117 results about "Borylation" patented technology

The invention discloses a nuclear power plant primary loop zinc injection control method, and the method comprises the steps: carrying out sampling detection, determining that the detected primary loop water chemical parameters meet the thermal state function test zinc injection conditions, and preparing a zinc ion solution; monitoring the zinc ion concentration of the primary loop, filling the zinc ion solution and adjusting the adding rate; monitoring is carried out, and zinc injection is stopped when abnormal conditions occur; after passivation timing is finished, zinc injection is stopped before boronizing; the unit commercial operation zinc injection control method comprises the steps that sampling detection is carried out to determine that hydrochemical parameters meet unit commercial operation zinc injection conditions; monitoring the zinc ion concentration of the primary loop, and filling a zinc ion solution; and zinc injection is continued after abnormal conditions are processed, and zinc injection is stopped when the conditions are met. According to the invention, primary side stress corrosion cracking can be relieved, and the external radiation field of the reactor core and the collective dose during unit overhaul can be reduced.

Borylated Amino Acid compositions comprising tyrosine derivatives BTS and BTS(OMe) and novel methods of making BTS and BTS(OMe) are disclosed herein. Consequently, the BTS and / or BTS(OMe) can be scaled up to commercial scale and administered to patients as a Neutron Capture Agent and provide a method of treating cancer, immunological disorders, and other disease by utilizing a Neutron Capture Therapy modality.

The present invention belongs to the technical field of oils for hydraulic supports and provides a biodegradable natural plant-extracted emulsified oil for hydraulic supports and a preparation method thereof. First, through multi-step chemical modification of palm oil, including epoxidation, boronation, phosphating, and block polymerization, the epoxidation reaction introduces epoxy groups, increasing the reactivity of the oil; the boronation and phosphating reactions further enhance the polarity of the oil and its ability to form a lubricating film; and through block polymerization with caprolactone, the stability and wear resistance of the lubricating film are enhanced. Second, through carboxymethylation of chitosan, the carboxyl groups in the carboxymethyl chitosan react with oxides on the metal surface to form a chemical passivation protective film; and the sulfonic acid groups in the sodium lignosulfonate bind to the metal surface through electrostatic adsorption, further forming a protective layer. The synergistic effect of the two forms a multi-layer dense protective film on the metal surface, significantly improving the anti-corrosion performance of the emulsified oil.

The invention discloses a high-performance clean type anti-wear hydraulic oil complexing agent which is prepared from the following substances in parts by mass: 30 to 60 parts of an antioxidant, 20 to 40 parts of an anti-wear agent, 2 to 5 parts of boronized polyisobutylene bis-succinimide, 2 to 7 parts of thiocarbamate, 4 to 10 parts of dodecenylsuccinic acid and 0.2 to 2 parts of graphene nanosheets. The lubricating oil is prepared from the following components in parts by weight: 0.5-1.5 parts of a metal deactivator, 0-2 parts of DISUPER S24 and 30-50 parts of base oil. The preparation method comprises the following steps: S21, heating the base oil, adding the boronized polyisobutylene bis-succinimide and the thiocarbamate, and stirring; s22, sequentially adding an antioxidant, an anti-wear agent, dodecenylsuccinic acid, DISUPER S24 and a metal deactivator into the solution obtained in the step S11, heating to 80 DEG C, and reacting for 2 hours; and S23, adding graphene nanosheets into the solution obtained in the step S22, and carrying out ultrasonic dispersion for 1 hour to obtain the product.

The invention provides a boron-doped nickel-molybdenum hydrogen evolution electrode and a preparation method thereof, and relates to the field of electrolytic hydrogen production. The electrode is a boron-doped nickel-molybdenum catalyst (NiMoB) which takes a nickel net as a conductive substrate and grows on a nickel metal net framework in situ; the preparation method comprises the following steps: firstly, carrying out hydrothermal reaction in a mixed solution of nickel salt, molybdenum salt and a pH buffer agent, growing nickel-molybdenum oxide (NiMoO4) on a nickel net conductive substrate in situ, and then reducing and boronizing the nickel-molybdenum oxide through boron and hydrogen substances decomposed from a boron-containing small molecular compound under a high-temperature condition to form the multi-element NiMoB hydrogen evolution catalyst. According to the method, a large number of high-activity hydrogen evolution sites are exposed after the nickel-molybdenum oxide is subjected to the reduction replacement process, and the defect-rich and high-activity boron-doped nickel-molybdenum hydrogen evolution electrode is formed and can be applied to the field of hydrogen production.

This invention relates to a method of reducing abnormal combustion events in a hydrogen fueled internal combustion engine (HICE) during operation of the engine. The method includes the steps of: a) providing to the HICE a lubricating oil composition including or resulting from the admixing of: i) a base oil having a KV100 of less than or equal to 12 cSt and included at greater than 50 wt.% of the composition and comprising a Group I base oil, a Group II base oil, a Group III base oil, a Group IV base oil, or combinations thereof; ii) at least one borated polyisobutylene succinimide (PIBSA-PAM) dispersant at from 0.25 wt.% to 8.0 wt.% of the composition to deliver from 30 to 1000 ppm by weight of total boron to the composition, wherein the borated PIBSA-PAM dispersant is selected from the group consisting of lower molecular weight PIBSA-PAM dispersant (Mn less than 1600 g / mol), higher molecular weight PIBSA-PAM dispersant (Mn 1600 g / mol or more), and combinations thereof; iii) at least one overbased metal containing detergent with a Total Base Number (KOH / g) greater than or equal to 9 and less than or equal to 500 and included at a treat level to deliver between 100 to 5000 ppm by weight of total metal and between 0.15 wt. % to 8.0 wt. % of total soap to the composition; and iv) the lubricating oil composition having a total sulfated ash of less than or equal to 2.5 wt.%, a total phosphorous level of less than or equal to 0.120 wt.%, and a SAE viscosity grade of 25W-X, 20W-X, 15W-X, 10W-X, 5W-X or 0W-X, where X represents any one of 8, 12, 16, 20, 30, 40, 50 or 60; b) providing a fuel comprising hydrogen to the HICE; and c) combusting the fuel in the HICE. Also provided are lubricating oil compositions and concentrates for use in a HICE to reduce the propensity for abnormal combustion events.

Disclosed herein are boronated amino acid compositions comprising tyrosine derivatives TC220 and TC221 and improved methods of making TC220 and TC221. Thus, the TC220 and / or TC221 can be expanded to commercial scale and administered to patients as neutron trapping agents, and methods of treating cancer, immune disorders, and other diseases by utilizing a neutron capture therapy pattern are provided.

The invention discloses a carbazole derivative embedded with a boron-nitrogen unit, a synthesis method and application. The synthesis method comprises the following steps: respectively carrying out nucleophilic substitution reaction on a raw material 1 or 6 and 4-bromo-1-butene, and separating and purifying to obtain a corresponding intermediate 2 or 7; further adding the intermediate 7, reduced iron powder and ammonium chloride into a solvent for reduction reaction, and quenching, separating and purifying to obtain an intermediate 8; respectively adding the intermediate 2 or 8 and a boronizing reagent into a solvent to carry out electrophilic boronizing reaction, and separating and purifying to obtain a corresponding intermediate 3 or 9; respectively adding the intermediate 3 or 9 and a Grubbs catalyst into a solvent for olefin metathesis reaction, and separating and purifying to obtain a corresponding intermediate 4 or 10; the intermediate 4 or 10, a dehydrogenation reagent and a sacrificial reagent are added into a solvent for an oxidative dehydrogenation reaction, separation and purification are performed to obtain a corresponding compound 5 or 11, and the carbazole derivative embedded with the boron-nitrogen unit has good fluorescence and can be efficiently applied to the fields of OLED and OPD.

The present invention discloses a preparation method and application of a sulfonylurea-structured thermosensitive color developer, relating to the technical field of color developers. The core of the thermosensitive color developer is a compound of formula 1 containing a sulfonylurea structure. The preparation method is achieved through three steps: esterification of raw materials to synthesize intermediate 1, borylation to obtain intermediate 2, and then synthesis of the target compound through the Suzuki reaction. Through the synergistic effect of the sulfonyl group and the urea group, the regulation of the hydrogen bond network and the optimization of the electron transfer efficiency are realized, solving the technical bottlenecks of the high-temperature activation requirement and insufficient color development stability of traditional thermosensitive color developers.

Provided is the synthesis of 17 novel neutral sp2-sp3 diboron compounds. Diboron reagents are widely utilized as borylation agents for the incorporation of the boron moiety into organic molecules. The incorporation of boron into organic molecules has significant implications in biomedicine and material science. Boron-containing compounds are pivotal in drug design and the creation of novel materials with enhanced properties. The neutral sp2-sp3 diboron compounds are unsymmetrical diborylation agents. These reagents are expected to facilitate the exploration of novel borylation methodologies and potential synthetic applications.

The invention discloses a composite catalyst for preparing acrylic acid through selective oxidation of propylene and a preparation method of the composite catalyst, and relates to the technical field of acrylic acid synthesis, and the preparation method of the catalyst comprises the following steps: (1) fully mixing pseudo-boehmite, aluminum hydroxide, a magnesium compound, a reinforcing agent and a pore forming agent to form a mixture, adding nitric acid into the mixture, forming a wet gel blank with plasticity; drying, grinding and sieving the wet gel blank, and then carrying out segmented calcination and nitric acid treatment to obtain a magnesium aluminate spinel carrier; and (2) preparing a salt solution from metal salts containing Mo, V, Cu, Ni, Ce and La, adding ammonia water to prepare a complexing solution, loading the metal in the slurry onto a carrier by a ball milling method, carrying out surface boronizing treatment, drying, and calcining to obtain the active catalyst. The prepared catalyst has good acrylic acid selectivity in one-step propylene oxidation preparation of acrylic acid, and also has very high mechanical strength and better stability.

This application discloses a method for offline analysis of powder ionization conditions, comprising the following steps: placing a silicon wafer on a target plate of a plasma device; generating a plasma beam under preset powder ionization conditions using the plasma device; injecting powder into the plasma device so that the plasma beam bombards the powder until powder injection is complete; detecting whether a first condition and a second condition are met, wherein the first condition includes at least 70% of the powder injected into the plasma device ablation and brightening upon bombardment by the plasma beam and / or forming a coating on the silicon wafer; the second condition includes the coating containing chemical bonds formed by elements of the powder and / or detecting spectral lines generated by ionization of the powder upon bombardment by the plasma beam. If the first and second conditions are met, the powder is determined to be effectively ionized. Otherwise, the powder is determined to be ineffectively ionized. The method of this application can obtain basic research data on the boronization of boron powder.

The invention discloses a preparation method of a vanadium-nickel boride nanoparticle electro-catalysis material, and belongs to the technical field of nano material electro-catalysis. Carbon black is used as an auxiliary source, sodium borohydride is used as a reducing agent, a nickel and vanadium mixed salt solution is adopted, precursor powder containing nickel, vanadium and boron is obtained through a one-step reduction method, then calcination treatment is conducted at a certain temperature to obtain NiVB2 / C, the morphology of the catalyst is regulated and controlled by controlling the molar ratio of sodium borohydride to metal salt and the calcination temperature, and the nano-particles NiVB2 / C are obtained. The production process is simple and controllable, the cost is low, the catalytic activity of the hydrogen evolution reaction is greatly improved, and the excellent electro-catalytic performance is achieved.

The invention discloses 2-phenyl-4-pinacol boryl-2, 1-boron aza-naphthalene, a 2-phenyl-4-pyrimidinyl-2, 1-boron aza-naphthalene compound and a preparation method of the 2-phenyl-4-pinacol boryl-2, 1-boron aza-naphthalene compound, and belongs to the technical field of organic synthetic chemistry. According to the preparation method, 2-phenyl-4-pinacolboryl-2, 1-boronaphthalene and bis (pinacol) diboron diboron ester are taken as raw materials, CuCl is taken as a catalyst, 4, 5-bis (diphenylphosphine)-9, 9-dimethyl xanthene is taken as a ligand, 2-adamantanone is taken as an additive, p-xylene is taken as a solvent, and the 2-phenyl-4-pinacolboryl-2, 1-boronaphthalene is efficiently obtained. The 2-phenyl-4-pyrimidinyl-2, 1-boron aza-naphthalene compound can be used as a key intermediate, the 2-phenyl-4-pyrimidinyl-2, 1-boron aza-naphthalene compound can be conveniently synthesized through efficient conversion of a C-B bond, and a new way is provided for functional modification of the boron-nitrogen heterocyclic compound.

The present invention discloses a method for synthesizing 2-bromo-6-hydroxybenzaldehyde, belonging to the field of fine chemical technology. 2,6-dibromobenzaldehyde is used as the raw material, first protected by the aldehyde group, then borated and oxidized with hydrogen peroxide to produce 2-bromo-6-hydroxybenzaldehyde. This method has a short process, high yield, and mild reaction conditions, avoiding the harsh reaction conditions of literature methods, has potential technical advantages, and is suitable for industrial scale-up production.

The invention discloses a preparation method of 2-bromo-4-chloro-3-fluorotoluene, and belongs to the technical field of medical intermediates. The preparation method comprises the following steps: brominating 4-chlorotoluene serving as a raw material; carrying out deprotonation / boronation reaction by adopting a lithiation reagent to obtain corresponding boric acid; converting into amino under the catalysis of copper salt; and finally, carrying out diazotization and fluorination reaction to generate the 2-bromo-4-chloro-3-fluorotoluene. In the method, all the raw materials can be conveniently purchased on the market, and each step of reaction is simple and convenient in process, high in yield and easy for industrial production.

To provide new and improved methods of treating cancer, immune disorders, and other diseases utilizing borylated amino acids and neutron capture therapy (NCT).SOLUTION: Disclosed herein are borylated amino acid ("BAA") compositions and methods of making BAAs. Accordingly, BAAs can be administered to patients as neutron capture agents and can provide methods of treating cancer, immune disorders, and other diseases by utilizing neutron capture therapy modalities. The invention described herein relates to the field of boron neutron capture therapy (BNCT). In particular, the present invention relates to borylated amino acid ("BAA") or ("BAAs") compositions that can be used as a vehicle for neutron capture therapy in humans. The invention further relates to the treatment of cancer and other immune disorders and diseases.SELECTED DRAWING: None

The present disclosure provides solid-state electrolytes based on a borylated-polymers (e.g., borylated-polybutadiene). Further provided are kits comprising, methods of synthesizing, and methods of using the solid-state electrolytes. In some aspects, the solid-state electrolytes demonstrate high ion conductivity at room temperature.

The invention discloses a method for preparing benzyl borate compounds through chromium catalysis, and belongs to the technical field of organic synthesis. According to the method, aryl carboxylic ester is taken as a raw material, pinacolborane is taken as a boron source and a hydrogen source, metal chromium salt is taken as a catalyst, a specific ligand and elemental magnesium are added, and reaction is performed in a tetrahydrofuran solvent, so that the deoxidation boronization reaction of the aryl carboxylic ester is realized. Benzyl monoborate or benzyl subunit diborate can be selectively prepared through ligand regulation and control. The method has the advantages of mild reaction conditions, cheap catalyst, wide raw material source, simple operation and good chemical selectivity.

The invention discloses a method for synthesizing aromatic borate through selective boronation of an aromatic compound, which comprises the following steps: (1) adding a boron reagent A into an organic solvent, and reacting under the action of organic strong alkali to obtain an active boron species and carbon negative ion intermediate reaction liquid; and (2) adding an aromatic compound Ar-X into the reaction liquid in the step (1), and carrying out boronation reaction to obtain the aromatic borate product. The method disclosed by the invention is mild in condition, simple to operate, free of transition metal participation and wide in substrate application range, and has wide research value and industrial application prospect.

The invention belongs to the field of medicine synthesis, and particularly relates to a preparation method of 3-hydroxy-4-fluorobenzoate. According to the preparation method disclosed by the invention, 3-bromo-4-fluorobenzaldehyde is taken as an initial raw material, and the compound 3-hydroxy-4-fluorobenzoate is prepared through four steps of reactions including aldolization, boronation, oxidation and esterification. The 3-hydroxy-4-fluorobenzoate can be used for preparing the acomidid or an intermediate 3-(3-(3, 5-dimethyl-1H-pyrazol-4-yl) propoxy)-4-fluorobenzoate of the acomidid, and the 3-(3, 5-dimethyl-1H-pyrazol-4-yl) propoxy)-4-fluorobenzoate can be used for preparing the acomidid. The preparation method has the advantages of easily available raw materials, mild reaction conditions, simple operation, high yield and purity, and suitableness for industrial production.

The invention discloses a method for modifying polypeptide with decarboxylated boric acid and trifluoroboric acid, which comprises the following steps: under a solid phase condition, carrying out active esterification reaction on polypeptide I under a condition (i) to prepare active esterified polypeptide II; then reacting the active esterified polypeptide II with a boric acid source under the action of a condition (ii) to form a borated polypeptide III; finally, under the condition (iii), the boric acid polypeptide III is subjected to fluorination treatment, and the trifluoroborate polypeptide IV is obtained. According to the method disclosed by the invention, decarboxylation and boric acid acidification of glutamic acid or aspartic acid residues in a polypeptide chain can be specifically realized, and controllable introduction of a trifluoroboric acid group is further completed.

The invention discloses a cerium-based photosensitizer, a preparation method and application of the cerium-based photosensitizer in photocatalytic reaction, and relates to the technical field of coordination chemistry and photocatalysis. The general formula of the cerium-based photosensitizer is Ce (L1) 3 (L2) m, and L1 comprises a strong field anion ligand of at least one strong electron withdrawing group or a strong field anion ligand of a rigid structure; l2 is a neutral nitrogen-containing heterocyclic ligand, and m is 0 or 1. According to the invention, strong visible light absorption and long excited state life can be achieved by introducing L1, and the Ce < + > / Ce < 4 + > oxidation potential can be reduced to a mild range, so that the Ce < 4 + > intermediate can be efficiently reduced by a mild reducing agent generated in the reaction, and simple catalytic circulation without an external reinforced reducing agent is realized. When being applied to boronation reaction of various alkenyl / aryl / heteroaryl halides and various organic boron reagents, the photosensitizer shows high catalytic activity (the yield is as high as 91%), the performance is superior to that of a noble metal photosensitizer, but the cost is remarkably reduced, and the photosensitizer is environment-friendly.

The invention relates to the field of medicines, in particular to a preparation method of an elastase inhibitor compound. The preparation method comprises the step of reacting a compound 10 in the presence of a boronizing reagent, an acidifying reagent and a reaction solvent to obtain the elastase inhibitor compound as shown in the formula (I). The method is environment-friendly, simple and convenient to operate, efficient, mild in reaction condition, easy to control the operation, safe, reliable, low in cost and good in economic benefit. Meanwhile, the preparation method is high in reaction yield, the obtained product is high in purity, and the preparation method is suitable for industrial production. # imgabs0 #

The invention discloses polyimine and polyamine containing an alkyl main chain and a preparation method of the polyimine and the polyamine, and belongs to the technical field of synthesis of high polymer materials. The preparation method comprises the following steps: firstly, reacting N, N '-diboryl diamine generated after boronizing alkyl diamine with organic dialdehyde under proper conditions to synthesize polyimine containing an alkyl main chain; and secondly, carrying out hydrogenation reduction reaction on the polyimine containing the alkyl main chain prepared in the first step under proper conditions to obtain polyamine. The method is used for solving the technical problems that an existing polyamine synthesis technology is limited by toxic monomers (such as ethyleneimine) and an alkyl-containing main chain structure cannot be synthesized by a traditional process, so that industrialization is difficult and varieties are scarce.

The invention belongs to the technical field of deuterated organic chemical synthesis, and particularly relates to a synthesis method of deuterated 9-phenyl anthraceneboronic acid-D8, which comprises the following steps of: 1, halogenation reaction: reacting 9-phenyl anthracene-D9, bromo-succinimide (NBS) and triethylamine (TEA) in dichloromethane at low temperature to generate an intermediate 9-phenyl-10-bromoanthracene-D8; step 2, carrying out nucleophilic reaction of forming carbon negative by pulling out bromine with strong in a low-temperature environment of-65 DEG C to-70 DEG C, reacting n-butyllithium with the intermediate 9-phenyl-10-bromoanthracene-D8 in 2-methyltetrahydrofuran to generate 9-phenyl anthracene lithium; then triisopropyl borate is added for a boronation reaction, and the 9-phenyl anthracene boric acid-D8 is obtained after hydrochloric acid hydrolysis and purification. The purity of the deuterated 9-phenyl anthracene boric acid-D8 is greater than or equal to 99.8%, the deuteration rate is greater than or equal to 98%, and the deuterated 9-phenyl anthracene boric acid-D8 is suitable for being used as

The present invention provides a diesel engine oil composition comprising an organophosphorus compound, a boronated polyisobutylene succinimide dispersant, an amine antioxidant, a detergent, a zinc dialkyl dithiophosphate, a viscosity index improver, and a major amount of a lubricating base oil. The organophosphorus compound has a structure as shown in Formula (I): #imgabs0# In Formula (I), at least one A group is selected from the group represented by Formula (II), the group represented by Formula (III), or the group represented by Formula (IV); #imgabs1# where the definitions of each group are as described in the specification. The diesel engine oil composition of the present invention exhibits excellent high-temperature antioxidant properties, high-temperature detergency, anti-wear properties, and anti-corrosion properties, meeting the requirements of high-performance diesel engine lubricants.

The present invention discloses a method for preparing a reinforcing agent composition for hydraulic transmission oil, comprising the following steps: 1. stirring dioctylamine, isopropyl alcohol, and sodium hydroxide, and adding disulfur dichloride under stirring; allowing the mixture to stand to separate the water layer; washing the oil layer with dilute hydrochloric acid and water until neutral; removing water, and then adding sulfuryl chloride with stirring to obtain a mixture A; 2. reacting the mixture A with 2,3-dihydro-2,2-dimethyl-7-benzofuranyl-methyl-N-ylcarbamate, adding an aqueous ammonia solution to the reaction; allowing the mixture to stand to separate the water layers; desolvating the oil layer under reduced pressure; and adding a base oil, heating, and stirring to obtain a mixture B; and 3. stirring the mixture B with a boronized dispersant to obtain a reinforcing agent composition. When added to hydraulic transmission oil, the reinforcing agent composition imparts excellent friction durability to the hydraulic transmission oil.

The invention provides a production method of 4-10B-boric acid-L-phenylalanine with high boron atom utilization rate, which comprises the following steps: A, adding strong base and a Turbo Grignard reagent into a 4-halogenated-phenylalanine derivative for reaction, and then adding glycol ester borane for continuous reaction to obtain a 4-boryl-phenylalanine derivative; and B, carrying out acidic hydrolysis on the 4-boryl-phenylalanine derivative, so as to obtain the 4-10B-boric acid-L-phenylalanine. The boron element is introduced into phenylalanine molecules through halogen-metal exchange and electrophilic substitution reaction, wherein the reagent combination of the Turbo Grignard reagent and the glycol ester borane ensures the efficient proceeding of the boronylation process. The production method disclosed by the invention is mild in reaction condition and simple to operate, has high-level comprehensive yield and 10B boron atom utilization rate, and provides a new way for realizing low-cost commercial production of 10B-BPA.

The present invention belongs to the field of wastewater treatment, and provides a method for efficiently catalyzing peracetic acid with an iron boride-based material to treat pollutants, and the operation is as follows: micron-sized zero-valent iron boride and peracetic acid are added to the wastewater containing organic pollutants, and the wastewater is treated under stirring conditions; during the wastewater treatment process, the micron-sized zero-valent iron boride catalytically activates peracetic acid to generate hydroxyl radicals, organic radicals CH<subgt;3< / subgt;C(O)O· and CH<subgt;3< / subgt> C(O)OO· to degrade the organic pollutants in the wastewater; after the treatment of a batch of wastewater is completed, the micron-sized zero-valent iron boride is recovered for the treatment of the next batch of wastewater; the micron-sized zero-valent iron boride is obtained by fully ball-milling a boron precursor and micron-sized zero-valent iron, and the boron precursor is at least one of boron oxide and boric acid. The present invention enriches the types of iron-based materials that can efficiently catalytically activate PAA to generate ROS to degrade pollutants, can improve the recyclability of iron-based materials and reduce the wastewater treatment cost.