly reduced. Furthermore, since D-allulose has been eaten by humans, it can provide a highly safe drug when combined with SU drugs.SELECTED DRAWING: Figure 3

The invention discloses a compound and application thereof, and belongs to the technical field of medicinal chemistry. The structure of the compound is shown as a formula I. In the formula I, A ring is selected from C6-C12 aryl or C5-C6 cycloalkyl; r1 and R2 are independently selected from one or more of hydrogen, C1-C10 straight chain or branched chain alkyl, C3-C6 naphthenic base, C1-C10 alkoxy, substituted C1-C10 straight chain or branched chain alkyl, substituted C3-C6 naphthenic base, substituted C1-C10 alkoxy, amino, halogen, nitrile group and nitryl; m and n respectively represent the numbers of R1 and R2, m + n = 5, and m > = 1; l is selected from a thioformamido group, a formamido group, a sulfonyl group, a sulfonamido group, a sulfonylurea group, an ester group or a carbonyl group. The compound is unique and novel in structure, and has relatively strong inhibitory activity and excellent analgesic effect as a TRPV1 inhibitor. # imgabs0 #

The application discloses a sulfonylurea herbicide hydrolytic enzyme TsmE mutant, a coding gene thereof and a use thereof. The amino acid sequence of the mutant is shown in SEQ ID NO. 4. The mutant M6 provided by the application has deesterification activity to macromolecular sulfonylurea herbicides methyldisulfuron and sodium salt of methyl iodosulfuron, and therefore has a good application prospect in sulfonylurea herbicide residual pollution bioremediation and anti-herbicide transgenic engineering.

The present invention discloses a preparation method and application of a sulfonylurea-structured thermosensitive color developer, relating to the technical field of color developers. The core of the thermosensitive color developer is a compound of formula 1 containing a sulfonylurea structure. The preparation method is achieved through three steps: esterification of raw materials to synthesize intermediate 1, borylation to obtain intermediate 2, and then synthesis of the target compound through the Suzuki reaction. Through the synergistic effect of the sulfonyl group and the urea group, the regulation of the hydrogen bond network and the optimization of the electron transfer efficiency are realized, solving the technical bottlenecks of the high-temperature activation requirement and insufficient color development stability of traditional thermosensitive color developers.

The embodiment of the present invention discloses an application of tristyrylphenol polyoxyethylene ether in a sulfonylurea herbicide aqueous suspension. The structural formula of the tristyrylphenol polyoxyethylene ether is as follows: R1-O-(CH2CH2-O) n , wherein R is tristyrylphenyl and n is 15-60. The present invention finds that tristyrylphenol polyoxyethylene ether can not only improve the physical stability of the sulfonylurea herbicide water suspension during storage, but also greatly improve the chemical stability of the sulfonylurea herbicide raw material, which not only keeps the preparation physically and chemically stable during storage, but also prolongs the stability of the sulfonylurea herbicide in a simulated field environment, and has a very broad application prospect.

Disclosed in the present invention are a compound as shown in formula 1, or a tautomer, mesomer, racemate, enantiomer and diastereomer thereof, a mixture form thereof, or a pharmaceutically acceptable salt thereof. The compound has excellent NLRP3 inhibitory activity, and the compound of the present invention lays a new material basis for the development of therapeutic drugs for NLRP3-related diseases.

The present application relates to a preparation method of cyprosulfamide, and the cyprosulfamide is prepared by using a one-pot method, and the method specifically comprises the following steps: adding an organic base, a reaction solvent, 2-chloro-3-(2,2,2-trifluoroethoxy)methyl-4-methylsulfonylbenzoic acid and a Curtius condensing agent into a reaction container, heating and refluxing for 3-5 h to generate an active ester intermediate; after the reaction solution containing the active ester intermediate is cooled, 1,3-cyclohexanedione and acetone cyanohydrin are added to perform a condensation rearrangement reaction, and cyprosulfamide is generated. The one-pot synthesis process is adopted, the use of dimethyl sulfoxide is avoided, compared with a traditional process, the method is green, environmentally friendly, has low safety risks, has high yield and good purity, and is more suitable for industrialized production.

The invention discloses a sulfonylurea structure-containing compound as well as a preparation method and application thereof, and relates to the technical field of preparation and application of medical inhibitor compounds. The structure of the compound containing the sulfonylurea structure is shown in the specification. The preparation method comprises the following three steps: synthesizing an intermediate 1 from raw materials through Suzuki coupling reaction, obtaining an intermediate 2 through Sonogashira coupling reaction, and synthesizing a target compound through Williamson reaction. Through the synergistic effect of sulfonyl and ureido, accurate recognition and efficient embedding of a kinase ATP binding pocket are achieved, and the technical bottlenecks that a traditional c-Met inhibitor is poor in selectivity, drug resistance is likely to be generated and the synthesis process is complex are solved.

The present invention belongs to the field of plant genetic engineering technology and specifically relates to a sulfonylurea herbicide-resistant rapeseed gene, protein, primer set, recombinant expression vector, engineered bacteria, and applications thereof. The sulfonylurea herbicide-resistant rapeseed gene of the present invention comprises one or more of BnALS1m1, BnALS1m2, BnALS3m1, and BnALS3m2; the nucleotide sequences of BnALS1m1, BnALS1m2, BnALS3m1, and BnALS3m2 are shown in SEQ ID NO. 1, SEQ ID NO. 2, SEQ ID NO. 3, and SEQ ID NO. 4, respectively. Transgenic expression of the sulfonylurea herbicide-resistant rapeseed gene of the present invention in crops can improve the crop's tolerance and resistance to sulfonylurea herbicides, thereby assisting in the breeding of new crop varieties with high sulfonylurea herbicide resistance.

The invention discloses a sulfonylurea derivative and application of the sulfonylurea derivative in a thermosensitive color developing agent, and relates to the technical field of color developing agents. The invention discloses a sulfonylurea derivative which is # imgabs0 #. Through the electron donor characteristic of the sulfonylurea group and the synergistic effect of substituent groups (such as tertiary butyl and methoxyl), the color development activation temperature threshold value is greatly reduced, so that a heat-sensitive material realizes rapid color development under lower energy consumption, and the problem of thermal response lag of a traditional color developing agent is effectively solved. The temperature-sensitive color developing agent has the advantages that the performance and the safety are considered in component selection, harmful substances are avoided from the source, meanwhile, the wide activation temperature zone of 60-120 DEG C meets the requirements of diversified temperature-sensitive equipment, and a more reliable and sustainable solution is provided for modern office and data storage.

The invention relates to sulfonylurea derivatives and medical application thereof. Specifically, the invention relates to a sulfonylurea derivative shown in a general formula (I), a preparation method of the sulfonylurea derivative, a pharmaceutical composition containing the sulfonylurea derivative and application of the sulfonylurea derivative in treatment of diseases and symptoms affected by neuronal injury, such as cerebral apoplexy, cerebral injury, neuropathic pain, migraine, inflammatory pain, chronic pain or depression. The definition of each group in the general formula (I) is the same as that in the specification. # imgabs0 #

The present invention relates to a sulfonylurea derivative and medical uses thereof, specifically relating to the sulfonylurea derivative shown in general formula (I), a preparation method thereof, a pharmaceutical composition containing same, and a use of same for treating diseases and disorders affected by neuronal damage, for example: cerebral stroke, brain damage, neuropathic pain, migraines, inflammatory pain, chronic pain, or depression. The definition of each group in the general formula (I) is the same as that in the description.

The invention provides a pharmaceutical composition of a sulfonylurea derivative. Specifically, the present disclosure provides a pharmaceutical composition comprising a compound represented by formula (I) or a pharmaceutically acceptable salt thereof, a stabilizer and a buffer agent. The composition has excellent stability. = = =

The present application relates to a sulfonylurea derivative or a pharmaceutically acceptable salt thereof and a use thereof. In particular, the present application relates to the use of the sulfonylurea derivative or the pharmaceutically acceptable salt thereof as an NLRP3 inflammasome inhibitor, wherein the structure of the sulfonylurea derivative is represented by formula I, wherein the definition of each substituent is detailed in the description.

The invention discloses a herbicide-resistant gene StGSTF8 in sagittaria trifolia and application of the herbicide-resistant gene StGSTF8, and belongs to the technical field of genetic engineering. The bensulfuron methyl resistance gene StGSTF8 (glutathione-S-transferase F8) is identified from sagittaria trifolia for the first time by means of proteomics, molecular biology, transgenic function verification and the like, the nucleotide sequence is as shown in SEQ ID NO: 1, the coded amino acid sequence is as shown in SEQ ID NO: 2, and the nucleotide sequence is as shown in SEQ ID NO: 1. It is proved that the strain endows plants with resistance through mediating herbicide detoxification metabolism and oxidative stress resistance, and reference is provided for improvement of the resistance of plants to sulfonylurea herbicides and research and development of novel herbicides.

The present invention discloses a low-cost rapeseed hybrid seed production method, which relates to the field of utilizing hybrid vigor in Brassica napus. The method comprises: (1) hybridizing an Ogura CMS sterile line as the female parent with a plant containing a sulfonylurea herbicide resistance locus to obtain an Ogura CMS sterile line containing the sulfonylurea herbicide resistance locus; (2) planting the Ogura CMS sterile line containing the sulfonylurea herbicide resistance locus as the female parent and an Ogura CMS restorer line as the male parent in a 5:1 ratio in a seed production field, employing conventional field management methods, and harvesting the Brassica napus seeds when mature; and (3) planting the harvested seeds in a conventional field and spraying the sulfonylurea herbicide at the seedling stage to obtain Brassica napus hybrid seeds of higher purity. The present invention mixes the improved Ogura CMS sterile line with the female sterile restorer line in a seed production field to obtain the first generation of offspring, and sprays herbicides at the seedling stage to obtain rapeseed hybrids with higher purity. This method can greatly reduce the cost of seed production. The present invention also provides an effective method for the reproduction of the restorer line 9538R.

The invention discloses a compound, application thereof and a pharmaceutical composition, and belongs to the technical field of pharmaceutical chemistry. The structure of the compound is shown as a formula (I), a ring A is selected from # imgabs0 # imgabs1 #, R1 and R2 are independently selected from one or more of hydrogen, C1-C20 straight chain or branched chain alkyl, C3-C20 cycloalkyl, C1-C10 alkoxy, substituted C1-C20 straight chain or branched chain alkyl, substituted C3-C20 cycloalkyl, substituted C1-C10 alkoxy, amino, halogen, nitrile group and nitryl; m and n respectively represent the numbers of R1 and R2, m + n = 5, and m > = 1; l is selected from a thioformamido group, a formamido group, a sulfonamido group, a sulfonylurea group, an ester group or a carbonyl group. The compound is unique and novel in structure, and has relatively strong inhibitory activity and excellent analgesic effect as a TRPV1 inhibitor. # imgabs2 #

This invention discloses the application of the WAT1 gene in regulating the absorption and accumulation of sulfonylurea herbicides in plants. The invention found that knocking out the OsWAT1 gene in rice reduces the absorption and accumulation of bensulfuron-methyl, lowers the bensulfuron-methyl content in rice, and increases resistance to bensulfuron-methyl. Rice with the OsWAT1 gene knocked out also developed resistance to ethoxysulfuron and sulfadiazine. Furthermore, knocking out the NtWAT1 homolog of flue-cured tobacco K326, indoor resistance verification experiments showed that the tobacco mutant also acquired bensulfuron-methyl resistance, also achieved by reducing herbicide absorption and accumulation. This indicates that the WAT1 gene plays a role in regulating the absorption and accumulation of sulfonylurea herbicides in plants and can be used to create new plant varieties with resistance to sulfonylurea herbicides.

The present disclosure relates to an agrochemical composition, and in particular, to a herbicidal composition comprising an aniline based herbicide and a pyrimidinylsulfonylurea based herbicide. The disclosure also relates to a method for preparing the herbicidal composition and a method for controlling weeds using the herbicidal composition.

Novel gene repressor systems are provided that are useful in animal cells that include engineered repressors with altered ligand-binding domains (LBDs) and DNA-binding domains (DBDs), as well as mutated operator sequences. In one aspect, the systems enable independent, drug-inducible control of multiple genes within a single animal or animal cell line. In one aspect, the disclosure provides both tetracycline-responsive repressors and sulfonylurea (SU)-responsive repressors — e.g., variants that respond specifically to ethametsulfuron-methyl (Es) or chlorsulfuron (Cs). Mutations are introduced to either the LBD (to alter ligand specificity), DBD (to alter operator binding), or the operator sequence itself, resulting in orthogonal systems.

The present invention relates to aqueous dispersions comprising an ALS inhibitor, typically a sulfonylurea herbicide, specifically from the class of triazolinones herbicides, a HPPD inhibitor, specifically a triketone as from the class of 2-benzoyl-1,3-cyclohexanedione herbicides, optionally a safener from the class of the sulfonamides, a water-soluble herbicide present as a salt, specifically glyphosate and to dispersions resulting from dispersing the concentrate suspension in water, to a method of making the aqueous suspension and to a method of controlling unwanted plants using these dispersions.

This invention belongs to the field of plant genetic engineering and plant stress resistance biotechnology, and discloses... ZmCYP81Q32 Application of genes in improving nicosulfuron resistance in plants. This invention provides... ZmCYP81Q32 The nucleotide sequence of the gene, as shown in SEQ ID NO:1, encodes a cytochrome P450 enzyme that can directly bind to sulfonylurea herbicides and promote their hydroxylation metabolism. This reduces the accumulation of the parent herbicide in the plant, alleviates herbicide-induced growth inhibition, leaf chlorosis, and oxidative damage, and significantly improves plant tolerance to sulfonylurea herbicides, especially enhancing plant resistance to nicosulfuron. This invention can be widely used for crop herbicide resistance improvement, herbicide-tolerant germplasm creation, and related molecular breeding.

This invention relates to a liquid herbicidal composition comprising a non-aqueous solvent system, at least one sulfonylurea herbicide and at least one inorganic or C1-C12 organic lithium salt. The invention also relates to the use of an inorganic or C1-C12 organic lithium salt to improve chemical stabilisation of a sulfonylurea herbicide in a liquid composition comprising a non-aqueous solvent system.

This invention relates to a liquid herbicidal composition comprising a non-aqueous solvent system, at least one sulfonylurea herbicide and at least one inorganic salt selected from the metal carbonates and metal phosphates. The invention also relates to the use of an inorganic salt selected from the metal carbonates and metal phosphates to improve chemical stabilisation of a sulfonylurea herbicide in a liquid composition comprising a non-aqueous solvent system.

The present invention relates to novel heterocyclic compounds of general formula (I), their pharmaceutically acceptable salts, pharmaceutically acceptable solvates, enantiomers, diastereomers and polymorphs. The present invention also relates to methods for preparing the compounds of the present invention, pharmaceutical compositions comprising said compounds, and the use of the compounds of the present invention as NLRP3 modulators belonging to the NOD-like receptor family (NLR) proteins. Accordingly, the present invention relates to novel NLRP3 modulators and to the use of novel inhibitor compounds in the treatment of diseases or disorders involving interleukin-1β activity.

The invention discloses application of a WAT1 gene to regulation of absorption and accumulation of plants to sulfonylurea herbicides. It is found that after the rice OsWAT1 gene is knocked out, absorption and accumulation of the rice to bensulfuron methyl can be reduced, the bensulfuron methyl content in the rice is reduced, the bensulfuron methyl resistance is improved, and the rice with the OsWAT1 gene knocked out also has resistance to ethoxysulfuron and cinosulfuron; after the homologous gene NtWAT1 of the flue-cured tobacco K326 is knocked out, an indoor resistance verification experiment finds that the tobacco mutant also obtains bensulfuron methyl resistance, and the bensulfuron methyl resistance is also realized by reducing the absorption and accumulation of the herbicide, so that the WAT1 gene has the effect of regulating the absorption and accumulation of the plant on the sulfonylurea herbicide; the method can be used for creating new plant varieties with sulfonylurea herbicide resistance.

The invention discloses a BnaALS1 linkage mutant protein based on gene editing, a mutant gene and an application of the BnaALS1 linkage mutant protein and the mutant gene. According to the invention, the BnaALS1 gene is edited by using a gene editing technology, and a germplasm resource with linkage mutation is created, so that the BnaALS1 gene has the characteristics of resisting sulfonylurea and imidazolone herbicides at the same time. The BnaALS1 linked mutant germplasm can effectively solve the problem of inhibition of soil residues on rape growth caused by application of imidazolone herbicides to preceding crops, and can also safely apply sulfonylurea herbicides during the rape planting period for field weed prevention and control.