Method for producing pregnenolone acetic ester and 16-dehydropregnenolone acetate by utilizing infrared heating ring opening

Abstract

A method for producing pregnenolone acetic ester and 16-dehydropregnenolone acetate by utilizing infrared heating ring opening comprises the steps of ring-opening cracking, extraction and refining, wherein infrared heating is carried out on a reaction kettle during ring-opening cracking process. In the invention, as a silicon carbide far infrared heating and radiation heating device and a tank body are assembled together, the reaction kettle is heated by controlling the voltage and current of a heating device, so that temperature and voltage can be automatically controlled, power can be automatically adjusted and randomly set, the temperature control is precise, heat buffer is small, personal errors are reduced, the stability of infrared heating ring-opening reaction is ensured, and further the reaction is more sufficient.

Description

technical field [0001] The invention belongs to the technical field of clean production of steroid hormone drug intermediates, and in particular relates to a process for producing mono- and dienolone acetates through silicon carbide far-infrared heating and ring-opening. Background technique [0002] Dienolone acetate (referred to as diene) Chemical name: 5.16-pregnadiene-3β-ol-20-one acetate, molecular formula C 23 h 32 o 3 , which has the parent nucleus of cyclopentane-perhydrophenanthrene, which is a typical steroid compound. Diene is an important intermediate in the synthesis of various steroid hormone drugs, which can be used as raw materials to produce progesterone drugs (progesterone, medroxyprogesterone, progesterone caproate), adrenal cortex hormone drugs (such as hydrocortisone , prednisone, betamethasone,) sex hormones and anabolic hormone drugs (methyl testosterone, medroxyprogesterone, anadrol, stanozolol), etc. [0003] The ring-opening cleavage reaction is...

AI Technical Summary

Problems solved by technology

When using traditional equipment, it is difficult to control the reaction temperature, pressure, and time during the production process. A little carelessness can easily lead to failure or incomplete reaction of the ring-opening cracking reaction, resulting in reduced yield and unqualified quality.

[0006] 2. The material in the kettle undergoes a high-temperature and high-pressure reaction. The reaction temperature is 210°C, the pressure is 0.6Mpa, the heating temperature of the heat transfer oil is high, and the electric heating tube is used for heating. Once leaked, it is easy to cause fire or burns. Hidden danger

[0007] 3. The heat transfer oil is carbonized and scaled at high temperature for a long time. It is necessary to replace the heat transfer oil and electric heating tube regularly and clean the jacket, which increases the production hours and prolongs the production cycle.

[0008] 4. The heat transfer coefficient of hot oil is small, the thermal efficiency is low, and the power consumption increases

[0009] The above reasons increase the cost of the enterprise's products and increase the security risk