28 results about "Chiral induction" patented technology

Provided are a chiral metal oxide-based water electrolysis electrode, a method for manufacturing same, and a water electrolysis device comprising same. The chiral metal oxide-based water electrolysis electrode includes an L-type or D-type chiral metal oxide disposed on a substrate, and the chiral metal oxide may have chirality-induced spin selectivity. Therefore, when the chiral metal oxide-based water electrolysis electrode is used in a water electrolysis electrode and a water electrolysis device including same, spin polarization can be controlled without an additional external magnetic field, and the efficiency of the electrode and the device can be improved.

Provided are a chiral metal oxide-based anion exchange membrane water electrolysis device and a manufacturing method therefor. The chiral metal oxide-based anion exchange membrane water electrolysis device includes an L-type or D-type chiral metal oxide, which may possess chirality-induced spin selectivity, and thus, when used in a water electrolysis device including same, spin polarization may be controlled without an additional external magnetic field, and the efficiency of an electrode and the device may be improved.

The present application relates to a kind of chiral imide group covalent organic framework material and its preparation method, belong to covalent organic framework material technical field.The chiral imide group covalent organic framework material of the present application is with imide bond as connecting unit, with higher thermal stability and chemical stability, and the precise construction of framework chirality is realized by chiral induction strategy, to give material clear chiral characteristics, with important application potential in chiral recognition, chiral separation and asymmetric catalysis etc.;Its preparation is with R / S-tetrahydrofuran-2-methyl acid as chiral inducer, isoquinoline as catalyst, imidazole as reaction medium, and imide bond connecting type covalent organic framework material with crystallinity and significant chiral signal can be prepared by solvothermal reaction.

Disclosed in the present invention are a chiral azobenzene polymer crosslinked thin film and preparation method therefor and application thereof. The present invention relates to a novel super-molecular chiral construction and chiral immobilization method based on an achiral side chain type azobenzene polymer thin film. According to the present invention, limonene steam is utilized to perform chiral induction on a polymer thin film at a high temperature, and then formaldehyde steam is utilized to perform acetal reaction with hydroxyl in an acidic environment to achieve crosslinking; and then differences in the stability of the super-molecular chirality of the polymer thin film before and after crosslinking is studied under the conditions of light, heat and good solvent dissolution, and the self-repairing properties of microcosmic helical chirality is researched. The crosslinked thin film prepared by the present invention has good chiral properties, and excellent solvent resistance, heat resistance, and self-repairing properties.

The invention discloses a chiral spiral gold nanorod with {111} crystal face oriented growth and a preparation method of the chiral spiral gold nanorod, and belongs to the technical field of nano materials. According to the chiral spiral gold nanorod, a single-surface gold nanorod is prepared to serve as a gold seed, then a chiral inducer is used for regulating and controlling parameters such as the proportion and concentration of a growth solution and the adding amount of a gold seed solution, and thermodynamics and dynamics of nanogold growth are regulated and controlled so as to promote formation of a spiral chiral structure and reduce generation of impurities; and finally, centrifugally purifying to obtain a high-purity product. The obtained chiral spiral gold nanorod is uniform in size and stable in chiral signal, the surface plasma resonance wavelength can be simply adjusted within the range of 700-900 nm, and the technical problems that in traditional chiral plasma nanostructure preparation, efficiency is low, the structure is unstable, and nanoscale size control is difficult to achieve are solved. The method has wide application value in the fields of chiral sensing, chiral asymmetric catalysis, plasma nano antennas and the like.

The application discloses a preparation method of a metalized chiral COF and application of the metalized chiral COF in electrochemical circular polarization light detection, and the preparation method of the metalized chiral COF comprises the following steps: taking 1,3,5-triformylphloroglucinol, trimethylaniline, a chiral inducer and 2,2'-bipyridine-5,5'-diamine as raw materials, and synthesizing a chiral COF through a solvothermal reaction; then, a coordination reaction is carried out with a metal salt in an alcohol solvent to obtain a metalized chiral COF material; the metalized chiral COF material is used as a photoanode material, spin polarization induced by circular polarization light (CPL) is coupled with a spin-selective oxygen evolution reaction (OER), and a nonlinear characteristic of OER reaction kinetics is used to amplify a micro-spin signal; the material has excellent photoelectric current anisotropy factor (g Iph ) and stability, and solves the problem of low sensitivity of an existing solid-state CPL detector.

The invention relates to the technical field of medicine synthesis, in particular to a synthesis method of remegapam. According to the method, a compound G1 (2-bromo-3-pyridylaldehyde) is taken as a starting raw material, key steps of Suzuki coupling, condensation, asymmetric cross coupling and the like are carried out, traditional chiral resolution is avoided through asymmetric synthesis and chiral induction strategies, and finally, a target product is prepared. The process route is short, the total yield is high, the atom economy is good, and the cost is low.

This invention belongs to the field of chromatographic separation materials technology, specifically relating to an amphiphilic carboxylated covalent organic framework composite stationary phase based on a chiral induction strategy and its application in chromatography. The stationary phase uses amino silica gel as a carrier and (R)-1-(1-naphthyl)ethylamine as a chiral inducer. The carboxylated functionalized covalent organic framework generated by the reaction of 2,4,6-tricarboxymethyl phloroglucinol with 4,4-diaminobiphenyl-2,2-dicarboxylic acid is in situ immobilized on the amino silica gel surface. The resulting stationary phase possesses both hydrophilic carboxyl groups and a hydrophobic aromatic skeleton, enabling the separation of hydrophobic and polar compounds in both reversed-phase and hydrophilic chromatographic modes, exhibiting excellent shape selectivity for isomers. This stationary phase features high column efficiency (up to 47,744 columns / meter), low column pressure, and good stability, making it suitable for the efficient separation of polar to nonpolar compounds in complex samples.

The invention discloses a cellulose nanocrystal composite circular polarization phosphorescent material processing device, and relates to the technical field of material processing equipment, the cellulose nanocrystal composite circular polarization phosphorescent material processing device comprises a bottom plate, the top of the bottom plate is provided with a mixing tank; according to the processing device for the cellulose nanocrystal composite circularly polarized phosphorescent material, by arranging the adjustable magnetic intensity monitoring orientation mechanism, precise closed-loop regulation and control of a magnetic field are realized, the oriented magnetic field can guide phosphorescent molecules to be orderly arranged along with a spiral structure of a CNC (Computer Numerical Control) matrix, and the performance of the circularly polarized phosphorescent material of a composite system is improved; the problems that in the processing process of an existing cellulose nanocrystal composite circularly polarized phosphorescent material, a targeted orientation regulation and control part is lacked, phosphorescent molecules are difficult to realize ordered arrangement along with spiral orientation of a CNC matrix, but random dispersion, local agglomeration or disordered orientation occurs, and further, the chiral induction effect of CNC cannot be fully utilized, so that the phosphorescent molecules are difficult to be arranged in order, and the production cost is low are solved. The circular polarization response synergism of phosphorescent molecules in a composite system is insufficient, and the CPL performance is relatively low.

This invention discloses an N-N axial chiral phase-transfer catalyst, its synthesis method, and its applications, belonging to the field of asymmetric catalytic synthesis technology. Using chiral 2,4-pentanediol and N-Boc-indolephenol as starting materials, this invention efficiently constructs an N-N axial chiral biscarbazole cyclic ether skeleton through a five-step reaction involving Mitsunobu etherification, deBoc protection, PIDA oxidative cyclization, radical bromoxymethylation, and intramolecular quaternization. This method eliminates the need for complex chiral resolution and noble metal coupling, employs mild reaction conditions, uses readily available and inexpensive starting materials, achieves high overall yield, and yields a product with an axial chirality ee value ≥98%. The resulting catalyst possesses excellent conformational rigidity, chiral induction ability, and phase-transfer performance, exhibiting broad substrate applicability. It also possesses bisindole ring bioactivity, making it widely applicable in asymmetric catalytic synthesis in pharmaceuticals, fine chemicals, and other fields, and providing new directions for the development of antibacterial and antitumor biomaterials.

The application discloses a chiral induction self-adaptive MOF@COF heterojunction and a large-scale preparation method and photocatalytic application thereof, and belongs to the technical fields of coordination polymers and photocatalysis. The application adopts a room-temperature step-by-step assembly combined with an emulsion polymerization method, first prepares MOF-808 from zirconium chloride and trimesic acid, then obtains MOF-D by chiral grafting of D-cysteine, and finally induces directional epitaxial growth of TpPa-COF to form a core-shell heterojunction, and a product of 130g can be produced in a single time. The heterojunction has multi-scale self-adaptive and spin regulation functions, the flexible side chain of D-cysteine optimizes charge transmission, spin regulation filters single spin state electrons, and significantly reduces the carrier recombination rate. The heterojunction is used for outdoor sunlight-driven photocatalytic overall water splitting, and the H2 production reaches 1058.64 micromoles per gram per 4 hours ‑1 , the activity retention rate is excellent after multiple tests, and the performance is far superior to that of a physical mixture of MOF-D and TpPa-COF.

The invention provides a synthesis method of (1R, 2S)-2, 6-dimethyl-2, 3-dihydro-1H-indene-1-amine, which comprises the following steps: reacting xylene with S-2-bromo-methyl propionate to generate a chiral ester intermediate, carrying out ring closing reaction to generate (2s)-2, 6-dimethyl-1-indanone, and directly generating (1R, 2S)-2, 6-dimethyl-2, 3-dihydro-1H-indene-1-amine through chiral induced reduction by utilizing the steric hindrance of chiral methyl, thereby obtaining the (1R, 2S)-2, 6-dimethyl-2, 3-dihydro-1H-indene-1-amine. According to the present invention, the 2, 3-dihydro-1H-indene-1-amine is synthesized through the method, the method is the chiral intermediate preparation process with characteristics of high selectivity and high directionality starting from the initial raw material, the use of the expensive heavy metal chiral catalyst is avoided, the reaction is simplified, and the method is the synthesis method with characteristics of economy, safety and easy expanded production.

This invention belongs to the field of polarized light-emitting materials technology, specifically relating to chiral perovskite thin films, their preparation methods, and circularly polarized light-emitting diode devices. The invention uses phenylalanine hydrochloride as a raw material, mixing phenylalanine hydrochloride solution and tetrafluoroborate solution to undergo an ion exchange reaction, forming a chiral compound with tetrafluoroborate as the anion and phenylalanine as the cation, thus obtaining a pseudohalogenated chiral ligand. Using an antisolvent, the pseudohalogenated chiral ligand is introduced into the perovskite precursor solution, forming a chiral perovskite thin film at the perovskite interface. This allows for the effective injection of spin-polarized charge carriers through chiral-induced spin selectivity, resulting in recombination within the device and the generation of circularly polarized light emission.

This invention discloses chiral gold nanoflowers, their preparation method, and applications. The method includes the following steps: S1, preparing a growth solution; adding deionized water, chloroauric acid aqueous solution, and ascorbic acid aqueous solution to a hexadecyltrimethylammonium bromide aqueous solution and mixing to obtain a growth solution; S2, introducing chiral molecules; injecting chiral molecules L-cysteine ​​or D-cysteine ​​into the growth solution and mixing to obtain a chiral induced growth system; S3, seed-induced growth; adding a gold nanorod solution to the chiral induced growth system and mixing; allowing the reaction to stand, and growing to obtain crude chiral gold nanoflowers. The preparation method uses gold nanorods as seed crystals, and the excessive growth of gold nanoflowers is induced in situ by chiral cysteine ​​molecules. The reaction conditions are mild, the operation is simple and easy to control, the product exhibits significant chiral characteristics, and high reproducibility. Chiral gold nanostructures can expand applications in catalysis, biosensing, chiral recognition, optical devices, and other fields, showing good application prospects and practical application value.

The invention discloses a chiral transition metal hydroxide spin catalyst as well as a preparation method and application thereof, and belongs to the technical field of inorganic non-metal energy materials. The preparation method comprises the following steps: dissolving a transition metal element source and a chiral inducer in deionized water, stirring, and slowly adding alkali liquor to adjust the pH value, so as to obtain steeping liquor; and immersing the pretreated carrier into the impregnation liquid, carrying out a hydrothermal reaction, cooling to room temperature, taking out the carrier, washing with deionized water and absolute ethyl alcohol in sequence, and drying to obtain the chiral transition metal hydroxide spin catalyst. The invention also provides application of the chiral transition metal hydroxide spin catalyst as an electrode material in electrocatalytic oxygen evolution reaction. The chiral transition metal hydroxide spin catalyst provided by the invention has excellent spin selectivity and high electro-catalytic oxygen evolution activity, and has great significance for developing an efficient water electrolysis hydrogen production catalyst and improving the clean energy conversion efficiency.

The invention discloses a dioxythiophene polymer, a composition, a chiral film and a preparation method thereof. The dioxythiophene polymer has a specific chemical structure. The dioxythiophene polymer and a specific chiral inducer form a composition, the composition is prepared into a film, and the film is annealed to obtain the chiral film with strong circular dichroism signals. According to the present invention, the efficient conversion from the achiral conjugated polymer to the long-range ordered chiral material is achieved through the simple post-doping and annealing process, the method is simple and convenient, the chiral regulation effect is significant, and the important value is provided in the circularly polarized light related application field.

This invention relates to the chiral resolution and scale-up of molecular materials. The invention utilizes the reaction of racemic 1-(4-bromophenylethylaminomethylphosphonic acid) (Rac-BrpempH2) with transition metal Ni2+ ions. Through a solvothermal reaction, the spontaneous resolution of racemic organophosphonic acid molecules is achieved via the molecular isomerism effect of the co-solvent butanol and the coordination-driven synergistic effect of the metal ions. Furthermore, the introduction of chiral amino acid molecules successfully induces the resolution and chiral scale-up of single chiral organophosphonic acid molecules. The advantages of this invention are that by controlling reaction conditions and introducing chiral inducers, a single macroscopic helical structure material can be successfully synthesized from racemic ligands, providing a new strategy for chiral resolution and opening new avenues for designing and constructing chiral coordination polymers with helical morphology.

The invention provides a liquid crystal polarizing body grating and a preparation method thereof, and relates to the technical field of liquid crystal optical element preparation, and the preparation method of the liquid crystal polarizing body grating depends on the photo-orientation polarization holographic technology of a 405nm wavelength laser, takes a single-layer glass substrate as a carrier, and adopts a single-layer glass substrate as a substrate. The double-sided polarizer grating structure with opposite chirality and matched parameters is accurately prepared according to the process of double-sided coating of a light alignment agent, fractional laser exposure and fractional coating and curing of liquid crystal. The polarization body grating layers with opposite inherent chiral induction directions and matched grating parameters are accurately prepared on the front face and the back face of the single-layer glass substrate, the preparation technology is remarkably simplified, the production cost is reduced, the structural stability and the optical performance of a product are effectively improved, and meanwhile the thickness and the weight of the optical waveguide module are greatly reduced.

The invention provides a nickel-doped chiral cobalt oxide catalyst, the chemical formula is L-Co (3-x) NixO4, and the preparation method comprises the following steps: mixing and stirring a reducing agent, L-cysteine, sodium citrate, cobalt chloride, nickel chloride and water, adding isopropanol, and standing to obtain the nickel-doped chiral cobalt oxide catalyst. The invention also provides a composite photo-anode for photoelectrochemical water decomposition, which comprises a BiVO4 photo-anode and a nickel-doped chiral cobalt oxide catalyst, the nickel-doped chiral cobalt oxide catalyst is loaded on the surface of the BiVO4 photo-anode, and the composite photo-anode is obtained by mixing the L-Co (3-x) NixO4 dispersion liquid and the BiVO4 photo-anode and carrying out heat treatment on the L-Co (3-x) NixO4 dispersion liquid and the BiVO4 photo-anode. The invention also provides a photoelectrochemical water decomposition device comprising the composite photo-anode. Spin selective charge transfer can be realized through a chiral induced spin selection effect, a reaction energy barrier is reduced, an OER path is optimized, the problems of high overpotential and low photocurrent density in the prior art are solved, H2O2 by-products can be inhibited, the stability is high, an external magnetic field is not needed, and a new thought is provided for photoelectrochemical water decomposition.

The application provides synthesis of a chiral diphosphine ligand and catalytic application thereof. The synthesis method is as follows: 2,3-diphenylphosphineoxy-1,3-butadiene and a Grignard reagent are subjected to an addition reaction to obtain a racemic phosphine oxide intermediate, then a chiral phosphine oxide intermediate is obtained by using a chemical resolution method, and finally a chiral diphosphine ligand is obtained by silicon hydrogen reduction; the chiral diphosphine ligand is obtained by using the above method. The application can realize asymmetric hydrogenation of neral, geranial and the like, and obtain a chiral product with high stereoselectivity. The synthesis method is novel, the synthesis route is short, the chiral diphosphine ligand is obtained through three steps, the overall yield of the route is high, and the operation is convenient. The diphosphine ligand obtained by the method has a good chiral induction effect, and compared with known methods, the stereoselectivity of asymmetric hydrogenation of neral, geranial and the like is improved.

Chiral rare-earth complexes constructed with bipyridine oxazoline ligands, their preparation, and applications belong to the field of circularly polarized luminescence technology. The selected bipyridine oxazoline ligand, through a C2-symmetric tetradentate coordination mode, interacts with Dy... 3+ The efficient chelation of rare-earth ions can precisely and efficiently transfer the chiral information carried by the chiral carbon on the oxazoline ring to the rare-earth coordination center, breaking the inherent centrosymmetry of rare-earth ions. This allows the originally optically inert rare-earth center to generate a significant and stable chiral optical response, providing an ideal ligand platform for constructing chiral rare-earth complexes. This chiral induction process is highly efficient and structurally controllable, effectively avoiding the problems of weak chiral transfer and disordered complex configurations associated with traditional ligands. These ligands have great potential applications in the field of circularly polarized luminescent materials. The bipyridine unit can exert an antenna effect to sensitize the characteristic luminescence of rare-earth elements, and, in conjunction with a chiral microenvironment, achieve circularly polarized luminescence with a high luminescence asymmetry factor.

The invention relates to the field of electrocatalysis, in particular to preparation of a chiral induced spin polarization catalyst L / D-MnO2 / RuOx and application of the chiral induced spin polarization catalyst to water electrolysis. MnSO4.H2O and a chiral inducer L / D-serine are complexed and then react with ammonium persulfate to synthesize chiral manganese dioxide nanorods (L / D-MnO2), and then Ru metal is loaded on the nanorods through an impregnation method to obtain the chiral induced spin polarization catalyst (L / D-MnO2 / RuOx). The L / D-MnO2 / RuOx catalyst with the chiral characteristic has good selectivity on electrons in different spin states, electrons in a specific spin direction can be polarized to efficiently pass through, a reaction energy barrier is greatly reduced, and the water electrolysis catalytic performance of the catalyst is remarkably improved.

The invention belongs to the field of synthetic chemistry and biological medicine, and particularly relates to a difluoromethyl modified chiral diamine derivative as well as a synthetic method and application thereof. The difluoromethyl modified chiral diamine derivative is obtained by taking p-toluenesulfonyl difluoromethyl diazomethane, aromatic amine, organic aldehyde and electron-rich aromatic hydrocarbon as raw materials and taking chiral phosphoric acid as a chiral inducer and an organic reagent as a solvent through a one-step reaction under the catalysis of transition metal. According to the difluoromethyl modified chiral diamine derivative and the synthesis method, the raw materials are cheap and easy to obtain, safe and non-toxic, the reaction condition is mild, the operation is simple and safe, and the synthesized difluoromethyl modified chiral diamine derivative has good anti-tumor activity and has huge development potential in the field of drug research and development.

The invention belongs to the technical field of biopesticides, and discloses a method for asymmetrically synthesizing sex pheromone of beeswax borers. The method comprises the following steps: by taking (R)-epoxypropane (2) as a raw material, firstly, reacting the (R)-epoxypropane (2) with pent-4-alkenyl magnesium bromide (3) to prepare (R)-octyl-7-ene-2-alcohol (4); then carrying out THP protection and NaIO4 oxidation synthesis to obtain (R)-6-[(tetrahydro-2H-pyran-2-yl) oxy] heptanoic acid (6); then introducing a chiral methyl group by utilizing a chiral induction strategy to prepare oxazolidinone imide 9; then, carrying out NaBH4 reductive cracking, Dess-Martin oxidation and Wittig reaction, so as to obtain THP protected dienol 12; and finally, carrying out deprotection and Pd / C catalytic hydrogenation to prepare the sex pheromone (2R, 6R, 10R)-6, 10, 14-trimethylpentadecan-2-ol (1) of the beewax borers. The method has the advantages of high total yield, simple synthetic route and the like.

The invention relates to a chiral polyamide ligand based on a Salen skeleton as well as a preparation method and application of the chiral polyamide ligand. According to the ligand, two amino groups are introduced into a Salen skeleton ligand monomer, so that the Salen skeleton ligand monomer can be subjected to condensation reaction with diacyl chloride, and a ligand polymer connected by an amido bond is constructed; in the preparation method, chiral catalytic active sites are embedded into a polyamide main chain in a solution polycondensation manner to prepare the novel functional polymer catalyst. The ligand polymer obtained by the invention has a chiral induction effect and the stability and recoverability of a high polymer material; in addition, molecular oxygen (O2) is used as a green oxidizing agent, use of CHP in the prior art is avoided, and environmental pollution is reduced.

The invention discloses a 3-position polysubstituted chiral oxindole derivative as well as a synthesis method and application thereof. According to the synthesis method of the 3-position polysubstituted chiral oxoindole derivative, organic alcohol, isatin diazo and allyl carbonate are used as raw materials, chiral phosphoric acid is used as a chiral inducer, an organic reagent is used as a solvent, and the chiral oxoindole derivative is obtained through a one-step reaction under the catalysis of palladium-rhodium bimetal. The raw materials are cheap, easy to obtain, safe and non-toxic, the reaction conditions of the synthesis method are mild, the operation is simple and safe, and the synthesized 3-position polysubstituted chiral oxindole derivative can be widely applied to the fields of organic synthesis and drug research and development.

The invention belongs to the field of synthetic chemistry and biological medicine, and mainly discloses a difluoromethyl modified polysubstituted chiral tetrahydroquinoline derivative as well as a synthetic method and application thereof. The difluoromethyl modified polysubstituted chiral tetrahydroquinoline derivative is obtained by taking p-toluenesulfonyl difluoromethyl diazomethane, aromatic amine and organic aldehyde as raw materials and taking chiral phosphoric acid as a chiral inducer and an organic reagent as a solvent through a one-step reaction under the catalysis of metal iron. The raw materials are cheap, easy to obtain, safe and non-toxic, the reaction condition of the synthesis method is mild, the operation is simple and safe, and the synthesized difluoromethyl modified polysubstituted chiral tetrahydroquinoline derivative has excellent anti-tumor activity and has bright application prospects in the field of drug research and development.

The invention provides a chiral inorganic bismuth oxyhalide material and a preparation method thereof, and the chiral inorganic bismuth oxyhalide material is finally prepared by carrying out hydrothermal reaction on achiral Bi4O5Br2 nanosheets, Yb2O3, Er2O3 and a chiral inducer and annealing. The chiral inorganic bismuth oxyhalide material prepared by the invention has an intrinsic chiral structure and a strong CD signal, can directly generate circularly polarized light, and does not need an additional polarization device. By regulating and controlling the pH value and the concentration of the chiral agent, controllable regulation of chiral signals and luminescence performance can be realized, and the preparation method is simple, controllable in condition and suitable for batch preparation and morphology regulation and control.