166results about How to "Process reaction conditions are mild" patented technology

The invention provides a chitosan grafted copolymer flocculation-bactericide for treating water bodies such as circulating cooling water, papermaking sewage, printing and dyeing sewage, domestic sewage, drilling fluid and the like. The bactericide is a compound agent which can kill the plankton such as viruses, bacteria, algae and the like in the water body and settles along with the colloid and suspended particles in the water body. The bactericide provided by the invention is prepared by graft copolymerization of chitosan and dimethyl diallyl ammonium salt and acrylamide triggered under the nitrogen protection.

The invention provides a 2,4-diamine-1,3,5-triazine compound represented as the formula (III). A preparation method includes the following steps: adding compounds represented as the formulas (I) and (II), a metal copper catalyst, a ligand, an alkaline substance and a solvent into a reaction container, stirring the reactants to perform a reaction at 80-140 DEG C for 6-14 h and performing after treatment to the reaction liquid to obtain the compound (III). The preparation method has mild reaction conditions and convenient operations, is low in cost and has wide industrial application prospect. The 2,4-diamine-1,3,5-triazine compound has certain antibacterial activity and can be used for preparing antibacterial medicines and agents, lays fundament for screening and developing new medicines and has great practical value.

The invention provides a preparation method of an s-triazine compound shown in formula (III). The preparation method comprises steps as follows: an alcohol compound shown in formula (I), biguanide hydrochloride shown in formula (II), a metal ruthenium catalyst and an alkaline matter are added to a solvent and subjected to a stirring reaction at 80-130 DEG C for 10-18 h, and then the s-triazine compound shown in formula (III) is obtained after post-treatment of a reaction liquid. The preparation method is convenient to operate and low in cost and has wide industrial application prospect, the reaction condition is mild, and raw materials are easy to obtain.

The invention relates to polycarbonate polyurethane and a green preparation method thereof. The polycarbonate polyurethane comprises polyurethane structural units and aliphatic polycarbonate structural units which are irregularly distributed. The polycarbonate polyurethane is successfully prepared by a nonisocyanate method, so that isocyanate and solvents are not used, and the development requirements of green chemical industry are met. In addition, the green preparation method of the polycarbonate polyurethane is relatively mild in reaction condition and low in requirement on devices; by selecting raw materials with different structures, the polycarbonate polyurethane having different linear structures and comprising two irregularly distributed structural units can be prepared, so that the structures are diverse and controllable; the prepared polycarbonate polyurethane is free of residue of isocyanate monomers, so that the application of polycarbonate polyurethane to the fields of foods and medicines is broadened.

The invention provides an imidazole-triazine type compound which is shown as the formula 3 in the description and a preparation method and application thereof. The method comprises the steps that a triazine compound and an alpha,beta-unsaturated ketone type compound are mixed and added into a solvent, under the existence of a metal copper catalyst and an oxidizing material, the mixed solution is stirred and reacts 5-20 hours under the temperature of 60-150 DEG C, after the reaction is finished, the reacted solution is subjected to post processing, and the imidazole-triazine type compound which is shown as the formula 3 is obtained; the metal copper catalyst is halogenide of the copper or a copper salt; the oxidizing material is a halogen elementary substance. The imidazole-triazine type compound can be applied to prepare antibacterial drugs or antibacterial agents, and the preferred antibacterial drugs are the drugs which inhibit activity of escherichia coli.

The invention discloses an environment-friendly method for metronidazole synthesis. Formic acid is replaced with acetic acid, alcohol is added for esterification, neutralization is performed for three times, sodium sulfate and ethylene glycol are recovered, a nitration product is effectively recovered from a metronidazole mother solution, derivatives such as acetic ester, anhydrous sodium sulfate and the like are obtained, by-products such as ethylene glycol and the like are chemical raw materials with wide applications, resources are recycled, the raw materials are greatly saved, the production cost is reduced, and the whole novel process adopts simple steps and is convenient to operate.

The method for preparing lithium carbonate from lepidolite comprises the following steps: take lepidolite (100-500 mesh), add 98% concentrated sulfuric acid in a mass ratio of 1: [0.8-3], stir, and dry step by step to obtain clinker , and crush the clinker into 100-500 mesh, add water to soak, stir, and boil to obtain a mixed solution; centrifuge the mixed solution while it is hot to obtain mother liquor A, cool the mother liquor A in a reaction vessel to 20-80°C, and crystallize Rubidium cesium alum is extracted, and then centrifuged to obtain mother liquor B; the mother liquor B is cooled to -30~20°C in the reaction vessel, potassium alum is crystallized, and then centrifuged to obtain mother liquor C; mother liquor C is neutralized with lye to the pH value After centrifugation, the mother liquor D is obtained, and then the mother liquor D is evaporated and concentrated, and then filtered to obtain the mother liquor E; the mother liquor E is mixed with potassium carbonate or sodium carbonate solution, heated to 80-100°C, and completed under stirring. That is, the crude product of lithium carbonate is prepared, and the crude product is centrifuged, washed and dried to obtain the finished battery grade lithium carbonate. The invention improves the leaching rate of lithium, saves raw materials, generates less slag, and lowers requirements on equipment.

The invention discloses a method for purifying chlorine-containing wastewater discharged during zinc hydrometallurgy. The process comprises the following steps: controlling flow of oxygen or air by a mass flow meter; feeding into an ozone generator after measurement; converting some oxygen into ozone under action of a high-pressure and high-frequency electric field by a discharge tube in the ozone generator; combining the generated ozone with unionized gas to form a mixed gas; uniformly dispersing the mixed gas by a gas distributor, then performing contact reaction on the mixed gas and chlorine-containing wastewater having a certain temperature so as to complete dechlorination; and feeding a tail gas into the ozone generator again after absorbing chlorine by lye so as to realize circulation. The method provided by the invention is mild in reaction condition, high in dechlorination rate, and low in cost due to the regenerated manganese oxide can be returned to a zinc hydrometallurgy system.

The invention discloses a preparation method of high-purity vortioxetine hydrobromide. The method comprises the following steps: firstly, synthesizing 2-(2,4-dimethyl phenyl sulfanyl) chlorobenzene from 2-chlorophenol and 2,4-dimethylbenzenethiol; then, adding di(dibenzylideneacetone)palladium, 1,1'-binaphthyl-2,2'-bis(diphenyl phosphine), sodium tert-butoxide, and methylbenzene into a reaction bottle to mix, and adding other materials so as to prepare vortioxetine; and dissolving the prepared vortioxetine by using 14-16 times of ethyl acetate, so that a vortioxetine hydrobromide coarse product is obtained; and finally, purifying the coarse product so as to obtain a vortioxetine hydrobromide fine-product. The method disclosed by the invention is easily-obtained in raw materials, mild in process reaction conditions, high in product yield, high in product purity, and convenient for industrial production. Prepared vortioxetine hydrobromide is white crystalline powder, and the purity is more than 99.5%.

The invention discloses a copper-based catalyst taking zirconia as a carrier, a preparation method of the copper-based catalyst and an application of the copper-based catalyst to furfuryl alcohol preparation by furfural hydrogenation. The copper-based catalyst taking the zirconia as the carrier is expressed by a formula Cu/ZrO2-M, wherein Cu is an active component, active metal Cu accounts for 0.05-40% of the total weight of the catalyst, and the carrier ZrO2-M is mesoporous zirconia and accounts for 99.95-60% of the total weight of the catalyst. According to the copper-based catalyst with thezirconia carrier, precious metal is not used as an active component, the copper-based catalyst is low in cost, only contains Cu and the zirconia carrier and is free from other components and simple in preparation process, and furfural conversion rate and furfuryl alcohol selectivity can be effectively improved. Besides, a process for preparing furfuryl alcohol by furfural is mild in reaction condition and high in reaction rate. A product system is simple in separation, and the catalyst is reusable and low in corrosion to equipment. Water serves as a reaction medium, any inorganic acid and alkali are omitted in reaction, and the problem of environmental pollution in the furfural hydrogenation process is avoided.

The invention discloses a method for preparing high-grade artificial rutile from high-calcium and high-magnesium rock-mineral ilmenite. The method comprises the following steps: step 1, sulfating and decomposing ilmenite at low temperature and converting titanium, iron, calcium, magnesium and other metal components into corresponding sulfates; step 2, selectively decomposing solid products obtained in the step 1 at moderate temperature to enable TiOSO4 to be resolved into water-insoluble TiO2, (NH4)2Fe(SO4)2 to be resolved into soluble FeSO4 and Fe2(SO4)3 and CaSO4, MgSO4, FeSO4, Fe2(SO4)3 and the like to be not resolved or almost not resolved; step 3, immersing a roasted product obtained in the step 2 with water to enable sulfates of soluble iron, calcium and magnesium to be dissolved so as to effectively separate TiO2 from other metal components to obtain titanium slag; step 4, adopting diluted hydrochloric acid to leach titanium slag in the step III so as to remove insoluble iron oxides generated by decomposition of a small quantity of FeSO2 and Fe2(SO4)3 in the moderate-temperature roasting process; step 5, performing alkaline treatment on the titanium slag obtained in the step 4 to remove acid-insoluble SiO2 in titanium slag; step 6, calcining and transforming the titanium slag obtained in the step 5 to obtain rutile titanium dioxide slag (artificial rutile).

The invention relates to a synergistic stable nitrogen fertilizer and a preparation method thereof. The fertilizer comprises the following components: a nitrogen fertilizer, medium trace elements, a nitrogen regulating synergist (urease inhibitor and/or nitrification inhibitor) and a carbon source synergist, wherein the nitrogen fertilizer is urea, and the medium trace elements comprise calcium, magnesium, sulfur, boron, silicon, iron and zinc. The weight part ratio of the nitrogen fertilizer to the medium trace elements to the nitrogen regulating synergist to the carbon synergist is 1: 0.05-0.1: 0.001-0.1: 0.1-0.3. By adding a certain amount of the carbon synergist and the nitrogen regulating synergist into the fertilizer, the release time and rate of the nitrogen fertilizer can be regulated, the fertilizer efficiency is slow and stable, the fertilizer meets various nutritional requirements of crops in different growth periods, solves the contradiction between crop fertilizer requirement and soil fertilizer supply, reduces greenhouse gas emission and nitrogen leaching loss, and is a novel synergistic stable nitrogen fertilizer.

The invention discloses a terphenyl compound represented by a formula (II) and discloses a preparation method for the terphenyl compound and an application of the terphenyl compound in preparing anti-tumor drugs. The preparation method for the terphenyl compound disclosed by the invention is simple in process, mild in reaction condition, convenient to operate and low in cost and has a wide industrial application prospect. The product is single in structure, generates no isomers and has anti-tumor activity. The formula (II) is as shown in the description.

The invention discloses a synthesis method of L-carnitine with a structure shown in a formula (1), which adopts L-(-)-3-cyan-2-hydroxyl propyl trimethylamine halide as a raw material and is prepared by hydrolysis and ion exchange; the hydrolysis is carried out in the following steps: in alkaline solution, hydrogen peroxide is used for hydrolyzing the L-(-)-3-cyan-2-hydroxyl propyl trimethylamine halide, and after full reaction, the hydrolysis reaction liquid is obtained. In the technique disclosed in the invention, the reaction condition is mild, the reaction time is short, the reaction yield is high, three wastes are less, and the implementation value and social and economic benefits are larger.

The invention relates to the technical field of calcium zincate synthesis and discloses a synthetic process for calcium zincate as a zinc-nickel battery negative electrode material. The synthetic process comprises the following steps of 1, mixing zinc oxide with organic acid, performing full reaction, performing filtering to remove impurities, then adding a certain quantity of strong alkaline solution, and performing mixing reaction to form a zincate solution; 2, (1) performing reaction on the organic acid and calcium hydroxide to produce an organic acid calcium solution, then dropwise addinga dispersant to form a mixed solution; or (2) adding the calcium hydroxide in a certain quantity of water, then dropwise adding the dispersant to form suspension liquid; 3, mixing products prepared instep 1 and step 2; 4, transferring reaction liquid obtained in step 3 into an ageing groove, performing still standing for 2-48 h, then performing centrifugal treatment, washing and drying filter residues, and performing crushing and sieving to obtain a product; and 5, recovering filtrate obtained in step 4 as a reaction medium for recycling use. The process realizes recycling of alkaline liquorand reduces pollution.

The invention discloses a synthetic method for a key tribenoside intermediate 1,2-di-O-isopropylidene-3,5,6-tri-O-benzyl-D-glucofuranose. The method comprises the following steps: adding 1,2-di-O-isopropylidene-D-glucofuranose as shown in a formula (I) which is described in the specification into benzyl chloride, controlling temperature, carrying out stirring and adding inorganic base; carrying out a nucleophilic substitution reaction under alkaline conditions; and then carrying out molecular distillation and purification so as to obtain high-purity high-content 1,2-di-O-isopropylidene-3,5,6-tri-O-benzyl-D-glucofuranose (II). The method provided by the invention has the advantages of mild reaction conditions, capacity of controlling generation of impurities, usage of a small amount of solvents, simple and convenient operation, no pollution and suitability for large-scale production; the manner of molecular distillation and purification can remove impurities which cannot be removed by using a common high temperature reduced-pressure distillation manner, product purity can reach 92.3%, and product content reaches 95%; and the high-content intermediate 1,2-di-O-isopropylidene-3,5,6-tri-O-benzyl-D-glucofuranose is beneficial for preparation of tribenoside (III).

The invention provides a production technique of tenofovir disoproxil fumarate. The production technique comprises the following steps: directly adding an ice-water mixture into a reaction solution in the tenofovir disoproxil fumarate preparation process, and crystallizing by physical cooling to obtain the tenofovir disoproxil fumarate, wherein excessive chloromethyl isopropyl carbonate and other organic solvents, the catalyst and impurities can completely enter the water layer; and dissolving in dichloromethane, and washing with water to remove a small amount of impurities entrained by the tenofovir disoproxil fumarate to obtain the tenofovir disoproxil fumarate with the purity of 95% or above, wherein the purity of the product after direct salification is up to 99% or above.

The invention provides an aromatic amido replaced s-triazine compound. A 2-amino-1,3,5-triazine compound and a cyanogen compound are mixed and then a solvent is added, reaction is performed under theeffect of a copper catalyst, and reaction liquid posttreatment is performed to obtain the compound. According to the preparation method of the compound, reaction conditions are mild, raw materials areeasy to obtain, operation is convenient, the cost is low, and the compound has a wide industrial application prospect. The aromatic amido replaced s-triazine compound has certain anti-human osteogenic sarcoma cell activity and can be applied to preparation of an antitumor drug, especially to preparation of drugs for treating osteogenic sarcoma. A structural general formula of the compound is shown in the description.

The invention discloses a synthesis process of an apremilast intermediate. The synthesis process comprises the following steps: (a) carrying out reaction on 3-ethoxyl-4-methoxystyrene and methanesulfonyl chloride under the action of a ruthenium catalyst to generate 4-[(1-chloro-2-methylsulfonyl)-ethyl]-2-ethoxyl-1-methoxybenzene; and (b) carrying out reaction on 4-[(1-chloro-2-methylsulfonyl)-ethyl]-2-ethoxyl-1-methoxybenzene and an alcohol liquid of ammonia, so as to obtain 1-(3-ethoxyl-4-methoxyl)phenyl-2-methylsulfonylethylamine. The synthesis process is simple and convenient to operate, and special reaction conditions are not needed, so that the synthesis process is more suitable for industrial production.