34results about How to "Less insoluble particles" patented technology

The invention belongs to the technical field of medicines and particularly relates to a drug composition of bortezomib and a preparation method thereof. The drug composition disclosed by the invention contains bortezomib, tert butyl alcohol, sodium chloride and an excipient in the mass ratio of 1:0.5:(1-5):(5-20). The drug composition adopts freeze-dried powder injection or water injection, preferably the freeze-dried powder injection. The drug composition contains tert butyl alcohol and sodium chloride besides the conventional excipient; through adding tert butyl alcohol, bortezomib can be rapidly dissolved and rapidly reacted with polyalcohol excipients such as mannitol to form more stable borate, so that the stability problem of the bortezomib freeze-dried powder injection per se is solved; and through adding the drug active constituent i.e. sodium chloride, the normal physiological and biochemical activities and functions in vivo are fully guaranteed.

The invention belongs to the technical field of medicines, and particularly relates to a dantrolene sodium freeze-dried powder injection for injection and a preparation method thereof. The freeze-dried powder injection is prepared by freeze drying dantrolene sodium, lactobiose, a pH regulator and water for injection, wherein a mass ratio of the dantrolene sodium to the lactobiose is (1:0.5) to (1:2.5). The preparation method comprises the following steps of: adding the dantrolene sodium to the lactobiose in a prescription amount into the water for the injection, stirring, regulating the pH value to 9.0 to 10.5 by using the pH regulator, adding active carbon for injection, removing a heat source, decolorizing, filtering for decarburizing, performing fine filtering by using a filter membrane, packaging in separate bags, freezing and drying. The dantrolene sodium freeze-dried powder injection is studied on the basis of a freeze-dried process, namely the dantrolene sodium freeze-dried powder injection is cooled, heated by a small margin and is cooled again, so that the moisture of the freeze-dried product is reduced, and the freeze-dried product is high in redissolution and visible foreign matters and does not have insoluble granules. The dantrolene sodium freeze-dried powder injection for the injection is high in resolubility, clarity and stability, and low impurity content.

The invention relates to a muscular amino acid and nucleoside extract containing polypeptide, amino acid, nucleoside, nucleotide and other medicinal components. The extract is prepared by crushing cardiac muscles and muscles of a rabbit of which the connective tissue is removed to be mixed with water, homogenizing, freeing and performing ultrasonic treatment; adding potassium chloride into the homogenate, and performing ultrasonic agitation; and centrifuging to obtain supernate, filtering with a filter membrane, and performing ultrafiltration. The invention also provides a muscular amino acid and nucleoside medicinal composition injection and lyophilized powder, wherein the muscular amino acid and nucleoside medicinal composition consists of the following components: 1000ml of muscular amino acid and nucleoside solution, 1.5g of sorbitol, 0.2g of thioglycerol, and 1.0g of poloxamer 188; and the concentration of the polypeptide in the muscular amino acid and nucleoside solution is between 1.58 and 1.92mg / ml, and the concentration of hypoxanthine is between 0.22 and 0.28mg / ml. The muscular amino acid and nucleoside pharmaceutical composition lyophilized powder is prepared by lyophilizing 1,000ml of muscular amino acid and nucleoside solution, 40g of dextran 40, 0.2g of thioglycerol, 1.0g of poloxamer 188, and 0.5g of hydroxypropyl betadex. The muscular amino acid and nucleoside extract and the pharmaceutical composition thereof have a good effect of improving the stability of muscular amino acid and nucleoside and maintaining low insoluble particles.

The invention discloses a high-purity mezlocillin sodium preparation. The high-purity mezlocillin sodium preparation comprises uniform granules with the grain sizes smaller than 50 micrometers. The content of total impurities in the high-purity mezlocillin sodium preparation is lower than or equal to 0.68%, and the content of polymers in the high-purity mezlocillin sodium preparation is lower than or equal to 0.06%. The invention further discloses a method for preparing the high-purity mezlocillin sodium preparation. The method includes six steps of preparing ampicillin sodium solution; preparing mezlocillin sodium condensation liquid; preparing mezlocillin dry powder; preparing mezlocillin sodium solution; preparing mezlocillin sodium active compounds; preparing the high-purity mezlocillin sodium preparation. The high-purity mezlocillin sodium preparation and the method have the advantages that existing problems can be solved by the aid of the high-purity mezlocillin sodium preparation prepared by the aid of novel crystallization technologies, and the quality of the high-purity mezlocillin sodium preparation can be greatly improved; the high-purity mezlocillin sodium preparation is high in dissolving rate and purity, low in impurity content and insoluble particle content, good in flowability and easy to separately package, and the like.

The invention belongs to the technical field of biomedicine, and particularly relates to a preparation method of a levocarnitine injection preparation. The injection preparation is prepared from raw auxiliary materials including levocarnitine, proline and a pH adjuster; the preparation method solves the problems that in the prior art, in the process of preparing injection levocarnitine, the stability of a preparation is poor, impurities are generated after long-term placement, and the quality requirements in the duration of validity cannot be met; a more reliable technical support is providedfor the use of injection levocarnitine.

The invention belongs to the technical field of medicine, and relates to a corimycin freeze-dried powder preparation and a preparation method thereof. The freeze-dried powder preparation is prepared by corimycin, an organic acid or an inorganic acid, a proppant and water for injection. to make. Wherein, every 1000ml of water for injection contains 40-115g of corimycin, 20-100g of organic acid or inorganic acid, and 15-30g of proppant. The weight ratio of carrimycin, organic acid or inorganic acid is: 1:1-5:1, preferably 2:1-4:1. Inorganic acid includes hydrochloric acid, sulfuric acid or phosphoric acid; described organic acid includes citric acid, anhydrous citric acid, maleic acid, adipic acid, acetic acid, methanesulfonic acid, ethanesulfonic acid, fumaric acid, tartaric acid, apple Acid, pyroglutamic acid, lactic acid, succinic acid or C1-C4 straight chain or branched chain alkane sulfonate unsubstituted or substituted by any position of 1-3 hydroxyl groups. The freeze-dried powder injection of the invention has the characteristics of short reconstitution time, few insoluble particles, easy preparation and relatively stable characteristics.

The invention discloses a stephanine hydrochloride freeze-dried powder, which comprises stepherine hydrochloride and freeze-drying excipients, and the excipients include trehalose, lactose and sorbitol. The content of stephanine hydrochloride in the freeze-dried powder of the present invention reaches the selection of scalar components and proportions, so that the stability of the freeze-dried powder is good, the bioavailability is high, and the frequency and frequency of medication for patients are reduced. The clinical effect is good, and the validity period is prolonged compared with the prior art. The water content of the products obtained in the present invention is all lower than 3%. In addition, the freeze-dried powder prepared by the preferred technical solution of the present invention will not produce a large amount of fine powder and will not stick to the container wall. Regardless of whether water for injection, sodium chloride injection or glucose injection is used, the stephine hydrochloride freeze-dried powder of the present invention can be quickly dissolved, and the dissolution speed is fast and the insoluble particles are few.

The invention relates to a sterile freeze-dried powder of S-pantoprazole sodium for injection, comprising active ingredient S-pantoprazole sodium, a stabilizer, and a freeze-drying protective agent; wherein the stabilizer is sulfobutyl-β One of ‑cyclodextrin, hydroxypropyl‑β‑cyclodextrin, glucosyl‑β‑cyclodextrin. The R-configuration isomer of the product of the present invention is less than 0.3% after 24 months of storage; the number of insoluble particles is significantly reduced through the optimization of the preparation process; the preparation process of the present invention is simple and easy, and is suitable for industrial scale production.

The invention discloses a preparation method of chlorinated rubber. The preparation method includes the steps that firstly, natural rubber is added into a reaction kettle containing reaction media and auxiliaries, stirring is performed for 10-20 min, the weight ratio of natural rubber to the reaction media and to the auxiliaries is 1: (10-15): (0.02-0.15), and the reaction media are a hydrochloric acid solution with the mass fraction being 10-15%; secondly, chlorine is added into the reaction kettle, a chlorination reaction is performed, a coarse chlorinated rubber product is obtained, and a chlorination reaction condition includes that firstly reaction is performed at 90-110 DEG C for 2-3 h, and then reaction is performed at 50-70 DEG C for 2-3 h; thirdly, the coarse chlorinated rubber product obtained in the second step is subjected to deacidifying treatment, and chlorinated rubber is obtained through drying. The chlorinated evenness degree is high, the chlorination degree is high, product transparency is high, and solubility is good.

The invention discloses a composition containing ibutilide fumarate and a preparation method and application thereof. The pH value of the composition containing ibutilide fumarate is smaller than 4.0. The preparation method comprises the step of adjusting the pH value of the composition to a set pH value by utilizing a pH regulating agent. The application refers to the application of the composition containing ibutililde fumarate in preparing antiarrhythmic drugs. The composition containing ibutilide fumarate has good thermal stability and has little change on the content of the ibutilide fumarate and reduction of impurities after sterilized.

The invention provides a rabeprazole sodium composition which comprises the active ingredients of rabeprazole, mannitol and ethylene diamine tetraacetic acid, wherein the weight ratio of ethylene diamine tetraacetic acid to rabeprazole sodium is 0.05-0.5:1. The method for preparing the composition into solid powder-needle preparation comprises the following steps: dissolving the ethylene diamine tetraacetic acid solution with the prescription amount into injection water, adding and stirring the rabeprazole sodium with the prescription amount at a temperature of 25-35 DEG C for dissolving, then adding mannitol with the prescription amount, stirring the mannitol for dissolving, cooling to a room temperature, and regulating the pH value of the solution to 11.5-12.5; adding active carbon into the confected solution, stirring and filtering for decarburization, and freezing and drying the obtained filtrate to obtain the rabeprazole frozen powder needle. The rabeprazole frozen powder needle has full appearance, favorable stability and solubility and little insoluble grains in the injection.

The invention relates to a pharmaceutical composition for treating cardiovascular and cerebrovascular diseases and its preparing process, wherein the composition comprises breviscapine and Radix Astragali saponin with a purity of over 80% extracted from astragalus root, the content of the Radix Astragali saponin being 20-30%.