77 results about "Adrenal cortex" patented technology

The present invention relates to efflux inhibitor compositions and methods of using these agents for treating conditions where the activity of efflux transporter proteins (e.g., Breast Cancer Resistance Protein (BCRP) and P-Glycoprotein (P-GP)) inhibit effective delivery of a therapeutic agent to a target tissue (e.g., brain, spinal cord, nerves, cerebrospinal fluid, testis, eyeballs, retina, inner ear, placenta, mammary gland, liver, biliary tract, kidney, intestines, lung, adrenal cortex, endometrium, hematopoietic cells, and / or stem cells).

The invention discloses a preparation method of an adrenal cortex hormone medicament and particularly relates to a preparation method of a high-purity R-budesonide isomer. According to the method disclosed by the invention, prednisolone is used as an original raw material and the budesonide acetic ester is prepared by cyclization, ring opening, esterification, elimination, oxidation, cyclization and hydrolysis. The method disclosed by the invention has a simple process and high yield and is suitable for industrial production.

The invention relates to a quality control method of a-l tonic traditional Chinese medicine medicament for lingering deficiency of vital energy and deficiency of qi and yin, belonging to the technical field of drug. The a-l tonic traditional Chinese medicine medicament consists of astragalus root and ligustrum japonicum and other Chinese medicinal materials. The invention has the effects of boosting qi and nourishing yin, enhancing body immunity, protecting marrow and adrenal cortex and is suitable for patients with lingering deficiency of vital energy and deficiency of qi and yin and other symptoms. Currently, the invention is widely used for matching operation, radiation therapy and chemotherapy and promoting recovery of normal function and the like in clinic. The invention provides a quality control method of a-l tonic traditional Chinese medicine medicament for lingering deficiency of vital energy and deficiency of qi and yin, which provides index and way of testing and technical method, etc. for appropriate producing and detecting institutions, thereby being convenient to control quality of tradition Chinese medicine medicament, ensure dosage safety, supervise production, more strictly and reasonably control production process, and completely recognize quality of products for customers.

A novel growth factor specific for vascular endothelial cells has been identified in conditioned medium of bovine pituitary derived folliculo stellate cells. This factor, named folliculo stellate derived growth facto (FSdGF) or vascular endothelial growth factor (VEGF), was purified to homogeneity by a combination of heparin sepharose affinity chromatography, Bio Gel P-60 exclusion chromatography, Mono S ion exchange chromatography and hydrophobic chromatography on a C4 reverse phase HPLC column. The factor is also found in the murine AtT-20 cell line. Alternatively, the growth factor is purified by a first reverse phase HPLC using acetonitrile gradient followed by a second reverse phase HPLC using an isopropanol gradient. FSdGF, having a molecular weight of about 43,000 da, was characterized as a glycoprotein composed of two homologous sub units with MW of about 23 kDa. FSdGF was a potent mitogen for vascular endothelial cells with activity detectable at 10 pg / ml and saturation at 500 pg / ml. It did not stimulate the proliferation of other cell types such as bovine corneal endothelial cells, adrenal cortex cells, granulosa cells, BALB / MK cells or BHK-21 cells. Microsequencing revealed an amino terminal sequence containing no significant homology to any known protein. The release of FSdGF by pituitary cells and its unique target cell specificity indicate that FSdGF is useful in angiogenesis.

The invention relates to the effect of a morinda officinalis extract on improving or treating sexual disorder, and an application thereof. The substance for treating or improving the sexual disorder has an effect on integrally regulating the hypothalamus, the pituitary gland, the sex gland and the adrenocortical function to improve or treat the sexual disorder, and simultaneously has selective specificity on different 5-HT receptors, i.e., the substance can selectively excite the 5-HT1 receptor, but has no excitation on the 5-HT2 receptor and the 5-HT3 receptor. The morinda officinalis extract can be used as a medicament and / or food for treating or assisting to improve the sexual disorder.

The present invention discloses an artificial substitute unit. It can be implanted into human body and can be used as temporary substitute for retaining specific tissue function. Said substitute includes a peripheral body, a hollow supporting frame placed in said peripheral body interior, intracavity filled cells placed in the inner cavity of said supporting frame and filler and functional cells and nutrient matrix body placed between said supporting frame and peripheral body, on the wall surfaces of the described supporting frame and peripheral body several through microporous channels are uniformly distributed, and the described intracavity filled cells can be induced and differentiated into endothelial tissue cells, and the extracavity filled cells can be changed according to the application direction of artificial substitute unit, and can be induced and differentiated into required functional cells, such as liver cells, pancreatic island beta cells, adrenal cortex cells and fat cells, etc.

The invention belongs to the field of Chinese medicines, and particularly relates to a medicinal composition which consists of epimedium herb, astragalus and rehmannia root or extracts of the medicaments. Results of animal experiments indicate that the medicinal composition has a better curative effect on the prevention and treatment of inflammation-related diseases such as bronchial asthma, chronic obstructive pulmonary diseases or atopic dermatitis. A curative effect mechanism of the composition is related to the improvement on hypothalamus-hypophysis-adrenal cortex, the regulation of immunity and the inflammation of antagonism. In the medicinal composition, pharmaceutically-acceptable auxiliary materials or carriers are added to prepare a medicinal preparation, and the preparation is any one formulation which is pharmacologically accepted.

A novel growth factor specific for vascular endothelial cells has been identified in conditioned medium of bovine pituitary derived folliculo stellate cells. This factor, named folliculo stellate derived growth facto (FSdGF) or vascular endothelial growth factor (VEGF), was purified to homogeneity by a combination of heparin sepharose affinity chromatography, Bio Gel P-60 exclusion chromatography, Mono S ion exchange chromatography and hydrophobic chromatography on a C4 reverse phase HPLC column. The factor is also found in the murine AtT-20 cell line. Alternatively, the growth factor is purified by a first reverse phase HPLC using acetonitrile gradient followed by a second reverse phase HPLC using an isopropanol gradient. FSdGF, having a molecular weight of about 43,000 da, was characterized as a glycoprotein composed of two homologous sub units with MW of about 23 kDa. FSdGF was a potent mitogen for vascular endothelial cells with activity detectable at 10 pg / ml and saturation at 500 pg / ml. It did not stimulate the proliferation of other cell types such as bovine corneal endothelial cells, adrenal cortex cells, granulosa cells, BALB / MK cells or BHK-21 cells. Microsequencing revealed an amino terminal sequence containing no significant homology to any known protein. The release of FSdGF by pituitary cells and its unique target cell specificity indicate that FSdGF is useful in angiogenesis.

A Chinese medicine in the form of dispersing tablet or oral liquid for improving immunity and constitution, protecting the function of bone marrow and adrenal cortex, and promoting the function recovery after radiotherapy and chemicotherapy is prepared from lucid ligustrum fruit and astragalus root.

Methods and compositions are provided for treatment of disorders associated with aberrant adrenal cortex cell behavior, including (but not limited to) treatment of adrenocortical carcinoma (ACC), Cushing's syndrome and / or pituitary ACTH excess (Cushing's Disease). Such methods involve administration of an effective amount N-(2,6-bis(1-methylethyl)phenyl)-N′-((1-(4-(dimethylamino)phenyl)cyclopentyl)-methyl)urea hydrochloride to the patient.

The present invention relates to efflux inhibitor compositions and methods of using these agents for treating conditions where the activity of efflux transporter proteins (e.g., Breast Cancer Resistance Protein (BCRP) and P-Glycoprotein (P-GP)) inhibit effective delivery of a therapeutic agent to a target tissue (e.g., brain, spinal cord, nerves, cerebrospinal fluid, testis, eyeballs, retina, inner ear, placenta, mammary gland, liver, biliary tract, kidney, intestines, lung, adrenal cortex, endometrium, hematopoietic cells, and / or stem cells).

A composite nanoliposome medicine in the form of liquid injection or freeze-dried powder injection for treating arthritis, viral cold, etc is prepared from anterior lobe of the hypophysis and adrenal cortex through extracting. It spreparing process is also disclosed.

The invention relates to a natural rose scent air freshener. The air freshener consists of tea tree essential oil, rose essential oil, sweet orange essential oil and alkali ionized water in a weight part ratio of 5-10:5-10:2-4:85-95. The tea tree essential oil contained in the natural rose scent air freshener of the invention is powerful sterilization essential oil and has anti-bacterial, anti-virus, sterilization, fungicidal, insecticidal functions and the like. The rose essential oil has fragrant and strong sweet smell, can act on a nervous system and has the effects of relieving the secretion of adrenal cortex, soothing emotion, invigorating spirit and relieving potential tense and pressure. Simultaneously, the rose essential oil has certain anti-bacterial and bacteriostatic functions. The sweet orange essential oil has clear and pleasant orange smell and refreshes indoor air. The natural rose scent air freshener of the invention has the advantages of natural, safe and nontoxic raw materials and remarkable sterilization and disinfection effects.

The invention relates to the extracting technics of the amylase of the privet and the astragalus and the production and the appliance. The amylose is gained from the extracting and retreated the active ingredient amylose of the privet and the astragalus root; the extracting technics is easy and reasonable; the cost is cheap; the gained production is tested to be the glossy privet fruit amylose and the astagalus root amylose; the production has the function of boosting up the body immunologic function and boosting the cell metabolize, regulating the composing of the rna, the deoxyribonucleic acid and the albuminoid, reinforcing the kidney and nourishing the liver; at the same time , it has other function of the antivirus, resisting the knub, fighting against senium, resisting the radiste, resisting the stress, the oxidation resisting ; it can be use to improved the body immunologic function and protect the function of the marrow and the adrenocrtication and cure the disease due to asthenia of viscera and cooperate the operation, radistion therapy, the chemic therapy and accelerate the resume of the positive function and the prevention and treatment of the hepatitis, the diabetes, the flu, the cerebral thrombosis clinically.

Screening methods for identifying compounds that bind to or activate corticotropin releasing factor2 receptors (CRF2R) and regulate or potentially regulate skeletal muscle mass or function in vivo are disclosed. Also disclosed are screening methods for identifying compounds that prolong or augment the activation of CRF2Rs or of CRF2R signal transduction pathways, increase CRF2R or increase CRF expression are provided. Pharmaceutical compositions comprising CRF2R agonists, antibodies to CRF2R and methods for increasing skeletal muscle mass or function or for the treatment of skeletal muscle atrophy using CRF2R as the target for intervention and methods for treatment of muscular dystrophies are described.

The invention discloses an external compound abafenjing drug composition, which comprises the following parts: 0.01-20% abafenjing, 0.005-1% adrenal cortex hormone, medical auxiliary material and antibacterial material. The invention reduces the injury of infected skin, which can treat vaginal candidiasis and vulvopathy.

The invention relates to the field of medicines and biotechnology, particularly to application of MTDH (metadherin) genes. Proliferation of adrenal cortex cancer cell line H295R can be restrained through reducing the expression quantity of MTDH based on the influence of MTDH on proliferation of adrenal cortex cancer cells in the in vitro experimental study; besides, the expression quantity of MTDH in primary hyperaldosteronism adenomata is obviously improved, therefore, the MTDH genes can be used for adjusting and controlling the proliferation of adrenal cortex cancer cells, and can be used in the preparation and screening of drugs for curing adrenocortical carcinoma or kidney cancer.

The invention discloses an etomidate analogue shown in a formula (I). The analogue which needs to be developed in the field keeps beneficial performances (such as quick action, almost no influences onblood pressure and high therapeutic index) of etomidate but does not cause a potential dangerous adrenal cortex function inhibition effect. The analogue enables safety in anesthetic action on critical patients. In the formula (I) as shown in the specification, R1 refers to polyhalogenated or non-substituted C1-C6 alkyl; R2 refers to hydrogen, methyl or ethyl; R3 refers to hydrogen, halogen, trifluoromethyl, trifluoroethyl or nitryl; when R2 refers to hydrogen, R3 is not hydrogen.

The present invention relates to one or more SGLT2 inhibitors or pharmaceutically acceptable forms thereof for use in the treatment and / or prevention of a metabolic disorder of an equine animal. In particular, the present invention relates to one or more SGLT2 inhibitors or a pharmaceutically acceptable form thereof for use in the treatment and / or prevention of laminitis, vascular dysfunction, hypertension, hepatic lipidosis, atherosclerosis, hyperadrenocorticism, Pituitary Pars Intermedia Dysfunction and / or Equine Metabolic Syndrome in an equine animal.

The invention relates to novel application of taurochenodeoxycholic, and particularly relates to novel application of the taurochenodeoxycholic acid in treating adverse reactions of glucocorticoid medicaments. Through studying on the taurochenodeoxycholic acid, the inventor discovers that the taurochenodeoxycholic acid can resist apoptosis of suprarenal gland cells and promote multiplication of adrenal cortex stem cells so as to recover the hypothalamic-pituitary-adrenal axis inhibition caused by the glucocorticoid medicaments, promotes osteoblast to secrete osteocalcin and improve the reduced bone mineral density so as to recover osteoporosis caused by the glucocorticoid medicaments, and can reinforce the mucosal immunity function and promote multiplication of small intestine stem cells; therefore, the taurochenodeoxycholic acid can be directly administrated or made into various preparations or mixtures for preventing and treating adverse reactions caused by the glucocorticoid medicaments.

The invention relates to the use of corticotropin-releasing hormone (CRH) receptor-1 (R1) antagonists and / or CRH-R2 receptor agonists for the treatment of inflammatory diseases via regulation of monocyte / macrophage cell activation, proliferation, differentiation, apoptosis, and inflammatory cytokine production. As CRH system we define natural and synthetic CRH and urocortin (UCN) agonists and antagonists for the CRH-R1 and CRH-R2 receptors and their subtypes as well as the CRH-binding protein (BP), a CRH pseudo-receptor. The invention is directed towards pharmacological intervention for the amelioration or treatment of inflammatory diseases using the CRH system-mediated control of monocyte / macrophage cells which play a key role in initiating and maintaining the inflammatory response via production of pro-inflammatory cytokines such as is the interleukin (IL)-1, IL-6 and tumor necrosis factor (TNF)-alpha. By the term inflammation we define the response of an organism to noxious endogenous or exogenous stimuli causing tissue injury. Inflammation is a host defence mechanism, which might harm the defending organism. The invention also provides methods for the in vitro and in vivo evaluation of natural and synthetic CRH system modulators for the control of the monocyte / macrophage system.

Screening methods for identifying compounds that bind to or activate corticotropin releasing factor2 receptors (CRF2R) and regulate or potentially regulate skeletal muscle mass or function in vivo are disclosed. Also disclosed are screening methods for identifying compounds that prolong or augment the activation of CRF2Rs or of CRF2R signal transduction pathways, increase CRF2R or increase CRF expression are provided. Pharmaceutical compositions comprising CRF2R agonists, antibodies to CRF2R and methods for increasing skeletal muscle mass or function or for the treatment of skeletal muscle atrophy using CRF2R as the target for intervention and methods for treatment of muscular dystrophies are described.

The invention discloses feed for enhancing immunity of special commercial big wild boars. Liriope, angelica sinensis and radix codonopsis can enhance the immunity function of animal bodies, benefit stomach, engender liquid, moisturize dryness by nourishing yin, inhibit various kinds of bacteria and enhance the function of a pituitary adrenal cortex system and can prevent the boars from getting crazy, prevent latent heat and increase feed intake in cooperation with cinnamon. Fennel and cortex phellodendri have the effects of eliminating cold to stop pain, regulating the flow of vital energy and harmonizing stomach and can promote intestinal peristalsis and prevent the big boars from eating less, vomiting and having diarrhea. Hawthorns and atractylodes have the function of increasing appetite and can increase the conversion rate of the feed. Perilla stems and radix astragali have the functions of clearing heat, drying dampness, calming and cooling down. Radix stemonae can improve the anti-disease ability, strengthen the right, expel the evil and prevent and cure animal diseases. After the feed is fed to the commercial big boars, the body constitution and mood of the commercial big boars can be regulated; the disease incidence is reduced by 70-80%; the digestible energy is increased by 20-25%; the absorptive amount of crude proteins is increased by 35-40%, and the daily gain of the body weight of the boars is controlled within 550-650 g. Meat fibers of the boars are compact, the fat elasticity is good, the rich protein content in meat is increased by 20-25%, and the linoleic acid content is increased by 6-9%.

The present invention provides a water-soluble propolis and its extraction method. The method utilizes the solubilization, ultrasonic technique and control of reasonable temp. and heating time to extract the active component in the propolis. The method does not utilize alcohol, and the total flavone content of propolis liquor extracted by said method can be up to 12.765 mg / ml. It has the good action of resisting inflammation, raising immunity, reducing blood sugar and preventing diabetic complicating disease. The invention can be extensively used in food, cosmetics and food additive.

Methods and compositions are provided for treatment of disorders associated with aberrant adrenal cortex cell behavior, including (but not limited to) treatment of adrenocortical carcinoma (ACC), Cushing's syndrome and / or pituitary ACTH excess (Cushing's Disease). Such methods involve administration of an effective amount N-(2,6-bis(1-methylethyl)phenyl)-N′-((1-(4-(dimethylamino)phenyl)cyclopentyl)-methyl)urea hydrochloride to the patient.

The invention discloses an external-application Chinese herbal medicine for treating neonatal jaundice. The external-application Chinese herbal medicine for treating neonatal jaundice is prepared from, by weight, 3-8 parts of bunge corydalis herbs, 5-15 parts of plantain herbs, 5-15 parts of herba hyperici japonica, 10-20 parts of climbing violet herbs and 5-15 parts of cape jasmine, and the raw materials are fresh medicines. When the external-application Chinese herbal medicine is prepared, the five fresh raw material medicines are taken in weight proportion, mixed and pounded into pulp, and the external-application Chinese herbal medicine can be obtained. The Chinese herbal medicine has the functions of clearing heat, reducing inflammation, detoxifying, purging intense heat, cooling blood, inducing diuresis, removing dampness, dispelling wind, eliminating stasis to subdue swelling and the like, the Chinese herbal medicine is externally applied to neonatal hand-wrist joints, is soaked to aortas through skin moisture permeability and rapidly enters the liver and the gallbladder and the human body, detoxifying and inflammation diminishing are carried out through blood circulation, the normal metabolic function of bilirubin is recovered, jaundice disease is rapidly cured, pains, caused by the western medicine blood exchanging treating method, the adrenal cortex hormone treating method, traditional Chinese medicine enema and the like, of neonatus are overcome, the problem that difficult neonatus medicine taking caused by oral medicine is solved, a preparing method is simple, the raw materials are easy to obtain, the cost is low, and the treating effect is good.

The invention belongs to the field of medical technology, and relates to a pharmaceutical composition for treating dermatitis and a preparation method thereof. The pharmaceutical composition for treating dermatitis is prepared by mixing the following materials: glycerin monostearate, PEG-100 stearate, liquid paraffin, emulsifier 60, stearic acid, glycyrrhetinic acid, DC250dimethicone, lauryl potassium phosphate, glycerol, diphenhydramine hydrochloride, purified water, propylene glycol, menthol, camphor and tetracaine hydrochloride. Based on the common biochemical character and symptom of the dermatitis, diphenhydramine antihistamine is added in the formula, so that the histamine level of inflammatory response on a dermatitis part is reduced. Besides, the licorice extract of glycyrrhetinic acid is added, so that the skin is stimulated to secrete adrenal cortex hormone at the physiological level, and the phenomenon that the cortical hormone level is higher than the physiological level which can be borne by the skin of the human body as the adrenal cortex hormone is externally used and supplemented is avoided.