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Anterior pituitary adrenocortical extract nano-liposome composite medicine, its preparation method and use

A technology of adrenal cortex and nano-liposomes, applied in the field of medicine, can solve the problems of human immunosuppression, strengthening the ulcer-induced effect of glucocorticoids, and the negative feedback effect of adrenal cortex

Inactive Publication Date: 2005-10-26
蔡海德
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, when the dose of glucocorticoids is large, it is easy to cause human immunosuppression, proteolysis and negative feedback to the adrenal cortex; aspirin and other non-steroidal anti-inflammatory drugs will strengthen the ulcer-causing effect of glucocorticoids
Although the existing pituitary anterior lobe adrenal cortex extract injection does not have the above-mentioned side effects, patients with painful injections will refuse to use it

Method used

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  • Anterior pituitary adrenocortical extract nano-liposome composite medicine, its preparation method and use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Prepare raw materials according to weight ratio as follows:

[0046] Pituitary adrenal cortex extract 8mg×1000

[0047] Reduced glutathione 1.2mg×1000

[0048] Lecithin or soybean lecithin 9.8mg×1000

[0049] Cholesterol 9mg×1000

[0050] Phosphate buffer solution of 0.01mol / L, pH value 2.5-3.0 2000mg×1000

[0051] Packed into 1000 sticks

[0052] Production operation:

[0053] (1) Dissolve 9800mg of lecithin or soybean lecithin with 30ml-50ml of absolute ethanol (analytically pure), and add dropwise to about 1200ml of phosphate buffer solution with a pH of 2.5-3.0 and a concentration of 0.01mol / L under stirring In the process, stir the mixture evenly, and distill under reduced pressure at 60°C±5°C until the ethanol evaporates completely.

[0054] (2) Put the liquid obtained in step 1 into a tissue pounder and stir for 5-10 minutes, then steam sterilize at 115°C-121°C for 15 minutes. Ultrasonic stirring was performed twice, each time for 10 minutes.

[0055] (3) A...

Embodiment 2

[0058] Prepare the raw materials according to the weight ratio as follows

[0059] Pituitary adrenal cortex extract: 16mg×1000 (molecular weight less than 8000)

[0060] Reduced glutathione 9mg×1000

[0061] Lecithin or soybean lecithin 18mg×1000

[0062] Cholesterol 17mg×1000

[0063] Phosphate buffer 0.01mol / L pH2.5-3.0 2000mg×1000

[0064] Packed into 1000 sticks

[0065] Production operation: with embodiment 1

[0066] Prepare freeze-dried injection of the present invention

[0067] Example 1

[0068] Prepare the raw materials according to the weight ratio as follows

[0069] Pituitary anterior lobe adrenal cortex extract with molecular weight less than 8000: 8mg×1000

[0070] 0.01mol / L, pH2.5-3.0 phosphate buffer 3000mg×1000

[0071] Reduced glutathione 1.2mg×1000

[0072] Lecithin or soybean lecithin 9.8mg×1000

[0073] Cholesterol 9.0mg×1000

[0074] Dextran-40 2mg×1000

[0075] Mannitol 7mg×1000

[0076] Packed into 1000 sticks

[0077] Preparation Proce...

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Abstract

A composite nanoliposome medicine in the form of liquid injection or freeze-dried powder injection for treating arthritis, viral cold, etc is prepared from anterior lobe of the hypophysis and adrenal cortex through extracting. It spreparing process is also disclosed.

Description

technical field [0001] The present invention relates to a kind of medicine, especially relate to a kind of nano liposome combination medicine of pituitary anterior lobe adrenal cortex extract, the preparation method of its aqueous injection and freeze-dried injection and its application in the preparation and treatment of arthritis, viral influenza, prevention and treatment. Application in medicines for the treatment of diseases such as viral influenza. Background technique [0002] Currently, the drugs used to treat rheumatoid arthritis and rheumatoid arthritis are non-steroidal anti-inflammatory drugs such as aspirin, glucocorticoids, and the like. However, when the dose of glucocorticoid is large, it is easy to cause human immunosuppression, proteolysis and negative feedback to the adrenal cortex; non-steroidal anti-inflammatory drugs such as aspirin will strengthen the ulcer-causing effect of glucocorticoid. Although the existing pituitary anterior lobe adrenal cortex e...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/55
Inventor 蔡海德
Owner 蔡海德
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