Chiral 6, 6'-2 carbazole base binaphthol

Abstract

A chiral binaphthol and chiral ligand adopting the chiral binaphthol as a framework show good chiral induction capability in unsymmetrical catalysis and obtain high enantioselectivity in a plurality of catalytic reactions. A membrane reactor can recycle homogeneous phase catalysts, and for expensige homogeneous phase chiral catalysts, recycling the chiral catalysts has more important values. The invention discloses a chiral compound 6,6'-2 carbazole base binaphthol derived from binaphthol with large molecular dimensions, and the 6,6'-2 carbazole base binaphthol is hopeful for being used as the chiral ligand of the membrane reactor. Chiral 6, 6'-2 carbazole base binaphthol is obtained by synthetizing 6,6'-carbazole base binaphthol, carbazole, palladium and alkali at a next step. The chiral compound can serve as the chiral ligand and used for unsymmetrical catalytic addition reaction of aryl acetylene and aromatic aldehyde.

Description

Technical field [0001] The patent involves the research field of organic synthesis, hand synthesis, and fine chemicals. Specifically, it is from hand 6,6' -dietine phenol and pagazole synthesis 6,6' -two pagazoleBackenol. Background technique [0002] Lianxinphenol is a molecular skeleton with good hand -induced capabilities.Lianxinol itself is a good hand ligand, which is used for a variety of asymmetric catalytic reactions.Double 衍 ligand BinaP ( Acc. Chem. Res. 1990, 23, 345 －350 ;; Chirrality inde. 1992, 313-323), nitrogen gyrus ligand Map (2 -amino -2' -two phenyl -based cymbal -1,1' -couplet, J. org. Chem. 1998, 63, 7738-7748), Monophos (US 6989461 B2) and so on. [0003] Membrane separation technology and membrane reactor are important technologies to promote green production, which are generally valued by scientists from various countries.The essence of the nanofilled membrane reactor circulation is used, which is due to the "screen" effect of the membrane, so that the p...

AI Technical Summary

Problems solved by technology

However, the molecule mentioned in the patent does not involve chirality, and there is no research work on the synthesis and characterization of the molecule, and there is no characterization of the possible chiral parameters such as the optical rotation of the molecule. Therefore, the patent The reported 6,6'-dicarbazolyl binaphthol can only be counted as racemate

In addition, the compound mentioned in the patent has no synthetic procedures and no relevant characterization data, so, in fact, the molecule has never existed

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