237 results about "Benzenesulfonyl chloride" patented technology

The invention provides a preparation method of 2,4-disubstituted benzenesulfonyl chloride. A solvent-free reaction is adopted, through accurate control of low-temperature stepwise reactions and introduction of a specific inorganic salt aid, the strong positioning effect, the steric hinerance effect and the like of superposition of two substituent groups in the meta-position are amplified to facilitate the positive effect of a main reaction, and production of byproducts such as various sulphone isomers, multiple sulfonated bodies, macromolecular conjugates and the like is significantly inhibited. Through combined use of small quantities of specific chlorination aids and chlorosulfonic acid, the conversion process of an acyl chloride structure is promoted, excessive use of inorganic chlorideis avoided, and the use amount of chlorosulfonic acid and the production of waste acid are both greatly reduced. With the adoption of the method, the total yields of various substrates are 85% or above, the product purity is 95% or above, the difficulty in separation and purification is reduced, the problems of severe side reactions, low product yield, poor quality and the like in existing methods and technologies are solved, and energy conservation and emission reduction are realized.