7 results about "Pinacol" patented technology

The application discloses a preparation method of baricitinib, and belongs to the technical field of drug synthesis. The method comprises the following steps: firstly, 2-[1-(ethylsulfonyl)-3-azetidinyl]acetonitrile and 4-pyrazole boron pinacol ester are subjected to a Michael addition reaction to obtain 1-(ethylsulfonyl)-3-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]-3-azetidine acetonitrile as an intermediate I; secondly, a protection group is introduced on the amino group of 4-chloropyrrolopyrimidine to obtain an intermediate II; finally, the intermediate I and the intermediate II are subjected to a Suzuki coupling process by adopting a method of combining a nickel pre-catalyst with a supporting ligand to obtain the baricitinib. The preparation method creatively realizes cross coupling of the baricitinib by adopting the cheap metal nickel as a catalyst, avoids the use of a heavy metal palladium catalyst, and has the advantages of low cost, low toxicity, small pollution, green environmental protection and the like.

This invention provides a method for the catalytic hydroboration of nitrile compounds, belonging to the field of nitrile reduction technology. The method uses nitrile compounds as substrates, molybdenum hexacarbonyl as a catalyst, and pinacolborane as a hydrogen source, with the hydroboration reaction occurring at 78-82°C for 7.5-8.5 h. The reaction utilizes molybdenum hexacarbonyl as a catalyst, which is simple and readily available, requiring no complex synthesis. Furthermore, the reaction process does not require the participation of ligands. Using pinacolborane as a hydrogen source eliminates the need for strictly nitrogen-protected experimental conditions, enabling the hydroboration of nitriles. The substrate applicability is broad, applicable not only to aromatic nitriles but also to aliphatic nitriles and even some dinitriles. The reaction process does not require solvents, making it environmentally friendly. The corresponding hydroboration product is obtained directly after the reaction without further purification, and the reaction yield is high, ranging from 84-100%.

This invention discloses a neuraminidase-ROS dual-responsive nanocarrier, its preparation method, and its applications. The raw materials for the nanocarrier include 4-hydroxyphenylboronic acid pinacol ester, N,N'-carbonyldiimidazole, and polysialic acid; the molar ratio of 4-hydroxyphenylboronic acid pinacol ester to N,N'-carbonyldiimidazole is 1:1~3, and the mass ratio of 4-hydroxyphenylboronic acid pinacol ester to polysialic acid is 1:0.1~1. The neuraminidase-ROS dual-responsive nanocarrier of this invention not only efficiently delivers antibacterial and anti-inflammatory drugs, but the carrier itself can also actively regulate the pathological microenvironment (such as scavenging reactive oxygen species), thereby achieving multiple synergistic therapies and improving the overall efficacy against complex bacterial infections.

The present invention relates to a novel additive, and to a non-aqueous liquid electrolyte and a gel-type or solid polymer electrolyte containing same. More specifically, the present invention relates to a novel additive and a non-aqueous liquid electrolyte and a gel-type or solid polymer electrolyte containing same, the novel additive comprising a siloxane compound that includes an amine group substituted with an electron-withdrawing functional group, or an isocyanate group, a boronate pinacol ester group, a butylate group, a hexanoate group, a heptanoate group, a cyclohexanopropionate group, and a diethyl phosphate group, and improving electrochemical stability, thermal stability, flame retardancy, and cycle life of an alkali metal battery to which the additive is added.

The application discloses a preparation method of a metal catalyst catalyzed synthesis of 3-boronate aniline, and relates to the field of organic synthesis. The specific reaction steps are as follows: under the condition of inert gas protection, imine (I) and pinacol diboron are used as raw materials, mixed with a certain amount of metal catalyst and ligand, reacted in an organic solvent, and then hydrolyzed with saturated ammonium chloride aqueous solution. After the reaction is completed, the 3-boronate aniline compound shown in structural formula (II) is obtained through the following steps: extracting three times with ethyl acetate, combining the organic phase and removing the solvent under reduced pressure, column chromatography separation and purification. The reaction of the chemical preparation method provided by the application can be carried out under normal pressure and at medium temperature, the operation is simple, the reaction condition is mild, the process condition is stable, the product is easy to purify, the production cost is low, the method is easy to realize in a standard organic synthesis laboratory, the reproducibility is good, and the method is suitable for industrial large-scale production.

This invention belongs to the technical field of electrochemistry, specifically relating to an electrolyte functional additive, an electrolyte, and a lithium-ion battery. It provides a fluorinated phenyl borate ester additive—3,5-difluorophenylboronic acid pinacol ester—which solves the problem of interfacial instability of lithium cobalt oxide under high voltage. It has a low oxidation potential and can preferentially oxidize and decompose on the positive electrode surface under high voltage, forming a robust, uniform, and thin CEI film rich in B-F bonds, B-O bonds, and fluorinated phenyl groups. This film has a low binding energy to lithium ions, which facilitates rapid lithium ion migration, thereby improving the rate performance and low-temperature performance of the pouch battery. 3,5-difluorophenylboronic acid pinacol ester can effectively capture fluorine in the electrolyte. ‑ This additive forms products containing B-F bonds in situ, significantly reducing the corrosion of the cathode material by HF and inhibiting cobalt leaching. With the added benefit of this additive, the cycle performance, rate performance, high-voltage resistance, and low-temperature performance of the graphite-cobalt oxide lithium-ion pouch cell are all improved.

This invention relates to the field of anti-oxidation coating technology for graphite molds, and discloses an anti-oxidation composite coating and its application in 3D hot-bending graphite molds. The composite coating is a zirconium-boron reinforced SiO2 coating, which is prepared by grafting 4-vinylphenylboronic acid pinacol ester onto ethoxy-containing hydrogen Zr-POSS via hydrosilylation reaction to obtain borate pinacol esterified ethoxy-Zr-POSS, and anchoring it onto the surface of a graphite mold containing hydroxyl functional groups via zirconium ethoxy-hydroxy condensation reaction to obtain a functionalized graphite mold. Using the dip-coating method and the in-situ composite sol-gel method, a zirconium-boron reinforced SiO2 gel is generated on the surface of the graphite mold, and then a zirconium-boron reinforced SiO2 coating is formed through a programmed heat treatment process. This coating integrates ZrO2 phase transformation toughening, B2O3 high-temperature flow self-healing, and SiO2 dense barrier, exhibiting excellent high-temperature oxidation resistance and crack self-healing performance.