Use of plant capsule in powder spray

Abstract

The invention relates to application of a vegetable capsule in a powder spray, and provides a novel capsule type aerosol inhalant administration device. In the invention, the vegetable capsule is selected to replace the prior hollow capsule; the vegetable capsule has good effect on administration application of the capsule type aerosol inhalant administration device, and can not generate capsule particles or powder, so that in the process of administration suction, the problem caused by the capsule particles and powder can be well solved. Meanwhile, the emptying rate of the vegetable capsule is basically equivalent to that of an animal capsule used in the aerosol inhalant under the condition of normal temperature, while the emptying rate of the vegetable capsule is superior to that of the animal capsule under other conditions with better administration effect.

Description

technical field [0001] The invention relates to the application of vegetable capsules, in particular to the application of vegetable capsules in powder spray. Background technique [0002] The literature Chem Pharm Bel, 1997, 45:911 mentions that a carrier with a particle size of 50 μm-100 μm is usually mixed with a drug powder with a particle size of 0.5-7 μm, so that the drug powder is adsorbed on the surface of the carrier. When inhaled, use the inspiratory airflow to make the powder aerosol get enough function and enter the upper respiratory tract. As the airway narrows during the inhalation process, the airflow speed increases and separates from the drug. After separation, the drug micropowder continues to enter the treatment site or human lungs under the action of high airflow to play a therapeutic role. [0003] The document "China Pharmaceutical Industry" 2005, Volume 14, No. 1, pp. 23-24, the capsule type inhalation powder mist drug delivery device is the first ge...

AI Technical Summary

Problems solved by technology

The reason may be that plant capsules are mainly composed of fibers and polysaccharides. The capsule wall density is small and the structure is fibrous. Using a microscope to observe and compare the inner and outer walls of plant capsules and gelatin capsules, it can be found that the inner and outer walls of plant capsules are compared with those of gelatin capsules. The roughness of the inner and outer walls of animal capsules is relatively large, while the main ingredients of powder aerosols are generally very fine. Usually, the roughness is too large, which will easily affect the emptying rate of the drug, because from a physical point of view, rough If the degree is large, the friction force between the main material and the capsule wall is relatively large

At the same time, the document "A New Generation of Capsules—Characteristics and Applications of Vegetable Capsules" mentions that the oxygen permeability of plant capsules is significantly greater than that of gelatin capsules (166 / 4.3=38.6 times), suggesting that their airtightness is relatively poor, and it is generally believed that the airtightness is relatively poor. Poor results in compaction of the capsule contents, thereby affecting the emptying rate

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