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Drying method for tirofiban hydrochloride

A drying method, tirofiban technology, applied in the direction of drying solid materials, drying gas arrangement, heating to dry solid materials, etc., can solve the problems of many impurities, high moisture, poor appearance, etc.

Inactive Publication Date: 2018-12-18
无锡富泽药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the applicant noticed that drying tirofiban hydrochloride wet products by normal temperature drying method and vacuum drying method usually has the disadvantages of poor appearance, as well as the disadvantages of high moisture content and more impurities.

Method used

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  • Drying method for tirofiban hydrochloride
  • Drying method for tirofiban hydrochloride
  • Drying method for tirofiban hydrochloride

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Take an appropriate amount of tirofiban hydrochloride wet product, and the moisture content of the tirofiban hydrochloride wet product is 8.55%. Adopt high-efficiency boiling dryer to carry out boiling drying to tirofiban hydrochloride wet product, the power of high-efficiency boiling dryer is 2.3kw. The process conditions are: drying temperature 44°C, drying time 10 minutes, air flow 70m 3 / h.

Embodiment 2

[0023] Take an appropriate amount of tirofiban hydrochloride wet product, and the moisture content of the tirofiban hydrochloride wet product is 8.55%. Adopt high-efficiency boiling dryer to carry out boiling drying to tirofiban hydrochloride wet product, the power of high-efficiency boiling dryer is 2.3kw. The process conditions are: drying temperature 41°C, drying time 12 minutes, air flow 60m 3 / h.

Embodiment 3

[0025] Take an appropriate amount of tirofiban hydrochloride wet product, and the moisture content of the tirofiban hydrochloride wet product is 8.55%. Adopt high-efficiency boiling dryer to carry out boiling drying to tirofiban hydrochloride wet product, the power of high-efficiency boiling dryer is 2.3kw. The process conditions are: drying temperature 43°C, drying time 15 minutes, air flow 45m 3 / h.

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Abstract

The invention provides a drying method for tirofiban hydrochloride. A tirofiban hydrochloride wet product is subjected to fluidized drying through an efficient fluidized drying machine, wherein the drying temperature in the efficient fluidized drying machine is 40-50 DEG C, the drying time is 10-20 minutes, and the air flow is 30-70 m3 / h. The tirofiban hydrochloride prepared through the drying method for the tirofiban hydrochloride is low in water content, is an off-white solid in appearance, meets the requirement for preparing a tirofiban hydrochloride sodium chloride injection, and has the advantages of being not likely to be caked and being low in impurity content.

Description

technical field [0001] The invention relates to the field of chemical pharmacy, in particular to a drying method for tirofiban hydrochloride. Background technique [0002] Tirofiban Hydrochloride, Tirofiban Hydrochloride, chemical name: N-(n-butylsulfonyl)-O-[4-(4-piperidinyl)butyl]-L-tyrosine hydrochloride monohydrate, Molecular formula: C 22 h 36 N 2 o 5 S·HCl·H 2 O, molecular weight 495.08. The product before the compound is salted - tirofiban is a non-peptide reversible antagonist of platelet glycoprotein Ⅱb / Ⅲa receptor, which can block the combination of fibrinogen and glycoprotein Ⅱb / Ⅲa Cross-linking of platelets and pharmacological activity of platelet aggregation. [0003] Tirofiban hydrochloride is suitable for patients with unstable angina or non-Q wave myocardial infarction. It can prevent cardiac ischemic events, and it is also suitable for patients with coronary ischemic syndrome undergoing coronary angioplasty or intracoronary atherectomy to prevent car...

Claims

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Application Information

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IPC IPC(8): F26B3/08F26B21/10F26B21/12
CPCF26B3/08F26B21/10F26B21/12
Inventor 蔡亮亮李怡谢卫锋曹敏吴鹏程
Owner 无锡富泽药业有限公司
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