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53 results about "Dibenzylideneacetone" patented technology
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Dibenzylideneacetone or dibenzalacetone, often abbreviated dba, is an organic compound with the formula C₁₇H₁₄O. It is a pale-yellow solid insoluble in water, but soluble in ethanol. Dibenzylideneacetone is used as a component in sunscreens and as a ligand in organometallic chemistry.
A novel process for the preparation of a drug lumacaftor intermediate
ActiveCN117700356BOrganic chemistryOrganic-compounds/hydrides/coordination-complexes catalystsBenzoic acidBenzylideneacetone
The application discloses a new method for preparing a lumacaftor intermediate. The method uses 5-bromo-6-chloropyridin-2-amine as a starting material, methyl boronic acid, palladium acetate and a ligand L1 to obtain a methylation product. Then, the methylation product is subjected to a Suzuki coupling reaction with m-tert-butoxycarbonyl phenyl boronic acid under the catalysis of tris(dibenzylideneacetone)dipalladium and a ligand L2 to synthesize 3-(6-amino-3-methylpyridin-2-yl)benzoic acid tert-butyl ester. The method can synthesize 3-(6-amino-3-methylpyridin-2-yl)benzoic acid tert-butyl ester at a high yield, and the method uses a small amount of catalyst, has mild reaction conditions and is easy to separate, so that the method is beneficial to industrial implementation and application promotion.
Owner:INNER MONGOLIA UNIVERSITY