Pentaerythrityl tetramizole and preparation method thereof

A technology of pentatetraimidazole and pentaerythritol, applied in the direction of organic chemistry, etc., can solve problems such as difficulty in synthesizing tetrahedral structure

Inactive Publication Date: 2011-11-23
HARBIN INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The present invention aims to solve the technical problem that it is difficult to synthesize compounds with tetrahedral structures or dendritic macromolecules from compounds with multiple imidazole groups, and provide pentaerythimidazole and its preparation method

Method used

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  • Pentaerythrityl tetramizole and preparation method thereof
  • Pentaerythrityl tetramizole and preparation method thereof
  • Pentaerythrityl tetramizole and preparation method thereof

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specific Embodiment approach 1

[0016] Specific embodiment 1: The structural formula of pentatetraimidazole in this embodiment is:

[0017]

[0018] The pentaerythritol of this embodiment is a derivative of pentaerythritol. Because of its steric tetrahedron and imidazole cyclic structure, it can be used as an initiator for the synthesis of multi-arm polymers and an important intermediate for the synthesis of dendrimers. Used as a carrier for the synthesis of polyacid catalysts.

specific Embodiment approach 2

[0019] Specific embodiment 2: The preparation method of pentaerythritol of this embodiment is carried out according to the following steps: 1. According to the molar ratio of pentaerythritol and benzenesulfonyl chloride of 1:4 to 4.6, the molar ratio of pentaerythritol to pyridine is 1:5 to Weigh pentaerythritol, benzenesulfonyl chloride and pyridine in a ratio of 7; then measure hydrochloric acid, water and methanol at a ratio of 1:1-2 to 2 by volume of hydrochloric acid and water. Add the pentaerythritol and pyridine weighed in step one to the three-necked flask, and add the benzenesulfonyl chloride weighed in step one dropwise to the three-necked flask under stirring conditions to obtain a mixed solution. In the flask, control the temperature to 25℃~30℃ during the dripping process. After the dripping is completed, heat up to 40℃~42℃ and continue stirring for 2.5h~3h to obtain the mixture; 3. Add the mixture obtained in step 2 to step In the prepared mixed solution, stir it e...

specific Embodiment approach 3

[0020] Specific embodiment three: This embodiment is different from specific embodiment two in that in step one, the molar ratio of pentaerythritol to benzenesulfonyl chloride is 1:4.1-4.5, and the molar ratio of pentaerythritol to pyridine is 1:5.2-6.8. Others are the same as the second embodiment.

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Abstract

The invention provides a preparation method of pentaerythrityl tetramizole, relating to a multi-imidazolyl compound and a preparation method thereof. The invention solves the technical problem that the existing multi-imidazolyl compounds are difficult to be synthesized into tetrahedral compounds or dendritic macromolecules. The structural formula of the pentaerythrityl tetramizole is shown in the figure. The preparation method comprises the following steps: carrying out esterification reaction on pentaerythritol and benzene sulfonyl chloride to obtain pentaerythritol tetrabenzene sulfonate; carrying out reaction on the pentaerythritol tetrabenzene sulfonate and sodium bromide to obtain pentaerythrityl tetrabromide; and carrying out reaction on the pentaerythrityl tetrabromide and imidazole to obtain pentaerythrityl tetramizole. The pentaerythrityl tetramizole is a derivative of pentaerythritol. Because of the spatial tetrahedron of the pentaerythritol and the ring structure of the imidazole, the pentaerythrityl tetramizole can be used as an important intermediate for synthesizing multi-arm polymer initiators and dendritic macromolecules, and can be also used as a carrier for synthesizing multi-acid catalysts.

Description

Technical field [0001] The invention relates to a compound of a polyimidazole group and a preparation method thereof. Background technique [0002] Compounds with polyimidazole groups have become important chemical raw materials because they can be used as important synthesis intermediates, but currently existing compounds containing multiple imidazole groups contain up to two imidazole groups, such as 1,4-diimidazole butane It is difficult for these compound intermediates to synthesize compounds with tetrahedral structure or dendritic macromolecules. Summary of the invention [0003] The present invention aims to solve the technical problem that it is difficult to synthesize compounds with tetrahedral structure or dendritic macromolecules from compounds with multiple imidazole groups, and provides pentatetraimidazole and a preparation method thereof. [0004] The structural formula of pentatetraimidazole of the present invention is: [0005] [0006] The preparation method of penta...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D233/56
Inventor 顾大明刘海燕刘国宇顾硕
Owner HARBIN INST OF TECH
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