131 results about "Chiral induction" patented technology

The invention discloses a preparation method and purpose of chiral light-controlled reduction-state molybdenum oxide nanometer particles having the purpose of targeting optothermal therapy of tumor cells. On the basis of molybdenum trioxide as mother liquid, a chiral enhanced double-channel oxygen-deletion molybdenum oxide nanometer material is innovatively obtained through a chiral induction effect; and through comparing variables of dosage of organic molecules, a combination manner and the like, an optothermal therapy reagent based on a chiral molybdenum oxide nanometer material is developed. The operating method is simple and convenient, and raw materials are cheap and easy to obtain. A chiral semiconductor nanometer material has highly chiral absorption on circular polarization visiblelight laser and near-infrared laser, and can generate high temperature to reach the optothermal therapy effects. A thinking is widened for the application of chiral nanometer materials to the optothermal therapy of the tumors, and the optothermal therapy cost of the cancer can be reduced.

The invention relates to a beta-naphthyl methyl substituted spiral bisoxazoline ligand, a synthetic method and an application. The ligand has the advantages of simple synthetic method, mild conditionand applicability for industrialization production. The ligand has a spiral framework and a feature of a plurality of chiral centers, therefore the ligand has high catalytic activity and chiral induction effect and strong adjustment capacity in an asymmetric catalytic reaction of transition metals. Pyrrolidine derivants with various optical activities are prepared through high region selectivity and high enantioselectivity from allenoic and o-iodoaniline by the catalysis of the ligand. With the important biological activity, the pyrrolidine derivant has a better prospect of industry and medicine applications.

The invention relates to a chiral silicon dioxide fiber-reinforced foamed polypropylene composite material which comprises a polypropylene resin, talcum powder, a chiral silicon dioxide fiber, a surfactant solution, a micro-pore foaming agent and a phase-change material microcapsule and an aid, wherein the surfactant solution is a linear sodium alkyl benzene sulfonate solution. Due to adoption ofthe chiral silicon dioxide fiber, the mechanical properties of the material can be improved; the chiral silicon dioxide fiber has chiral induction under the action of hydrogen bonds among molecules, orientation of polypropylene molecular chain fragments can be reduced, the polypropylene molecular chain fragments can be regularly arranged, and thus the mechanical properties of a polypropylene injection molding finished product can be improved; meanwhile, due to a chiral spiral structure of the chiral silicon dioxide fiber, and through chiral spiral induction on polypropylene, winding of molecular chains can be intensified, and the mechanical properties of the polypropylene injection molding finished product can be further improved; and due to adoption of the chiral silicon dioxide fiber, mechanical properties of a polypropylene material and an injection molding part thereof can be effectively improved.

The invention belongs to the technical field of green pesticides, and discloses a novel method for synthesizing (R)-cacopsylla pyricola sex pheromone. The method comprises the steps: by taking n-tetradecanoic acid 1 as an initial raw material, firstly reacting with oxalyl chloride to generate n-tetradecanoyl chloride, and then reacting with (R)-4-benzyl-2-oxazolidinone to generate oxazolidinone amide 2; reacting with CH3I in the presence of NaHMDS to generate oxazolidinone amide 3 with one or more methyl groups, and reducing the oxazolidinone amide 3 into chiral alcohol 4 through sodium borohydride; carrying out bromination, and reacting with PPh3 to generate quaternary phosphonium salt 6; and finally carrying out Wittig reaction and catalytic hydrogenation to prepare the (R)-cacopsylla pyricola sex pheromone, namely (R)-13-methylheptacosanoic acid. The chiral methyl is constructed by using an Evans chiral induction method, and the method has the advantages of simple synthetic route, mild reaction conditions, easiness in amplification and the like.

The invention relates to a method of synthesizing (S)-3-(4-bromophenyl)-piperidine or salt thereof with chiral induction. Particularly, the method comprises the following steps of by taking methyl ortho-4-bromophenylacetate and (S)-(-)-2-methyl-2-propanesulfinamide as starting materials, sequentially performing reactions including condensation, replacement, reduction, ring closure, removal of chiral induced groups and the like, and the (S)-3-(4-bromophenyl)-piperidine or the salt thereof can be obtained, wherein after the reduction reaction, a high-purity single diastereoisomer can be obtainedwith recrystallization; and after the ring closure reaction, a high-purity single diastereoisomer can be further obtained with recrystallization. The method provided by the invention has the advantages of cheap and available raw material, simple operation, high yield, and low cost and is suitable for industrial production.

The invention belongs to the technical field of chemical pharmacy, and relates to a synthetic method of (R)-2-(2, 5-difluorophenyl)pyrrolidine. The synthesis method comprises the following steps: (1) carrying out dehydration condensation reaction on a compound as shown in a formula 1 and a chiral induction reagent (R) tert-butylsulfinamide to obtain a compound as shown in a formula 2; (2) carrying out addition reaction on the compound in the formula 2 and a Grignard reagent to obtain a compound in a formula 3; (3) carrying out a reduction / cyclization reaction on the compound shown in the formula 3, trifluoroacetic acid and triethylsilane to obtain a compound shown in a formula 4; (4) splitting the compound shown in the formula 4 by (D)-malic acid to obtain the (R)-2-(2, 5-difluorophenyl) pyrrolidine*D malate compound with EE being greater than 98% shown in the formula 5; and (5) dissociating the compound in the formula 5 with a sodium hydroxide solution to obtain (R)-2-(2, 5-difluorophenyl) pyrrolidine. By utilizing the synthetic method of (R)-2-(2,5-difluorophenyl)pyrrolidine, the cost is low, the optical purity is high, the subsequent separation process is simplified, the raw materials are easy to obtain, the process conditions are mild, and the synthetic method is suitable for synthesizing (R)-2-(2, 5-difluorophenyl) pyrrolidine in large-scale production.

A chiral binaphthol and chiral ligand adopting the chiral binaphthol as a framework show good chiral induction capability in unsymmetrical catalysis and obtain high enantioselectivity in a plurality of catalytic reactions. A membrane reactor can recycle homogeneous phase catalysts, and for expensige homogeneous phase chiral catalysts, recycling the chiral catalysts has more important values. The invention discloses a chiral compound 6,6'-2 carbazole base binaphthol derived from binaphthol with large molecular dimensions, and the 6,6'-2 carbazole base binaphthol is hopeful for being used as the chiral ligand of the membrane reactor. Chiral 6, 6'-2 carbazole base binaphthol is obtained by synthetizing 6,6'-carbazole base binaphthol, carbazole, palladium and alkali at a next step. The chiral compound can serve as the chiral ligand and used for unsymmetrical catalytic addition reaction of aryl acetylene and aromatic aldehyde.

The invention relates to an organic high molecular compound, in particular to a method for preparing optically active poly(alkyl-aryl) silane. As the traditional method for synthesizing optically active poly(alkyl-aryl) silane is extremely limited, the invention provides a novel method for preparing optically active poly(alkyl-aryl) silane. Polysilane which is not optically active is used as a raw material in an organic solvent A, alkyl lithium is a reactant, chiral diamine is used as a chiral inductor, and saturated ammonium chloride is used for quenching reaction to prepare the optically active poly(alkyl-aryl) silane. The preparing method has the advantages of convenience for operation and low cost.

The invention relates to alkoxy ether thermosensitive chiral polymer nano-microspheres and a preparation method thereof. The nano-microspheres are prepared by carrying out copolymerization reaction on alkoxy ether dendronized macromonomer with chiral induction primitive and p-alkynyl benzaldehyde to obtain a copolymer, and cross-linking the copolymer by using adipic dihydrazide as a cross-linking agent to form the alkoxy ether chiral polymer nano-microspheres, wherein the mol ratio of the aldehyde group in the copolymer to the cross-linking agent is 2:1. The nano-microspheres have good dispersibility in water solution and excellent thermosensitive behavior, and by adjusting temperature, concentration and molecular weight, chiral nano-microspheres with different particle sizes can be prepared. Simultaneously, compared with variable helical conformation of copolymers, the conformation of the obtained nano-microspheres is stable and single. The nano-microspheres are constructed by cross-linking a dynamic bond with a thermosensitive polymer, chiral transference of the chiral induction primitive provides a theoretical basis, and the nano-microspheres are of important significance in fields of realizing selectivity, identification or function control of some protein and amino acid, medicine release, envelop and the like.

The invention discloses a making method chiral amine protonic acid salt with general formula as III and IV, which comprises the following steps: dissolving chiral amine with imidazole sulfide structure as general formula I or II in the organic solvent; adding the solution of protonic acid HY into chiral amine solution; stirring to react completely; removing solvent; obtaining the product as chiral agent, catalyst and chiral material or ionic liquid.

The invention discloses a chiral small organic molecule catalyst loaded by heteropoly acid and the preparation and the application thereof. Chiral small organic molecule catalyst A is loaded on heteropoly acid POM through acid and alkali ion pairs, and the catalyst can be represented as n(POM), wherein n can be 3, 4 or 6. The invention creatively provides a small organic molecule catalyst loadmode, i.e. noncovalent load mode, the chiral small organic molecule and the solid heteropoly acid are adopted to form an organic-inorganic macromolecule catalyst assembly through acid-base effect, the small organic molecule in the assembly acts as the active and chiral induction center of the catalyst, the heteropoly acid is not only the carrier of the catalyst, but also the indispensable important component of the catalyst. The loaded catalyst has the advantages of simple preparation, biphasic catalysis property, high activity and good selectivity of homogencous catalyst, and conveniently realized recovery and cyclic utilization.