The preparation method of tirofiban hydrochloride freeze-dried powder injection preparation includes the following steps: using 30-1200g of lactose, adding water for injection, dissolving, adding active carbon, stirring for 10-60 min at 25-100deg.C, filtering and removing carbon, adding 5.62g of tirofiban hydrochloride monohydrate, stirring, adding water for injection to 1500-4000ml, regulating pH value of solution to 2-3, sterile filtering, filling, freeze-drying, squeezing cap and packaging, etc.