147results about How to "The drug effect is good" patented technology

The present invention discloses a topical scalp and transdermal preparation with excellent penetration to the skin and follicle, containing a [γ-hydroxy-N-methyl-L-leucine4] cylosporin derivative which is a non-immunosuppressive component with hair growth stimulating ability. The topical scalp and transdermal preparation is prepared by incorporating the cyclosporin derivative into a liposome, microcapsule, micro-sphere, composite particle or emulsion, capable of being employed as a hair growth stimulating agent and applied for the prevention of hair loss.

The invention belongs to the field of medicine, and relates to D-configuration polypeptide with high stability and capable of realizing mediated targeting of acetylcholine receptor high-expression cells and crossing corresponding barrier membranes and a nano drug delivery system thereof as well as an application in in-vivo and in-vitro brain targeting and in treatment of brain diseases and the like. Test results indicate that DCDX and the acetylcholine receptor are combined with IC50 to obtain 84.5nM which is stable in serum and tolerates hydrolysis of protease; the model drug carried by DCDX is specifically taken in by the positive cells expressing the acetylcholine receptor and has an ability of crossing the barrier formed by the kind of cells; and the nano drug delivery system made of a DCDX-modified polymer carrier material can deliver the entrapped model drug to the target tissue while the drug effect is remarkably improved. The D-configuration polypeptide DCDX provided by the invention can mediate active targeting of the drug or nano drug delivery system and has a good application prospect in the diagnosis and treatment of multiple diseases.

The invention discloses a precursor suspension of a lyotropic liquid crystal. The precursor suspension comprises lyotropic liquid crystal material, organic solvent, oil phase and a drug, wherein the weight percentage of the oil phase in the precursor suspension is 2-50 percent, the weight percentage of the drug in the precursor suspension is 1-30 percent, and the weight ratio of the lyotropic liquid crystal material and the organic solvent in the precursor suspension is 2-9:1. According to the invention, through the adding of the oil phase into the precursor suspension, the stability of the suspension is improved, the sedimentation rate is reduced, and the strength and the adhesive force of the gel formed are enhanced at the same time; the gel formed in the body is more liable to stay at a lesion location and less liable to be relocated and the shape is less liable to be damaged by the mechanical motion of the body, so that the drug therapy can be located effectively; and the preparation technology is simple and the precursor suspension of the lyotropic liquid crystal is a partial slow-release drug delivering system provided with a favorable perspective.

The invention discloses a disinfectant used in the breeding industry. The disinfectant comprises the components in percent by volume: 20-30mL of a sodium hydroxide solution with the mass percent of 30-45 percent, 3-7mL of peroxyacetic acid, 5-9mL of chloramine, 12-17mL of a sodium bicarbonate solution with the mass percent of 20-45 percent, 4-12mL of absolute ethyl alcohol and 12-19mL of a saponated cresol solution. All components are stirred for a certain time at a normal temperature and a normal pressure, and sub-packaged and plastic-packaged to obtain the disinfectant. By adopting the mode, according to the disinfectant used in the breeding industry, disclosed by the invention, the components adopted by the disinfectant are low in price, so that the total cost of the disinfectant is reduced, the disinfection effect is good, a good medication effect can be achieved by only consuming less disinfectant, the medication efficiency is high, toxic and hazardous effects on bred livestock and fishes are avoided, and no toxin accumulation is caused.

The invention discloses a clathrate compound of artemisinin series (artemisinin, dihydroartemisinin and artesunate) and alkaline cyclodextrin and a method for preparing the same. The alkaline cyclodextrin in the clathrate compound refers to an amido-substituted cyclodextrin; and due to the amido substituting of the cyclodextrin, an alkaline environment is formed in an aqueous solution apart from clathration between the cavity of the cyclodextrin and the artemisinin series, and forms ionic interaction with hydroxyls or carboxyls on the artemisinin series; and therefore, the artemisinin series can be dissolved in water to form a solution within an extremely wide concentration range so that liquid artemisinin series preparations can be formed. The clathrate compound provided by the invention is high in stability, high in bioavailability, simple in preparation, easy for operation, moderate in condition, and suitable for industrial production.

The invention relates to a degradable microstructure body and a preparation method thereof. The degradable microstructure body is mainly composed of a microneedle and a base where the microneedle is erected. The preparation method includes the steps that firstly, gel used for preparing the base and the microneedle is provided, and an antalgic material is added into the gel of the microneedle; secondly, a mould is provided; thirdly, injection molding is carried out; fourthly, curing and sterilizing are carried out. The microstructure body has the advantages of being long-acting in sustained release, good in experience feeling, simple in process and the like, and can be applied to the fields of biological medicine and medical cosmetology.

The invention discloses a drug substrate fertilizer particle agent to prevent cotton seeding pest, which is characterized by the following: adopting nitrogen, phosphor, potassium or composite fertilizer as carrier; allocating imidacloprid, thiram, triazole ketone and adjuvant according to certain proportion; making the drug particle agent; modifying the nourishing condition and seeding growing environment; reinforcing pest-proof and growing property.

The invention provides a drag sustained release stent. The drag sustained release stent is characterized by comprising a stent body and a polymer membrane, and the stent body and the polymer membraneare connected together; the polymer membrane is a biodegradable polymer membrane or a non-biodegradable polymer membrane, the polymer membrane and / or the stent body is provided with at least one layerof drug coating, and the drug coating includes one or several kinds of antibacterial drugs, anti-inflammatory drugs, anti-cancer drugs and hemostatic drugs. The drug sustained release stent is applied to the treatment of sinusitis, and can not only play a supporting and continuously dosing role in a lesion location after FESS surgery, but also play a role in hemostasis after the surgery.

The invention relates to a composition for strengthening an immune regulation function in a human body and applications thereof. The composition comprises effective components of panax japonicus saponin and panax japonicus polysaccharide or the effective components and an acceptable carrier on a health medicament, health food, health tea, health wine or a beverage. The composition has the function of improving the immune function of an immunocompromised mouse. In an animal model with a weak immune system caused by cyclophosphamide (Cy), the composition can enhance the spleen index of the immunocompromised mouse, enhance the proportions of CD<4+> to CD<8+> and B lymphocytes to NK cells, and increase the content of cell factors IL-2 and IFN-gamma. The composition enhances the medicament effect and the medical value of panax japonicus; therefore, the planting of medicinal materials and the development of medicaments can be promoted. The composition has better social and economic benefits.

The present invention relates to solid dispersed Nimoldipine tablet and features that solid dispersed Nimoldipine tablet is prepared with Nimoldipine in 5-15 wt%, polyvidon K30 in 25-45 wt% and cross-linked PVP in 45-65 wt%, and through the following steps: heating and mixing Nimoldipine and polyvidon K30, adding alcohol in 1.1 times and heating to 65-70 deg.c for dissolving, adding cross-linked PVP for adsorption, sieving and pelletizing, drying and finishing at 55-65 deg.c, tabletting and coating. The present invention has the advantages of raised intracorporal leaching rate of Nimoldipine, less loss of the medicine during absorption and raised medicine effect.

The present invention relates to a Chinese medicine for preventing and curing fowl respiratory tract diseases with excellent effect. Said Chinese medicine is made up by using 10 Chinese medicinal materials of wild chrysanthemum flower, andrographis, houttuynia, bupleurum root, isatis leaf, apricot kernel and others through a certain preparation process.

The invention provides a Rapamycin intraocular implantable drug releasing system taking bletilla striata gum as the carrier, which includes the medicine Rapamycin served as medicine and the carrier. The Rapamycin intraocular implantable drug releasing system is characterized in that the carrier is bletilla striata gum, the main component of the bletilla striata gum is glucomannan which is polymerized by mannose and glucose at the ratio of 1 to 4; the average molecular weight is from 65000 to 150000, the bletilla striata gum is accounted as glucomannan with a content being more than 85 percent, and the amount of the added medicine is accounted as the dry weight of the bletilla striata gum, being 0.05-50 percent. Cross-linking agent is also added in the bletilla striata gum. The cross-linking agent is formaldehyde, glutaraldehyde, glycol diglycidyl ether, and propanediol diglycidyl ether. Albumin, gelatin, etc. are also added in the bletilla striata gum. The bletilla striata gum can inhibit neovascularization and can resist tumor, the joint usage can take the effect of synergetic treatment. The system of the invention takes the full advantages that the bletilla striata gum are biodegraded inside the body; active medicine is slowly released; the dosage, the taking times, and the harmful side effect of the medicine are reduced; better curative effect can also be realized on the site at which the medicine is difficult to be absorbed.

The invention relates to a sterile microstructure body and a preparation method thereof. The microstructure body is mainly composed of micro-needle pillars and a substrate on which the micro-needle pillars stand; and the preparation method comprises the following steps: 1) preparing the substrate; 2) dropping gels on the substrate; 3) drawing the gels which are dropped, so that the micro-needle pillars are formed; and 4) sterilizing. The microstructure body provided by the invention has the advantages of excellent hardness, controllable degradation, sustained release, simple preparation and the like; and the microstructure body is applicable to the fields of biomedicine and medical cosmetic.

The invention relates to application of a vegetable capsule in a powder spray, and provides a novel capsule type aerosol inhalant administration device. In the invention, the vegetable capsule is selected to replace the prior hollow capsule; the vegetable capsule has good effect on administration application of the capsule type aerosol inhalant administration device, and can not generate capsule particles or powder, so that in the process of administration suction, the problem caused by the capsule particles and powder can be well solved. Meanwhile, the emptying rate of the vegetable capsule is basically equivalent to that of an animal capsule used in the aerosol inhalant under the condition of normal temperature, while the emptying rate of the vegetable capsule is superior to that of the animal capsule under other conditions with better administration effect.

An antivirus medicine in the form of capsule is prepared from zedoary, oil as primary component, semisynthetic glycerine ester of fatty acid, polyethanediol and surfactant through proportioning, heating zedonary oil to 30-150 deg.c, sieving by 40-100 meshes, mixing with polyethanediol and surfactant, sirring for 30-60 min, and loading in capsule at 10-60 deg.C. Its advantages are high curative effect and no toxic by-effect.

This invention relates to a medicament-carrier composition for use in delivering medicaments or fixing the action site of biological active compounds, which mainly comprises a mucoadhesive polymer and a thermoresponsive polymer. The medicament-carrier composition according to this invention is quite suitable for use in topically delivering biological active compounds, especially those useful in photodynamic diagnosis or therapy, e.g. 5-aminolevulinic acid (called as “ALA” for short).

The invention relates to a dermatological smearing device, which solves the problem that the dermatology treatment is troublesome and easy to cause cross infection when the drug is applied in a largearea. The device comprises a casing, wherein a downward push rod is arranged in the casing, a first medicine bottle is arranged below the push rod, a first medicine feeding tube is fixedly connected below the casing, and a taper liquid outlet is inserted into the first medicine feeding tube for fixation, the outer side of the first medicine feeding tube is provided with a protection cylinder body,and the protection cylinder body is fixedly connected with the casing, the lower end of the first medicine feeding tube is screwed and fixedly connected with a second medicine feeding tube, and the second medicine feeding tube is provided with a clamping device, the clamping device is rotatable, the clamping device is provided with a smearing wheel, and the smearing wheel is arranged below the second medicine feeding tube. The dermatological smearing device improves the effect of the medicine; saves time and labor, has flexible operation, high efficiency, less failure and reusability, and improves the working efficiency for the medical staff.

The present invention relates to acid stabilized compositions containing as an active ingredient a quinazolinone derivative, preferably halofuginone or a pharmaceutically acceptable salt of halofuginone. More particularly the present invention relates to use of an acid for improving the stability of a topical, parenteral or oral composition containing quinazolinone derivatives as an active ingredient, preferably halofuginone. Surprisingly, even dry solid tablet dosage forms showed improved stability by addition of an acidic component.

The invention discloses an intelligent examining, medicine applying and sampling integrated device for the department of gynaecology and obstetrics. The intelligent examining, medicine applying and sampling integrated device comprises a handle. A support is arranged at the upper end of the handle, a working cavity is connected to the left end of the support, a medicine storage groove is formed in the surface of the support, a high-pressure pump is arranged in the medicine storage groove, the outlet end of the high-pressure pump is connected with an inlet of an atomizer through a connecting pipe, an outlet of the atomizer is connected with the right end of a telescopic pipe through a connecting pipe, the telescopic pipe penetrates through a sliding rod in the working cavity, a dividing valve is arranged at the end, exposed out of the sliding rod, of the telescopic pipe, and the dividing valve is connected with a dividing pipe in a medicine applying device. According to the intelligent examining, medicine applying and sampling integrated device for the department of gynaecology and obstetrics, the examining, medicine applying and sampling device integrated design is adopted, and a controller is adopted to perform centralized intelligent control, so that treatment steps are reduced, the working intensity of medical workers is relieved, and the medicine applying device is good in medicine applying effect and convenient to use.

The invention discloses a nasal cavity suction administration device. The device comprises a main sleeve, wherein a push rod is arranged in the main sleeve, and a piston is arranged on the push rod. The device is characterized in that an integral spray head is arranged at the discharge end of the main sleeve, and a buffering device capable of reducing the speed for a drug to enter the nasal cavity is arranged in the integral spray head. The device aims to overcome the defects in the prior art and is simple in structure and convenient to use. The dedicated rotary smashing buffering device in the device can minimize fogdrops which are sprayed out and can also effectively reduce the speed and pressure of the drug entering the nasal cavity, and has a good administration effect.

The invention provides an integrated mould box capable of forming and delivering an external preparation, and relates to a mould box for the external preparation in order to solve the problems that a suppository can not be accurately delivered to a diseased position of a patient, and is easy to get polluted as the suppository is easy to remain in a lower cover when in use and the remaining suppository needs to be taken out by a hand and replaced in a suppository shell of the conventional dual-purpose mould box capable of forming and packaging the suppository. The mould box comprises a middle die, a lower die and a push rod, wherein the middle die is composed of a die sleeve, a first retainer ring and a second retainer ring, the first retainer ring and the second retainer ring are sequentially arranged on the outer side wall of the die sleeve from top to bottom, the first retainer ring, the second retainer ring and the die sleeve are arranged in a coaxial manner, and are formed into a whole, one end of the die sleeve is sleeved in a die cavity of the lower die, the lower surface of the second retainer ring is in close contact with the upper end face of the lower die, an annular bulge is arranged in a ring slot, and is matched with the ring slot in a sliding manner, and the push rod is matched with an inner chamber of the die sleeve in a sliding manner. The integrated mould box is used for forming and using the external preparation such as the suppository, ointment or gels and the like.

The invention discloses an environment-friendly disinfectant and a preparation method thereof. The disinfectant is prepared by mixinga component A with a component B, wherein the component A contains a disinfectant, compound alcohol, a sterilization preservative, a smell covering agent and deionized water; and the component B contains an aerosol tank, a valve, a propellant, a press head and a cover. The environment-friendly disinfectant disclosed by the invention has the following beneficial effects: (1) by compounding a mixture of nano silver ions, artemisia stelleriana essential oil and water-based resin with the compound alcohol and the sterilization preservative, the sterilization and disinfection effect is remarkably improved; and the nano silver ions, the artemisia stelleriana essential oil and nano TiO2 / BiVO4 are adhered to an object surface by use of the water-based resin to form a sterilization film, so that the acting time of sterilization and disinfection is prolonged; (2) the low-temperature freezing resistance is good; and by adopting a low-toxicity environment-friendly material, the requirements for low toxicity and environmental protection are met; (3) the construction operation is flexible, simple and convenient, multi-angle use can be realized, and the sterilization and disinfection of a special or complicated-structure object are facilitated; and (4) the odor removal effect is good, and peculiar smell in air can be effectively removed; and meanwhile, fake products can be avoided according to the essence type.

The invention discloses application of earthworm extract to medicines. The earthworm extract is prepared by the following steps: cleaning fresh pheretimaasperfillm, discharging mud by clear water for 30 minutes, adding a 0.02mol / L phosphate buffer with pH value of 7.3 and a 3wt% sodium benzoate aqueous solution which have the same volume as the clear water, keeping the constant temperature of 37 DEG C, centrifuging at the speed of 8,000r / min and the temperature of 4 DEG C for 30 minutes, adding ethanol into a supernatant, staying overnight at 4 DEG C, centrifuging, drying settlings in vacuum, and storing; purifying a crude extract by adopting an ion-exchange column chromatography method, freeze-drying, and storing. Compared with PFD, the earthworm extract has the characteristics that the treatment and prevention effects of the earthworm extract are equivalent to those of the PFD, and the lumbrukinase activity in the unit weight of earthworm extract reaches up to 220,000U / mg by adopting the extraction method, so that the effective dosage of the earthworm extract is remarkably lower than that of the PFD.

The invention relates to new application of FG-4592 or salt thereof as well as a medicine product and a health-care product. The new application is the application of the FG-4592 or pharmaceutically acceptable salt thereof to preparation of products for treating and / or preventing nerve injury diseases or neurodegenerative diseases. The products can be medicine products and / or health-care products.The limitation that the existing FG-4592 is only used for treating anemia is overcome; and the FG-4592 can obviously improve the spatial memory function of APP / PS1 transgenic mice, can improve the condition that the cognitive function is reduced, and can be used for treating early cognitive impairment, stroke, Alzheimer disease, cognitive impairment, vascular dementia, Parkinson's disease and thelike.

The invention relates to novel application of Apatinib or pharmaceutically acceptable salts, ester and solvent compounds thereof for preparing a medicine for treating acute myelogenous leukemia. The Apatinib restrains acute myelogenous leukemia cell amplification and induces apoptosis of cells by activating the mitochondrion-mediated endogenesis apoptosis way and lowering the VEGFR2 phosphorylation level and the PLCgama / PKC / S6 signal channel of the downstream thereof, and finally the effect of treating acute myelogenous leukemia is obtained; Apatinib or pharmaceutically acceptable salts, esterand solvent compounds thereof have no toxic or side effect on normal marrow mononuclear cells, the safety is good, the theoretical basis is provided for researching the treatment strategy for acute myelogenous leukemia, and an embedded point is supplied to preparation of the medicine for treating the acute myelogenous leukemia.

The invention relates to a drug used to treat myocardial ischemia, which uses Chinese green onion as raw material, uses CO2 ultra-critical extracted Chinese green onion benzene; and the extraction comprises: a, breaking the Chinese green onion, and cooling it into -10 to -80Deg. C by refrigerating drier, to make solid Chinese green onion powder; b, extracting the powder via CO2 ultra-critical extraction method, at 25MPa pressure, 38Deg. C, and the flux of CO2 is 9kg.h-1, and extracting for 2h, to obtain the Chinese green onion extractive; using Chinese green onion benzene as effective component to obtain drop and spray agent. The invention can improve micro cycle, reduce the blood vessel resistance, and reduce the heart load.

The present invention relates to a medicament and method for treating dermatopathy, especially a medicament and a treatment method for beriberi, psoriasis, dermatitis and flat wart. The traditional Chinese medicine provided by the invention comprises the following raw materials by weight: 13-18 portions of garlic stem core, 13-18 portions of tobacco leaf, 13-18 portions of mugwort leaf, 13-19 portions of equisetum, 15-20 portions of realgar and 15-20 portions of quicklime. An application method of the medicament is as below: breaking and grinding the above medicines into a fine powder, mixing well according to the proportion, smearing the power on affected parts daily in the morning and evening time. The medicament has no side effect, can be used for a long time until a healing, does not cause any pain for the patients during treatment and achieves a cure rate higher than 95%. The medicines in the medicament are easily available and at low price; and the medicament has good treatment effect, assures a minimal chance of relapse, is especially adapted to the vast rural areas lack of medicines, and shows very high values in popularization and application.

The invention relates to an accurate intelligent medical digital system based on a blockchain. The system comprises a user module, a medical supplier module, a blockchain module, an accurate intelligent medical module and a telemedicine module. The user module is used for storing the information of a user and a local medical record and defining a blockchain intelligent contract. The medical supplier module is used for providing an access platform for serving the user for a medical service supplier. The blockchain module is used for storing and reading a user medical record in a distributed mode. The accurate intelligent medical module is used for intelligently analyzing and excavating accurate medical data. The telemedicine module is used for providing a communication platform between theuser and a doctor.

The present invention discloses a kind of Chinese medicine, named as Tongjing capsule, for treating protrusion of lumbar intervertebral disc and hyperosteogeny. The Chinese medicine is prepared with notopterygium, pubescent angelica root, clematis root, acanthopanax bark, kudzu vine root and other 12 kinds of Chinese medicinal materials. The medicine of the present invention is combined with the application of pelvic traction and hand restitution so as to reach high treating effect.

The invention discloses a murine prescription bait which comprises the following raw materials with the parts by weight: an adhesive ingredient: 31.9-35.9 parts of industrial paraffin wax with the melting point to be 60 DEG C; 62.9-69.9 parts of a mouse luring ingredient: the components of each part consist of 28-32% of rice flour, 64-68% of fine bran powder, 0.2-0.3% of common salt, 0.3-0.5% of saccharin, 0.8-1.1% of fish meal, 0.7-0.8% of medical tasteless mineral oil and 1.6-1.8% of a vomitory; an additional ingredient: 1.2-1.6 parts of benzoic acid and 0.1-0.3 part of blue pigment. The invention further discloses the application of the murine prescription bait used for preparing an anticoagulant raticide prescription poison bait. The murine prescription bait takes paraffin wax with the melting point to be 60 DEG C as the adhesive, which has higher palatability and longer lasting period than other wax baits; the murine prescription bait takes the rice flour and the fine bran powder as the main ingredients, which saves corn consumption to over 60% and has no impact on deratization effect.