39 results about "Artemisinins" patented technology

The invention relates to the technical field of biomedical materials, in particular to a thermoelectric bionic skin for promoting healing of diabetic wounds by restoring a biological electric field microenvironment, and a preparation method comprises the following steps: adding silver selenide nanoparticles into a 10% methacryloyl gelatin solution, putting the precursor solution into a mold, adding 0.25% phenyl (2, 4, 6-trimethyl-1, 3-pentanedione), and stirring for 20-30 minutes to obtain the thermoelectric bionic skin for promoting healing of diabetic wounds by restoring a biological electric field microenvironment. 2, 6-trimethylbenzoyl) lithium phosphate (LAP) photoinitiator is added, ultraviolet light curing forming is carried out, and after demolding, soaking is carried out to remove residual monomers and the initiator; wherein the drug-containing group is prepared by replacing water with an artemisinin solution, and Ag2Se-coated GelMA or Ag2Se-coated GelMA / ART composite hydrogel is obtained. The electric field generated by the thermoelectric effect in the invention activates a voltage-gated calcium ion channel, inhibits PHD2, and up-regulates an HIF-1 / VEGF-A signal axis, thereby promoting angiogenesis. Meanwhile, the artemisinin also plays an anti-inflammatory role.

The present invention relates to the field of biomedical technology, and particularly to a preparation method and application of an anti-hepatic fibrosis nano-drug. Ammonium ferrous sulfate, trisodium citrate and ethylene glycol are mixed to obtain solution A; solution A and a polyethyleneimine solution are mixed to obtain solution B; solution B and a thioacetamide solution are mixed to obtain solution C; solution C and triethanolamine are mixed and then reacted to obtain iron sulfide nanosheets; the iron sulfide nanosheets, SH-PEG-NH2 and absolute ethanol are mixed to obtain FP; FP, artemisinin and absolute ethanol are mixed to obtain the anti-hepatic fibrosis nano-drug. The synthesis method of FPA is simple and highly operable; the product is stable and has repeatability; FPA has good biocompatibility and biodegradability. After entering the hepatic fibrosis microenvironment, it responds to degrade highly expressed hydrogen peroxide, promotes the change of the hepatic fibrosis cell microenvironment, and then induces apoptosis.

The invention belongs to the technical field of medical instruments, and particularly relates to an absorbable suture and a preparation method and application thereof. Two coatings are loaded, from inside to outside, the first coating is the rapamycin coating with the anti-scar effect, the second coating is the artemisinin coating with the antibacterial and anti-inflammatory effects, and stable loading and slow release of the rapamycin medicine and the artemisinin are achieved through the structure of the two coatings. The suture can release artemisinin in the surgical suture incision inflammation period, infection is prevented, and inflammatory response is reduced. The rapamycin is released in a surgical suture incision scar proliferation period, so that scar proliferation of a surgical incision is prevented and reduced.

The present invention discloses the application of deoxyartemisinin B synthase and its isoenzyme A0A2U1PPI9 in catalyzing the biosynthesis of dihydrodeoxyartemisinin B from dihydroartemisinin acid. In the biosynthetic pathway of artemisinin, the present invention for the first time discloses the process of the biosynthesis of dihydrodeoxyartemisinin B from dihydroartemisinin acid. Through bioinformatics analysis and in vitro activity verification of candidate enzymes, it is shown that both deoxyartemisinin B synthase and its isoenzyme A0A2U1PPI9 have the new function of catalyzing the biosynthesis of dihydrodeoxyartemisinin B from dihydroartemisinin acid, enriching the route of the artemisinin biosynthetic pathway and providing a theoretical basis for the analysis of the terminal biosynthetic pathway of artemisinin and the heterologous synthesis of artemisinin compounds.

The invention relates to the technical field of medicine and chemical industry, and discloses an artemisinin C-16-bit derivative and a preparation method and application thereof, the structural general formula of the artemisinin C-16-bit derivative is as shown in formula (1): # imgabs0 #, R1 is one of 4-(tert-butyl) benzenesulfonyl, 4-chlorobenzenesulfonyl, 4-fluorobenzenesulfonyl, 4-(trifluoromethyl) benzenesulfonyl, 4-methyl benzoyl and cyclopropyl formyl; and n is 1 or 2. According to the artemisinin C-16 site derivative disclosed by the invention, a specific aryl ester group is introduced to the C-16 site, so that the molecular polarity and the pharmacokinetic property are optimized, and the anti-tumor activity is improved. The artemisinin C-16-bit derivative disclosed by the invention provides a new strategy for chemical research and development of novel artemisinin derivatives and cancer treatment.

The invention relates to the technical field of medicine, and discloses an artemisinin external gel composition as well as a preparation method and application thereof, the gel composition comprises 0.1-5 parts of artemisinin, 1-20 parts of a solubilizer, 0.5-15 parts of a gel matrix, 5-30 parts of a penetration enhancer, 0.01-1 part of a stabilizer, 0.01-2 parts of a pH regulator, 0.05-1.5 parts of a preservative, 1-15 parts of a humectant and purified water. According to the technical scheme, a peroxide bridge structure of artemisinin is used for removing active oxygen, the multiple effects of resisting inflammation, resisting oxidation, resisting bacteria, promoting repair and resisting scars are achieved by regulating and controlling channels such as NF-kappa B and TGF-beta, and meanwhile, a gel matrix maintains a moist environment of a wound surface and promotes transdermal absorption of drugs. Experiments prove that the composition can reduce MDA content of wound surfaces, increase SOD activity, inhibit IL-6, TNF-alpha and other inflammatory factors, reduce collagen deposition and inhibit bacterial growth, can effectively improve the pathological process of scalds and burns, and provides a novel multi-mechanism synergistic external composition for clinical treatment.

The invention belongs to the technical field of biological medicine, provides application of horse radish peroxidase as an exogenous activator of artemisinin and derivatives thereof, and is based on the characteristic that the horse radish peroxidase can catalyze the artemisinin and the derivatives thereof to generate high-level ROS (reactive oxygen species). The invention also provides an application of the horse radish peroxidase in preparation of anti-tumor nano drug-loaded particles.

This invention relates to the fields of pharmaceuticals and nanomedicine, specifically disclosing the preparation of a dual-targeting liposome drug delivery system and its application in stroke. The dual-targeting liposome drug delivery system comprises neutrophils, artemisinin, edaravone, and liposomes. The liposomes co-load artemisinin and edaravone, and their surfaces are modified with sialic acid derivatives and phosphatidylserine to form liposome nanomedicines. The neutrophils act as carriers, transporting the drug across the brain border (BBB) ​​and targeting it to the ischemic brain region. This dual-targeting strategy achieves precise two-stage drug delivery to the ischemic brain region. This delivery system can inhibit NLRP3 inflammasome activation, reduce pyroptosis, and promote microglial polarization towards the M2 anti-inflammatory phenotype, thereby effectively treating cerebral ischemia-reperfusion injury or ischemic stroke.

The invention belongs to the technical field of preparation of artemisinin, and discloses a preparation method of artemisinin, which comprises the following steps: reacting diisopropylamine with n-butyllithium in anhydrous THF (tetrahydrofuran) to generate strong base lithium diisopropylamide and obtain a strong base lithium diisopropylamide solution; step 2, then adding a mixed solution of artemisinin and THF into the strong base lithium diisopropylamide solution; the strong base lithium diisopropylamide is used as a strong base to capture specific acidic hydrogen in artemisinin molecules to form an enol salt intermediate; benzene sulfonyl chloride is added to react with hydroxyl of the enol salt intermediate to generate sulfonate; taking a sulfonate group as a good leaving group, carrying out beta-elimination under an alkaline condition to form a double bond, reacting to obtain an artemisinin solution, and purifying the artemisinin solution to obtain a pure product artemisinin; according to the method, benzenesulfonyl chloride and artemisinin which are low in price and easy to obtain are used as main raw materials, the artemisinin is synthesized through a one-pot method, and the method is simple in process, environmentally friendly, high in yield and suitable for industrial production.

The invention discloses a method for producing aviation kerosene by utilizing artemisinin leftovers, which comprises the following steps: (1) crushing and drying the artemisinin leftovers to obtain a pretreated material; (2) performing primary hydrotreatment under the action of a nickel-molybdenum-based catalyst to obtain a primary treated material; (3) performing secondary hydrotreatment under the action of a nickel-tungsten-based catalyst to obtain a secondary treated material; (4) carrying out isodewaxing on the secondary treatment material by adopting a Pt and Pd loaded ZSM-48 molecular sieve catalyst to obtain a dewaxed material; and (5) fractionating, cutting the dewaxed material, and collecting aviation fuel components with the distillation range of 150-300 DEG C and light components with the distillation range of 50-150 DEG C. The catalyst adopted by the invention has the advantages of long service life and low energy consumption, the production cost is reduced by 15-20%, the impurity removal efficiency is high, the total removal rate is about 95-98%, the product quality can reach the ASTM D7566-23 standard, fossil aviation kerosene can be directly replaced, the resource utilization of waste artemisinin leftovers is realized, and compared with the fossil aviation kerosene, the cost is low, and the cost is low. CO2 emission can be reduced by about 3 tons per ton of biological aviation kerosene.

The Artemisinin-Proteasome inhibitor conjugate compounds of the present application are represented by the following compounds having Formula (I) where the substituents R1-R5, X, Y, Y', and Z are defined herein. These compounds are used in the treatment of cancer, immunologic disorders, autoimmune disorders, neurodegenerative disorders, or inflammatory disorders, infectious disease, or for providing immunosuppression for transplanted organs or tissues.

The invention discloses a multi-modal imaging guided bone hydatid cyst fluid suction and artemisinin in-situ injection method, which relates to the technical field of medical treatment, and comprises the following steps: step 1, turning on devices corresponding to MRI (Magnetic Resonance Imaging), CT (Computed Tomography) and ultrasound to form a multi-modal imaging device, and carrying out multi-modal imaging on a to-be-treated part of a patient; 2, the suction and injection integrated device is placed at the treatment position, and the skin at the treatment position is adsorbed through the suction and injection integrated device; 3, medical staff sutures the wound, a circular ring is placed at the treatment position of a patient, traction and fixation are conducted through a traction frame on an operating table, then a central control computer controls micro air pumps to output corresponding power, each suction cup has the corresponding comprehensive suction index, the skin of the patient is sucked, and the wound is sutured through the medical staff. The skin of the treated part of the patient is adsorbed through the three circles of suction cups, manual work can be replaced, the treatment intelligence is improved, quick response can be made when throb conditions occur, and the treatment reliability is improved.

The utility model discloses an artemisinin chromatographic separation device relates to chromatography field, including fixed frame and chromatographic column body, the fixed frame is fixedly connected with material tank, the vertical fixedly connected with sleeve in material tank, the open lower extreme of sleeve and penetrate material tank bottom, a plurality of through -holes are seted up on the sleeve, the surface of chromatographic column body is equipped with the seal cover, and the seal cover and sleeve inner wall gap cooperation. Advantageous effect lies in: the utility model creatively combines the sedimentation method with chromatographic column separation. Set up sleeve and through -hole in material tank, cooperate the use of the precipitate, first through the sedimentation method and make the impurity precipitate to material tank bottom, control chromatographic column body's elevation again, only let the solution above the precipitate layer enter chromatographic column body and carry out chromatographic separation. This kind of double method cooperation operation, both reduce the interference of impurity to chromatographic process, and make up the defect of single sedimentation method purity deficiency, improve separation efficiency and artemisinin purity greatly.

The invention provides an artemisinin-chitosan multifunctional microcapsule as well as a preparation method and application thereof. The preparation method comprises the following steps: mixing artemisinin and Span80 with degraded chitosan and Tween 80 to obtain an emulsion; adjusting the pH value to 9-11, and carrying out a single condensation reaction; after dilution, rapidly cooling with an ice-water bath, and adding glutaraldehyde for low-temperature cross-linking curing; and after the reaction is finished, carrying out suction filtration at room temperature, washing and drying to obtain the microcapsule. Based on the synergistic effect of chitosan and artemisinin, a low-temperature composite crosslinking technology is developed, and efficient encapsulation and controllable release of artemisinin in the microcapsule are achieved; the problem that artemisinin is prone to thermal degradation is solved by optimizing the core-wall ratio, pH regulation and control and low-temperature cross-linking curing, and meanwhile, the long-acting slow release performance of the microcapsule in a complex oral environment is remarkably improved by utilizing a dual stabilization mechanism of chitosan single condensation reaction and glutaraldehyde cross-linking. The product has higher active matter loading capacity and release efficiency, and has long-acting application in the scenes of oral cavity bacteria (spots) resistance (inhibition), gingival problem alleviation, hemostasis and the like.

An artemisinin continuous gradient forward and reverse flow forward and reverse rotation extraction method belongs to the technical field of artemisinin extraction, and comprises the following steps: enabling an artemisia apiacea material to sequentially pass through a plurality of extraction sections connected in series along a first direction; injecting the extraction solvent along the direction opposite to the overall direction of the material, and controlling by a solvent bridge pipe, so that the solvent sequentially and reversely fills the subsequent sections to form a continuous gradient forward and reverse flow extraction environment in which the solvent flow direction is the same as the material flow direction in part of the sections and opposite to the material flow direction in part of the sections; in the extraction process, materials are stirred in a periodic positive and negative rotation mode, and an ultrasonic field is applied to a specific section for assistance; the device is a special system for implementing the method. According to the method disclosed by the invention, the extraction yield of the artemisinin is remarkably improved through the cooperation of'gradient forward and reverse flow design ', 'dynamic forward and reverse rotation stirring' and'ultrasonic assistance ', the extraction time is shortened to about 2 hours, and the production efficiency is greatly improved.

The application discloses a method for preparing artemisitene (ARE) and deoxyarteannuin B (DB) from arteannuin B (ART-B), wherein ART-B is used as a reaction substrate, a Fenton oxidation reaction system is constructed by adding ferrous salt and hydrogen peroxide in a water-methanol mixed solvent system, and a UVA light is used to assist in a catalytic oxidation reaction, so that the ARE and DB products are generated. The application realizes specific directional conversion of ART-B to ARE and DB by using a light-Fenton synergistic oxidation system for the first time, confirms that ART-B is a natural synthesis precursor of ARE, and proves an oxidation conversion path of ART-B to ARE, and the whole reaction system has the advantages of mild conditions, clear conversion path, controllable product selectivity and the like, and provides a new technical method and a key theoretical basis for artificial synthesis of artemisitene and analogues thereof, deep analysis of a biosynthesis path of artemisinin compounds, and innovative application of the Fenton reaction in the field of directional structure conversion of natural products.

The invention discloses a composition for inducing dental pulp cell reprogramming, the composition comprises a TGF-beta pathway inhibitor, an MEK inhibitor, a GSK3 inhibitor, coptisine, astragaloside and artemisinin, and the components have a synergistic effect to realize the dental pulp cell reprogramming; the invention further discloses a reprogramming culture medium composed of the composition and an alpha-MEM basic culture medium. The invention also discloses a reprogramming method for reprogramming the dental pulp cells by using the reprogramming culture medium, the method comprises the steps of dental pulp cell culture, cell inoculation, reprogramming culture and the like, and the induced pluripotent stem cells can be obtained by culturing the dental pulp cells in the reprogramming culture medium for 14 days. The composition disclosed by the invention is definite in component, the reprogramming efficiency of the dental pulp cells can be remarkably improved, and the reprogrammed induced pluripotent stem cells are good in dryness and high in hereditary stability, and can be widely applied to the cell reprogramming fields such as regenerative medicine, oral disease treatment and drug development.

Provided are an artemisinin derivative and a preparation method and use thereof. A structural formula of the artemisinin derivative is shown in Formula I. The compound has suitable solubility and is relatively stable under storage conditions. Pharmacokinetic experiments on the compound have shown that artemisinin is detectable in ocular tissues and is present in cornea, conjunctiva, and aqueous humor at a relatively high drug concentration. The compound is therefore an excellent precursor to artemisinin. The compound shown in Formula I exhibits remarkable absorbability, and the drug concentration in the ocular tissues indicates that the compound is well absorbed. The compound exhibits significantly better inhibitory effects on neovascularization in burn models than artemisinin, and can be prepared into liquid formulations such as eye drops, injection, etc., for treatment of ocular tissue diseases.

The utility model relates to the technical field of recovery devices, in particular to an artemisinin extraction solvent recovery treatment tank cleaning assembly which comprises a treatment tank body, a feeding pipe is fixedly connected to the side face of the treatment tank body, a discharging pipe is fixedly connected to the bottom of the treatment tank body, and a water pipe is fixedly connected to the top of the treatment tank body. A motor is fixedly connected to the top of the treatment tank body, a rotating shaft is fixedly connected to the output end of the motor, a water spraying structure is arranged on the surface of the rotating shaft, a scraping and sweeping structure is arranged on the surface of the rotating shaft, a moving rod is fixedly connected to the bottom of a limiting block, and a scraping plate is fixedly connected to the bottom of the moving rod. The water sprinkling structure is arranged, follow-up cleaning in the treatment tank is facilitated, a water pipe is convenient to place, damage to the water sprinkling structure is prevented, the scraping and sweeping structure is arranged, thorough cleaning is conducted, dead corners are avoided, and follow-up production work is facilitated.

The invention provides a preheating device for artemisinin extraction, and belongs to the technical field of artemisinin processing, the preheating device comprises an inner preheating cylinder, the outer side of the inner preheating cylinder is sleeved with an outer shell sleeve, a space exists between the outer shell sleeve and the side wall of the inner preheating cylinder, one side of the outer shell sleeve is fixedly connected with an input channel, the other side of the outer shell sleeve is fixedly connected with an output channel, and the outer side of the outer shell sleeve is fixedly connected with the output channel. The upper side of the inner preheating barrel is in threaded connection with an upper shell cover, a delivery shell is arranged on the upper portion of the upper shell cover, a motor is arranged in the middle of the upper portion of the upper shell cover, a rotating rod of the motor is fixedly connected with a linkage rod, and a ring-shaped removing assembly is arranged in the inner preheating barrel. The problems that due to the fact that the situation of unbalanced heating is likely to occur and temperature difference exists, preheating cannot be rapidly and sufficiently executed, and in the preheating process and the discharging period of artemisinin raw materials, part of the materials are attached to the barrel wall face, and sufficient discharging is not facilitated are solved.

The invention discloses a method for supercritical extraction of artemisinin, which comprises the following steps: crushing an artemisia apiacea raw material, adding cellulase and pectinase for composite enzymatic hydrolysis, directionally degrading an intercellular cellulose-pectin connection structure, and breaking a compact raw material system; then carrying out puffing treatment on the enzymolysis filter cake, and forming a large number of through pores in the material by regulating and controlling temperature and pressure; the pretreated material and a low-viscosity binder are mixed and granulated, then the granulated material is fed into a supercritical extraction system, and mass transfer is enhanced in cooperation with intermittent stirring. Through composite enzymolysis and puffing treatment, the particles can maintain high porosity, sufficient mass transfer channels are provided for the supercritical state, and diffusion resistance is greatly reduced. The method effectively solves the problems of compact particles, difficult permeation and insufficient dissolution of a core area in a traditional process, significantly improves the yield of artemisinin, the dissolution rate and purity of the core area, shortens the extraction time, and gives consideration to the extraction efficiency.

The present application relates to artemisinin compounds shown in formula (I), its preparation method and application. The compound structure of the present application is novel, and has significant anti-autoimmune disease effect.

The invention relates to an anti-tumor self-assembly targeted nano-drug as well as a preparation method and application thereof, and belongs to the technical field of nanotechnology. The self-assembled nano-drug is composed of hemin and dihydroartemisinin and is formed by self-assembling a prodrug with an ROS sensitive bond and hemin, the molar ratio of the prodrug to hemin is 1: 1-1: 10, and the prodrug molecule is formed by connecting a hemin drug molecule with an iron supplementing effect and an artemisinin derivative through the ROS sensitive bond. The invention has the advantages that: the EPR effect is utilized to passively transport to the tumor tissue, the responsive drug release in the tumor tissue is realized, the tumor cells are stimulated to generate ICD, the expression of PD-L1 protein is down-regulated, the immune escape is prevented, and the multi-mechanism tumor killing is realized, so that the immune response of the body is enhanced, the anti-tumor effect is exerted, and the drug effect is improved.

This invention relates to an artemisinin trimer derivative, its preparation method, and its application. This invention is the first to synthesize and isolate β,β,α trimer, β,α,α trimer, and α,α,α trimer. The isomers of these three trimers were successfully isolated by the new synthetic method and characterized and their activity was tested. The test results showed that they have high antitumor activity.

The utility model discloses a chromatography tank protection structure for extracting artemisinin, and relates to the technical field of chromatography tanks, the chromatography tank protection structure comprises a protection assembly, the protection assembly comprises two rows of protection units, each row of protection units comprises a plurality of protection boxes which are movably attached to one another, the protection boxes are provided with connecting assemblies and buffer assemblies, and the buffer assemblies are arranged on the protection boxes. The buffering assembly comprises a protection hole, the protection hole is fixedly formed in the middle of the protection box and penetrates through the upper surface and the lower surface of the protection box at the same time, and a connecting ring is fixedly arranged on the inner wall of the protection hole. Through installation of the connecting assembly and the buffering assembly, when the tank body is collided during transportation, impact force can be absorbed and buffered through the air column bag, then the problem that the tank body is prone to being damaged due to collision during transportation is avoided, meanwhile, a plurality of protection boxes can be fixedly connected conveniently, and the service life of the protection boxes is prolonged. Therefore, the integrity of connection between the tank bodies is improved, and the problem that the tank bodies incline or even topple over due to bumpy road conditions is solved.

The invention relates to the technical field of plant effective component extraction, and discloses a method for extracting artemisinin through enzymolysis pretreatment, which comprises the steps of raw material pretreatment, composite enzymolysis pretreatment, ultrasonic-assisted extraction, impurity removal and concentration, purification and crystallization, and recrystallization and refining. A compound enzyme system composed of cellulase, hemicellulase and pectinase is adopted to conduct enzymolysis on artemisia annua powder, cell wall structures are destroyed to promote artemisinin release, ultrasonic-assisted extraction is combined to strengthen the extraction effect, and the product purity is improved through chitosan impurity removal, silica gel chromatography and two times of crystallization. The method is simple in process, environmentally friendly and energy-saving, effectively solves the problems that a traditional extraction method is low in extraction rate, insufficient in purity and high in cost, is suitable for large-scale industrial production, and has high practical value and industrialization prospects.

The invention relates to a method for preparing a nanogold compound for treating peritoneal cancer based on artemisinin, and aims to prepare and modify nanogold particles for treating peritoneal cancer. The compound is composed of nanogold modified by artemisinin. The compound brings a brand new treatment scheme for the field of peritoneal cancer treatment due to excellent biocompatibility and high targeting property. By guiding artemisinin modified nanogold to peritoneal cancer cells, the invention aims to improve the accuracy and effect of treatment, thereby reducing the damage to normal cells in the treatment process.

The invention discloses a method for detecting dehydroartemisinin, 9-epiartemisinin and artemisinin in an artemether raw material and application thereof.The detection method comprises the step that a reference substance solution and a test solution of the artemether raw material are detected through high performance liquid chromatography, specifically, octadecylsilane chemically bonded silica is used as a filler, acetonitrile is used as a mobile phase A, the mobile phase B is used as a mobile phase C, and the mobile phase B is used as a mobile phase D; and carrying out gradient elution by taking water as a mobile phase B. The method disclosed by the invention is simple to operate, strong in specificity, good in precision and high in sensitivity, can be used for simultaneously detecting dehydroartemisinin, 9-epiartemisinin and artemisinin, and can be completely separated from four known impurities (an artemether impurity I, an artemether impurity II, dihydroartemisinin and alpha-artemether) of artemether.

An artemisinin continuous gradient forward and reverse flow forward and reverse rotation extraction device belongs to the technical field of artemisinin extraction equipment and comprises a forward flow charging tank, a first reverse flow transition extraction tank, a reverse flow extraction tank, a second reverse flow transition extraction tank, a forward flow extraction tank, a third reverse flow transition extraction tank and a reverse flow slag discharge tank which are communicated with one another in a welding manner; stirring shafts are arranged in the downstream charging tank, the countercurrent extraction tank, the downstream extraction tank and the countercurrent deslagging tank; spiral stirring propelling blades and positive and negative rotation driving motors are arranged on the stirring shafts; a material inlet, a slag outlet, a solvent injection pipe and a liquid taking and collecting pipe are arranged; three solvent bridge tubes and an ultrasonic transducer are additionally arranged; the device has the beneficial effects that the components form a four-stage continuous gradient forward and reverse flow forward and reverse rotation and ultrasonic extraction system, so that the artemisinin extraction yield can be effectively improved, the whole extraction period is shortened, and the production efficiency is improved.

This invention belongs to the field of pharmaceutical technology and relates to the research and application of drugs for the treatment of lymphedema, specifically the application of systemic artemisinin in the treatment of secondary lymphedema. Specifically, this invention provides the use of artemisinin or its derivatives in the preparation of drugs or formulations for the prevention and / or treatment of lymphedema, wherein the drugs or formulations are used to: relieve lymphedema, relieve fat deposition caused by lymphedema, and / or promote lymphatic vessel regeneration.