57 results about "Artemisinins" patented technology

The invention relates to the technical field of biomedical materials, in particular to a thermoelectric bionic skin for promoting healing of diabetic wounds by restoring a biological electric field microenvironment, and a preparation method comprises the following steps: adding silver selenide nanoparticles into a 10% methacryloyl gelatin solution, putting the precursor solution into a mold, adding 0.25% phenyl (2, 4, 6-trimethyl-1, 3-pentanedione), and stirring for 20-30 minutes to obtain the thermoelectric bionic skin for promoting healing of diabetic wounds by restoring a biological electric field microenvironment. 2, 6-trimethylbenzoyl) lithium phosphate (LAP) photoinitiator is added, ultraviolet light curing forming is carried out, and after demolding, soaking is carried out to remove residual monomers and the initiator; wherein the drug-containing group is prepared by replacing water with an artemisinin solution, and Ag2Se-coated GelMA or Ag2Se-coated GelMA / ART composite hydrogel is obtained. The electric field generated by the thermoelectric effect in the invention activates a voltage-gated calcium ion channel, inhibits PHD2, and up-regulates an HIF-1 / VEGF-A signal axis, thereby promoting angiogenesis. Meanwhile, the artemisinin also plays an anti-inflammatory role.

Disclosed herein are methods for using an antimalarial endoperoxide compound, such as artemisinin, in treating a subject suffering from myelodysplastic syndromes (MDS), and in slowing or preventing the progression of MDS in the subject to development of acute myeloid leukemia (AML).

The invention relates to the technical field of gel materials, and discloses a preparation method and application of a biogel antibacterial material.The preparation method comprises the steps that polyethylene glycol diimidazole phenoxy ethylene oxide serves as a cross-linking agent, in a sodium hydroxide alkaline catalytic system, double-end epoxy groups of the polyethylene glycol diimidazole phenoxy ethylene oxide can react with hydroxyl groups of cellulose, and the cross-linking agent can react with hydroxyl groups of cellulose; the preparation method comprises the following steps: carrying out chemical cross-linking on cellulose to obtain a biogel material with a porous cross-linked network structure, and finally carrying out quaternization reaction on a chloroalkyl compound and an imidazole group to introduce a large amount of quaternary ammonium salt groups into the cellulose biogel material. The water absorption rate and the antibacterial performance of the gel material are obviously improved. And moreover, the coating has very good coating performance on wormwood essential oil and artemisinin essential oil, and has better practical application in antibacterial hygienic products such as paper diapers, maintenance pads and the like.

Methods of treating cancer, such as leukemia, via administration of therapeutically effective amounts of artemisinins and one or more additional therapeutic agents are detailed herein. The artemisinins include ART714. The one or more additional therapeutic agents include BCL-2 inhibitors such as ABT-199, ABT-263, and ABT-737; kinase inhibitors such as lestaurtinib, midostaurin, sorafenib, and gilteritinib; and anti-neoplastic agents such as cytarabine, doxorubicin, etoposide, cyclophosphamide, triplotide, vinorelbine, cisplatin, and rituximab.

The present invention relates to the field of biomedical technology, and particularly to a preparation method and application of an anti-hepatic fibrosis nano-drug. Ammonium ferrous sulfate, trisodium citrate and ethylene glycol are mixed to obtain solution A; solution A and a polyethyleneimine solution are mixed to obtain solution B; solution B and a thioacetamide solution are mixed to obtain solution C; solution C and triethanolamine are mixed and then reacted to obtain iron sulfide nanosheets; the iron sulfide nanosheets, SH-PEG-NH2 and absolute ethanol are mixed to obtain FP; FP, artemisinin and absolute ethanol are mixed to obtain the anti-hepatic fibrosis nano-drug. The synthesis method of FPA is simple and highly operable; the product is stable and has repeatability; FPA has good biocompatibility and biodegradability. After entering the hepatic fibrosis microenvironment, it responds to degrade highly expressed hydrogen peroxide, promotes the change of the hepatic fibrosis cell microenvironment, and then induces apoptosis.

The invention belongs to the technical field of medical instruments, and particularly relates to an absorbable suture and a preparation method and application thereof. Two coatings are loaded, from inside to outside, the first coating is the rapamycin coating with the anti-scar effect, the second coating is the artemisinin coating with the antibacterial and anti-inflammatory effects, and stable loading and slow release of the rapamycin medicine and the artemisinin are achieved through the structure of the two coatings. The suture can release artemisinin in the surgical suture incision inflammation period, infection is prevented, and inflammatory response is reduced. The rapamycin is released in a surgical suture incision scar proliferation period, so that scar proliferation of a surgical incision is prevented and reduced.

The present invention discloses the application of deoxyartemisinin B synthase and its isoenzyme A0A2U1PPI9 in catalyzing the biosynthesis of dihydrodeoxyartemisinin B from dihydroartemisinin acid. In the biosynthetic pathway of artemisinin, the present invention for the first time discloses the process of the biosynthesis of dihydrodeoxyartemisinin B from dihydroartemisinin acid. Through bioinformatics analysis and in vitro activity verification of candidate enzymes, it is shown that both deoxyartemisinin B synthase and its isoenzyme A0A2U1PPI9 have the new function of catalyzing the biosynthesis of dihydrodeoxyartemisinin B from dihydroartemisinin acid, enriching the route of the artemisinin biosynthetic pathway and providing a theoretical basis for the analysis of the terminal biosynthetic pathway of artemisinin and the heterologous synthesis of artemisinin compounds.

The invention relates to the technical field of medicine and chemical industry, and discloses an artemisinin C-16-bit derivative and a preparation method and application thereof, the structural general formula of the artemisinin C-16-bit derivative is as shown in formula (1): # imgabs0 #, R1 is one of 4-(tert-butyl) benzenesulfonyl, 4-chlorobenzenesulfonyl, 4-fluorobenzenesulfonyl, 4-(trifluoromethyl) benzenesulfonyl, 4-methyl benzoyl and cyclopropyl formyl; and n is 1 or 2. According to the artemisinin C-16 site derivative disclosed by the invention, a specific aryl ester group is introduced to the C-16 site, so that the molecular polarity and the pharmacokinetic property are optimized, and the anti-tumor activity is improved. The artemisinin C-16-bit derivative disclosed by the invention provides a new strategy for chemical research and development of novel artemisinin derivatives and cancer treatment.

The invention relates to the technical field of medicine, and discloses an artemisinin external gel composition as well as a preparation method and application thereof, the gel composition comprises 0.1-5 parts of artemisinin, 1-20 parts of a solubilizer, 0.5-15 parts of a gel matrix, 5-30 parts of a penetration enhancer, 0.01-1 part of a stabilizer, 0.01-2 parts of a pH regulator, 0.05-1.5 parts of a preservative, 1-15 parts of a humectant and purified water. According to the technical scheme, a peroxide bridge structure of artemisinin is used for removing active oxygen, the multiple effects of resisting inflammation, resisting oxidation, resisting bacteria, promoting repair and resisting scars are achieved by regulating and controlling channels such as NF-kappa B and TGF-beta, and meanwhile, a gel matrix maintains a moist environment of a wound surface and promotes transdermal absorption of drugs. Experiments prove that the composition can reduce MDA content of wound surfaces, increase SOD activity, inhibit IL-6, TNF-alpha and other inflammatory factors, reduce collagen deposition and inhibit bacterial growth, can effectively improve the pathological process of scalds and burns, and provides a novel multi-mechanism synergistic external composition for clinical treatment.

The invention relates to a method for reducing energy consumption and safety risk during regeneration of artemisinin separated silica gel, belongs to the technical field of artemisinin extraction, and discloses a mixing step: mixing a solvent with waste silica gel; a separation step: carrying out air filter pressing on the material to separate mother liquor adsorbed in the silica gel from the silica gel, and recovering the mother liquor; a cleaning step: cleaning the silica gel, and recovering the solvent; a drying step: performing vacuum drying on the silica gel to obtain dried silica gel; the four steps are integrally completed in a three-in-one silica gel regeneration tank; the silica gel regeneration device has the beneficial effects that silica gel regeneration can be completed by only one main tank body, multiple times of high-temperature heating can be avoided, and the energy consumption is greatly reduced; silica gel and a solvent are transferred in closed equipment, safety risks and solvent consumption are reduced, a safety valve is arranged on the main tank body, potential safety hazards are greatly reduced, repeated carrying can be avoided, manpower is reduced, and economic benefits are greatly increased.

Provided is use of an endoperoxide in preparing an anti-microbial drug. In an anoxic condition, the endoperoxide can partially and effectively inhibit the survival of Mycobacterium tuberculosis. Provided is use of an endoperoxide in combination with a respiratory chain inhibitor in preparing an anti-microbial drug. The endoperoxide includes artemisinin and derivatives thereof, and other endoperoxides with a two-oxygen bridge structure. The endoperoxide has synergistic effects with a variety of respiratory chain inhibitors, and the combination has a more effective inhibition effect on Mycobacterium tuberculosis.

The invention belongs to the technical field of biological medicine, provides application of horse radish peroxidase as an exogenous activator of artemisinin and derivatives thereof, and is based on the characteristic that the horse radish peroxidase can catalyze the artemisinin and the derivatives thereof to generate high-level ROS (reactive oxygen species). The invention also provides an application of the horse radish peroxidase in preparation of anti-tumor nano drug-loaded particles.

The invention relates to a high-stability dihydroartemisinin emulsion which is prepared by the following steps: preparing a mixed solution from dihydroartemisinin, sodium bicarbonate and polyethylene glycol 600, carrying out loading treatment in a carbon dioxide supercritical extraction instrument by taking glycerol and n-butyl alcohol as a composite solvent to form an intermediate product, and specifically, after running for 1-2 hours under the conditions that the CO2 flow is 10-15kg / h, the pressure is 15-20Mpa and the temperature is 35 DEG C, increasing the pressure to 25-30Mpa, keeping the temperature for 1-2 hours, and carrying out constant-temperature extraction to obtain the dihydroartemisinin emulsion. The temperature is raised to 45-50 DEG C and kept for 30-60 min, a product is collected and placed at the room temperature after the temperature is raised to 45-50 DEG C, an intermediate product is obtained, and the intermediate product is added into an emulsion matrix to form the nano-emulsion. The transfer rate of the dihydroartemisinin in the prepared intermediate product reaches 94.37%, the particle size of the loaded nano intermediate product is uniformly distributed at about 50nm, the prepared emulsion is uniform, the dihydroartemisinin has excellent stability in the system, the dihydroartemisinin is not easy to decompose in environments of long-term high temperature, high-humidity illumination and the like, the stability of the emulsion property is excellent, and the stability of the product is good. The problems of layering, sedimentation and the like are avoided, and the bioavailability is excellent.

This invention relates to the fields of pharmaceuticals and nanomedicine, specifically disclosing the preparation of a dual-targeting liposome drug delivery system and its application in stroke. The dual-targeting liposome drug delivery system comprises neutrophils, artemisinin, edaravone, and liposomes. The liposomes co-load artemisinin and edaravone, and their surfaces are modified with sialic acid derivatives and phosphatidylserine to form liposome nanomedicines. The neutrophils act as carriers, transporting the drug across the brain border (BBB) ​​and targeting it to the ischemic brain region. This dual-targeting strategy achieves precise two-stage drug delivery to the ischemic brain region. This delivery system can inhibit NLRP3 inflammasome activation, reduce pyroptosis, and promote microglial polarization towards the M2 anti-inflammatory phenotype, thereby effectively treating cerebral ischemia-reperfusion injury or ischemic stroke.

The invention belongs to the technical field of cosmetics, and discloses application of sesquiterpene lactone compounds in whitening. The invention finds that the arnica lactone D and artemisinin have related whitening effects for the first time, specifically, the arnica lactone D and artemisinin are capable of inhibiting melanogenesis and tyrosinase activity, good in inhibition effect, low in onset concentration and non-irritant to red blood cells, so that the arnica lactone D and artemisinin have certain safety, also have relatively good anti-inflammatory activity, can improve hyperpigmentation after inflammation, and can be used for preventing and treating inflammation. The method has great potential in the fields related to cosmetics.

The invention belongs to the technical field of preparation of artemisinin, and discloses a preparation method of artemisinin, which comprises the following steps: reacting diisopropylamine with n-butyllithium in anhydrous THF (tetrahydrofuran) to generate strong base lithium diisopropylamide and obtain a strong base lithium diisopropylamide solution; step 2, then adding a mixed solution of artemisinin and THF into the strong base lithium diisopropylamide solution; the strong base lithium diisopropylamide is used as a strong base to capture specific acidic hydrogen in artemisinin molecules to form an enol salt intermediate; benzene sulfonyl chloride is added to react with hydroxyl of the enol salt intermediate to generate sulfonate; taking a sulfonate group as a good leaving group, carrying out beta-elimination under an alkaline condition to form a double bond, reacting to obtain an artemisinin solution, and purifying the artemisinin solution to obtain a pure product artemisinin; according to the method, benzenesulfonyl chloride and artemisinin which are low in price and easy to obtain are used as main raw materials, the artemisinin is synthesized through a one-pot method, and the method is simple in process, environmentally friendly, high in yield and suitable for industrial production.

The invention discloses a method for producing aviation kerosene by utilizing artemisinin leftovers, which comprises the following steps: (1) crushing and drying the artemisinin leftovers to obtain a pretreated material; (2) performing primary hydrotreatment under the action of a nickel-molybdenum-based catalyst to obtain a primary treated material; (3) performing secondary hydrotreatment under the action of a nickel-tungsten-based catalyst to obtain a secondary treated material; (4) carrying out isodewaxing on the secondary treatment material by adopting a Pt and Pd loaded ZSM-48 molecular sieve catalyst to obtain a dewaxed material; and (5) fractionating, cutting the dewaxed material, and collecting aviation fuel components with the distillation range of 150-300 DEG C and light components with the distillation range of 50-150 DEG C. The catalyst adopted by the invention has the advantages of long service life and low energy consumption, the production cost is reduced by 15-20%, the impurity removal efficiency is high, the total removal rate is about 95-98%, the product quality can reach the ASTM D7566-23 standard, fossil aviation kerosene can be directly replaced, the resource utilization of waste artemisinin leftovers is realized, and compared with the fossil aviation kerosene, the cost is low, and the cost is low. CO2 emission can be reduced by about 3 tons per ton of biological aviation kerosene.

The invention discloses a gas-liquid-solid separation solution collector for artemisinin extraction, and relates to the technical field of gas-liquid-solid separation solution collection, the gas-liquid-solid separation solution collector comprises a collection cylinder, the top end of the collection cylinder is movably provided with a top cover, the middle part of the upper end of the top cover is fixedly provided with a motor, one side of the upper end of the top cover is fixedly connected with a liquid inlet pipe, and the other side of the top cover is fixedly connected with a liquid outlet pipe. An exhaust mechanism is arranged at the rear end of the top cover, a bottom cover is movably installed at the lower end of the collecting barrel, a liquid outlet pipe is fixedly connected to the lower end of the bottom cover, and an electromagnetic valve is fixedly connected to the liquid outlet pipe. Through the residue collecting mechanism, the artemisinin extraction solution can be subjected to multi-stage filtration by utilizing two groups of filter frames, then the artemisinin extraction solution and residual solid residues can be subjected to solid-liquid separation, the separated artemisinin extraction solution is discharged through a liquid outlet pipe, and the solid residues are left on the filter frames; and subsequent treatment is facilitated.

The utility model relates to the technical field of support components, specifically an artemisinin extraction support component, including a support ring: limiting slides are inserted inside the two sides of the support ring, a positioning clamp is connected to the top of the limiting slide, and a bearing is connected to one side of the positioning clamp. The utility model inserts the extractor into the support ring, and then rotates the threaded rod to move it inside the threaded hole opened in the support ring, and the threaded rod drives the limiting slide to slide inside the slide groove opened in the support ring, and the bearing does not affect the movement of the limiting slide when the threaded rod rotates, and the limiting slide is used to drive the positioning clamp to be sleeved on the outer walls on both sides of the extractor to clamp and fix the extractor, and the support frame and the support seat are used to support the bottom of the support ring, thereby realizing the adjustment of the positioning clamp, avoiding the problem of being unable to disassemble and assemble, and unable to support extractors of different sizes.

The Artemisinin-Proteasome inhibitor conjugate compounds of the present application are represented by the following compounds having Formula (I) where the substituents R1-R5, X, Y, Y', and Z are defined herein. These compounds are used in the treatment of cancer, immunologic disorders, autoimmune disorders, neurodegenerative disorders, or inflammatory disorders, infectious disease, or for providing immunosuppression for transplanted organs or tissues.

The invention discloses a multi-modal imaging guided bone hydatid cyst fluid suction and artemisinin in-situ injection method, which relates to the technical field of medical treatment, and comprises the following steps: step 1, turning on devices corresponding to MRI (Magnetic Resonance Imaging), CT (Computed Tomography) and ultrasound to form a multi-modal imaging device, and carrying out multi-modal imaging on a to-be-treated part of a patient; 2, the suction and injection integrated device is placed at the treatment position, and the skin at the treatment position is adsorbed through the suction and injection integrated device; 3, medical staff sutures the wound, a circular ring is placed at the treatment position of a patient, traction and fixation are conducted through a traction frame on an operating table, then a central control computer controls micro air pumps to output corresponding power, each suction cup has the corresponding comprehensive suction index, the skin of the patient is sucked, and the wound is sutured through the medical staff. The skin of the treated part of the patient is adsorbed through the three circles of suction cups, manual work can be replaced, the treatment intelligence is improved, quick response can be made when throb conditions occur, and the treatment reliability is improved.

The utility model discloses an artemisinin chromatographic separation device relates to chromatography field, including fixed frame and chromatographic column body, the fixed frame is fixedly connected with material tank, the vertical fixedly connected with sleeve in material tank, the open lower extreme of sleeve and penetrate material tank bottom, a plurality of through -holes are seted up on the sleeve, the surface of chromatographic column body is equipped with the seal cover, and the seal cover and sleeve inner wall gap cooperation. Advantageous effect lies in: the utility model creatively combines the sedimentation method with chromatographic column separation. Set up sleeve and through -hole in material tank, cooperate the use of the precipitate, first through the sedimentation method and make the impurity precipitate to material tank bottom, control chromatographic column body's elevation again, only let the solution above the precipitate layer enter chromatographic column body and carry out chromatographic separation. This kind of double method cooperation operation, both reduce the interference of impurity to chromatographic process, and make up the defect of single sedimentation method purity deficiency, improve separation efficiency and artemisinin purity greatly.

The invention provides an artemisinin-chitosan multifunctional microcapsule as well as a preparation method and application thereof. The preparation method comprises the following steps: mixing artemisinin and Span80 with degraded chitosan and Tween 80 to obtain an emulsion; adjusting the pH value to 9-11, and carrying out a single condensation reaction; after dilution, rapidly cooling with an ice-water bath, and adding glutaraldehyde for low-temperature cross-linking curing; and after the reaction is finished, carrying out suction filtration at room temperature, washing and drying to obtain the microcapsule. Based on the synergistic effect of chitosan and artemisinin, a low-temperature composite crosslinking technology is developed, and efficient encapsulation and controllable release of artemisinin in the microcapsule are achieved; the problem that artemisinin is prone to thermal degradation is solved by optimizing the core-wall ratio, pH regulation and control and low-temperature cross-linking curing, and meanwhile, the long-acting slow release performance of the microcapsule in a complex oral environment is remarkably improved by utilizing a dual stabilization mechanism of chitosan single condensation reaction and glutaraldehyde cross-linking. The product has higher active matter loading capacity and release efficiency, and has long-acting application in the scenes of oral cavity bacteria (spots) resistance (inhibition), gingival problem alleviation, hemostasis and the like.

An artemisinin continuous gradient forward and reverse flow forward and reverse rotation extraction method belongs to the technical field of artemisinin extraction, and comprises the following steps: enabling an artemisia apiacea material to sequentially pass through a plurality of extraction sections connected in series along a first direction; injecting the extraction solvent along the direction opposite to the overall direction of the material, and controlling by a solvent bridge pipe, so that the solvent sequentially and reversely fills the subsequent sections to form a continuous gradient forward and reverse flow extraction environment in which the solvent flow direction is the same as the material flow direction in part of the sections and opposite to the material flow direction in part of the sections; in the extraction process, materials are stirred in a periodic positive and negative rotation mode, and an ultrasonic field is applied to a specific section for assistance; the device is a special system for implementing the method. According to the method disclosed by the invention, the extraction yield of the artemisinin is remarkably improved through the cooperation of'gradient forward and reverse flow design ', 'dynamic forward and reverse rotation stirring' and'ultrasonic assistance ', the extraction time is shortened to about 2 hours, and the production efficiency is greatly improved.

The application discloses a method for preparing artemisitene (ARE) and deoxyarteannuin B (DB) from arteannuin B (ART-B), wherein ART-B is used as a reaction substrate, a Fenton oxidation reaction system is constructed by adding ferrous salt and hydrogen peroxide in a water-methanol mixed solvent system, and a UVA light is used to assist in a catalytic oxidation reaction, so that the ARE and DB products are generated. The application realizes specific directional conversion of ART-B to ARE and DB by using a light-Fenton synergistic oxidation system for the first time, confirms that ART-B is a natural synthesis precursor of ARE, and proves an oxidation conversion path of ART-B to ARE, and the whole reaction system has the advantages of mild conditions, clear conversion path, controllable product selectivity and the like, and provides a new technical method and a key theoretical basis for artificial synthesis of artemisitene and analogues thereof, deep analysis of a biosynthesis path of artemisinin compounds, and innovative application of the Fenton reaction in the field of directional structure conversion of natural products.

The present invention provides a method for preparing artemisinin by using a continuous flow reactor, comprising: using dihydroartemisinic acid as a starting material, converting it into MPDHAA in the presence of two metal catalysts such as sodium molybdate and hydrogen peroxide in a continuous flow reactor, and then, MPDHAA generates artemisinin in the presence of TFA and oxygen in a continuous flow reactor. Compared with a traditional kettle reaction process, this method significantly saves time and solvent, and reduces production costs.

The invention discloses a composition for inducing dental pulp cell reprogramming, the composition comprises a TGF-beta pathway inhibitor, an MEK inhibitor, a GSK3 inhibitor, coptisine, astragaloside and artemisinin, and the components have a synergistic effect to realize the dental pulp cell reprogramming; the invention further discloses a reprogramming culture medium composed of the composition and an alpha-MEM basic culture medium. The invention also discloses a reprogramming method for reprogramming the dental pulp cells by using the reprogramming culture medium, the method comprises the steps of dental pulp cell culture, cell inoculation, reprogramming culture and the like, and the induced pluripotent stem cells can be obtained by culturing the dental pulp cells in the reprogramming culture medium for 14 days. The composition disclosed by the invention is definite in component, the reprogramming efficiency of the dental pulp cells can be remarkably improved, and the reprogrammed induced pluripotent stem cells are good in dryness and high in hereditary stability, and can be widely applied to the cell reprogramming fields such as regenerative medicine, oral disease treatment and drug development.

Provided are an artemisinin derivative and a preparation method and use thereof. A structural formula of the artemisinin derivative is shown in Formula I. The compound has suitable solubility and is relatively stable under storage conditions. Pharmacokinetic experiments on the compound have shown that artemisinin is detectable in ocular tissues and is present in cornea, conjunctiva, and aqueous humor at a relatively high drug concentration. The compound is therefore an excellent precursor to artemisinin. The compound shown in Formula I exhibits remarkable absorbability, and the drug concentration in the ocular tissues indicates that the compound is well absorbed. The compound exhibits significantly better inhibitory effects on neovascularization in burn models than artemisinin, and can be prepared into liquid formulations such as eye drops, injection, etc., for treatment of ocular tissue diseases.

The utility model relates to the technical field of recovery devices, in particular to an artemisinin extraction solvent recovery treatment tank cleaning assembly which comprises a treatment tank body, a feeding pipe is fixedly connected to the side face of the treatment tank body, a discharging pipe is fixedly connected to the bottom of the treatment tank body, and a water pipe is fixedly connected to the top of the treatment tank body. A motor is fixedly connected to the top of the treatment tank body, a rotating shaft is fixedly connected to the output end of the motor, a water spraying structure is arranged on the surface of the rotating shaft, a scraping and sweeping structure is arranged on the surface of the rotating shaft, a moving rod is fixedly connected to the bottom of a limiting block, and a scraping plate is fixedly connected to the bottom of the moving rod. The water sprinkling structure is arranged, follow-up cleaning in the treatment tank is facilitated, a water pipe is convenient to place, damage to the water sprinkling structure is prevented, the scraping and sweeping structure is arranged, thorough cleaning is conducted, dead corners are avoided, and follow-up production work is facilitated.

The invention provides a preheating device for artemisinin extraction, and belongs to the technical field of artemisinin processing, the preheating device comprises an inner preheating cylinder, the outer side of the inner preheating cylinder is sleeved with an outer shell sleeve, a space exists between the outer shell sleeve and the side wall of the inner preheating cylinder, one side of the outer shell sleeve is fixedly connected with an input channel, the other side of the outer shell sleeve is fixedly connected with an output channel, and the outer side of the outer shell sleeve is fixedly connected with the output channel. The upper side of the inner preheating barrel is in threaded connection with an upper shell cover, a delivery shell is arranged on the upper portion of the upper shell cover, a motor is arranged in the middle of the upper portion of the upper shell cover, a rotating rod of the motor is fixedly connected with a linkage rod, and a ring-shaped removing assembly is arranged in the inner preheating barrel. The problems that due to the fact that the situation of unbalanced heating is likely to occur and temperature difference exists, preheating cannot be rapidly and sufficiently executed, and in the preheating process and the discharging period of artemisinin raw materials, part of the materials are attached to the barrel wall face, and sufficient discharging is not facilitated are solved.