16 results about "Artemisinins" patented technology

The invention belongs to the technical field of medical instruments, and particularly relates to an absorbable suture and a preparation method and application thereof. Two coatings are loaded, from inside to outside, the first coating is the rapamycin coating with the anti-scar effect, the second coating is the artemisinin coating with the antibacterial and anti-inflammatory effects, and stable loading and slow release of the rapamycin medicine and the artemisinin are achieved through the structure of the two coatings. The suture can release artemisinin in the surgical suture incision inflammation period, infection is prevented, and inflammatory response is reduced. The rapamycin is released in a surgical suture incision scar proliferation period, so that scar proliferation of a surgical incision is prevented and reduced.

This invention relates to the fields of pharmaceuticals and nanomedicine, specifically disclosing the preparation of a dual-targeting liposome drug delivery system and its application in stroke. The dual-targeting liposome drug delivery system comprises neutrophils, artemisinin, edaravone, and liposomes. The liposomes co-load artemisinin and edaravone, and their surfaces are modified with sialic acid derivatives and phosphatidylserine to form liposome nanomedicines. The neutrophils act as carriers, transporting the drug across the brain border (BBB) ​​and targeting it to the ischemic brain region. This dual-targeting strategy achieves precise two-stage drug delivery to the ischemic brain region. This delivery system can inhibit NLRP3 inflammasome activation, reduce pyroptosis, and promote microglial polarization towards the M2 anti-inflammatory phenotype, thereby effectively treating cerebral ischemia-reperfusion injury or ischemic stroke.

The Artemisinin-Proteasome inhibitor conjugate compounds of the present application are represented by the following compounds having Formula (I) where the substituents R1-R5, X, Y, Y', and Z are defined herein. These compounds are used in the treatment of cancer, immunologic disorders, autoimmune disorders, neurodegenerative disorders, or inflammatory disorders, infectious disease, or for providing immunosuppression for transplanted organs or tissues.

The utility model discloses an artemisinin chromatographic separation device relates to chromatography field, including fixed frame and chromatographic column body, the fixed frame is fixedly connected with material tank, the vertical fixedly connected with sleeve in material tank, the open lower extreme of sleeve and penetrate material tank bottom, a plurality of through -holes are seted up on the sleeve, the surface of chromatographic column body is equipped with the seal cover, and the seal cover and sleeve inner wall gap cooperation. Advantageous effect lies in: the utility model creatively combines the sedimentation method with chromatographic column separation. Set up sleeve and through -hole in material tank, cooperate the use of the precipitate, first through the sedimentation method and make the impurity precipitate to material tank bottom, control chromatographic column body's elevation again, only let the solution above the precipitate layer enter chromatographic column body and carry out chromatographic separation. This kind of double method cooperation operation, both reduce the interference of impurity to chromatographic process, and make up the defect of single sedimentation method purity deficiency, improve separation efficiency and artemisinin purity greatly.

An artemisinin continuous gradient forward and reverse flow forward and reverse rotation extraction method belongs to the technical field of artemisinin extraction, and comprises the following steps: enabling an artemisia apiacea material to sequentially pass through a plurality of extraction sections connected in series along a first direction; injecting the extraction solvent along the direction opposite to the overall direction of the material, and controlling by a solvent bridge pipe, so that the solvent sequentially and reversely fills the subsequent sections to form a continuous gradient forward and reverse flow extraction environment in which the solvent flow direction is the same as the material flow direction in part of the sections and opposite to the material flow direction in part of the sections; in the extraction process, materials are stirred in a periodic positive and negative rotation mode, and an ultrasonic field is applied to a specific section for assistance; the device is a special system for implementing the method. According to the method disclosed by the invention, the extraction yield of the artemisinin is remarkably improved through the cooperation of'gradient forward and reverse flow design ', 'dynamic forward and reverse rotation stirring' and'ultrasonic assistance ', the extraction time is shortened to about 2 hours, and the production efficiency is greatly improved.

Provided are an artemisinin derivative and a preparation method and use thereof. A structural formula of the artemisinin derivative is shown in Formula I. The compound has suitable solubility and is relatively stable under storage conditions. Pharmacokinetic experiments on the compound have shown that artemisinin is detectable in ocular tissues and is present in cornea, conjunctiva, and aqueous humor at a relatively high drug concentration. The compound is therefore an excellent precursor to artemisinin. The compound shown in Formula I exhibits remarkable absorbability, and the drug concentration in the ocular tissues indicates that the compound is well absorbed. The compound exhibits significantly better inhibitory effects on neovascularization in burn models than artemisinin, and can be prepared into liquid formulations such as eye drops, injection, etc., for treatment of ocular tissue diseases.

The invention provides a preheating device for artemisinin extraction, and belongs to the technical field of artemisinin processing, the preheating device comprises an inner preheating cylinder, the outer side of the inner preheating cylinder is sleeved with an outer shell sleeve, a space exists between the outer shell sleeve and the side wall of the inner preheating cylinder, one side of the outer shell sleeve is fixedly connected with an input channel, the other side of the outer shell sleeve is fixedly connected with an output channel, and the outer side of the outer shell sleeve is fixedly connected with the output channel. The upper side of the inner preheating barrel is in threaded connection with an upper shell cover, a delivery shell is arranged on the upper portion of the upper shell cover, a motor is arranged in the middle of the upper portion of the upper shell cover, a rotating rod of the motor is fixedly connected with a linkage rod, and a ring-shaped removing assembly is arranged in the inner preheating barrel. The problems that due to the fact that the situation of unbalanced heating is likely to occur and temperature difference exists, preheating cannot be rapidly and sufficiently executed, and in the preheating process and the discharging period of artemisinin raw materials, part of the materials are attached to the barrel wall face, and sufficient discharging is not facilitated are solved.

This invention relates to an artemisinin trimer derivative, its preparation method, and its application. This invention is the first to synthesize and isolate β,β,α trimer, β,α,α trimer, and α,α,α trimer. The isomers of these three trimers were successfully isolated by the new synthetic method and characterized and their activity was tested. The test results showed that they have high antitumor activity.

The invention relates to the technical field of plant effective component extraction, and discloses a method for extracting artemisinin through enzymolysis pretreatment, which comprises the steps of raw material pretreatment, composite enzymolysis pretreatment, ultrasonic-assisted extraction, impurity removal and concentration, purification and crystallization, and recrystallization and refining. A compound enzyme system composed of cellulase, hemicellulase and pectinase is adopted to conduct enzymolysis on artemisia annua powder, cell wall structures are destroyed to promote artemisinin release, ultrasonic-assisted extraction is combined to strengthen the extraction effect, and the product purity is improved through chitosan impurity removal, silica gel chromatography and two times of crystallization. The method is simple in process, environmentally friendly and energy-saving, effectively solves the problems that a traditional extraction method is low in extraction rate, insufficient in purity and high in cost, is suitable for large-scale industrial production, and has high practical value and industrialization prospects.

An artemisinin continuous gradient forward and reverse flow forward and reverse rotation extraction device belongs to the technical field of artemisinin extraction equipment and comprises a forward flow charging tank, a first reverse flow transition extraction tank, a reverse flow extraction tank, a second reverse flow transition extraction tank, a forward flow extraction tank, a third reverse flow transition extraction tank and a reverse flow slag discharge tank which are communicated with one another in a welding manner; stirring shafts are arranged in the downstream charging tank, the countercurrent extraction tank, the downstream extraction tank and the countercurrent deslagging tank; spiral stirring propelling blades and positive and negative rotation driving motors are arranged on the stirring shafts; a material inlet, a slag outlet, a solvent injection pipe and a liquid taking and collecting pipe are arranged; three solvent bridge tubes and an ultrasonic transducer are additionally arranged; the device has the beneficial effects that the components form a four-stage continuous gradient forward and reverse flow forward and reverse rotation and ultrasonic extraction system, so that the artemisinin extraction yield can be effectively improved, the whole extraction period is shortened, and the production efficiency is improved.

This invention belongs to the field of pharmaceutical technology and relates to the research and application of drugs for the treatment of lymphedema, specifically the application of systemic artemisinin in the treatment of secondary lymphedema. Specifically, this invention provides the use of artemisinin or its derivatives in the preparation of drugs or formulations for the prevention and / or treatment of lymphedema, wherein the drugs or formulations are used to: relieve lymphedema, relieve fat deposition caused by lymphedema, and / or promote lymphatic vessel regeneration.

The application discloses a preparation method of a dual-function antibacterial and anti-inflammatory absorbable coating material, which comprises the following steps: (1) blending rifampicin, artemisinin and an absorbable polymer A with a mixed solvent to obtain coating solution A; blending minocycline hydrochloride, aspirin and an absorbable polymer B with the mixed solvent to obtain coating solution B; the mixed solvent is selected from hexafluoroisopropanol and ethyl acetate; (2) uniformly spraying the coating solution A and the coating solution B on the surface of a degradable substrate by ultrasonic spraying, and performing drying treatment to obtain the dual-function antibacterial and anti-inflammatory absorbable coating material. According to the preparation method, the proportion of antibiotic active ingredients, anti-inflammatory drug active ingredients and absorbable polymers is regulated, the antibacterial and anti-inflammatory drug coating is uniformly and stably fixed on the surface of the degradable substrate by ultrasonic spraying, and the dual-function absorbable antibacterial and anti-inflammatory coating material with controllable release is prepared by optimizing process parameters.

The invention discloses a preparation method of an artemisinin nano-silver antibacterial agent, and relates to the field of nano materials and antibacterial agents. Chitosan and L-ascorbic acid are used for preparing a reducing agent, a silver nitrate solution and artemisinin which is dissolved in an acetic acid solution in advance are mixed and react under the proper condition, standing is conducted after the reaction, and finally the brownish red stable artemisinin-nano-silver composite material is obtained. The method is mild and simple, the nano-composite antibacterial agent with good dispersity and high stability can be obtained, and the nano-composite antibacterial agent has the biological activity of artemisinin and the broad-spectrum bactericidal ability of silver nanoparticles.

The application provides a hemoglobin cascade response nano vesicle and a preparation method and application thereof, and belongs to the technical field of biological medicine. The first hemoglobin response nano vesicle (DecAS-PC@NM) is designed, and disease-specific treatment is realized through cascade reaction of two functional phospholipids. First, hemoglobin activates artemisinin-modified phospholipid (A-PC) to generate active oxygen, the active oxygen oxidizes the sulfide structure in another phospholipid (S-PC), and the transformation from hydrophilicity to hydrophobicity is caused, so that the vesicle is disintegrated. Through co-assembly with neutrophil membranes, the chemotaxis to inflammatory sites is further enhanced. In vitro studies show that DecAS-PC@NM has unique hemoglobin responsiveness, and in vivo data emphasize its targeting to ischemic cores and significant therapeutic effect. This innovative hemoglobin-triggered phospholipid cascade reaction provides a promising strategy for the treatment of myocardial ischemia-reperfusion injury.

The invention discloses application of artesunate in preparation of medicines and health care products for preventing and treating iron-deficiency anemia caused by iron absorption disorder and / or iron transport dysfunction, in-vitro experiments find that artesunate can target divalent metal transport protein (DMT1), DMT1 is oxidized through free radicals to form disulfide bonds, the space structure of DMT1 is changed, and the iron-deficiency anemia caused by iron absorption disorder and / or iron transport dysfunction is prevented. The iron transport function of the DMT1 protein is enhanced, so that the uptake of divalent iron by cells is effectively increased; animal experiments further prove that the artesunate can remarkably improve anemia symptoms of mice with iron-deficiency anemia, anemia related indexes of the mice are effectively recovered, and the iron content in red blood cells and livers is recovered to the normal level. In-vitro and in-vivo experiments prove the treatment effect of artesunate on iron-deficiency anemia, a new treatment scheme is provided for treatment of iron-deficiency anemia patients, and the indication types of artemisinin drugs are expanded.

The utility model relates to the technical field of heat preservation devices, in particular to a heat preservation device for artemisinin extraction, which comprises a device body, a heat preservation device, a heat preservation device and a heat preservation device, the device body comprises a heat preservation tank, and a heat supply port is arranged on the surface of the heat preservation tank; and the outer surface of the heat supply opening is rotationally connected with an assembly structure, the assembly structure comprises a threaded sleeve, one end of the threaded sleeve is connected with a heat supply pipe, one side of the inner surface of the threaded sleeve is connected with a fixing ring, and a sliding rod is inserted into the fixing ring. By moving the positioning rod, the sliding rod and the interior of the annular sliding groove formed in the fixing ring move, so that one end of the positioning rod is inserted into the supporting frame, the movable direction of the threaded sleeve is limited, then the threaded sleeve is rotationally connected to the outer surface of the heat supply opening, and the effect of rapidly assembling the heat supply opening and the heat supply pipe is achieved; and the problem that the installation is unstable due to the fact that the angle cannot be controlled in the butt joint process is solved.