34 results about "Dehydropregnenolone acetate" patented technology

The invention provides a method for recycling dehydropregnenolone acetate waste liquor. The method comprises the following steps of: separating and recycling sodium acetate from the treated waste liquor through NaOH sedimentation, decoloration, filtration, solvent washing, concentration, crystallization, drying and the like, and completely recovering sodium acetate by utilizing the hot water generated by concentration and the mother liquor generated by crystallization. Product inspection proves that the content of the active ingredient in a product is more than 98.5%, various indexes meet chemical purity grades specified by national standard GB / T693-1996, and therefore the product can be directly applied to the production of the dehydropregnenolone acetate or sold as a commodity; and at the same time, the filter residue obtained from the filtration process is calcined to obtain the chromium oxide green which has a plurality of uses and high added value. The waste liquor treatment method provided by the invention is simple in process, capable of achieving energy conservation and emission reduction, and conductive to environment protection to generate social benefit; and by adopting the method, sodium acetate can be completely recovered, and the chromium oxide green with high added value can be obtained to generate great economic efficiency.

The invention discloses a synthetic method of pregnenolone acetate. The method comprises the following steps of: 1, carrying out hydrogenation reaction of dehydropregnenolone acetate at a temperature ranging from 35 to 45 DEG C and under 0.4 MPa to 0.8 MPa by taking ethyl acetate as a solvent and a compound catalyst of a palladium / carbon catalyst and ammonium acetate; 2, filtering the reaction liquid after reaction, concentrating the filtrate under normal pressure, then adding a mixed solvent to the concentrated filtrate, and carrying out centrifugal drying after cooling to obtain crude pregnenolone acetate; 3, washing the crude pregnenolone acetate, then carrying out drip washing by using methanol, and drying to obtain white sandy solid pregnenolone acetate. The synthetic method provided by the invention is mild in reaction conditions; ethyl acetate is used as the solvent, and the solvent is high in recovery and low in dosage; as the palladium / carbon catalyst and ammonium acetate are used as the compound catalyst, the catalytic hydrogenation selectivity is high and no impurity is generated; besides, the aftertreatment is simple and the yield is high; the mass purity of the product can be higher than 99.5%.

The invention provides a method for recycling dehydropregnenolone acetate waste liquor. The method comprises the following steps of: separating and recycling sodium acetate from the treated waste liquor through NaOH sedimentation, decoloration, filtration, solvent washing, concentration, crystallization, drying and the like, and completely recovering sodium acetate by utilizing the hot water generated by concentration and the mother liquor generated by crystallization. Product inspection proves that the content of the active ingredient in a product is more than 98.5%, various indexes meet chemical purity grades specified by national standard GB / T693-1996, and therefore the product can be directly applied to the production of the dehydropregnenolone acetate or sold as a commodity; and at the same time, the filter residue obtained from the filtration process is calcined to obtain the chromium oxide green which has a plurality of uses and high added value. The waste liquor treatment method provided by the invention is simple in process, capable of achieving energy conservation and emission reduction, and conductive to environment protection to generate social benefit; and by adopting the method, sodium acetate can be completely recovered, and the chromium oxide green with high added value can be obtained to generate great economic efficiency.

The invention provides a novel production method of 16-dehydropregnenolone acetate oxime. The novel production method comprises the following steps: on the basis of taking 16-dehydropregnenolone acetate as a raw material, alcohol or halohydrocarbon or arene as a solvent and organic base or inorganic base as an acid-binding agent, reacting by using hydroxylammonium chloride, then crystallizing and drying to obtain 16-dehydropregnenolone acetate oxime. The novel production method has the remarkable characteristics that the dissolving property problem of 16-dehydropregnenolone acetate and hydroxylammonium chloride is solved by using the mixed solvent, and meanwhile, a water absorbent and a catalyst are added, so that the influences of oximation reaction speed and the generated water on the reaction are eliminated. Compared with the traditional method, the novel production method provided by the invention has the remarkable advantages that the reaction speed is high, and the reaction time is at least shortened to less than 1 / 2 of the time needed by using the traditional method; the reaction selectivity is good, the yield is high, and the molar yield is up to 99% which is five times as high as that of the traditional method; the quality of 16-dehydropregnenolone acetate oxime is high, and the content of 16-dehydropregnenolone acetate oxime is up to more than 98%; the process is clean, and less wastewater is generated; and the novel production method is simple and convenient to operate and can be used for easily realizing industrial production.

The invention relates to a method of recycling acid wastewater generated during the production of dehydropregnenolone acetate. The method starts with the diene production process and recycles the acid wastewater which can be recycled and reused in all the processes. The obtained by-product contains high-purity chromic hydroxide and sodium acetate, both of which can be sold. Compared with the conventional acid wastewater treatment method, the method provided by the invention is simple and easy to operate and low in energy consumption, improves the utilization rate of the acid wastewater, reduces the production water using amount, lowers the cost and burden of the wastewater treatment, and reduces the pollution caused by the acid wastewater to the environment.

The invention relates to a synthesis method of a chemical medicine, and concretely relates to a synthesis method of a spironolactone intermediate testosterone lactone. The method is characterized in that a compound I 4-androstenedione (4AD) undergoes a two-step reaction of addition siloxane removal and oxidation cyclization to obtain the compound III testosterone lactone, and the reaction route is shown in the specification. Compared with traditional methods adopting a traditional raw material 16-dehydropregnenolone acetate with high price, the method provided by the invention adopting the cheap and easily available 4-androstenedione (4AD, I) as an initial raw material has extremely high production application and economic values under the affection of market supply and demand.

The invention relates to the technical field of dehydropregnenolone acetate extraction, and discloses a dehydropregnenolone acetate extraction process which comprises the following steps: mixing 5-15 parts of acetic anhydride and 10-30 parts of acetic acid, and adding 10-30 parts of saponin into the mixed solution of acetic anhydride and acetic acid. According to the dehydropregnenolone acetate extraction process, acetic anhydride, acetic acid and saponin are subjected to a ring-opening reaction, an obtained solution can be oxidized, then hydrogen peroxide is used for replacing traditional chromium trioxide to serve as an oxidizing agent, the production cost is low, almost no pollution is caused, and redundant hydrogen peroxide is simple to treat; sodium sulfite is only required to be poured to react with hydrogen peroxide to obtain sodium sulfate and water, sodium sulfate can be recycled in a layered manner in the last step of filtration, and compared with the adoption of chromium trioxide as an oxidant, the production cost is low, the pollution is low, the obtained product can be recycled, and the reaction process is relatively mild and easy to control; and the purpose of good environmental protection is achieved.

The invention discloses an organic anti-aging beverage and a preparation method thereof. The organic anti-aging beverage comprises the following raw materials: dehydropregnenolone acetate, ethanol, pyridine, 1-aminoanthraquinone, epichlorohydrin, ethyl acetate, tetrahydrofuran, edible essence, a preservative, vitamins, a sweetening agent, purified water and the like. According to the invention, dehydroepiandrosterone reacts with free radicals under the catalysis of acetic acid so as to block a peroxidation reaction, so the aging degree of an organism is relieved; the side amine chain of amine chain-substituted anthraquinone reacts with cell telomerase, so the content of D-galactose is increased, the atrophy and degeneration of thymus are delayed, and the aging phenomenon of an organism is relieved; an amine N-oxyalkyl side chain is reduced and activated into amine molecules with positive charges by hormone enzyme in a body, so anthraquinone can be diffused to the whole body to play a role; and after a traditional process is conducted, a crude 1-aminoanthraquinone product is dissolved in tetrahydrofuran, chloroform is used for packing a column for column chromatography separation, and a hydroxyl group is not easy to reduce after being immobilized by the tetrahydrofuran, so the quality and yield of the product are improved.

The invention relates to a synthesis method of a chemical medicine, and concretely relates to a synthesis method of a spironolactone intermediate testosterone lactone. The method is characterized in that a compound I 4-androstenedione (4AD) undergoes a two-step reaction of addition siloxane removal and oxidation cyclization to obtain the compound III testosterone lactone, and the reaction route is shown in the specification. Compared with traditional methods adopting a traditional raw material 16-dehydropregnenolone acetate with high price, the method provided by the invention adopting the cheap and easily available 4-androstenedione (4AD, I) as an initial raw material has extremely high production application and economic values under the affection of market supply and demand.

The invention discloses a synthetic method of pregnenolone acetate. The method comprises the following steps of: 1, carrying out hydrogenation reaction of dehydropregnenolone acetate at a temperature ranging from 35 to 45 DEG C and under 0.4 MPa to 0.8 MPa by taking ethyl acetate as a solvent and a compound catalyst of a palladium / carbon catalyst and ammonium acetate; 2, filtering the reaction liquid after reaction, concentrating the filtrate under normal pressure, then adding a mixed solvent to the concentrated filtrate, and carrying out centrifugal drying after cooling to obtain crude pregnenolone acetate; 3, washing the crude pregnenolone acetate, then carrying out drip washing by using methanol, and drying to obtain white sandy solid pregnenolone acetate. The synthetic method provided by the invention is mild in reaction conditions; ethyl acetate is used as the solvent, and the solvent is high in recovery and low in dosage; as the palladium / carbon catalyst and ammonium acetate are used as the compound catalyst, the catalytic hydrogenation selectivity is high and no impurity is generated; besides, the aftertreatment is simple and the yield is high; the mass purity of the product can be higher than 99.5%.