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Pharmacetutical for treating cardiovascular and cerebrovascular disease and its preparing process

A technique for cardiovascular and cerebrovascular diseases and injection, which is applied in the field of injection drugs for the treatment of cardiovascular and cerebrovascular diseases and their preparation, can solve problems such as no effect of invigorating qi and the like, so as to ensure the safety of medication, enhance the effect of invigorating qi and invigorating blood, and improve the effect. Effect

Inactive Publication Date: 2008-05-14
成都和康药业有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Existing breviscapine injection has a better effect of promoting blood circulation and removing blood stasis, but it has no effect of nourishing qi

Method used

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  • Pharmacetutical for treating cardiovascular and cerebrovascular disease and its preparing process
  • Pharmacetutical for treating cardiovascular and cerebrovascular disease and its preparing process
  • Pharmacetutical for treating cardiovascular and cerebrovascular disease and its preparing process

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0087] The specific approach in this example is:

[0088] (1), extracting high-purity astragalosides:

[0089] a. Alcohol extraction: cut the Radix Astragali medicinal material into oblique slices with a thickness of 2 to 3 mm, add 70% ethanol with 4 times the amount of the medicinal material, circulate and reflux leaching and extraction for 5 hours, the leaching temperature is 45° C., and combine ethanol to obtain an extract. b. Alcohol precipitation: recover the ethanol from the extract in step a under reduced pressure until it has no alcohol smell, then add ethanol until the alcohol content is 80%, let it stand, and filter; During the alcohol extraction, water twice the weight of the medicinal material of Astragalus membranaceus was used, kept in cold storage, and filtered to obtain the filtrate. c, ultrafiltration: the filtrate of b step is carried out ≥ 20000 rpm high-speed centrifugal filtration with tubular centrifuge, and the ultrafiltration column (membrane) ultrafil...

Embodiment 2

[0092] The specific approach in this example is:

[0093] (1), extracting high-purity astragalosides:

[0094] a. Alcohol extraction: cut the Radix Astragali medicinal material into oblique slices with a thickness of 2 to 3 mm, add 80% ethanol with 5 times the amount of medicinal material, circulate and reflux leaching extraction for 6 hours, the leaching temperature is 50° C., and combine ethanol to obtain an extract; b. , Alcohol precipitation: recover the ethanol from the extract in step a under reduced pressure until it has no alcohol smell, then add ethanol until the alcohol content is 85%, let it stand, and filter; the filtrate is decompressed again to recover ethanol until it has no alcohol smell, then add alcohol When extracting water with 2 times the weight of the Radix Astragali medicinal material, put it aside in refrigeration, and filter to obtain the filtrate; c, ultrafiltration: carry out high-speed centrifugal filtration of the filtrate in step b with a tubular ...

Embodiment 3

[0097] The specific approach in this example is:

[0098] (1), extracting high-purity astragalosides:

[0099] a. Alcohol extraction: cut the Radix Astragali medicinal material into oblique slices with a thickness of 2 to 3 mm, add 60% ethanol of 3 times the amount of the medicinal material, circulate and reflux leaching extraction for 4 hours, the leaching temperature is 40° C., and combine ethanol to obtain an extract;

[0100] b. Alcohol precipitation: recover the ethanol from the extract in step a under reduced pressure until it has no alcohol smell, then add ethanol until the alcohol content is 70%, let it stand, and filter; Water of 0.5 times the weight of the Astragalus medicinal material during alcohol extraction, refrigerated and left standing, and filtered to obtain the filtrate;

[0101] c, ultrafiltration: the filtrate of b step is carried out ≥ 20000 rpm high-speed centrifugal filtration with tubular centrifuge, and the ultrafiltration column (membrane) ultrafilt...

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Abstract

The invention relates to a pharmaceutical composition for treating cardiovascular and cerebrovascular diseases and its preparing process, wherein the composition comprises breviscapine and Radix Astragali saponin with a purity of over 80% extracted from astragalus root, the content of the Radix Astragali saponin being 20-30%.

Description

Technical field [0001] The invention relates to a medicine for treating cardiovascular and cerebrovascular diseases and a preparation method thereof, in particular to an injection medicine for treating cardiovascular and cerebrovascular diseases composed of breviscapine and astragaloside extracted from astragalus and a preparation method thereof. Background technique [0002] Chinese medicine believes that "Qi is the commander of blood, and blood is the mother of Qi". When Qi flows, blood flows, and poor blood circulation will also affect the biochemical operation of Qi. Therefore, when treating related diseases, it is generally recommended to use Qi tonic drugs It is used in combination with blood-promoting medicine to achieve the effect of treating qi and blood simultaneously. [0003] Astragalus is a traditional Chinese medicine that strengthens qi, strengthens the surface, protects the heart, and improves the immune function of the body. It mainly contains saponins, pol...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7048A61K36/481A61K9/08A61K9/14A61P9/10A61P9/04
Inventor 陈谨唐灿
Owner 成都和康药业有限责任公司
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