6 results about "Artemisinins" patented technology

This invention relates to the fields of pharmaceuticals and nanomedicine, specifically disclosing the preparation of a dual-targeting liposome drug delivery system and its application in stroke. The dual-targeting liposome drug delivery system comprises neutrophils, artemisinin, edaravone, and liposomes. The liposomes co-load artemisinin and edaravone, and their surfaces are modified with sialic acid derivatives and phosphatidylserine to form liposome nanomedicines. The neutrophils act as carriers, transporting the drug across the brain border (BBB) ​​and targeting it to the ischemic brain region. This dual-targeting strategy achieves precise two-stage drug delivery to the ischemic brain region. This delivery system can inhibit NLRP3 inflammasome activation, reduce pyroptosis, and promote microglial polarization towards the M2 anti-inflammatory phenotype, thereby effectively treating cerebral ischemia-reperfusion injury or ischemic stroke.

The utility model discloses an artemisinin chromatographic separation device relates to chromatography field, including fixed frame and chromatographic column body, the fixed frame is fixedly connected with material tank, the vertical fixedly connected with sleeve in material tank, the open lower extreme of sleeve and penetrate material tank bottom, a plurality of through -holes are seted up on the sleeve, the surface of chromatographic column body is equipped with the seal cover, and the seal cover and sleeve inner wall gap cooperation. Advantageous effect lies in: the utility model creatively combines the sedimentation method with chromatographic column separation. Set up sleeve and through -hole in material tank, cooperate the use of the precipitate, first through the sedimentation method and make the impurity precipitate to material tank bottom, control chromatographic column body's elevation again, only let the solution above the precipitate layer enter chromatographic column body and carry out chromatographic separation. This kind of double method cooperation operation, both reduce the interference of impurity to chromatographic process, and make up the defect of single sedimentation method purity deficiency, improve separation efficiency and artemisinin purity greatly.

This invention relates to an artemisinin trimer derivative, its preparation method, and its application. This invention is the first to synthesize and isolate β,β,α trimer, β,α,α trimer, and α,α,α trimer. The isomers of these three trimers were successfully isolated by the new synthetic method and characterized and their activity was tested. The test results showed that they have high antitumor activity.

This invention belongs to the field of pharmaceutical technology and relates to the research and application of drugs for the treatment of lymphedema, specifically the application of systemic artemisinin in the treatment of secondary lymphedema. Specifically, this invention provides the use of artemisinin or its derivatives in the preparation of drugs or formulations for the prevention and / or treatment of lymphedema, wherein the drugs or formulations are used to: relieve lymphedema, relieve fat deposition caused by lymphedema, and / or promote lymphatic vessel regeneration.

The application discloses a preparation method of a dual-function antibacterial and anti-inflammatory absorbable coating material, which comprises the following steps: (1) blending rifampicin, artemisinin and an absorbable polymer A with a mixed solvent to obtain coating solution A; blending minocycline hydrochloride, aspirin and an absorbable polymer B with the mixed solvent to obtain coating solution B; the mixed solvent is selected from hexafluoroisopropanol and ethyl acetate; (2) uniformly spraying the coating solution A and the coating solution B on the surface of a degradable substrate by ultrasonic spraying, and performing drying treatment to obtain the dual-function antibacterial and anti-inflammatory absorbable coating material. According to the preparation method, the proportion of antibiotic active ingredients, anti-inflammatory drug active ingredients and absorbable polymers is regulated, the antibacterial and anti-inflammatory drug coating is uniformly and stably fixed on the surface of the degradable substrate by ultrasonic spraying, and the dual-function absorbable antibacterial and anti-inflammatory coating material with controllable release is prepared by optimizing process parameters.

The application provides a hemoglobin cascade response nano vesicle and a preparation method and application thereof, and belongs to the technical field of biological medicine. The first hemoglobin response nano vesicle (DecAS-PC@NM) is designed, and disease-specific treatment is realized through cascade reaction of two functional phospholipids. First, hemoglobin activates artemisinin-modified phospholipid (A-PC) to generate active oxygen, the active oxygen oxidizes the sulfide structure in another phospholipid (S-PC), and the transformation from hydrophilicity to hydrophobicity is caused, so that the vesicle is disintegrated. Through co-assembly with neutrophil membranes, the chemotaxis to inflammatory sites is further enhanced. In vitro studies show that DecAS-PC@NM has unique hemoglobin responsiveness, and in vivo data emphasize its targeting to ischemic cores and significant therapeutic effect. This innovative hemoglobin-triggered phospholipid cascade reaction provides a promising strategy for the treatment of myocardial ischemia-reperfusion injury.